Mao, CA
Chungsheng Mao, Vancouver CA
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20100099612 | RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS - This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer. | 04-22-2010 |
Chunsheng Mao, Vancouver CA
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20080312148 | RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS - This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer. | 12-18-2008 |
20100129904 | RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS - This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer. | 05-27-2010 |
20100303759 | RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS - This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer. | 12-02-2010 |
20130189226 | RECOMBINANT HUMAN INTERFERON-LIKE PROTEINS - This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human inteferon like alpha 2b (HuIFN-α2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer. | 07-25-2013 |
Dun Dun Mao, Burnaby CA
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20130215037 | MULTI-TOUCH SURFACE KEYBOARD WITH MULTI-KEY ZONES ON AN ADAPTABLE HOME LINE AND METHOD OF INPUTTING TO SAME - A multi-touch surface such as of a touch screen on a platform of an electronic device has a distribution of touch sensitive keys each corresponding to a letter, number, symbol or function. The keys are grouped into pads, each pad being operable by a different one of a user's ten fingertips. The locations of the pads may conform to the shape and size of a user's hands, and to their position and orientation in relation to the screen, and is such that the screen can comfortably be used for typing. Sub-pads may be arranged in proximity to the pads for access by the corresponding finger. A modified version of the key pattern can be used for smaller touch screens. | 08-22-2013 |
Dun Dun (duncan) Mao, Burnaby CA
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20130113714 | Electronic Device Having Single Hand Multi-Touch Surface Keyboard and Method of Inputting to Same - A multi-touch surface such as of a touch screen on a platform of an electronic device has a distribution of touch sensitive keys each corresponding to a letter, number, symbol or function. The keys are grouped into pads, each pad being operable by a different fingertip of the same hand. The locations of the pads may conform to a user's hand shape, size and position in relation to the screen, and is such that a single hand can comfortably be used for typing. A modified version of the key pattern can be used for smaller touch screens. | 05-09-2013 |
Ivy Mao, Kanata CA
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20130094521 | NAI SUBSCRIPTION-ID HINT DIGIT HANDLING - Various exemplary embodiments relate to a method of identifying a subscriber at a network node. The method may include: receiving a message including a network access identifier (NAI); removing the first digit from the NAI to form a stripped NAI; determining whether the stripped NAI corresponds to a subscriber; determining whether the NAI corresponds to a subscriber; adding a hint digit to form an extended NAI, and determining whether the extended NAI corresponds to a subscriber; and if any of the NAIs correspond to a subscriber, using the corresponding NAI to identify the subscriber. Various exemplary embodiments relate to a policy and charging rules node including: a subscriber cache including a subscriber identifier; an interface configured to receive a NAI; a NAI modifier configured to form an extended NAI and a stripped NAI; and a subscriber identification module configured to determine whether a NAI is stored in the subscriber cache. | 04-18-2013 |
20130324078 | TEMPORARILY DISABLE OUT-OF-CREDIT PCC RULE - Various exemplary embodiments relate to a method performed by a policy and charging rules node (PCRN), the method comprising: receiving an event trigger from a policy and charging enforcement node (PCEN) indicating that a subscriber is out of credit; installing temporary PCC rules to handle the out of credit status of the subscriber; receiving an indication that the subscriber has completed a reallocation of credit action; uninstalling the temporary PCC rules and restoring the original PCC rules after receiving an indication of reallocation of credit. | 12-05-2013 |
20140050098 | HANDLING SESSION LINKING STATUS IN GXX UPDATE - Various exemplary embodiments relate to a method of linking sessions at a Policy and Rules Charging Node (PCRN). The method may include: receiving a gateway control session establishment request from a first gateway, the establishment request indicating a first session linking status; establishing a gateway control session between the gateway and the PCRN; receiving a second message from the first gateway for the established gateway control session including a Session-Linking-Indicator AVP indicating a second session linking status; determining whether the PCRN has linked the gateway control session to an IP-CAN session; if the PCRN has not linked the gateway control session to an IP-CAN session, replacing the first session linking status with the second session linking status for the established gateway control session; and linking the gateway control session with an IP-CAN session according to the second session linking status. | 02-20-2014 |
20140051384 | OUT OF CREDIT FINAL-UNIT-ACTION RESTRICT_ACCESS HANDLING - Various exemplary embodiments relate to a method performed by a policy and charging rules node (PCRN), the method including: receiving an event trigger and a restriction filter rule associated with a first set of policy and charging control (PCC) rules from a policy and charging enforcement node (PCEN) indicating that a subscriber is out of credit; producing a second set of PCC rules to implement the restriction filter to handle the out of credit status of the subscriber; installing the second set of PCC rules; receiving an indication that the subscriber has received a reallocation of credit; and uninstalling the second set of PCC rules after receiving an indication that the subscriber has completed the reallocation of credit operation. | 02-20-2014 |
20140064151 | SY SESSION CREATION AND RECOVERING FROM INCONSISTENT SESSION STATE BETWEEN PCRF AND OCS - Various exemplary embodiments relate to a method performed by a policy and charging rules node (PCRN), the method including: sending a first Sy spending limit request (SLR) to an online charging system (OCS) without specifying any policy counters; receiving from the OCS a first spending limit answer (SLA) including policy counters and associated status reports for a subscriber; creating an Sy session; determining required policy counters based upon the policy counter statuses; sending a second Sy SLR to the OCS for the required policy counters; and receiving a second SLA including status reports for the required policy counters. | 03-06-2014 |
20140066004 | HANDLING OF OCS COUNTER INFORMATION - Various exemplary embodiments relate to a method performed by a policy and charging rules node (PCRN), the method including: sending a first Sy spending limit request (SLR) to an online charging system (OCS); receiving from the OCS a first spending limit answer (SLA) including policy counters and associated status reports for a subscriber; creating an Sy session; storing policy counter data in the Sy session; and making a policy decision based upon policy counter statuses associated with the Sy session. | 03-06-2014 |
Jianning Mao, Montreal CA
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20100183597 | DRAK2 EXPRESSION IS ASSOCIATED WITH DIABETES - Drak2 is a member of the death-associated protein family and a serine threonine kinase. In this study, we investigated its role in beta-cell survival and diabetes. Drak2 mRNA and protein were rapidly induced in islet beta-cells after stimulation by inflammatory cytokines known to be present in type 1 diabetes. Drak2 upregulation was accompanied by increased beta-cell apoptosis, beta-cell apoptosis caused by the said stimuli was inhibited by Drak2 knockdown using siRNA. Conversely, transgenic (Tg) Drak2 overexpression led to aggravated beta-cell apoptosis triggered by the stimuli. Further in vivo experiments demonstrated that Drak2 overexpressed in Tg islets is responsible for type 1 diabetes-prone phenotype. Purified Drak2 could phosphorylate ribosomal protein S6 (p70S6) kinase in an in vitro kinase assay. Drak2 overexpression in NIT-1 cells led to enhanced p70S6 kinase phosphorylation, while Drak2 knockdown in these cells reduced it. These mechanistic studies proved that p70S6 kinase was a bona fide Drak2 substrate in vitro and in vivo. | 07-22-2010 |
Mingxian Mao, Waterloo CA
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20120030454 | SYSTEM AND METHOD FOR DYNAMICALLY CONFIGURING PROCESSING SPEEDS IN A WIRELESS MOBILE TELECOMMUNICATIONS DEVICE - There is disclosed a system and method executable in a wireless mobile communication device for dynamically configuring processing speed for a main processor in the device during device initialization. In an embodiment, the method comprises: initiating a boot-rom procedure; determining whether a battery is present in the device, and in response to the presence of the battery, determining whether the battery charge level is above a predetermined threshold; determining whether a USB connection to the device is present, and in response to the presence of a USB connection, enumerating the USB connection; and wherein, in response to the presence of the battery and the battery charge level being above a predetermined threshold, or in response to the USB connection being enumerated at a higher current, the processing speed of the main processor is increased. | 02-02-2012 |
Xinliang Mao, Markham CA
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20100144685 | INHIBITING CYCLIN D POLYPEPTIDES - This document involves methods and materials related to inhibiting cyclin D polypeptide activity. For example, this document provides methods and materials that can be used to (1) identify mammals or cells in need of cyclin D polypeptide inhibition and (2) administer an agent capable of inhibiting cyclin D polypeptide activity. | 06-10-2010 |
20110123617 | CLIOQUINOL FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES - The present invention relates to compositions and methods for treating hematological malignancies and proliferative diseases, disorders and conditions involving increased D-cyclin expression. In particular, the present invention relates to compositions and methods for treating the hematological malignancies acute myeloid leukemia (AML) and multiple myeloma (MM) using clioquinol. | 05-26-2011 |
20110144155 | 8-HYDROXYQUINOLINE DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES - The application relates to compositions and methods for treating hematological malignancies and proliferative diseases, disorders and conditions involving increased D-cyclin expression. In particular, the application relates to compositions and methods for treating the hematological malignancies acute myeloid leukemia (AML), lymphoma and multiple myeloma (MM) using 5-nitrogen substituted hydroxy quinolones as well as 7-bromo-5-chloro substituted hydroxy quinolones and 5-chloro substituted hydroxy quinolones. | 06-16-2011 |
Yanmin Mao, Waterloo CA
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20110261543 | Molded Printed Circuit Board - Described herein is a molded printed circuit board. The printed circuit board may be placed inside of a mold and a material is injected therein. The material hardens in the mold around the printed circuit board thereby forming an overmolded printed circuit board. The overmolded material may have apertures in it to allow access to the leads on the printed circuit board so that components to be connected to it. The overmolded printed circuit boards may allow a plurality of electrical components to selectively and removably attach to it. Further, the printed circuit board may be attached in a housing which may itself removably and selectively connect to components. | 10-27-2011 |
Yanmin Mao, Mississauga CA
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20120061118 | REPLACEABLE KEYPAD BEZEL - A keypad bezel for attaching to a housing of a handheld computer comprises a main body including plurality of screw holes and tabs for connecting the main body to the computer housing and a plurality of leverage points in the main body useful for removing the keypad bezel from the housing. To remove the keypad bezel, the screws are removed from the screw holes and a removal tool is positioned so that it mates with recesses the keypad bezel and force is applied to the removal tool in a direction way from the housing. The force removes the tabs out of corresponding slots in the housing allowing the bezel to be removed. | 03-15-2012 |
Yanmin Mao, Brampton CA
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20110261509 | DOCKING CRADLE WITH FLOATING CONNECTOR ASSEMBLY - A docking cradle for a portable electronic device has a floating connector assembly which isolates a portable electronic device connected to the connector assembly from at least some of the shock, vibration or other motion imposed on the rest of the docking cradle. The connector assembly is positioned above a base frame and comprises a platform, a device interface on the platform, a device securing mechanism connected to the platform and connectable to the portable electronic device to physically secure the portable electronic device to the connector assembly; and at least one connector assembly spring connecting the connector assembly to the base frame such that the connector assembly is movable laterally relative to the base frame. | 10-27-2011 |
20110262788 | BATTERY MODULE MOUNT - A battery module mount for securing a battery module to a housing of a handheld device, including one or more latch elements attached to the housing and movable between a free position and an unlatched position, with a tab portion, and one or more elongate resilient elements biasing each latch element to the free position. Each latch element is positionable in a latched positions. The mount also includes one or more mating means attached to the battery module with an abutment with which the tab portion is engageable when the latch element is in the latched position, to hold the abutment in a retainable position, thereby securing the battery module to the housing. The tab portion is disengaged from the abutment when the latch element is in the unlatched position, to permit removal of the battery module from the housing. | 10-27-2011 |
20140011395 | MOLDED PRINTED CIRCUIT BOARD - Described herein is a molded printed circuit board. The printed circuit board may be placed inside of a mold and a material is injected therein. The material hardens in the mold around the printed circuit board thereby forming an overmolded printed circuit board. The overmolded material may have apertures in it to allow access to the leads on the printed circuit board so that components to be connected to it. The overmolded printed circuit boards may allow a plurality of electrical components to selectively and removably attach to it. Further, the printed circuit board may be attached in a housing which may itself removably and selectively connect to components. | 01-09-2014 |
Yida Mao, Victoria CA
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20080263471 | METHOD AND SYTEM FOR CALENDAR-BASED IMAGE ASSET ORGANIZATION - A calendar-based image asset organizer, including a user interface for designating at least one date range, an image date reader for determining a date associated with an image, and an image query manager for identifying images having an associated date within the designated at least one date range. A method and a computer readable storage medium are also described and claimed. | 10-23-2008 |
Youxin Mao, Ottawa CA
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20110257486 | Optical catheter with rotary optical cap - A scanning optical head for a catheter is locally controlled by a motor at an insertion end of the catheter uses a hollow motor through which a longitudinal optical path of the catheter passes. This permits the motor to be positioned between a control base of the catheter and avoids rotating the whole fibre, and therefore makes the beam scanning stable and accurate. In addition, because there is no coupling component, it also eliminates the light reflection between additional surfaces as well as varying fiber birefringence, which becomes a cause of noise when imaging the deep structure. | 10-20-2011 |
Zhihong Mao, Stouffville CA
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20090312999 | SYSTEMS AND METHODS FOR PREDICTING MAINTENANCE OF INTELLIGENT ELECTRONIC DEVICES - Predictive maintenance systems and methods are described. A method includes measuring environmental conditions using a plurality of sensors within the IED, processing the environmental measurements to determine long-term exposure factors representing historical operating conditions of the IED, applying a reliability model to the long-term exposure factors, determining a numerical measure of IED life based on the long-term exposure factors and the reliability model, comparing the numerical measure of IED life to preselected boundary values, and signaling if the numerical measure of IED life is outside of the preselected boundary values. | 12-17-2009 |
20110267620 | ARC FLASH DETECTION SYSTEM AND METHOD - A sensor to simultaneously detect light and acoustic waves is presented. The sensor includes one or more optical fibers and a diaphragm disposed near one end of at least one of the one or more optical fibers. The diaphragm is configured to vibrate upon incidence of acoustic waves from an arc flash and reflect a light beam into at least the one of the one or more of the optical fibers. A semi-transparent region is disposed around the one or more optical fibers to diffuse light originating from the arc flash into at least one of the one or more optical fibers. | 11-03-2011 |
20120002195 | ARC FLASH DETECTION METHOD - An arc flash detection method includes transmitting light via an optical fiber to a sensor and transmitting light from the sensor that includes components representative of acoustic waves and light for filtering and processing to detect an occurrence of an arc flash. | 01-05-2012 |
Zhihong Roy Mao, Stouffville CA
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20120286795 | METHODS, SYSTEMS, AND APPARATUS FOR DETECTING LIGHT AND ACOUSTIC WAVES - A sensor includes a sensor head including an acoustic detector configured to receive light from a first light source and to reflect the light upon incidence of acoustic waves. The sensor also includes at least one optical fiber and at least one fluorescent material within at least one of the sensor head and the at least one optical fiber. The at least one fluorescent material is configured to receive light from a second light source external to the sensor and emit visible light in response to the light received from the second light source. | 11-15-2012 |