Maria Del Carmen
Maria Del Carmen Acosta Boj, Alicante ES
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20100286230 | MODULATION OF TRPV EXPRESSION LEVELS - The present invention relates to methods and compositions for the treatment and/or the prevention of conditions related to high levels of expression and/or activity of the transient receptor potential vanilloid-1 (TRPV1). Amongst others, the conditions to be treated are eye conditions such as discomfort and altered sensitivity of the cornea following refractive surgery, use of contact lenses, dry eyes and diabetic retinopathy. | 11-11-2010 |
Maria Del Carmen Banuls Polo, Valencia ES
Maria Del Carmen Cabrera Reyes, Mexico City MX
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20100193401 | Ionic Liquid Catalyst for Improvement of Heavy and Extra Heavy Crude - The present invention relates to improving heavy crude oil, and extra through a scheme considering the use of ionic liquids catalysts based on Mo and Fe catalyst is highly miscible with crude oil and are in the homogeneous phase crude oil. | 08-05-2010 |
Maria Del Carmen Cajarville Basaistegui, Montevideo UY
Maria Del Carmen Carmona Orozco, Terrassa ES
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20140315795 | Compositions and Methods for Selective Delivery of Oligonucleotide Molecules to Cell Types - The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a receptor which can be internalised by the cell in response to the binding of said selectivity agent. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interest and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of contrast agents to the cells for diagnostic purposes. | 10-23-2014 |
20150315575 | COMPOSITIONS AND METHODS FOR SELECTIVE DELIVERY OF OLIGONUCLEOTIDE MOLECULES TO CELL TYPES - The invention provides a conjugate comprising (i) a nucleic acid which is complementary to a target nucleic acid sequence and which expression prevents or reduces expression of the target nucleic acid and (ii) a selectivity agent which is capable of binding with high affinity to a receptor which can be internalised by the cell in response to the binding of said selectivity agent. The conjugates of the present invention are useful for the delivery of the nucleic acid to cell of interests and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of contrast agents to the cells for diagnostic purposes. | 11-05-2015 |
20160083726 | Compositions and Methods for the Treatment of Parkinson Disease by the Selective Delivery of Oligonucleotide Molecules to Specific Neuron Types - The invention provides a conjugate comprising (i) a selectivity agent which binds specifically to one or more neurotransmitter transporters selected from the group consisting of a dopamine transporter (DAT), serotonin transporter (SERT) or a norepinephrine transporter (NET) and (ii) a nucleic acid capable of specifically binding to a target molecule which is expressed in the same cell as the neurotransmitter transporter wherein said target molecule is α-synuclein or the mRNA encoding α-synuclein. The conjugates of the present invention are useful for the delivery of the nucleic acid to a cell of interest and thus, for the treatment of diseases which require a down-regulation of the protein encoded by the target nucleic acid as well as for the delivery of imaging agents to the cells for diagnostic purposes. | 03-24-2016 |
Maria Del Carmen Carneiro Freire US
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20120184452 | METHODS FOR DIAGNOSING FOLLICULAR THYROID CANCER - Methods for diagnosing follicular thyroid cancer, providing a prognosis for follicular thyroid cancer, and monitoring treatment of follicular thyroid cancer, using biomarkers that are differentially expressed in follicular thyroid cancer are provided. | 07-19-2012 |
Maria Del Carmen De Lucas Collantes, Madrid ES
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20110165264 | USE OF CILASTATIN TO REDUCE NEPHROTATOXICITY OF VARIOUS COMPOUNDS - Use of cilastatin to reduce the nephrotoxicity of different compounds. The invention refers to use of cilastatin to prepare a medicinal product to reduce the nephrotoxicity of a nephrotoxic compound that enters the cells of the proximal tubule through cholesterol rafts. The invention is based on the discovery that a great number of nephrotoxic compounds, including drugs, enter the cells of the proximal tubule through the cholesterol rafts, and that cilastatin is able to interfere with this transport mechanism, decreasing the nephrotoxicity of such compounds to a variable extent. The nephroprotective effect is common to compounds of different chemical nature and solubility and is specific for the kidney, causing no interference with the effects of nephrotoxic drugs having their targets in other organs. Therefore, administration of cilastatin allows for decreasing the nephrotoxic effects of different drugs without reducing their therapeutic effects. | 07-07-2011 |
Maria Del Carmen Fernandez Becerra US
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20120321676 | EXOSOMES DERIVED FROM RETICULOCYTES INFECTED WITH PLASMODIUM SP., METHOD FOR OBTAINING THEM AND USES THEREOF - The present invention belongs to the field of vaccines for the prevention and prophylaxis against malaria, more specifically it relates to exosomes isolated from reticulocytes infected with | 12-20-2012 |
Maria Del Carmen Hernandez-Villavicencio, Menlo Park, CA US
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20140173737 | DEVICE AND METHOD FOR REMEDIATING VULNERABILITIES - Exemplary methods, apparatuses, and systems receive data describing a first software component used by a software product and vulnerability data describing a vulnerability in the first software component. A vulnerability score is calculated for the software product based upon the vulnerability data for the first software component. The vulnerability score is recalculated for the software product based upon receiving an updated status of the vulnerability in the first software component from bug tracking software, a waiver of the vulnerability of a software component, the addition of another software component, or another update to the software product or component(s). The task of remediation of the vulnerability in the first software component can be assigned to a user and tracked. A user interface is provided to enable users to monitor the vulnerabilities of software products or components. | 06-19-2014 |
Maria Del Carmen Jimenez Arevalo, Grenoble FR
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20130260024 | METHOD FOR PRODUCING LITHIUM-BASED LAYERS BY CVD - A method for forming by CVD a lithium-based layer, according to which the lithium precursor is in liquid form in a mixture containing a solvent and a Lewis base. | 10-03-2013 |
Maria Del Carmen Luzardo Lorenzo, La Habana CU
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20130149376 | VACCINE COMPOSITION BASED ON STICHOLYSIN ENCAPSULATED INTO LIPOSOMES - The current invention relates to the field of Biotechnology applied to human health. Here it is described a vaccine vehicle wherein toxins from eukaryotic organisms are encapsulated into multilamellar vesicles obtained by the dehydration-rehydration procedure whose lipidic composition is dipalmitoylphosphatidylcholine:cholesterol in a 1:1 molar ratio for subcutaneous or intramuscular administration. These compositions do not require the use of other adjuvants. | 06-13-2013 |
Maria Del Carmen Martinez Ballesta, Murcia ES
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20140161874 | PROCESS OF PREPARATION AND USES OF PLASMA MEMBRANE VESICLES EXTRACTED FROM PLANTS ENRICHED IN MEMBRANE TRANSPORT PROTEINS - The invention relates to a method for obtaining membrane vesicles enriched in membrane transport proteins of plant origin, for cosmetic or therapeutic use, which can contain other substances, such as natural bioactive compounds. Preferably, said vesicles are obtained from plants of the Brassicaceae (cruciferae) family. In addition, the invention relates to a method for increasing these proteins of plant origin. | 06-12-2014 |
Maria Del Carmen Martinez Guerrero, Mexico City MX
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20100025303 | Application of microporous carbon adsorbent for reducing the benzene content in hydrocarbon streams - The present invention is related with the application of an adsorbent material of microporous carbon (MCA), prepared from the direct pyrolysis of copolymers generically known as Saran, in adsorption processes to reduce the benzene content in naphtha boiling range hydrocarbon streams, between 27 and 191° C., in which is preferable to perform a first separation by distillation of the C6's fraction, and a further separation of Benzene by adsorption through an adsorbent material bed, obtaining the fraction of C6's free of Benzene and an adsorbent with Benzene, which is further regenerated by pressure or temperature swing desorption or by displacement using a desorbent such as an inert gas at high temperature or by passing a desorbent which after the process, the desorbent and Benzene are separated by distillation. The fraction of C6's free of Benzene is reintegrated to the hydrocarbon stream and providing a gasoline with a Benzene content less than 1 volume %. Besides, the application of the MCA in this type of process allows obtaining Benzene with a minimum purity of 99.8 weight % and a maximum toluene content of 0.1 weight %, satisfying the specifications of ASTM D-2359-02 for Refined Benzene-535 | 02-04-2010 |
Maria Del Carmen Masdeu Margalef, Barcelona ES
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20090029996 | Pyridazin-3(2H)-One Derivatives And Their Use As Pde4 Inhibitors - The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives, to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention and suppression of related pathological conditions, diseases and disorders, in particular asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, topic dermatitis, psoriasis or irritable bowel disease. | 01-29-2009 |
Maria Del Carmen Ochoa Nieto, Navarra ES
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20120244118 | CONJUGATES AND COMPOSITIONS FOR IMMUNOTHERAPY AND ANTI-TUMORAL TREATMENT - The present invention relates to compositions capable of promoting both the innate immune response as well as the adaptive immune response in a subject based on the jointly use of ApoA, interleukin 15 and the Sushi domain of the IL15 receptor alpha chain, as well as to the use of these compositions for the stimulation of the immune response in a patient and to therapeutic methods for the treatment of infectious and neoplastic diseases. | 09-27-2012 |
Maria Del Carmen Pastoriza Rodriguez, Santiago De Compostela ES
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20120184452 | METHODS FOR DIAGNOSING FOLLICULAR THYROID CANCER - Methods for diagnosing follicular thyroid cancer, providing a prognosis for follicular thyroid cancer, and monitoring treatment of follicular thyroid cancer, using biomarkers that are differentially expressed in follicular thyroid cancer are provided. | 07-19-2012 |
Maria Del Carmen Ramos Martín, Armilla ES
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20130197073 | HYPOCHOLESTEROLEMIC, ANTI-INFLAMMATORY AND ANTIEPILEPTIC NEUROPROTECTIVE COMPOUND - The present invention describes a compound of formula (I) | 08-01-2013 |
Maria Del Carmen Ramos Martín, Armilla-Granada ES
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20110319484 | NEUROPROTECTIVE COMPOUNDS - The invention describes the use of (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl-1-naphthalenyl propanoate derivatives, optionally mono- or di-methylated at the carbon in the alpha position of propanoic acid, of formula (I), where R is CH | 12-29-2011 |
20120095091 | ANTIEPILEPTIC, HYPOCHOLESTEROLEMIC AND NEUROPROTECTIVE COMPOUND - The present invention describes a compound of formula (I) | 04-19-2012 |
Maria Del Carmen Ramos Martín, Armilla ES
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20130197073 | HYPOCHOLESTEROLEMIC, ANTI-INFLAMMATORY AND ANTIEPILEPTIC NEUROPROTECTIVE COMPOUND - The present invention describes a compound of formula (I) | 08-01-2013 |
Maria Del Carmen Ramos MartÍn, Armilla-Granada ES
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20140309295 | ANTIEPILEPTIC, HYPOCHOLESTEROLEMIC AND NEUROPROTECTIVE COMPOUND - The present invention describes a compound of formula (I) | 10-16-2014 |
Maria Del Carmen Romero Delgado, Sevilla ES
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20130199517 | MOLTEN SALT SOLAR RECEIVER AND PROCEDURE TO REDUCE THE TEMPERATURE GRADIENT IN SAID RECEIVER - Molten salt solar receiver and procedure to reduce the temperature gradient in said receiver. The receiver consists of at least one panel of semi cylindrical geometry, formed by a combination of vertical pipes. The receiver ( | 08-08-2013 |
Maria Del Carmen Rotger Pons, Palma De Mallorca ES
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20110294772 | USE OF CYCLOSQUARAMIDE COMPOUNDS AS ANTI-TUMOUR AGENTS - Use of squaramide-based macrocylic compounds as kinase inhibitor agents and as anti-tumour agents. More specifically, said compounds are used to treat diseases such as cancer, diabetes, neurodegenerative diseases, HIV replication, etc. Furthermore, the present invention likewise relates to pharmaceutical compositions that contain said compounds | 12-01-2011 |
Maria Del Carmen Serra Comas, Esplugues De Llobregat (barcelona) ES
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20110207769 | STABLE CRYSTALLINE SALT OF (R)-3-FLUOROPHENYL-3,4,5-TRIFLUOROBENZYLCARBAMIC ACID 1-AZABICYCLO [2.2.2]OCT-3-YL ESTER - The present invention refers to a stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo[2.2.2]oct-3-yl ester and its use as medicament, in particular for the treatment of urinary incontinence or other diseases involving genitourinary disorders | 08-25-2011 |
20140051721 | STABLE CRYSTALLINE SALT OF (R)-3-FLUOROPHENYL-3,4,5-TRIFLUOROBENZYLCARBAMIC ACID 1-AZABICYCLO [2.2.2]OCT-3-YL ESTER - The present invention refers to a stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabicyclo [2.2.2]oct-3-yl ester and its use as medicament, in particular for the treatment of urinary incontinence or other diseases involving genitourinary disorders | 02-20-2014 |
Maria Del Carmen Serra Comas, L'Hospitalet De Llobregat ES
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20100075984 | DICARBONYLIC COMPOUNDS WITH ANTIBACTERIAL ACTIVITY - Compounds of formula (I), and their pharmaceutically acceptable salts and solvates, wherein X represents —O—, —NH—, —S—, —NHC(═O)— or —NHC(═S)—; R1 represents —H or a hydrocarbon chain; R2 represents —H, alkoxy, amino, a hydrocarbon chain or a radical of a cycle; R3 represents —H, a hydrocarbon chain or a radical of a cycle; R4 represents —H or a hydrocarbon chain; alternatively R3 and R4 form together a cycle; R5 and R6 represent —H or halogen, and R7 represents —H, a hydrocarbon chain or heteroaryl, are useful against bacterial infections in animals, including humans. | 03-25-2010 |
Maria Del Carmen Thomas Carazo, Armilla ES
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20140286974 | CHIMERIC MOLECULE USEFUL IN IMMUNOTHERAPY FOR LEISHMANIASIS, WHICH INCLUDES A FRAGMENT OF THE PFR1 PROTEIN OF LEISHMANIA INFANTUM WITH SPECIFIC IMMUNODOMINANT EPITOPES - The present invention claims an isolated nucleotide sequence characterized by encoding the PFR1 protein of | 09-25-2014 |
Maria Del Carmen Trigo Romero, Cornebarrieu FR
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20160103827 | AUTOMATIC INTEGRATION OF DATA RELATING TO A MAINTENANCE OPERATION - Automation of the extraction and the consolidation of maintenance data and relates to a method and a system for automatic integration of data among a plurality of maintenance data, the plurality of maintenance data being diffused through a set of maintenance documentary elements comprising a set of directed links, the system including a processor configured for extracting a subset of pertinent links according to predetermined extraction rules and for integrating into a resultant element pertinent maintenance data sourced from a subset of pertinent maintenance documentary elements associated with the subset of pertinent links. | 04-14-2016 |
Maria Del Carmen Vall Pares, Barcelona ES
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20090324717 | Extended release pharmaceutical formulation of metoprolol and process for its preparation - The invention provides an extended release coated granule comprising a granule having a particle size ranging from 0.2 to 2 mm, a friability lower than or equal to 1% and comprising metoprolol succinate as active ingredient in an amount ranging from 10 to 75% by weight of the granule and at least one binder selected from microcrystalline cellulose and methylcellulose, coated with a film-former coating agent. It also provides a process for the preparation of said extended release coated granules, as well as pharmaceutical formulations containing them. | 12-31-2009 |
Maria Del Carmen Velazquez Pereda, San Paulo BR
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20120164196 | SERICIN CATIONIC NANOPARTICLES FOR APPLICATION IN PRODUCTS FOR HAIR AND DYED HAIR - The objective of this patent application is the application/use of sericin nanoparticles m cosmetic formulas for hair care, as an agent that bestows/gives gloss and softness and promotes maintenance of coloration in dyed hair | 06-28-2012 |
Maria Del Carmen Velazquez Pereda, Sao Paulo -Sp BR
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20110251415 | XYLITOL ESTERS AND ETHERS APPLIED AS ALTERNATIVE EMULSIFIERS, SOLVENTS, CO-EMULSIFIERS AND PRESERVATIVE SYSTEMS FOR PHARMACEUTICAL AND COSMETIC PRODUCTS - This patent application has as purpose the application/utilization of esters and ethers derived from xylitol, obtained by organic synthesis, as alternative emollient, moisturizing, emulsifier and co-emulsifier and preservatives for pharmaceutical, cosmetic and veterinarian products. The molecules required in this invention patent are mainly xylitol esters and ethers associated to the chains of fatty acids and alcohols (FIGS. | 10-13-2011 |
Maria Del Carmen Velazquez Pereda, Sao Paulo BR
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20120283224 | CHEMICAL STRUCTURE COMPRISING PHOSPHATES WITH POLYOL SUBSTRUCTURES FOR HAIR AND SKIN COSMETICS USAGE - A composition suitable for application to hair and/or skin comprises Phosphates Esters, such as Xylitol Phosphate Esters and other Polyol Units Phosphoric Acid Esters. This composition can be used to improve or treat skin, including scalp, conditions in cosmetic or pharmaceutical products for acne, dandruff, seborrheic dermatitis and malodor and/or can be incorporate in such formulations as a coemulsifying agent or a preservative, alone or in combination to other emulsifying or preservative agents in order to increase such activities. | 11-08-2012 |
María Del Carmen Abrahantes Pérez, La Habana CU
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20140112976 | Cyclic Peptides with an Anti-Neoplasic and Anti-Angiogenic Activity - The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems. | 04-24-2014 |
María Del Carmen Abrahantes Pérez, Ciudad De La Habana CU
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20110218138 | Pharmaceutical composition containing polypeptide fragments of serralysins - The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's “in vivo” administration has antitumoral, antiangiogenic and protective effect against malignant tumors. | 09-08-2011 |
María Del Carmen Arévalo Morales, Santiago CL
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20130209346 | CARBON ELECTRODE FROM HIGH ELECTROCATALYTIC ACTIVITY WASTES: METHOD FOR OBTAINING AND APPLICATION - The present invention refers to a procedure for obtaining a carbon electrode from acid cell wastes with extremely high electrocatalytic activity that can be used as cathode or anode for various applications such as electrochemistry, electroplating, electrolytic refining, etc. One of its most interesting applications is in the field of sensor electrodes. The process comprises the stages of: a) extraction of the carbon from the cell and then removing its covering; b) boiling in distilled water between 5 and 30 minutes; c) washing the electrode with detergent, preferably neutral; d) sanding and washing with boiling water and then with detergent until no residue is obtained; e) sonicating between 5 and 30 minutes in distilled water; f) subjecting the electrode to washing with petroleum ether or other highly nonpolar solvent; g) sonicating and washing with organic solvents from low to high polarity, ending with water and changing the water until clean water is obtained; h) boiling the electrode in a solution containing a strong oxidant and acid pH during 5 minutes to one hour; i) repeating the washing and sonication procedure if necessary; j) polishing in the conventional manner for its use; and k) if desired, it can be inserted in teflon or PVC to insulate part of the surface. The electric connection can be made by making an inner thread in the carbon. | 08-15-2013 |
María Del Carmen Arévalo Morales, Santiago CL
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20130209346 | CARBON ELECTRODE FROM HIGH ELECTROCATALYTIC ACTIVITY WASTES: METHOD FOR OBTAINING AND APPLICATION - The present invention refers to a procedure for obtaining a carbon electrode from acid cell wastes with extremely high electrocatalytic activity that can be used as cathode or anode for various applications such as electrochemistry, electroplating, electrolytic refining, etc. One of its most interesting applications is in the field of sensor electrodes. The process comprises the stages of: a) extraction of the carbon from the cell and then removing its covering; b) boiling in distilled water between 5 and 30 minutes; c) washing the electrode with detergent, preferably neutral; d) sanding and washing with boiling water and then with detergent until no residue is obtained; e) sonicating between 5 and 30 minutes in distilled water; f) subjecting the electrode to washing with petroleum ether or other highly nonpolar solvent; g) sonicating and washing with organic solvents from low to high polarity, ending with water and changing the water until clean water is obtained; h) boiling the electrode in a solution containing a strong oxidant and acid pH during 5 minutes to one hour; i) repeating the washing and sonication procedure if necessary; j) polishing in the conventional manner for its use; and k) if desired, it can be inserted in teflon or PVC to insulate part of the surface. The electric connection can be made by making an inner thread in the carbon. | 08-15-2013 |
María Del Carmen Barroso Alvarez, La Habana CU
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20140363494 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF TUMORS EXPRESSING EGFR AND GM3 N-GLYCOLYL GANGLIOSIDE (NeuGcGM3) - The present invention relates to pharmaceutical compositions for the treatment of malignant tumors. Particularly those tumors that express EGFR and GM3 N-glycolyl ganglioside targets to enhance the therapeutic effect produced by separated therapies against these targets. The pharmaceutical compositions of the invention include antibodies and/or vaccines against each of the targets. Additionally the present invention relates to methods for applying the compositions of the invention. | 12-11-2014 |
María Del Carmen Bernabeu Martínez, Rubí-Barcelona ES
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20150037406 | NOVEL CRYSTALLINE FORM OF SITAGLIPTIN SULFATE - A novel crystalline form of sitagliptin sulfate is provided. In addition, a method for obtaining the crystalline form, pharmaceutical compositions comprising the novel crystalline form and the crystalline form for use as a medicament are provided. | 02-05-2015 |
María Del Carmen Cuevas Marchante, Madrid ES
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20110118343 | Antitumoral Macrolides - Antitumoral compounds of general formula I: | 05-19-2011 |
20110207674 | ANTITUMORAL COMPOUNDS - Antitumoral compounds of Formula I, and pharmaceutically acceptable salts, derivatives, tautomers, prodrugs or stereoisomers thereof | 08-25-2011 |
20120190870 | ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS - Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus | 07-26-2012 |
20130040921 | ANTICANCER STEROIDAL LACTONES UNSATURATED IN POSITION 7 (8) - A compound of general formula (I), wherein R | 02-14-2013 |
María Del Carmen Domínguez Horta, Ciudad De La Habana CU
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20100144642 | PEPTIDES AND APL-TYPE DERIVATIVES OF HSP60 AND PHARMACEUTICAL COMPOSITIONS - Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis. | 06-10-2010 |
María Del Carmen Domínguez Horta, Ciudad De La Habana CU
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20090171069 | Peptides And Apl-Type Derivatives Of Hsp60 And Pharmaceutical Compositions - Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis. | 07-02-2009 |
20100144642 | PEPTIDES AND APL-TYPE DERIVATIVES OF HSP60 AND PHARMACEUTICAL COMPOSITIONS - Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis. | 06-10-2010 |
20120035106 | USE OF APL-TYPE PEPTIDE FOR TREATING INTESTINAL INFLAMMATORY DISEASES AND TYPE 1 DIABETES - The present invention is related with the field of the medicine, particularly with the use of an APL peptide or its analogues derived from the human heat shock protein of 60 kDa, for the manufacture of a pharmaceutical composition for the treatment of Crohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptide is biodistributed into the gastrointestinal tract and also promotes the induction of apoptosis in activated intestinal lamina propria and peripheral blood T cells of patients with Crohn's disease. Furthermore, this peptide induces apoptosis in mononuclear cells of patients with diabetes mellitus type 1. | 02-09-2012 |
María Del Carmen Durántez Delgado, Pamplona-Navarra ES
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20110268757 | USE OF PHENOL-SOLUBLE MODULINS FOR VACCINE DEVELOPMENT - The invention relates to methods for increasing immunogenicity of an antigenic peptide by means of its covalent coupling to a modulin derived peptide (PSM, phenol soluble modulin). In particular, the binding of PSMα, PSMγ and PSMδ peptides to an antigen (from a pathogen or a tumor associated protein) increases the capacity of the antigen to activate an immune response in vivo. Thus, the PSMα, PSMγ and PSMδ peptides bound to these antigens may be used in the development of vaccines for preventing or treating infectious diseases or cancer | 11-03-2011 |
María Del Carmen Escobedo Lucea, Valencia ES
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20120078136 | DEVICE FOR COLLECTING SEMEN SAMPLES - The invention relates to a device for collecting semen samples, which is configured such that the patient/donor can perform ejaculation and the corresponding semen collection in his own home, for subsequent transfer to a medical centre or laboratory where the semen can be analyzed. The invention is characterized in that it consists of a preferably plastic cylindrical tube including mouth that is provided with a peripheral flange having a rounded edge in order to allow the condom into which the patient/donor ejaculates to be securely fastened thereto, and a closure cover that is screwed onto the cylindrical tube in order to press and secure the semen-filled condom housed inside said tube. | 03-29-2012 |
María Del Carmen Fäbregas Cleveria, Madrid ES
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20120135041 | IMMUNOSUPPRESSOR BASED ON THE BLOCKAGE OF TCR-NCK INTERACTION - The present invention relates to a compound of structural formula (I) and its derivatives for use as medicinal drugs. They are preferably immunosuppressive agents, with mechanism of action based on the blockage of TCR-Nck interaction. | 05-31-2012 |
María Del Carmen Masdeu Margalef, San Sebastian - Guipúzcoa ES
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20150336889 | INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS DNA METHYLATION MODULATORS - The present invention refers to compounds of formula (I): | 11-26-2015 |
María Del Carmen Masdeu Margalef, San Sebastián ES
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20160122340 | HISTONE DEACETYLASE INHIBITORS BASED ON DERIVATIVES OF TRICYCLIC POLYHYDROACRIDINE AND ANALOGS POSSESSING FUSED SATURATED FIVE-AND-SEVEN-MEMBERED RINGS - The present invention refers to compounds of formula (I): | 05-05-2016 |
María Del Carmen Masdeu Margalef, Donostia - San Sebastian ES
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20150038545 | HYDROXYPHENYL PYRROLE COMPOUNDS CONTAINING AN HYDROXAMIC ACID AS HDAC INHIBITORS AND MEDICINAL APPLICATIONS THEREOF - The present invention refers to compounds derived from hydroxyphenyl 1H-pyrrole rings, which have the following formula (I): | 02-05-2015 |
María Del Carmen Masdeu Margalef, Donostia - San Sebastian ES
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20120196885 | NEW HISTONE DEACETYLASE INHIBITORS BASED SIMULTANEOUSLY ON TRISUBSTITUTED 1H-PYRROLES AND AROMATIC AND HETEROAROMATIC SPACERS - The present invention refers to compounds derived from trisubstituted 1H-pyrrole rings and aromatic rings, which have the following formula (I): | 08-02-2012 |
María Del Carmen Méndez Fernández, Oviedo ES
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20120270823 | AUREOLIC ACID DERIVATIVES, THE METHOD FOR PREPARATION THEREOF AND THE USES THEREOF - Aureolic acid derivatives, process for obtaining them and uses thereof. This invention provides a bacterial strain that produces compound belonging to the family of aureolic acids useful in the treatment of cancer or nervous system diseases. | 10-25-2012 |
María Del Carmen Montoliu Félix, Valencia ES
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20130177932 | EX-VIVO METHOD FOR THE EARLY DIAGNOSIS OF MINIMAL HEPATIC ENCEPHALOPATHY BY MEANS OF THE DETERMINATION OF THE 3-NITROTYROSINE IN SERUM - An ex-vivo method for the early diagnosis of minimal hepatic encephalopathy by means of determining serum 3-nitrotyrosine relates to an ex-vivo method for the detection and early diagnosis of minimal hepatic encephalopathy (MHE) in patients with liver diseases, including cirrhosis, based on the presence of specific serum biomarkers, specifically by means of determining 3-nitrotyrosine (3-NT), which comprises obtaining serum or plasma obtained from the blood of patients and controls, and determining whether or not the measurement of the concentration of 3-nitrotyrosine obtained is greater than a specific level. | 07-11-2013 |
María Del Carmen Montoliu Félix, Valencia ES
Patent application number | Description | Published |
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20130177932 | EX-VIVO METHOD FOR THE EARLY DIAGNOSIS OF MINIMAL HEPATIC ENCEPHALOPATHY BY MEANS OF THE DETERMINATION OF THE 3-NITROTYROSINE IN SERUM - An ex-vivo method for the early diagnosis of minimal hepatic encephalopathy by means of determining serum 3-nitrotyrosine relates to an ex-vivo method for the detection and early diagnosis of minimal hepatic encephalopathy (MHE) in patients with liver diseases, including cirrhosis, based on the presence of specific serum biomarkers, specifically by means of determining 3-nitrotyrosine (3-NT), which comprises obtaining serum or plasma obtained from the blood of patients and controls, and determining whether or not the measurement of the concentration of 3-nitrotyrosine obtained is greater than a specific level. | 07-11-2013 |