Patent application number | Description | Published |
20080213297 | Method of producing conjugate vaccines - The present invention relates to a method of production of a hydrazide modified sugar comprising a step of reacting a sugar with a hydrazide in a reaction solvent at a pH of between 3 and 5.5, wherein the solvent comprises an aqueous based solvent and an optional polar organic co-solvent. A further aspect of the invention relates to a method of production of a polysaccharide epitope carrier protein conjugate comprising the steps of: (a) reacting a polysaccharide epitope with a hydrazide to form a hydrazide modified polysaccharide epitope; (b) reacting the hydrazide modified polysaccharide epitope with a linker that has been pre-coupled to a carrier protein. Another aspect of the invention relates to a method of production of a sugar-dihydrazide-aldehyde adduct comprising the steps of: (a) producing a hydrazide modified sugar using a method according to the invention, wherein the hydrazide modified sugar includes a further unreacted hydrazide moiety; and (b) reacting the further hydrazide moiety with the aldehyde functionality of a linker group. | 09-04-2008 |
20090005575 | Preparation of diazapentalene derivatives via epoxydation of dihydropyrroles - The present invention relates to a process for preparing a compound of formula I, | 01-01-2009 |
20090131502 | Biologically active compounds - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease and diseases involving matrix or cartilate degradation. | 05-21-2009 |
20090186831 | Tetrahydrofuro(3,2-B) pyrrol-3-one derivatives as inhibitors of cysteine proteinases - A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, | 07-23-2009 |
20090186906 | Furo[3, 2-b] pyrrol derivatives - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R | 07-23-2009 |
20090192170 | Furo[3,2-B] pyrrol -3-one derivatives and their use as cysteinyl porteinase inhibitors - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof (I), wherein: R | 07-30-2009 |
20090192322 | Tetrahydrofuro[3,2-b] pyrrol-3-one intermediates - The present invention relates to a process for preparing a compound of formula (Ia), (Ib), (Ic) or (Id), or a pharmaceutically acceptable salt, hydrate, solvate, complex or prodrug thereof, said process comprising the steps of: (A) (i) treating a compound of formula (IVa), where R | 07-30-2009 |
20090197817 | Tetrahdrofuro[3,2-B] pyrrol-3- one as cathepsin k inhibitors - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, | 08-06-2009 |
20090203714 | Furo[3,2-B]pyrrol-3-one derivatives and their use as cysteinyl proteinase inhibitors - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, | 08-13-2009 |
20090247471 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES - Compounds of general formula (I) or general formula (II):— | 10-01-2009 |
20100010009 | Furo[3,2-B] pyrrol -3-one derivatives and their use as cysteinyl porteinase inhibitors - The present invention relates to compounds of formula (1), and pharmaceutically acceptable salts thereof, A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof (I), wherein: one of R | 01-14-2010 |
20100216811 | FURO[3. 2-B] PYRROL DERIVATIVES - The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein: R | 08-26-2010 |
20130252969 | Compounds - A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, | 09-26-2013 |
20140038944 | FURO[3, 2-B] PYRR0L-3-ONES AS CATHESPIN S INHIBITORS - A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof, | 02-06-2014 |