| Patent application number | Description | Published |
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| 20090087375 | ActRIIB Fusion Polypeptides and Uses Therefor - Methods and compositions for inhibiting growth and differentiation factor-8 (GDF-8) activity in vitro and in vivo are provided. The methods and composition can be used for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or glucose homeostasis. | 04-02-2009 |
| 20090087433 | ActRIIB Fusion Polypeptides and Uses Therefor - Methods and compositions for inhibiting growth and differentiation factor-8 (GDF-8) activity in vitro and in vivo are provided. The methods and composition can be used for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or glucose homeostasis. | 04-02-2009 |
| 20110020330 | ANTIBODY INHIBITORS OF GDF-8 AND USES THEREOF - The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism. | 01-27-2011 |
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| 20090215091 | DIAGNOSTIC PANEL OF CANCER ANTIBODIES AND METHODS FOR USE - The invention provides a method for detection of a malignancy in a specimen of bodily fluid. The method comprises contacting the specimen with at least two antigens selected from the group consisting of p53, IGFBP2, Topo2α, cathepsin D, cyclin B, cyclin D1, MUC1, HER-2/neu and CEA. The method further comprises incubating the specimen and the antigen for a duration and under conditions that are sufficient for the formation of immunocomplexes; and detecting the presence or absence of immunocomplex formation between the antigens and antibodies specific for the antigens in the specimen, thereby determining the presence or absence of the malignancy. Also provided is a method for monitoring the effectiveness of cancer therapy related to a malignancy in a warm-blooded animal, a method for distinguishing between Stage I and Stage II colorectal cancer in a specimen of bodily fluid. | 08-27-2009 |
| 20100010075 | COMPOUNDS FOR ELICITING OR ENHANCING IMMUNE REACTIVITY TO HER-2/neu PROTEIN FOR PREVENTION OR TREATMENT OF MALIGNANCIES IN WHICH THE HER-2/neu ONCOGENE IS ASSOCIATED - Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/neu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/neu oncogene is associated. | 01-14-2010 |
| 20100087621 | IMMUNE REACTIVITY TO HER-2/NEU PROTEIN FOR DIAGNOSIS AND TREATMENT OF MALIGNANCIES IN WHICH THE HER-2/NEU ONCOGENE IS ASSOCIATED - Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies. | 04-08-2010 |
| 20100092523 | MOLECULES AND METHODS FOR TREATMENT AND DETECTION OF CANCER - The invention provides a method for inhibiting proliferation of cancer cells, as well as methods for detecting and treating various cancers, including cancer of the ovary, breast, prostate and colon. The method comprises contacting a cancer cell with an IGF-related molecule of the invention or administering an IGF-related vaccine to the cancer patient. In one embodiment, the molecule is an immunogenic peptide derived from IGFBP-2 or from IGF1 R. The invention additionally provides methods for detecting and treating cancer using IGF-related molecules. | 04-15-2010 |
| 20100310640 | HLA-DR BINDING PEPTIDES AND THEIR USES - The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines. | 12-09-2010 |
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| 20080243354 | Prediction based engine control system and method - A prediction based engine control system is disclosed. The engine control system may have sensor configured to sense a current engine operation and generate a corresponding signal and a controller in communication with the sensor. The controller may be configured to receive the signal, compare the current engine operation to an allowable range of engine operation, predict a future engine operation based on the signal, and limit current engine operation based on the prediction, even when the current engine operation is within the allowable range of operation. | 10-02-2008 |
| 20080312756 | Virtual sensor system and method - A method is provide for providing sensors for a machine. The method may include obtaining data records including data from a plurality of sensors for the machine and determining a virtual sensor corresponding to one of the plurality of sensors. The method may also include establishing a virtual sensor process model of the virtual sensor indicative of interrelationships between at least one sensing parameters and a plurality of measured parameters based on the data records and obtaining a set of values corresponding to the plurality of measured parameters. Further, the method may include calculating the values of the at least one sensing parameters substantially simultaneously based upon the set of values corresponding to the plurality of measured parameters and the virtual sensor process model and providing the values of the at least one sensing parameters to a control system. | 12-18-2008 |
| 20100050025 | Virtual sensor network (VSN) based control system and method - A method for providing a virtual sensor network based system. The method may include obtaining project data descriptive of a virtual sensor network to be used in a control system of a machine; establishing a virtual sensor network including a plurality of virtual sensors based on the project data. Each virtual sensor may have a model type, at least one input parameter, and at least one output parameter. The method may also include recording model information, measurement data, and performance information of the virtual sensor network including the plurality of virtual sensors; creating one or more calibration certificates of the virtual sensor network including a plurality of virtual sensors based on the model information, the measurement data, and the performance information; and generating a documentation package associated with the virtual sensor network. The documentation package may include at least an identification, the project data, and at least one calibration certificate of the virtual sensor network including a plurality of virtual sensors. | 02-25-2010 |
