Patent application number | Description | Published |
20100125064 | 3-Imidazolyl-Indoles for the Treatment of Proliferative Diseases - The invention relates to 3-heterocyclyl indolyl compounds capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, said compounds having the formula I, | 05-20-2010 |
20110230457 | Substituted Isoquinolinones and Quinazolinones - The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) | 09-22-2011 |
20110263560 | Organic Compounds - 3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification. | 10-27-2011 |
20120149661 | TETRA-SUBSTITUTED HETEROARYL COMPOUNDS AND THEIR USE AS MDM2 AND/OR MDM4 MODULATORS - The invention relates to tetra-substituted heteroarylic compounds of the formula (I) | 06-14-2012 |
20130281473 | SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES - The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) | 10-24-2013 |
20130317024 | PYRROLOPYRROLIDINONE COMPOUNDS - The invention relates to compounds of formula (I): | 11-28-2013 |
20140135306 | HDYROXY SUBSTITUTED ISOQUINOLINONE DERIVATIVES - The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof. | 05-15-2014 |
20140275158 | CYCLOHEXYL ISOQUINOLINONE COMPOUNDS - The invention relates to compounds of formula (I): as defined in the application. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof. | 09-18-2014 |
20140343084 | IMIDAZOPYRROLIDINONE COMPOUNDS - The invention relates to compounds of formula (I): | 11-20-2014 |
20140350010 | Pyrazolopyrrolidine Compounds - The invention relates to compounds of formula (I) as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds. | 11-27-2014 |