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Matthew Clark
Matthew Clark, Darlington GB
| Patent application number | Description | Published |
|---|---|---|
| 20100224450 | REVERSIBLE OIL PAN WITH INTEGRATED OIL SUCTION TUBE - A reversible oil pan assembly including an oil suction tube. In one aspect, an oil pan assembly includes an oil pan and a suction tube connected to the oil pan. The suction tube includes an inlet to draw oil from the oil pan, and a plurality of outlets, each outlet configured to output oil that has been moved through the suction tube from the inlet. | 09-09-2010 |
Matthew Clark, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090062147 | Methods for synthesis of encoded libraries - The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. | 03-05-2009 |
| 20100120771 | AURORA KINASE INHIBITORS FROM AN ENCODED SMALL MOLECULE LIBRARY | 05-13-2010 |
| 20100120772 | P38 KINASE INHIBITORS - Compounds of formula (I) and (II) are disclosed, as well as methods for their identification, their preparation, pharmaceutical compositions containing them, and their use in treating disease. The compounds inhibit the production of TNF-alpha and interleukins (IL) by the inhibition of p38 kinase. They are useful in the treatment of inflammation and arthritis. | 05-13-2010 |
| 20110136697 | METHODS FOR SYNTHESIS OF ENCODED LIBRARIES - The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. | 06-09-2011 |
Matthew Clark, New York, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090193732 | Method and System for Twisting Building Construction - A structure and method of construction for a building, includes a core wall structure, a plurality of support walls attached to the core wall structure and cantilevered from the core wall structure, a plurality of floor structures arranged vertically and attached to the core wall structure so that each floor structure of the plurality of floor structures is supported from below by a first set of the plurality of support walls and from above by a second set of the plurality of support walls, a position of the second set of the plurality of support walls radially offset from a position of the first set of the plurality of support walls, and a plurality of openings in the core wall, wherein at least one opening is provided between any two successive floor structures and alternating openings in a vertical direction are arranged to align along an angle of vertical offset. | 08-06-2009 |
| 20110219712 | METHOD AND SYSTEM FOR TWISTING BUILDING STRUCTURE - A structure and method of designing and constructing a building that includes a core wall structure, a plurality of support walls attached to and cantilevered from the core wall structure, a plurality of floor structures arranged vertically and attached to the core wall structure so that each floor structure of the plurality of floor structures is supported from below by a first set of the plurality of support walls and from above by a second set of the plurality of support walls, a position of the second set of the plurality of support walls radially offset from a position of the first set of the plurality of support walls, and a plurality of openings in the core wall, wherein at least one opening is provided between any two successive floor structures and alternating openings in a vertical direction are arranged to align along an angle of vertical offset. | 09-15-2011 |
Matthew Clark, Dacula, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20090192244 | NATURAL RUBBER LATEX HAVING REDUCED ALLERGENICITY AND METHOD OF MAKING - A rubber latex composition is disclosed having reduced allergenicity. Methods for producing a rubber latex composition having reduced allergenicity are also disclosed. | 07-30-2009 |
Matthew Clark, Wayne, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090094012 | METHODS AND SYSTEMS FOR GRAND CANONICAL COMPETITIVE SIMULATION OF MOLECULAR FRAGMENTS - Methods and systems for analyzing a macromolecule for potential binding sites are disclosed. Multiple molecular species and a free energy value may be selected. An operation for a molecular fragment of one of the molecular species may be selected from insertion, deletion and movement operations. The selected operation may be performed on a computer representation of an instance of a molecular fragment at one of a plurality of binding sites based on a grand canonical ensemble probability density function associated with the selected operation. Information may be stored pertaining to the plurality of binding sites. The operation selecting, performing and information storing operations may be performed multiple times. Multiple occupation probabilities may be provided based on the stored information. The occupation probabilities may include, for each molecular species, a probability that an instance of a molecular fragment of the molecular species resides at a binding site. | 04-09-2009 |
| 20090171642 | METHODS AND SYSTEMS FOR IMPROVING FREE ENERGY ESTIMATION OF FRAGMENTS - Methods and systems for estimating the free energy of molecules from a plurality of fragments are disclosed. A number of poses for each fragment in an unbound state and a sum of the free energy values for each fragment may be determined. A number of acceptable poses for each of a plurality of fragments when bound may also be determined. An entropy loss may be estimated based on at least the number of acceptable poses for each of the plurality of fragments when bound and the number of poses for each fragment in an unbound state. A free energy value may be determined for the plurality of fragments when bound based on the entropy loss. | 07-02-2009 |
| 20110130968 | Method for computing ligand - host binding free energies - Methods and systems for computing the binding free energy of a ligand to a host are disclosed. The method entails selecting random poses of a ligand, including translation, rotation, and conformation, and computing the ligand-host interaction energy. The poses are accepted or rejected based on the Metropolis criteria. The entropies of interaction are estimated from the log of the ratio of accepted poses to attempted poses. The free energy of the entire sampling region, and of sub-regions of the binding region, can be accumulated by storing the energies and acceptance ratios for both the entire region and the sub regions. In order to better shape the protein to the ligand, energy minimization of the host atoms in the region of the ligand is carried out in the presence of the lowest free-energy pose of the ligand, optionally preceded by random perturbation of the Cartesian coordinates of the host atoms in the vicinity of the ligand. | 06-02-2011 |
Matthew Clark, Blaine, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20110199225 | USE OF TOKEN SWITCH TO INDICATE UNAUTHORIZED MANIPULATION OF A PROTECTED DEVICE - An apparatus to indicate unauthorized manipulation of at least one protected device enclosed in a housing is provided. The apparatus includes a structure attached to a first portion of the housing and a token switch attached to a second portion of the housing. The token switch is operably positioned with reference to the structure. The token switch includes a plunger, and a register programmed with a value. The register is communicatively coupled with a processor in a circuit. The circuit is communicatively coupled to drive the device. The structure, the token switch, and the circuit are internal to the housing when the housing is in a closed position. The plunger and the structure are positioned to generate a current when the housing is opened. The programmed value in the register is changed by the generated current and the processor takes an action responsive to the change in the programmed value. | 08-18-2011 |
Matthew Clark, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110251089 | METHODS FOR SYNTHESIS OF ENCODED LIBRARIES - The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag. | 10-13-2011 |