Marcella
Marcella Calfon, New York, NY US
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20100105064 | METHOD OF SCREENING TEST SUBSTANCES FOR TREATING OR PREVENTING A DISEASE MEDIATED BY PLASMA CELLS - The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described. | 04-29-2010 |
Marcella Capezzuto, Sedriano IT
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20140353780 | DETECTION STRUCTURE FOR A MEMS ACOUSTIC TRANSDUCER WITH IMPROVED ROBUSTNESS TO DEFORMATION - A micromechanical structure for a MEMS capacitive acoustic transducer, has: a substrate of semiconductor material; a rigid electrode, at least in part of conductive material, coupled to the substrate; a membrane, at least in part of conductive material, facing the rigid electrode and coupled to the substrate, which undergoes deformation in the presence of incident acoustic pressure waves and is arranged between the substrate and the rigid electrode and has a first surface and a second surface, in fluid communication, respectively, with a first chamber and a second chamber, the first chamber being delimited at least in part by a first wall portion and by a second wall portion formed by the substrate, and the second chamber being delimited at least in part by the rigid electrode; and a stopper element, connected between the first and second wall portions for limiting the deformations of the membrane. At least one electrode-anchorage element couples the rigid electrode to the stopper element. | 12-04-2014 |
Marcella Carissimi, Treviolo IT
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20110157975 | FTP MEMORY DEVICE WITH PROGRAMING AND ERASING BASED ON FOWLER-NORDHEIM EFFECT - An embodiment of a non-volatile memory device integrated in a chip of semiconductor material is proposed. The memory device includes a plurality of memory cells. Each memory cell includes a first well and a second well of first type of conductivity that are formed in an insulating region of a second type of conductivity. The memory cell further includes a first, a second, a third and a fourth region of the second type of conductivity that are formed in the first well; these regions define a sequence of a first selection transistor of MOS type, a storage transistor of floating gate MOS type, and a second selection transistor of MOS type that are connected in series. The first region is short-circuited to the first well. Moreover, the memory device includes a first gate of the first selection transistor, a second gate of the second selection transistor, and a floating gate of the storage transistor. A control gate of the storage transistor is formed in the second well; the control gate is capacitively coupled with the floating gate. | 06-30-2011 |
20140112080 | IDENTIFICATION OF A CONDITION OF A SECTOR OF MEMORY CELLS IN A NON-VOLATILE MEMORY - An embodiment solution for operating a non-volatile memory of a complementary type is proposed. The non-volatile memory includes a plurality of sectors of memory cells, each memory cell being adapted to take a programmed state or an erased state. Moreover, the memory cells are arranged in locations each formed by a direct memory cell and a complementary memory cell. Each sector of the non-volatile memory is in a non-written condition when the corresponding memory cells are in equal states and is in a written condition wherein each location thereof stores a first logic value or a second logic value when the memory cells of the location are in a first combination of different states or in a second combination of different states, respectively. In an embodiment, a corresponding method includes the following steps: selecting at least one of the sectors, determining an indication of the number of memory cells in the programmed state and an indication of the number of memory cells in the erased state of the selected sector, and identifying the condition of the selected sector according to a comparison between the indication of the number of memory cells in the programmed state and the indication of the number of memory cells in the erased state. | 04-24-2014 |
Marcella Devoto, Philadelphia, PA US
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20100062445 | Chromosome 1p36 polymorphisms and low bone mineral density - The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353. | 03-11-2010 |
Marcella Fasso, Richmond, CA US
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20140186387 | SIGNAL PEPTIDE FUSION PARTNERS FACILITATING LISTERIAL EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS OF PREPARATION AND USE THEREOF - The present invention provides nucleic acids, expression systems, and vaccine strains which provide efficient expression and secretion of antigens of interest into the cytosol of host cells, and elicit effective CD4 and CD8 T cell responses by functionally linking Listerial or other bacterial signal peptides/secretion chaperones as N-terminal fusion partners in translational reading frame with selected recombinant encoded protein antigens. These N-terminal fusion partners are deleted (either by actual deletion, by mutation, or by a combination of these approaches) for any PEST sequences native to the sequence, and/or for certain hydrophobic residues. | 07-03-2014 |
Marcella Gagliardo, Castricum NL
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20120107519 | RADIATION CURING OF COATINGS - The invention relates to a process of coating a substrate with a non-aqueous coating composition comprising a) a polyol, b) a polyisocyanate crosslinker, c) a metal based catalyst for the addition reaction of hydroxyl groups and isocyanate groups, d) a thiol-functional compound at least partly deactivating the metal based catalyst, and e) a photolatent base which can be activated by actinic radiation, wherein the photolatent base prior to activation has a pKa value below 8, and wherein at least 60 mol-% of all isocyanate-reactive groups are hydroxyl groups, comprising the steps of: i) applying the coating composition to a substrate and ii) curing the coating composition. | 05-03-2012 |
20130230648 | KIT OF PARTS FOR CURABLE COATING COMPOSITION - The invention relates to a kit of parts for preparation of a crosslinkable coating composition comprising a) a binder module comprising a film-forming binder comprising crosslinkable functional groups A, b) a crosslinker module comprising a crosslinker comprising at least two functional groups B capable of reacting with the crosslinkable functional groups A of the binder, c) a thermal activator module comprising one or more components which exhibit an accelerating effect on the reaction between functional groups A and B of the mixture of the binder module and the crosslinker module, d) an ultraviolet activator module comprising one or more components which after irradiation with ultraviolet light exhibit a greater accelerating effect on the reaction between functional groups A and B of the mixture of the binder module and the crosslinker module than before irradiation with ultraviolet light. | 09-05-2013 |
20150017336 | NON-AQUEOUS LIQUID COATING COMPOSITION - The invention relates to a non-aqueous liquid coating composition comprising a) a polyol, b) a polyisocyanate crosslinker c) one or more thiol-functional compounds, d) a metal-based curing catalyst for catalyzing the addition reaction of isocyanate groups and hydroxyl groups, e) a base having a pKa value of at least 7, and which base does not react with isocyanate groups in a way wherein the basicity is reduced, and f) one or more acid group-containing compounds, wherein the one or more thiol-functional compounds are present in an amount to provide a molar ratio of thiol groups over the metal atoms of the metal-based curing catalyst of 1 or higher, and wherein the base is present in a molar amount lower than the molar amount of thiol groups, and wherein the molar ratio of acid groups and base groups is 1:1 or higher. | 01-15-2015 |
Marcella Kanfer Rolnick, Akron, OH US
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20140197924 | SYSTEMS AND METHODS FOR LOCATING A PUBLIC FACILITY - In an exemplary method of locating a public facility, a public facility is provided at a fixed location and includes a facility locating module. A wireless signal is generated from the facility locating module. Software code accessible to the portable electronic device is provided. The software code causes the portable electronic device to detect the wireless signal and to generate a location indicating output from the portable electronic device to identify at least one of a location of the public facility, a distance to the public facility from the portable electronic device, and a direction from the portable electronic device to the public facility. | 07-17-2014 |
Marcella Mirata, Las Vegas, NV US
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20120097017 | ARMOR SYSTEM AND METHOD OF MANUFACTURE - An armor system includes a hard face and at least one reinforcing layer covering a rear surface of the hard face. The reinforcing layer is fabricated from a glass-ceramic material exhibiting crystalline bodies throughout the mass of the glass-ceramic material. At least one resilient layer forms a rearward outer layer of the armor system. The hard face and cooperating reinforcing layers serve to disburse energy caused by the impact of an incoming projectile with the armor system, while the resilient layer serves to retain any pieces of the hard face and reinforcing layers fractured during ballistic impact. In certain embodiments, a plurality of hard faces, each with cooperating reinforcing and resilient layers, are held in parallel and spaced apart arrangement. | 04-26-2012 |
Marcella Mirata, Livermore, CA US
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20090217813 | Glass-Ceramic with laminates - A transparent armor system includes a hard face fabricated from a substantially transparent glass-ceramic material exhibiting crystalline bodies throughout the mass of the glass-ceramic material and a backing covering a rear surface of the hard face opposite an anticipated incoming projectile. The backing has a refractive index substantially matching that of the hard face such as to allow substantial transparency of the transparent armor system. The hard face serves to disburse energy caused by the impact of an incoming projectile with the transparent armor system, while the backing serves to retain any pieces of the hard face fractured during ballistic impact. In certain embodiments, a plurality of hard faces are held in parallel and spaced apart arrangement. | 09-03-2009 |
Marcella Mirata US
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20130019741 | GLASS-CERAMIC WITH LAMINATES - A transparent armor system includes a hard face fabricated from a substantially transparent glass-ceramic material exhibiting crystalline bodies throughout the mass of the glass-ceramic material and a backing covering a rear surface of the hard face opposite an anticipated incoming projectile. The backing has a refractive index substantially matching that of the hard face such as to allow substantial transparency of the transparent armor system. The hard face serves to disburse energy caused by the impact of an incoming projectile with the transparent armor system, while the backing serves to retain any pieces of the hard face fractured during ballistic impact. In certain embodiments, a plurality of hard faces are held in parallel and spaced apart arrangement. | 01-24-2013 |
Marcella Rebola, Airasca IT
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20100028935 | CONVEX BOTTOM MICROWELL - Convex-bottom microwells for laboratory use in optical analyses of colorimetric or enzymological type useful for avoiding interferences with the luminous beam of the detecting instrument by corpuscular elements present in the sample to be analysed. | 02-04-2010 |
Marcella Trembley, Basel DE
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20090087462 | Use of pyrimidine derivatives for cosmetic purposes - The present invention is directed to the use of certain pyrimidine derivatives for cosmetic purposes, i.e. for the preparation of a composition for providing a cosmetic effect. It was found that said pyrimidine derivatives are particularly useful for treating wrinkles but also for thickening the epidermis, for improving hair growth and for treating grey hair. The present invention is also directed to a composition containing said pyrimidine derivatives. In particular, said composition is a cosmetic preparation. | 04-02-2009 |