Patent application number | Description | Published |
20080284187 | MICROFABRICATED MECHANICALLY ACTUATED MICROTOOL AND METHODS - Apparatus and processes are disclosed that provide a microfabricated microtool having a mechanically actuated manipulating mechanism. The microtool comprises a tweezer having flexible arms, and an actuating mechanism. A biological, electrical, or mechanical component is grasped, cut, sensed, or measured by the flexible arms. The actuating mechanism requires no electric power and is achieved by the reciprocating motion of a smooth, rigid microstructure applied against the flexible arms of the microtool. In certain implementations, actuator motion is controlled distally by a tethered cable. A process is also disclosed for producing a microtool, and in particular, by micropatterning. Photolithography may be used to form micro-molds that pattern the microtool or components of the microtool. In certain implementations, the tweezer and actuating mechanism are produced fully assembled. In other implementations, the tweezer and actuating mechanism are produced separately and assembled together. | 11-20-2008 |
20090115396 | Communicating with an Implanted Wireless Sensor - The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal. | 05-07-2009 |
20090131905 | Microneedle devices and methods of manufacture and use thereof - Microneedle devices are provided for transport of therapeutic and biological molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver fluid material into or across a biological barrier from one or more chambers in fluid connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps. | 05-21-2009 |
20090318846 | METHODS AND APPARATUS FOR SURFACE ABLATION - The various embodiments of the present invention relate generally to methods and apparatus for surface ablation. More particularly, various embodiments of the present invention are related to methods and apparatus for ablation of barrier surfaces, such as skin, to increase the permeability of the barrier surface. Embodiments of the present invention comprise rapid thermo-mechanical ablation of the skin by a microfluidic jet generated by an arc discharge to produce micron-scale holes localized to the stratum corneum, which increases skin permeability. | 12-24-2009 |
20100019778 | PHYSICAL PROPERTY SENSOR WITH ACTIVE ELECTRONIC CIRCUIT AND WIRELESS POWER AND DATA TRANSMISSION - Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna. | 01-28-2010 |
20100048744 | Particle Based Molding - Various apparatuses, arrangements, and methods are provided for creating various structures including microstructures. In one embodiment, a method for creating a microstructure is provided comprising packing a plurality of particles into a micromold, and then applying energy to the particles in the micromold. As a result of the application of energy, a microstructure is formed in the micromold out of the particles. Thereafter, the microstructure is removed from the micromold. | 02-25-2010 |
20100120626 | APPARATUS AND METHODS FOR HIGH THROUGHPUT NETWORK ELECTROPHYSIOLOGY AND CELLULAR ANALYSIS - Provided herein are apparatus and methods relating to the development of instrumentation for high throughput network electrophysiology and cellular analysis. More specifically, provided herein are multiwell microelectrode arrays (MEAs) and methods for the development of such an apparatus in an inexpensive fashion with a flexible, ANSI/SBS-compliant (American National Standards Institute/Society for Biomolecular Screening) format. Microelectrode arrays are a grid of tightly spaced microelectrodes useful for stimulating and sensing electrically active cells, networks and tissue. The techniques described herein relate to the use of microfabrication in combination with certain large-area processes that have been employed to achieve multiwell MEAs in ANSI/SBS-compliant culture well formats, which are also transparent for inverted/backside microscopy compatibility. These multiwell MEAs can be used to investigate two and three-dimensional networks of electrically active cells and tissue such as cardiac, neural, and muscular in a high throughput fashion. Also being ANSI/SBS-compliant, they are compatible with machinery and robotics developed for the pharmaceutical industry for drug screening applications. | 05-13-2010 |
20100195082 | Device, System, And Method For Multidirectional Ultraviolet Lithography - A system according to an embodiment of the present invention comprises a movable stage having a top surface. A photosensitive material may be deposited on the top surface and a mask may be placed on the photosensitive material. A vessel, having a top portion, one or more flexible sides, and a transparent base, is configured to be placed adjacent to the mask. The base is configured to be movable relative to the top portion of the vessel. In this way, the movable stage, photosensitive material, and mask may move in conjunction with the base of the vessel. | 08-05-2010 |
20120016207 | ELECTROMAGNETICALLY COUPLED HERMETIC CHAMBER - An electromagnetically coupled hermetic chamber includes a body defining a hermetic chamber. A distributed LC circuit is disposed within the hermetic chamber and a second conductive structure is attached to the body outside of the hermetic chamber. The distributed LC circuit is electromagnetically coupled to the second conductive structure without direct electrical paths thereby allowing coupling of the distributed LC circuit to external electronics without the need for electrical feedthroughs or vias that could compromise the integrity of the hermetic chamber. | 01-19-2012 |
20120313649 | Physical Property Sensor With Active Electronic Circuit And Wireless Power And Data Transmission - Wireless sensors configured to record and transmit data as well as sense and, optionally, actuate to monitor physical properties of an environment and, optionally, effect changes within that environment. In one aspect, the wireless sensor can have a power harvesting unit; a voltage regulation unit, a transducing oscillator unit, and a transmitting coil. The voltage regulation unit is electrically coupled to the power harvesting unit and is configured to actuate at a minimum voltage level. The transducing oscillator unit is electrically coupled to the voltage regulation unit and is configured to convert a sensed physical property into an electrical signal. Also, the transmitting coil is configured to receive the electrical signal and to transmit the electrical signal to an external antenna. | 12-13-2012 |
20130305978 | MARINE VEHICLE SYSTEMS AND METHODS - Marine vehicle systems and methods are disclosed. The marine vehicle can be buoyancy controlled, enabling efficient, extended use of the marine vehicle. Buoyancy actuation can enable roll, pitch, and yaw of the marine vehicle, as well as translation in any direction. One or more elastic bladders can be disposed on or in the marine vehicle. The bladders can be selectively inflated and deflated to control movement of the marine vehicle. | 11-21-2013 |
20130306356 | METHOD FOR MAKING ELECTRICALLY CONDUCTIVE THREE-DIMENSIONAL STRUCTURES - Methods are provided for fabricating three-dimensional electrically conductive structures. Three-dimensional electrically conductive microstructures are also provided. The method may include providing a mold having at least one microdepression which defines a three-dimensional structure; filling the microdepression of the mold with at least one substrate material; molding the at least one substrate material to form a substrate; and depositing and patterning of at least one electrically conductive layer either during the molding process or subsequent to the molding process to form an electrically conductive structure. In one embodiment, the three-dimensional electrically conductive microstructure comprises an electrically functional microneedle array comprising two or more microneedles, each including a high aspect ratio, polymeric three dimensional substrate structure which is at least substantially coated by an electrically conductive layer. | 11-21-2013 |