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Margot Brickelmaier, Boxford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090104150 | Polymer conjugates of interferon Beta-1a and uses - An interferon beta polypeptide comprising interferon-beta 1a coupled to a polymer containing a polyalkylene glycol moiety wherein the interferon-beta-1a and the polyalkylene glycol moiety are arranged such that the interferon-beta-1a has an enhanced activity relative to another therapeutic form of interferon beta (interferon-beta-1b) and exhibits no decrease in activity as compared to non-conjugated interferon-beta-1a. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications. | 04-23-2009 |
| 20090286958 | INTERFERON-BETA FUSION PROTEINS AND USES - A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described. | 11-19-2009 |
Margot Mayer-Proschel, Pittsford, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20080226609 | Transplantation of Glial Restricted Precursor-Derived Astrocytes for Promotion of Axon Growth - Provided herein are compositions and methods for the treatment of central nervous system (CNS) lesions comprising administration of glial restricted precursor (GRP) derived astrocytes (GDAs). | 09-18-2008 |
| 20090004689 | Lineage Restricted Glial Precursors from the Central Nervous System - A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5 | 01-01-2009 |
| 20090162330 | Method of Isolating Human Neuroepithelial Precursor Cells from Human Fetal Tissue - A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided. | 06-25-2009 |
| 20100119493 | Telencephalic Glial-Restricted Cell Populations and Related Compositions and Methods - Provided herein are telencephalic glial-restricted precursor cell populations and related compositions. Related compositions include, but are not limited to, any cell or cell population derived from a population of telencephalic glial-restricted precursor cells. Further provided are methods of using and producing telencephalic glial-restricted precursor cell populations and related compounds. | 05-13-2010 |
Margot Mayer-Proschel, Sandy, UT US
| Patent application number | Description | Published |
|---|---|---|
| 20090087851 | Lineage-Restricted Neuronal Precursors - A self-renewing restricted stem cell population has been identified in developing (embryonic day 13.5) spinal cords that can differentiate into multiple neuronal phenotypes, but cannot differentiate into glial phenotypes. This neuronal-restricted precursor (NRP) expresses highly polysialated or embryonic neural cell adhesion molecule (E-NCAM) and is morphologically distinct from neuroepithelial stem cells (NEP cells) and spinal glial progenitors derived from embryonic day 10.5 spinal cord. NRP cells self renew over multiple passages in the presence of fibroblast growth factor (FGF) and neurotrophin 3 (NT-3) and express a characteristic subset of neuronal epitopes. When cultured in the presence of RA and the absence of FGF, NRP cells differentiate into GABAergic, glutaminergic, and cholinergic immunoreactive neurons. NRP cells can also be generated from multipotent NEP cells cultured from embryonic day 10.5 neural tubes. Clonal analysis shows that E-NCAM immunoreactive NRP cells arise from an NEP progenitor cell that generates other restricted CNS precursors. The NEP-derived E-NCAM immunoreactive cells undergo self renewal in defined medium and differentiate into multiple neuronal phenotypes in mass and clonal culture. Thus, a direct lineal relationship exists between multipotential NEP cells and more restricted neuronal precursor cells present in vivo at embryonic day 13.5 in the spinal cord. Methods for treating neurological diseases are also disclosed. | 04-02-2009 |
| 20100015702 | Generation, Characterization and Isolation of Neuroepithelial Stem Cells and Lineage Restricted Intermediate Precursor - Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed. | 01-21-2010 |
Margot Reichmann-Schurr, Baden-Baden DE
| Patent application number | Description | Published |
|---|---|---|
| 20080225635 | Device for Adding a Powdery or Granulated Liquid-Soluble Polymer Flocculation Aid to a Liquid - The invention relates to a device for adding a powdery or granulated flocculation aid to a liquid. The device includes a container for receiving the flocculation aid to be added, the flocculation aid being mixed with a liquid by a controllable dosing element. The device is provided with scales for determining the weight of the flocculation aid to be supplied by the dosing element, and the quantity of flocculation aid is adapted to the quantity of liquid flowing through by a control system. A rotor-stator arrangement has a plurality of perforated disks arranged downstream from each other in the axial direction, used for the final reliable dissolution of the flocculation aid in the liquid. | 09-18-2008 |
Margot Spindeman, Brooklyn, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090315257 | MUSICAL PLAYING CARD BOARD GAME - A musical board game and playing method that permits players to respond to playing cards both visually and aurally without requiring additional manual intervention by the game player. By incorporating computer-readable indicia such as RFID tags or bar codes in player's cards and providing a suitable computer assisted reader in the game board, it is possible to play music when enabled player cards come within proximity of a reader. | 12-24-2009 |
Margot Van Grootel, Eindhoven NL
| Patent application number | Description | Published |
|---|---|---|
| 20090236960 | ELECTRIC LAMP AND INTERFERENCE FILM - An electric lamp has a light-transmitting lamp vessel ( | 09-24-2009 |