Maria Cecilia

Maria Cecilia Palumbi, Rome IT

Patent application number	Description	Published
20110183989	SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS - The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.	07-28-2011

Patent application number	Description	Published
20110144529	Method and Apparatus for the Objective Detection of Auditive Disorders - The invention relates to a method and apparatus for the objective detection of auditive disorders, by recording arising potentials of a steady state with simultaneous acoustic stimulation via the bones or the airway to be used in newborns. The apparatus comprises the necessary means for the independent generation of two different sound stimuli presented to the subject simultaneously via osseous and airway electroacoustic transducers, the synchronous recording of the cerebral electrical activity of the subject, the continuous evaluation of the contact of the electrodes, the interactive measurement of the levels of ambient noise, and the wireless digital transmission of the bioelectric activity towards a computer. The method according to the invention statistically processes and detects the potentials provoked by the osseous-airway stimulation, automatically providing a categorical final result, according to the presence or absence of the auditive sensitivity disorders, the type of disorder (conductive or sensorineural), and the validity of the result.	06-16-2011

Patent application number	Description	Published
20110165578	METHODS FOR DETECTING AND QUANTIFYING OVERSULFATED GLYCOSAMINOGLYCANS - The invention relates to novel methods for detecting and/or quantifying oversulfated or persulfated glycosaminoglycans based on inhibition of nucleic acid polymerases. The methods can be utilized to detect and quantify oversulfated or persulfated glycosaminoglycans in pharmaceutical preparations, such as heparin preparations or therapeutic medical devices. When used to detect or quantify oversulfated glycosaminoglycans in heparin containing solutions, the samples are prepared by treatment with heparinases to degrade the heparin. Titration of the inhibition of the activity of the polymerases allows quantitation of the oversulfated glycosaminoglycans in the sample.	07-07-2011