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Maria C.
Maria C. Buniel, Cleveland, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20080306074 | Compositions Comprising Addl Receptors, Related Compositions, and Related Methods - Disclosed and claimed herein are compositions comprising ADDL receptors, related compositions, and related methods. ADDL receptors are typically, but perhaps not exclusively, localized at the post-synaptic density (PSD) of neuronal cells. Related compositions include, but are not limited to, compounds that affect, positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise. Related methods include, but are not limited to, procedures to screen for compounds that affect, either positively or negatively, ADDL binding to neuronal cells, either via one or more receptors localized at the post-synaptic density (PSD) or otherwise. Other related methods include, but are not limited to, prevention and treatment of ADDL-related diseases, such as Alzheimer's disease, mild cognitive impairment, Down's syndrome, and the like, using compositions that inhibit, block, or otherwise interfere with ADDL binding to one or more receptors localized at the post-synaptic density of neuronal cells. | 12-11-2008 |
Maria C. Caiozzo, Portland, OR US
| Patent application number | Description | Published |
|---|---|---|
| 20100206243 | CANINE EXERCISE AND MOBILITY APPARATUS, KIT, AND SYSTEM - A canine exercise and mobility product, kit, and system is disclosed. The product may include a reconfigurable canine exercise, and mobility, apparatus. The apparatus may be reversibly reconfigurable between a first configuration and a second configuration. A contact element may be attached to a platform in the first configuration, to contact an underlying surface, and to allow the platform to tilt, and/or to wobble, while the canine stands or leans on the platform. The platform may be configured to be held by human user to control an amount, and/or a rate, of tilt, and/or wobble. A translational element may be attached to the platform in the second configuration to support the platform in a substantially stable manner, and to allow the platform to translate across the surface while supporting at least a portion of the canine's weight. | 08-19-2010 |
Maria C. Kolins, Boca Raton, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100001093 | Personal aromatherapy device - A personal device for releasing the aroma of an essential oil includes an inner flexible container received within a rigid outer shell that is open on opposite sides to expose side portions of the inner flexible container. An interior chamber of the flexible container is partially filled with cotton or other fibrous material and a charge of an essential oil that saturates the cotton material. A cap fitted to an open top end of the flexible container includes a flip nozzle with a ball valve. The flip nozzle is operable between a lowered position to close the ball valve and seal the open top of the flexible container closed, and a raised straight up position to open the ball valve and permit release of beneficial aromas of the essential oil from an open end of the nozzle upon squeezing the exposed sides of the flexible container while holding the nozzle below the user's nostrils so that the aromas are released for direct inhalation through the user's nostrils. | 01-07-2010 |
Maria C. Lepera, Huntington, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20110272055 | Device and method for transferring air from a first tire to second tire - A device and method for transferring air from a first tire to a second tire which comprises an elongated flexible tube having an air flow passageway therethrough. Two coupling adaptor components are provided, with each attached to a free end of the elongated flexible tube to engage with an air valve of one of the tires. A mechanism in each of the coupling adaptor components is for opening the air valves in one of the tires, to allow air to transfer from the second tire to the first tire that is under inflated, to balance some of the air pressure between the tires. | 11-10-2011 |
Maria C. Manduley, Miami, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100145734 | Automated claims processing system - A computer system-based automated loss verification system for evaluating the validity of claims filed under an insurance policy or debt protection contract is provided by this invention. Instead of requiring the claimant to contact the insurance company or lender to file the claim and provide exhaustive documentary proof of the validity of the claimed loss, the system pre-scores the relative risk of the claim using a risk assessment tool based upon predictive modeling and a number of potential risk factors. The associated automated loss verification tool uses this risk score and other information connected with the claim to assign a relative confidence level of proof of valid loss that must be satisfied before the claim can be approved through the adjudication process, and assigns a third-party supplied source or combination of sources of proof that can be automatically accessed by the system to validate the claim. | 06-10-2010 |
Maria C. Roque-Biewer, Davis, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100096548 | SPECTRAL CALIBRATION OF FLUORESCENT POLYNUCLEOTIDE SEPARATION APPARATUS - The invention relates to methods, compositions, and systems for calibrating a fluorescent polynucleotide separation apparatus. One aspect of the invention is multiple color calibration standards and their use. A multiple color calibration standard is a mixture of at least two polynucleotides of different length, wherein each of the polynucleotides is labeled with a spectrally distinct fluorescent dye. Another aspect of the invention is to produce total emission temporal profiles of multiple color calibration standards for use in calibrating fluorescent polynucleotide separation apparatus. The peaks corresponding to the fluorescently labeled polynucleotides in the total emission temporal profile may be detected using a peak detector that is driven by changes in the slopes of the total emission temporal profile. Calibration of fluorescent polynucleotide separation apparatus, with various embodiments of the methods of the invention, includes the step of identification of the labeled polynucleotides of the multiple color calibration standards. The process of spectral calibration of a fluorescent polynucleotide separation apparatus using a multiple color calibration standard may include the step of the estimating (extracting) of the dyes' reference spectra, using information from the peak detection process performed on the total emission temporal profile. Other aspects of the invention include systems for separating and detecting fluorescently labeled polynucleotides, wherein the system is designed for spectral calibration in accordance with the subject calibration methods employing multiple color calibration standards. Another aspect of the invention is methods and compositions for detecting the flow of electrical current through a separation channel of a fluorescent polynucleotide separation apparatus. These methods and compositions employ monitoring dyes. Monitoring dyes are fluorescent dyes that are spectrally distinct from the dye on the polynucleotide intended to convey genetic information, e.g., fluorescent polynucleotide sequencing reaction products. | 04-22-2010 |
Maria C. Sage-Umana, Clearwater, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20100269597 | PASSIVE DETECTION SYSTEMS AND METHODS - Systems and methods for passively determining when a threshold force has been exceeded. An example apparatus includes a housing and a substrate that is attached at one end to an interior portion of the housing. The substrate includes at least one conductive trace, each having two ends. The substrate is configured to fail when the threshold force has been experienced. The metal trace ends are electrically accessible from an exterior side of the housing. Prior to delivery, the housing is connected to a package that includes one or more force sensitive devices. Upon arrival of the package, the at least one conductive trace is electrically tested to determined if the substrate has failed. If the substrate has failed the package has experienced a force greater than the threshold force. | 10-28-2010 |