Patent application number | Description | Published |
20080223132 | Vibration Piezoelectric Acceleration Sensor - A vibration piezoelectric acceleration sensor including a pair of diaphragms linearly and oppositely disposed on a frame, a support body supporting the diaphragm, and a holding part holding the support body slidably in a linear direction, and another pair of diaphragms disposed linearly and oppositely crossing the pair of diaphragms detecting acceleration in two axes, i.e. X and Y directions. The diaphragms are extended and retracted by the acceleration transmitted to the support body through the holding part, changing a natural oscillation frequency. Accordingly, a high change ratio of resonance frequency can be provided with the detection of the acceleration, and the acceleration in two axes directions can be detected without being affected by a change in temperature. | 09-18-2008 |
20080237039 | EXTRACELLULAR POTENTIAL SENSING ELEMENT, DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL, APPARATUS FOR MEASURING EXTRACELLULAR POTENTIAL AND METHOD OF MEASURING EXTRACELLULAR POTENTIAL BY USING THE SAME - A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell. | 10-02-2008 |
20080257726 | EXTRACELLULAR POTENTIAL SENSING ELEMENT, DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL, APPARATUS FOR MEASURING EXTRACELLULAR POTENTIAL AND METHOD OF MEASURING EXTRACELLULAR POTENTIAL BY USING THE SAME - A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell. | 10-23-2008 |
20080257727 | EXTRACELLULAR POTENTIAL SENSING ELEMENT, DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL, APPARATUS FOR MEASURING EXTRACELLULAR POTENTIAL AND METHOD OF MEASURING EXTRACELLULAR POTENTIAL BY USING THE SAME - A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding drug. The well is provided at the bottom with a depression, and a first throughhole penetrating through the depression and the lower surface of the substrate. The well is for mixing a subject cell, a culture solution and the drug together. The above-configured sensing element accurately measures a change generated by a subject cell. | 10-23-2008 |
20090035846 | DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL AND METHOD OF MANUFACTURING DEVICE - A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well and extending toward a second face of the substrate, a first hollow section communicating with the first opening via a first connecting portion, and a second opening extending reaching the second surface and communicating with the first hollow section via a second connecting portion. The first connecting portion has a diameter smaller than a maximum diameter of the first hollow section, greater than a diameter of the second connecting portion, and smaller than a diameter of the test cell. The device can retain the test cell securely and accept chemicals and the test cell to be put into the device easily. | 02-05-2009 |
20090047731 | CELLULAR ELECTROPHYSIOLOGICAL MEASUREMENT DEVICE AND METHOD FOR MANUFACTURING THE SAME - A cellular electrophysiological measurement device includes a thin plate and a frame. The thin plate has a first surface with a depression and a second surface with a through-hole. The frame is in contact with an outer periphery on the second surface of thin plate. The thin plate has a laminated structure of at least two layers including a first material layer on the first surface and a second material layer on the second surface. The frame is formed of a third material layer. The structure allows the cellular electrophysiological measurement device to be not so vulnerable to breakage of thin plate and other damages, thereby having high production yield. | 02-19-2009 |
20090081765 | CELL ELECTROPHYSIOLOGICAL SENSOR AND METHOD FOR MANUFACTURING THE SAME - In a cell electrophysiological sensor having a thin plate with a through hole, a support plate with a through hole and a container plate with a through hole stuck to an upper portion of this support plate, the support plate and the container plate are stuck to each other through fusion with a portion of the outer shape of a first electrode in a ring shape intervening in a portion of the interface. In this configuration, a cell electrophysiological sensor which allows for measurement with high precision can be attained, and a manufacturing method which is excellent in terms of mass production can be provided. | 03-26-2009 |
20090152110 | Chip For Cell Electrophysiological Sensor, Cell Electrophysiological Sensor Using The Same, and Manufacturing Method of Chip for Cell Electrophysiological Sensor - A chip for a cell electrophysiological sensor has a substrate. The substrate has a through-hole formed from the upside to the downside, and the opening of the through-hole is formed in a curved surface curved from the upside and downside of the substrate toward the inner side of the through-hole. In this configuration, the electrolyte solution (first electrolyte solution and second electrolyte solution) flows more smoothly, and the sample cell can be sucked accurately, and the trapping rate of the sample cells is improved. | 06-18-2009 |
20090250406 | COMPONENT SEPARATING DEVICE AND METHOD OF SEPARATING COMPONENT - A component separating device includes a substrate, a fluid channel provided at the substrate, an actuator and a groove provided at a surrounding of the actuator, the fluid channel contains a fluid including a liquid component and a solid component, and the actuator generates a standing wave at inside of the fluid channel. By such a constitution, a vibration loss is reduced by reflecting a vibration by the groove to be transmitted to a side of the fluid channel, the standing wave having a strong intensity is generated at inside of the fluid channel, and the small-sized highly accurate component separating device is provided. | 10-08-2009 |
20090281410 | DEVICE FOR CELLULAR ELECTROPHYSIOLOGY SENSOR, CELLULAR ELECTROPHYSIOLOGY SENSOR USING THE DEVICE, AND METHOD FOR MANUFACTURING THE CELLULAR ELECTROPHYSIOLOGY SENSOR DEVICE - A leakage current on a side surface of a sensor chip of a cell electrophysiological sensor is reduced. In order to do so, a sensor chip having a continuity hole and a chip holding part covering the side surface of the sensor chip are provided. The sensor chip includes silicon as a main component, and the chip holding part is made of glass. The chip holding part is adhesively bonded to the side surface of the sensor chip by glass welding. Thus, in the cell electrophysiological sensor device of the present invention, the airtightness between the side surface of the sensor chip and the chip holding part is improved, so that a leakage current can be reduced. | 11-12-2009 |
20100019756 | DEVICE FOR MEASURING CELLULAR POTENTIAL, SUBSTRATE USED FOR THE SAME AND METHOD OF MANUFACTURING SUBSTRATE FOR DEVICE FOR MEASURING CELLULAR POTENTIAL - A device for measuring cellular potential includes a substrate, a first electrode tank, a first electrode, a second electrode tank and a second electrode. The first electrode tank and the second electrode tank are disposed on the upper side and lower side of the substrate, respectively. The first electrode is disposed inside the first electrode tank and the second electrode is disposed inside the second electrode tank. The substrate includes a single crystal plate having a diamond structure with (100) plane orientation or (110) plane orientation. The substrate has a first surface provided with a depression and a second surface facing this first surface. From the depression to the second surface, a through-hole is formed. The depression has an inner wall extending from the opening of the through-hole to the outer periphery, curving and being connected to the first surface. | 01-28-2010 |
20100019782 | CELLULAR POTENTIAL MEASUREMENT CONTAINER - The present invention provides a cellular potential measurement container that can measure a cellular potential with high accuracy while suppressing noise even when the number of the cells to be subjected to the measurement is increased. The cellular potential measurement container includes a first solution reservoir | 01-28-2010 |
20100078323 | COMPONENT SEPARATING DEVICE AND CHEMICAL ANALYSIS DEVICE USING THE SAME - A vibrator has a large strength of a standing wave even with a low driving voltage, thereby improving the accuracy of component separation. A device according to the present invention includes a substrate having a channel groove provided in an upper surface of the substrate, a seal provided above the substrate so as to cover an upper opening of the channel groove, a projection provided on an outer side wall opposite to the channel groove, and a vibrator causing the projection to warp and vibrate in a depth direction of the channel groove. The warping vibration of the projection is amplified due to effect of leverage, and generates a large stress on the outer wall of the channel groove having the projection provided thereon. Consequently, the strength of a standing wave in the channel groove increases even for a low driving voltage, thereby improving the accuracy of component separation. | 04-01-2010 |
20100126922 | COMPONENT SEPARATION DEVICE - A component separating device includes a flow channel, an acoustic wave generator for generating an acoustic wave in the flow channel, a first inlet channel for introducing a fist solution containing solid particles into the flow channel, a second inlet channel for introducing a second solution, and outlet channels for discharging a solution from the flow channel. A density grade generator is provided at the first inlet channel for forming a density grade of the solid particles. This component separating device extracts the solid particles into a high-purity solution at a high collecting rate. | 05-27-2010 |
20100147682 | PROBE FOR MEASURING ELECTRIC POTENTIAL OF CELL - A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottom surface of the first cavity. The first flow passage having first and second openings is provided in the plate. The first and second openings of the first flow passage open to the second cavity and outside the plate, respectively. The sensor element includes a thin plate, and a supporting substrate provided around the thin plate and in the first cavity of the plate. The thin plate has a through-hole therein having a first opening and a second opening communicating with the second cavity of the plate. The first flow passage allows fluid to flow therein. A sucking device is coupled with the second opening of the first flow passage as to suck the fluid flowing in the first flow passage. This probe can measure an electric potential of a cell floating in solution as it is in this environment. | 06-17-2010 |
20100170790 | BIOSENSOR - A sensor includes a diaphragm having a through-hole ( | 07-08-2010 |
20100203621 | BIOSENSOR - A biosensor has the following elements: a diaphragm having a through-hole; a frame supporting the diaphragm and having a cavity; and pillars formed on the side of inner wall surface of the frame and on the surface of the diaphragm. This structure can suppress the occurrence of bubbles in the vicinity of the through-hole, and easily remove the remaining bubbles. Thus the measuring reliability of the biosensor can be improved. | 08-12-2010 |
20100219488 | SILICON STRUCTURE, METHOD FOR MANUFACTURING THE SAME, AND SENSOR CHIP - A silicon structure of the present invention is provided with a silicon substrate ( | 09-02-2010 |
20100270148 | CELL ELECTROPHYSIOLOGICAL SENSOR - A cell electrophysiological sensor is provided with: a well having a wall formed by at least one curved face, with opening sections being formed on the two ends thereof; a frame substrate having a through hole and an electrode; a cell electrophysiological sensor chip that is provided with a thin plate having a second through hole; and a void substrate, and in this structure, the frame substrate has a thickness greater than the thickness of the cell electrophysiological sensor chip and the opening diameter of the third opening section is made larger than the opening diameter of the fourth opening section. | 10-28-2010 |
20110111984 | SEQUENCER - A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon; and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion. | 05-12-2011 |
20110120864 | CELLULAR ELECTROPHYSIOLOGY SENSOR CHIP AND CELLULAR ELECTROPHYSIOLOGY SENSOR USING THE CHIP, AND METHOD OF MANUFACTURING CELLULAR ELECTROPHYSIOLOGY SENSOR CHIP - A cellular electrophysiology sensor is adapted to measure an electrical change of a test cell. A chip for the sensor includes a diaphragm, and a thermally-oxidized film mainly containing silicon dioxide on the diaphragm. The diaphragm includes a silicon layer and a silicon dioxide layer on an upper surface of the silicon layer. A through-hole passing through the silicon layer and the silicon dioxide layer is formed. The through-hole has an opening which opens at the silicon dioxide layer and is adapted to capture the test cell. The thermally-oxidized film is provided on an inner wall surface of the through-hole, and unified with the silicon dioxide layer at the opening of the through-hole. This cellular electrophysiology sensor chip can stably capture the test cell and provides a gigaseal stably even if test cells have different properties, | 05-26-2011 |
20110126590 | PROCESS FOR PRODUCING CELL ELECTROPHYSIOLOGICAL SENSOR AND APPARATUS FOR PRODUCING THE CELL ELECTROPHYSIOLOGICAL SENSOR - A process including holding sensor chip; holding glass tube surrounding the outer periphery of the side surface of sensor chip; applying a wind pressure to the side surface of glass tube from the outside of glass tube and melting glass tube to be glass-welded to the side surface of sensor chip. Thereby, the outer periphery of sensor chip can be surrounded by a highly hydrophilic glass tube. Thus, a cell electrophysiological sensor with high measurement accuracy can be produced. | 06-02-2011 |
20110232794 | FLOW CHANNEL STRUCTURE AND METHOD OF MANUFACTURING SAME - A flow channel structure includes a substrate having a flow channel formed therein, and plural fibrous bristles extending from the inner wall of the flow channel. The flow channel is configured to allow a solution to flow through the flow channel. The inner wall of the flow channel is made of silicon. The flow channel is configured to allow a solution to flow through the flow channel. This flow channel structure can homogenize the solution inside the flow channel. | 09-29-2011 |
20110267621 | SURFACE PLASMON RESONANCE SENSOR, LOCALIZED PLASMON RESONANCE SENSOR, AND METHOD FOR MANUFACTURING SAME - A surface plasmon resonance sensor includes a substrate, a dielectric film having a nonlinear optical effect on a first surface of the substrate, and a probe fixed to the dielectric film. A plasmon resonance is produced by resonating a surface plasmon generated on the first surface of the substrate with an evanescent wave generated on a second surface of the substrate by incident light radiated to the second surface. The plasmon resonance is detected by measuring a change of a component of light reflected on the second surface of the substrate. The component of the reflected light is caused by the nonlinear optical effect. This surface plasmon resonance sensor has a high measuring sensitivity. | 11-03-2011 |
20120009097 | FLOW PATH DEVICE - A flow path device includes a substrate having a trench and columns extending from a bottom of the trench. The trench is configured to have a fluid flowing therein. Each of columns has a side surface having grooves formed therein. The grooves have an annular shape or an arcuate shape. This flow path device reduces damage to the columns, and has a high reliability. | 01-12-2012 |
20120213671 | MEASURING DEVICE - A measuring device includes a first substrate; and a second substrate bonded on the first substrate. The second substrate has at least two inflow ports, at least two outflow ports, and an injection port. The two inflow ports, the two outflow ports, and the injection port penetrate the second substrate. The first substrate includes partition wall portions opposing to each other, and forming a first cavity between the partition wall portions, and forming at least two second cavities close against one of the partition wall portions. Each second cavity is provided adjacent to the first cavity. Through holes are provided in the respective partition wall portions to connect the first cavity and the second cavity to each other, and the through holes are adapted to capture an object to-be-tested introduced in the first cavity. | 08-23-2012 |
20120325657 | SENSOR DEVICE - A sensor device includes a substrate and a sensor chip held on the substrate. The substrate includes a flow channel. The sensor chip includes a plate. The plate includes a first surface and a second surface opposite to the first surface. A plurality of through holes each penetrates through the first surface and the second surface. A direction of a line segment connecting centers of any two adjacent through holes among the plurality of through holes is neither parallel nor perpendicular to the center line of the flow channel. | 12-27-2012 |
20130001149 | FILTER DEVICE - A filter device of the present disclosure includes a first port from which a solution containing a substance is to be input, and a first flow passage communicating with the first port. A filter portion made of a plurality of fibrous substances including inorganic oxide is formed in at least one part in the first flow passage. The plurality of fibrous substances has one peak in the diameter distribution. | 01-03-2013 |
20130005614 | SILICON STRUCTURE, ARRAY SUBSTRATE USING THE SAME AND METHOD FOR PRODUCING SILICON STRUCTURE - A silicon structure has a substrate, a first layer formed on a surface of the substrate, and a fibrous film formed on a surface of the first layer. The first layer and the fibrous film are silicon compounds made of the same elements, and the first layer and the fibrous film are directly bonded together. | 01-03-2013 |
20130008786 | SENSOR CHIP AND STORAGE METHOD THEREOF - A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon. | 01-10-2013 |
20130011318 | APPARATUS FOR PRODUCING METAL OXIDE NANOFIBERS AND METHOD FOR PRODUCING METAL OXIDE NANOFIBERS - An apparatus for producing metal oxide nanofibers includes a jetting unit, a mixing unit, a heating unit, and a cooling unit. The jetting unit jets particles made of a metal. The mixing unit prepares a mixture by mixing the metal particles and a gas containing an oxidizing component that includes oxygen in molecules of the component. The heating unit heats the mixture to raise the temperature of the mixture up to a temperature at which the metal evaporates. The cooling unit cools the product thus-produced in the heating unit. | 01-10-2013 |
20130015065 | MEASURING DEVICEAANM Nakatani; MasayaAACI HyogoAACO JPAAGP Nakatani; Masaya Hyogo JPAANM Takahashi; MakotoAACI OsakaAACO JPAAGP Takahashi; Makoto Osaka JP - A measuring device is configured to measure a reaction of test objects suspended in a first liquid. The measuring device includes a base and a vibration generator. The base has a first cavity and second cavities provided therein. The first cavity is configured to store the first liquid. The vibration generator generates a standing wave in the first liquid stored in the first cavity. The base has through-holes provided therein. Each of the through-holes allows respective one of the second cavities to communicate with the first cavity. The through-holes have opening sections. The opening sections open to the first cavity and are configured to capture the test objects. This measuring device can measure a test objects with a high efficiency. | 01-17-2013 |
20130017450 | SHEET-LIKE FIBER STRUCTURE, AND BATTERY, HEAT INSULATION MATERIAL, WATERPROOF SHEET, SCAFFOLD FOR CELL CULTURE, AND HOLDING MATERIAL EACH USING THE SHEET-LIKE FIBER STRUCTURE - A sheet-like fiber structure including a plurality of fibers made of amorphous silicon dioxide. The plurality of fibers are intertwined with each other and thus connected to each other, thereby forming void portions. Consequently, the sheet-like fiber structure has not only liquid permeability and voltage resistance but also high heat resistance and chemical resistance. The sheet-like fiber structure is therefore applicable to a separator for preventing a short circuit between electrodes, a scaffold for cell culture, to holding a biomolecule, or the like. | 01-17-2013 |
20130017979 | SENSOR SUBSTRATE AND ARRAY SUBSTRATE USING THE SAME - A sensor substrate includes a base and fibrous projections on an upper surface of the base. The fibrous projections have fixed ends fixed to the upper surface of the base and free ends opposite to the fixed ends, respectively. The fibrous projections provide a fixed end-side region including the fixed ends and a free end-side region including the free ends. The total surface area at which the fibrous projections in the fixed end-side region is larger than that in the free end-side region. | 01-17-2013 |
20130040094 | FIBROUS PROJECTIONS STRUCTURE - A silicon structure of the present invention is provided with a silicon substrate ( | 02-14-2013 |
20130045536 | CELL CULTURE SUBSTRATE AND CELL CULTURE METHOD USING SAME - The present invention provides a cell culture substrate capable of culturing cells efficiently. The cell culture substrate of the present invention includes a substrate, a plurality of fibrous protrusions formed on the substrate, and water-repellent film formed on a surface of each of the fibrous protrusions. The fibrous protrusions are intertwined with each other to form a matrix structure. According to such a cell culture substrate, when a culture solution containing a specimen is discharged to the water-repellent fibrous protrusions, cells can be cultured easily without contact, thus enabling cells to be cultured efficiently. | 02-21-2013 |
20130102099 | METHOD OF MANUFACTURING CELLULAR ELECTROPHYSIOLOGY SENSOR CHIP - A cellular electrophysiology sensor is adapted to measure an electrical change of a test cell. A chip for the sensor includes a diaphragm, and a thermally-oxidized film mainly containing silicon dioxide on the diaphragm. The diaphragm includes a silicon layer and a silicon dioxide layer on an upper surface of the silicon layer. A through-hole passing through the silicon layer and the silicon dioxide layer is formed. The through-hole has an opening which opens at the silicon dioxide layer and is adapted to capture the test cell. The thermally-oxidized film is provided on an inner wall surface of the through-hole, and unified with the silicon dioxide layer at the opening of the through-hole. This cellular electrophysiology sensor chip can stably capture the test cell and provides a gigaseal stably even if test cells have different properties. | 04-25-2013 |
20130288350 | SENSOR - A sequencer that measures a nucleic acid sequence in a nucleic acid strand includes: a base material having a surface made of silicon, and a fibrous protrusion that is made of silicon dioxide and is directly joined to the surface of the base material made of silicon, wherein a plurality of the nucleic acid strands are fixed onto the fibrous protrusion. | 10-31-2013 |
20140004527 | DIAGNOSIS KIT AND METHOD OF USING THE SAME | 01-02-2014 |
20150014552 | FLUORESCENCE DETECTION DEVICE - To provide a fluorescence detection device that can effectively remove autofluorescence using a simple configuration. A fluorescence detection device comprises: semiconductor laser for emitting excitation light; an objective lens for converging excitation light onto a sample on a biosensor substrate; an anamorphic lens which introduces astigmatism to fluorescence that is from the biosensor substrate and incident on the objective lens and that passed through the objective lens; a spectral element for separating the fluorescence into a plurality of light rays; and a fluorescence detector for receiving the light rays separated by the spectral element. On the light receiving surface of the fluorescence detector, the spectral element splits the fluorescence so that the fluorescence generated at the sample is separated from the fluorescence generated at a specific depth position other than the sample position. | 01-15-2015 |
20150031121 | SAMPLE HOLDING CARRIER AND FLUORESCENCE DETECTION DEVICE USING SAME - Disclosed is a sample holding carrier allowing samples to be measured accurately, and a fluorescence detection device for use with the sample holding carrier. A biosensor substrate includes a base substrate, a plurality of wells formed on a first surface side of the base substrate; and grooves formed on the first surface side of the base substrate separately from the wells and generating fluorescence under exposure to excitation light. The fluorescence detection device applies excitation light to the grooves, thereby figuring out the level of the fluorescence to be detected from the biosensor substrate. As a result, the fluorescence detection device can amplify the detection signals of the fluorescence generated when the excitation light is applied to the wells to an appropriate level, thereby accurately detecting the fluorescence generated in the samples. | 01-29-2015 |
20150048256 | SAMPLE HOLDING CARRIER, AND FLUORESCENCE DETECTION SYSTEM AND FLUORESCENCE DETECTION DEVICE THAT USE SAME - The present invention provides a sample holding carrier that can accurately measure a sample with a simple configuration, and a fluorescence detection system and device that use the same. Biosensor substrate includes: base substrate on which excitation light is incident from a lower surface; reflecting film that is arranged on an upper surface of base substrate to partially reflect the excitation light; and plural wells that are arranged on an upper surface side of reflecting film and have bottom surface portions. The excitation light is converged to be incident on base substrate. Distance from reflecting surface that is of a boundary between reflecting film and base substrate to bottom surface portion of well is less than or equal to a focal depth of the excitation light. Therefore, the sample accommodated in bottom surface portion of well can surely and efficiently be irradiated with the excitation light, and accurately be measured. | 02-19-2015 |