Patent application number | Description | Published |
20080208485 | System and Method for Tracking and Quantitating Chemical Entities - In complex separations, more than one entity may have the same molecular weight, to within the ability of an instrument to distinguish. Accurate mass measurements are used in light of the previously unknown regularities in retention time to determine a retention time (N pairs of values (t | 08-28-2008 |
20090057547 | MASS SPECTROMETER - A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Q | 03-05-2009 |
20090215103 | GENERATION AND USE OF A CATALOG OF POLYPEPTIDE-RELATED INFORMATION FOR CHEMICAL ANALYSES | 08-27-2009 |
20090224148 | APPARATUS AND METHOD FOR PERFORMING MASS SPECTROSCOPY - Embodiments of the present invention are directed to apparatus and methods for performing mass spectrometry. Data pair information is subjected to an ion audit process in which data pair information that relates to scored compounds is subtracted from the data pair information. The depleted information more readily reveals data pair information for compounds present with smaller signals. | 09-10-2009 |
20090294645 | ION DETECTION AND PARAMETER ESTIMATION FOR N-DIMENSIONAL DATA - Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data. | 12-03-2009 |
20090317791 | Methods and apparatus for performing retention-time matching | 12-24-2009 |
20100187414 | Apparatus And Method For Identifying Peaks In Liquid Chromatography/Mass Spectrometry Data And For Forming Spectra And Chromatograms - Chromatograms and mass spectra produced by an LC/MS system are analyzed by creating a two-dimensional data matrix of the spectral and chromatographic data. The two-dimensional matrix can be created by placing the spectra generated by the mass spectrometer portion of the LC/MS system in successive columns of the data matrix. In this way, the rows of the data matrix correspond to chromatographic data and the columns of the data matrix correspond to the spectra. A two-dimensional filter is specified and applied to the data matrix to enhance the ability of the system to detect peaks associated with ions. The two-dimensional filter is specified according to desired criteria. Rank-1 and rank-2 filters can be specified to improve computational efficiency. One method of applying the two-dimensional filter is through convolution of the data matrix with the two-dimensional filter to produce an output data matrix. Peaks corresponding to detected ions are identified in the output data matrix. Parameters of the peaks are determined and stored for later processing including quantitation, or simplification of chromatograms or spectra by, for example, identifying peaks associating with ions having retention times falling within a specified retention time window or having mass-to-charge ratios falling within a specified mass-to-charge ratio window. | 07-29-2010 |
20100280811 | BASELINE MODELING IN CHROMATOGRAPHY - An apparatus and a method of chemical analysis entail acquiring a chromatogram, median filtering the chromatogram to produce a model baseline, smoothing the model baseline to reduce noise, and subtracting the smoothed model baseline from the acquired chromatogram to produce a modified chromatogram having a substantially flat baseline. | 11-04-2010 |
20110184648 | METHODS AND APPARATUS FOR PERFORMING RETENTION-TIME MATCHING - A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and a control unit in communication with the chromatography module and the mass-spectrometry module. | 07-28-2011 |
20110226941 | Techniques For Performing Retention-Time Matching Of Precursor And Product Ions And For Constructing Precursor And Product Ion Spectra - Techniques are described for matching a precursor ion with one or more related product ions, including providing a plurality of input data sets obtained from a plurality of injections, each of the plurality of input data sets including a same precursor ion and one or more product ions, normalizing the plurality of input data sets in accordance with a single retention time for the precursor ion, for each of the plurality of input data sets, determining which product ions are within a predetermined retention time window with respect to the single retention time for the precursor ion, and if a product ion is within the predetermined retention time window in at least one of the plurality of input data sets, determining that the product ion is related to the precursor ion having the single retention time | 09-22-2011 |
20120225444 | METHODS AND APPARATUS FOR FRACTIONATION-BASED CHEMICAL ANALYSES - A method for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each include portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS-provided intensity data. A set of precursor-ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide. | 09-06-2012 |
20120253684 | METHODS AND APPARATUS FOR PERFORMING RETENTION-TIME MATCHING - A method for matching a precursor ion with one or more related product ions includes providing input data sets obtained from sample injections, each of the data sets including a precursor ion and one or more product ions, normalizing the input data sets in accordance with a single retention time for the precursor ion, determining which product ions are within a predetermined retention time window with respect to the single retention time, and, if a product ion is within the predetermined retention time window for a specified number of the input data sets, determining that the product ion is related to the precursor having the single retention time. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module in communication with the chromatography module, and control unit in communication with the chromatography module and the mass-spectrometry module. | 10-04-2012 |
20120259557 | ION DETECTION AND PARAMETER ESTIMATION FOR N-DIMENSIONAL DATA - Methods and apparatus for LC/IMS/MS analysis involve obtaining noisy raw data from a sample, convolving the data with an artifact-reducing filter, and locating, in retention-time, ion mobility, and mass-to-charge-ratio dimensions, one or more ion peaks of the convolved data. | 10-11-2012 |
20130299688 | TECHNIQUES FOR ANALYZING MASS SPECTRA FROM THERMAL DESORPTION RESPONSE - Techniques are described for sample analysis. Thermal desorption of components of the sample occurs at atmospheric pressure at a plurality of times by applying one of a plurality of temperatures included in a temperature gradient at each of the times to a surface of the sample. Desorption of each component occurs at a different temperature thereby allowing differentiation of the components based on one of the times corresponding to the temperature at which desorption occurs for the component. Ions are generated from the thermally desorbed components. Mass spectra generated from the ions are analyzed to determine mass spectral features about the components. Analyzing includes associating one of the ions with a component if the one ion has an ion intensity apex or peak that is detected in the mass spectra and occurs at a time corresponding to a one of the temperatures at which thermal desorption occurs for the component. | 11-14-2013 |