Patent application number | Description | Published |
20090062422 | Spinal Intervertebral Disk Replacement Material for Nucleus Pulposus and Production Method Thereof - To provide a spinal intervertebral disk replacement material for nucleus pulposus which is relatively superior in load resistance that causes smaller damage of the anulus fibrosus by insertion during operation, remains in the anulus fibrosus stably after operation, and also allows prevention of the damage of the vertebral body cartilage endplate and the anulus fibrosus surrounding the prosthetic portion by sliding, and a production method thereof. The present invention relates to a spinal intervertebral disk replacement material for nucleus pulposus, comprising a dry polyvinylalcohol gel having a percentage of saturated water content of 18 to 50 wt % that changes its shape at a shape deformation rate of 150 vol % or more by water absorption. The present invention also relates to a method of producing the spinal intervertebral disk replacement material for nucleus pulposus above, comprising a step of preparing a polyvinylalcohol gel having a percentage of saturated water content of 20 to 53 wt %, a step of converting the polyvinylalcohol gel into a polyvinylalcohol hydrogel in the hydrated state and forming it into a shape having a hollow region, a step of irradiating the polyvinylalcohol hydrogel with γ ray at an intensity of 20 to 100 kGy, and a step of drying the PVA hydrogel in such a manner that the resulting hydrogel is so deformed that the hollow region disappears. | 03-05-2009 |
20110027757 | MEDICAL DEVICE AND METHOD FOR PRODUCING THE SAME - An object is to provide a medical device having excellent antithrombotic and sliding characteristics, which can exert a cell adhesion inhibitory effect. A medical device comprising: a substrate capable of forming hydroxyl groups; and a biocompatible material layer laminated on the substrate at an appropriate position, wherein the hydroxyl groups are formed on a surface of the substrate at least at a required position by a surface treatment, while the biocompatible material layer is formed from a polymer containing phosphorylcholine groups, and wherein the substrate and the biocompatible material layer are joined via a binder layer formed from silica being covalently bonded with the hydroxyl groups and the biocompatible material, respectively. | 02-03-2011 |
20110274940 | GRAFT POLYMERIZATION METHOD AND PRODUCT OBTAINED THEREBY - Disclosed is a graft polymerization method which has solved problems involved in use of a solvent, a radical initiator and high-energy radiation when a monomer is graft-polymerized on the surface of a polymer base. The graft polymerization method is characterized in that a polymerization product is obtained by immersing a polymer base (i) having a ketone group on the surface into a reaction system containing a monomer (ii) and then irradiating the polymer base (i) with light so that polymerization of the monomer starts from the surface of the polymer base (i). | 11-10-2011 |
20120022665 | POLYMER SLIDING MATERIAL, ARTIFICIAL JOINT MEMBER, MEDICAL APPLIANCE, AND MANUFACTURING METHOD THEREFOR - Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured. | 01-26-2012 |
20120197407 | HIGHLY LUBRICATING SLIDING MEMBER AND ARTIFICAL JOINT USING SAME - Disclosed are: a sliding member which is capable of maintaining wear resistance over a long period of time; an artificial joint member in which the polymer base is reduced in thickness; and an artificial joint which exhibits high lubricating properties in the body, biocompatibility and resistance to dislocation. Specifically disclosed is a polymer sliding material which has a coating layer (B) that is composed of a graft polymer containing a phosphorylcholine group and having a density of at least 1.4 g/cm | 08-02-2012 |
20120197413 | BIOCOMPATIBLE AND LOW-ABRASION MEMBER, AND ARTIFICIAL JOINT USING THE SAME AND METHOD OF PRODUCING THE SAME - The object of the present invention is to provide a sliding member, a prosthesis and a method of producing the sliding member, which can suppress production of abrasive wear debris by suppressing friction of the sliding section, and also can maintain satisfactory mechanical characteristics in vivo. A sliding member comprising: a substrate | 08-02-2012 |
20130211527 | SPINAL INTERVERTEBRAL DISK REPLACEMENT MATERIAL FOR NUCLEUS PULPOSUS AND PRODUCTION METHOD THEREOF - The present invention is directed to a method for replacing a nucleus pulposus in an intervertebral disk, which method includes: providing a spinal intervertebral disk replacement molded-dry-product for nucleus pulposus including a polyvinylalcohol gel having a percentage of saturated water content of 18 to 50 wt % before irradiation and being irradiated with γ ray at an intensity of 20 to 100 kGy; and inserting the spinal intervertebral disk replacement molded-dry-product for nucleus pulposus into a prosthetic space inside an anulus fibrosus through an incision opening of the anulus fibrosus, wherein the molded-dry-product changes its shape into an almost cylindrical or almost elliptically cylindrical shape so that a hollow region comes into existence at a shape deformation rate of 150 vol % or more and at a volume swelling ratio of 135 vol % or less by water absorption. | 08-15-2013 |
20140170331 | BIOMATERIAL, JOINT PROSTHESIS USING THE BIOMATERIAL AND METHOD OF PRODUCING THE SAME - The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer. | 06-19-2014 |