Marhefka
Craig Marhefka, Rockville, MD US
Patent application number | Description | Published |
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20090036654 | Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof - The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain. | 02-05-2009 |
20120065213 | C-MET PROTEIN KINASE INHIBITORS - Described herein are compounds that are useful as ROCK inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including cardiovascular, inflammatory, neurological, or proliferative diseases or disorders. | 03-15-2012 |
Duane Marhefka, Winona, OH US
Patent application number | Description | Published |
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20110128265 | VIDEO RATE ChLCD DRIVING WITH ACTIVE MATRIX BACKPLANES - A device and method providing a pixel architecture that, in at least one embodiment, contains both an on/off memory element and a switching element to utilize low-power liquid crystal displays for video or near-video applications. Such an embodiment can be implemented, for example, using a pair of TFTs for implementing the memory element and switching element on a common substrate. Other embodiments can utilize actual memory devices for the memory elements. This device and method are particularly useful for driving cholestric display elements for video or near video rate applications. | 06-02-2011 |
20120268420 | WRITING TABLET INFORMATION RECORDING DEVICE - A writing/drawing tablet utilizing a data capture device such as a pressure sensitive display with data capture component that can capture data from the resulting image drawn on the device for storage. In general, Bistable Liquid Crystal Displays (BLCD), and in particular, Cholesteric Liquid Crystal Displays (ChLCDs), can be utilized in the tablet. The tablet can also be adapted to connect to external devices for displaying images being drawn on the tablet or that were previously stored. | 10-25-2012 |
20130107144 | WRITING TABLET INFORMATION RECORDING DEVICE | 05-02-2013 |
20130342432 | Cholesteric Liquid Crystal Writing Tablet Erased By A Piezoelectric Transducer - A display device includes a cholesteric liquid crystal writing tablet and a piezoelectric transducer. The piezoelectric transducer is subjected to a mechanical force that generates a voltage that is applied to the writing tablet that erases writing on the writing tablet. A further feature is a display device comprising a cholesteric liquid crystal display and a piezoelectric transducer. The piezoelectric transducer is subjected to a mechanical force that generates a voltage that is applied to the display that places the display in at least one of a color reflective planar state, a substantially transparent focal conic state and a gray scale state. Also featured is a method of erasing a cholesteric liquid crystal writing tablet. | 12-26-2013 |
Duane W. Marhefka, Winona, OH US
Patent application number | Description | Published |
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20090284691 | Electronic skin having uniform gray scale reflectivity - The invention features electronic skin including an active layer formed of bistable cholesteric liquid crystal material and articles comprising the skin, the electronic skin having uniform gray scale reflectivity. Also featured is method for producing suitable reduction pulses that will provide a display (e.g., the electronic skin) with uniform gray scale reflectivity. Reduction pulses of narrow width are used to create uniform levels of gray in the electronic skin to overcome display imperfections that cause discontinuity in the gray scale reflectivity. | 11-19-2009 |
20120086735 | ELECTRONIC SKIN HAVING UNIFORM GRAY SCALE REFLECTIVITY - The invention features electronic skin including an active layer formed of bistable cholesteric liquid crystal material and articles comprising the skin, the electronic skin having uniform gray scale reflectivity. Also featured is method for producing suitable reduction pulses that will provide a display (e.g., the electronic skin) with uniform gray scale reflectivity. Reduction pulses of narrow width are used to create uniform levels of gray in the electronic skin to overcome display imperfections that cause discontinuity in the gray scale reflectivity. | 04-12-2012 |
20140043547 | WRITING TABLET INFORMATION RECORDING DEVICE - A drawing tablet device, utilizing a data capture device in connection with a pressure sensitive display, provides electronic information corresponding to images drawn on the pressure sensitive display to an external device. The drawing tablet includes a communication interface to couple the drawing tablet to the external device to transmit electronic information corresponding to images in real-time or as stored files. | 02-13-2014 |
John Scott Marhefka, Mansfield, OH US
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20090205407 | MACHINE FOR TESTING THE BREATH ALCOHOL (ETHANOL) CONTENT OF PERSONS HAVING DRUNK ALCOHOLIC BEVERAGES - A method for testing the breath alcohol (ethanol) content with an embedded PC computer with a touch screen display uses software graphics with icons and graphs displaying an instant representation of the flow rate and breath alcohol concentration of the breath being delivered by the person taking the test. A software graphics using icons and graphs provides control panels by which a test administrator or technician is able to control fundamental operations and adjustments of the instrument. A geared, stepped, multiple optical component placement system having dual plates retains these components, and is capable of precision placement of all components using one electro-mechanical device. An infrared optical filter system operates between 3 and 10 microns. The results are stored in memory and are capable of comparisons to empirical tables for chemical identification. | 08-20-2009 |
Joie N. Marhefka, Pittsburgh, PA US
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20140120633 | Devices and Methods for Detection and Quantification of Immunological Proteins, Pathogenic and Microbial Agents and Cells - The present invention provides a method and microfluidic immunoassay pScreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, RNA, RNA fragments, functionalized magnetic micro-beads specific to CD | 05-01-2014 |
Matthew David Marhefka, Doylestown, PA US
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20100140117 | TOILET BRUSH CADDY - A toilet brush caddy is provided, includes a unitary one-piece housing, and is capable of supporting a toilet brush. The housing includes a brush receptacle and the toilet brush includes a handle and a cleaning head having a plurality of bristles. The caddy is capable of supporting the toilet brush such that the toilet brush is supported at an angle relative to the vertical, only contacts a front side of the brush receptacle, and the bristles do not contact any other portion of the brush receptacle when the brush is supported by the caddy. | 06-10-2010 |
20110094047 | CLEANING TOOL HAVING AN ARCUATELY SHAPED CLEANING HEAD AND AN ADJUSTABLE SCRUBBER - A cleaning tool is provided and includes an arcuately shaped cleaning head and a scrubber movable between a plurality of positions. The cleaning head includes an arcuate top surface and an arcuate bottom surface substantially parallel to each other along their lengths. A plurality of cleaning implements, such as bristles, extend downward from the bottom surface and a plurality of scrubber cleaning implements, such as bristles, extend forward from the scrubber. The cleaning implements of the cleaning head increase in length from a longitudinal center of the cleaning head toward longitudinal ends of the cleaning head to provide a substantially flat and coplanar cleaning surface. The cleaning implements of the cleaning head extend substantially perpendicular from the bottom surface of the cleaning head. The scrubber is moveable between at least a horizontal position and a vertical position. | 04-28-2011 |