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Masahiko Hagihara

Masahiko Hagihara, Ube-Shi JP

Patent application numberDescriptionPublished
20090170887Novel indazole derivative having spiro ring structure in side chain - An object of the present invention is to create a novel indazole derivative having a spiro ring structure in a side chain, which is useful as a pharmaceutical, and to find a new pharmacological activity of the derivative. The present invention compound is represented by the general formula [I] and has an excellent Rho kinase inhibitory activity. In the formula, the ring X represents a benzene ring or a pyridine ring; R07-02-2009
20090264468Methods for treating a disease in which Rho kinase is involved - A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof:10-22-2009
20110039891Methods for treating a disease in which Rho kinase is involved - A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof:02-17-2011

Patent applications by Masahiko Hagihara, Ube-Shi JP

Masahiko Hagihara, Yamaguchi JP

Patent application numberDescriptionPublished
20090036453Pyrrolopyridazinone Compound - The present invention discloses a pyrrolopyridazinone compound represented by the formula (1):02-05-2009
20090170826Acid Addition Salt of Optically Active Dihydropyridine Derivative - There is provided an excellent medicine for treating or preventing hypertension or the like. A specific acid addition salt of (R)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenyl-methylazetidin-3-yl) ester 5-isopropyl ester is useful as a medicine for treating or preventing hypertension or the like.07-02-2009
20090170827Acid Addition Salt of Dihydropyridine Derivative - There is provided an excellent medicine for treating or preventing hypertension or the like. A specific acid addition salt of 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl)ester 5-isopropyl ester is useful as a medicine for treating or preventing hypertension or the like.07-02-2009
20090203729Process for Producing High-Purity Prasugrel and Acid Addition Salt Thereof - The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.08-13-2009
20100249396BENZAZEPINONE COMPOUND - The present invention relates to a benzazepinone compound represented by the following formula (I):09-30-2010

Patent applications by Masahiko Hagihara, Yamaguchi JP