Patent application number | Description | Published |
20110124623 | PYRROLOTRIAZINE KINASE INHIBITORS - The invention provides compounds of formula I | 05-26-2011 |
20110294816 | PYRROLOTRIAZINE KINASE INHIBITORS - The present invention provides compounds of formula I | 12-01-2011 |
20120302747 | PYRROLOTRIAZINE KINASE INHIBITORS - The invention provides compounds of formula I | 11-29-2012 |
20130184254 | AZAINDAZOLE COMPOUNDS - Disclosed are azaindazole compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein W is CR | 07-18-2013 |
20130231354 | SUBSTITUTED AZAINDAZOLE COMPOUNDS - Disclosed are azaindazole compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein: Q is: (i) 5-membered heteroaryl comprising at least one nitrogen heteroatom and substituted with zero to 2 Rg; or (ii) 9- to 10-membered bicyclic heteroaryl selected from Formula (II) and; wherein Ring A is a 5- to 6-membered aryl or heteroaryl fused ring substituted with zero to 2 Rg; and R1, R2, R3, and Rg are defined herein. Also disclosed are methods of using such compounds in the treatment of at least one CYP17 associated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds. | 09-05-2013 |
20130281657 | MACROCYCLES AND MACROCYCLE STABILIZED PEPTIDES - The invention provides methods of preparing macrocycles including macrocycle stabilized peptides (MSPs). Macrocycles and MSPs are prepared according to nucleophilic capture of an iminoquinomethide type intermediate generated from a suitably substituted 2-amino-thiazol-5-yl carbinol. The preferred nucleophile may be selected from an electron rich aromatic moiety in the case of macrocycles and, in the case of MSPs, at least one amino acid comprises an electron rich aromatic moiety. In addition, the concept can be extended to other related 5-membered heterocyclic systems in place of the thiazole, such as imidazole or oxazole. The conditions for the generation of the corresponding iminoquinomethide type intermediates may be similar or different than the conditions used for the 2-amino-thiazol-5-yl carbinol. | 10-24-2013 |
20150231152 | FLUOROALKYL AND FLUOROCYCLOALKYL 1,4-BENZODIAZEPINONE COMPOUNDS - Disclosed are compounds of Formula (I): (Formula (I)) wherein: R | 08-20-2015 |
20150274679 | SUBSTITUTED 1,5-BENZODIAZEPINONES COMPOUNDS - Disclosed are compounds of Formula (I): wherein: R | 10-01-2015 |