Patent application number | Description | Published |
20080261237 | Inositol-Phosphate Derivatives and Method of Detecting Inositol-1-Phosphate - The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being linked to IP1 via a linkage group L, M being chosen from the following group: a tracer, an immunogen, a member of a binding partner pair, a solid support. | 10-23-2008 |
20090162861 | METHOD FOR SUPPRESSING A FRET SIGNAL, FRET SIGNAL SUPPRESSOR AGENTS AND USE IN A METHOD FOR MULTIPLEXING BIOLOGICAL EVENTS - The invention relates to a method for suppressing the FRET emitted by a reaction medium containing a pair of fluorescent FRET partner conjugates specific for a biological event, characterized in that a FRET signal killer which does not disturb said biological event is introduced into this medium. | 06-25-2009 |
20090215106 | METHOD FOR DETECTING INTRACELLULAR INTERACTION BETWEEN BIOMOLECULES - The present invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules, on living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair. | 08-27-2009 |
20090220988 | METHOD OF REVEALING A BIOLOGICAL PROCESS USING A FRET MEASUREMENT - The present invention relates to a method of revealing a biological process using a FRET measurement, which comprises the following steps:
| 09-03-2009 |
20090294691 | Method for Improving the Detection of Fluorescence Signals During a Resonance Energy Transfer - The invention concerns the use of the fluorescence polarization phenomenon to improve detection of fluorescent signals during a fluorescence resonance energy transfer (FRET). In particular, the invention concerns a method for improving signal/noise ratio in a FRET measurement. The invention also concerns an apparatus for measuring fluorescence following an energy transfer between a donor fluorescent compound and an acceptor fluorescence compound in a measurement medium. | 12-03-2009 |
20100086943 | METHOD FOR THE DETECTION OF POST-TRANSLATIONAL MODIFICATIONS - Method for the detection in homogeneous medium of a post-translational modification of a protein substrate catalyzed by a cell enzyme, characterized in that the post-translational modification reaction takes place in intact living cells, in that these cells comprise a heterologous expression vector coding for a fusion protein comprising the protein substrate and a first coupling domain and in that it comprises the following stages: (v) Incubation of the cells in the presence or in the absence of a compound to be tested capable of modulating the activity of said enzyme, (vi) Addition to the reaction medium of a first fluorescent compound member of a first pair of FRET partners covalently bonded to a coupling agent capable of binding specifically to the first coupling domain present on the protein substrate, (vii) Addition to the reaction medium of a second fluorescent compound member of this first pair of FRET partners, and covalently bonded to a binding domain specific to the site of the protein substrate having undergone the post-translational modification and not binding to the non-modified protein substrate, (i) Measurement of the FRET signal emitted by the sample, this signal being representative of the quantity of protein substrate having undergone said post-translational modification; and cells for the implementation of said method. | 04-08-2010 |
20140242611 | METHOD FOR DETECTING AND/OR QUANTIFYING AN ANALYTE AT THE SURFACE OF A CELL - The invention relates to a method for quantifying a protein of interest expressed at the surface of a cell or else present in a tissue sample, said method comprising the use of two ligands capable of binding specifically to a domain of said protein. | 08-28-2014 |
20150185150 | METHOD FOR NORMALIZING THE LUMINESCENCE EMITTED BY A MEASURING MEDIUM - The subject matter of the invention is a method for measuring the luminescence of a long-life fluorescent compound present in a measuring medium, said medium containing a biological sample, characterized in that it comprises the following steps:
| 07-02-2015 |
20150198602 | THERANOSTIC METHOD BASED ON THE DETECTION OF HER2-HER2 DIMERS - The present invention relates to an ex vivo method for determining the susceptibility of a patient suffering from cancer to respond to a therapeutic treatment based on the administration of an antibody specific for the HER2 protein, this method comprising the quantification of HER2-HER2 dimers in a tissue sample from said patient using the FRET technique. | 07-16-2015 |
Patent application number | Description | Published |
20080314716 | Finishing Machines Used to Orient Objects - An improvement to finishing machines that are used to orient objects. The finishing machine includes a hopper for receiving loose objects, such as lids, and an endless belt for extracting the lids from the hopper. The belt moves vertically upwards with the lids and sorts the lids automatically, such that only correctly-oriented lids are retained. The machine is also equipped with a combined system for ejecting and conveying oriented lids, including: a plate which covers the upper part of the belt and which extends laterally beyond the belt, downstream thereof, in order to support the lids as they are ejected from the grooves in the belt; devices for ejecting the lids from the grooves and for subsequently conveying same beyond the grooves downstream, the ejection devices including jets of propellant fluid which pass through the plate by an arrangement of eyes; and a casing which is disposed on the plate and into which the propellant fluid is introduced and maintained under pressure by a turbine, the casing extending over the entire surface of the plate. In addition, the downstream part of the casing includes a routing conveyor with an adjustable height, which transports the oriented lids toward the use stations. | 12-25-2008 |
20090166153 | Conveyor for a preparation machine used to orient objects - The invention relates to a conveyor which can be used to route oriented objects, such as caps, covers, lids, etc. from a finishing machine of the type comprising a belt, a vibrating bowl or other. The inventive conveyor consists of a module ( | 07-02-2009 |