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Mannino, US
Anthony Mannino, Maryland Heights, MO US
| Patent application number | Description | Published |
|---|---|---|
| 20080312441 | Use of Oripavine as a Starting Material For Buprenorphine - There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group. | 12-18-2008 |
| 20080312442 | Process for Preparing Morphinan-6-One Products with Low Levels of Alpha, Beta-Unsaturated Ketone Compounds - The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of α,β-unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound. (A) | 12-18-2008 |
| 20100081816 | Processes for synthesis of opiate alkaloid derivatives - The present invention provides processes for the synthesis of opiate alkaloids. In particular, the opiate alkaloids produced by the process of the invention are typically intermediate compounds that may be utilized to produce a variety of biologically active alkaloids including buprenorphine and diprenorphine. | 04-01-2010 |
| 20100087647 | Processes for the production of buprenorphine with reduced impurity formation - The present invention provides process for the production of opiate alkaloids. In particular, the present invention provides processes for the production of buprenorphine or a derivative of buprenorphine that minimizes the formation of impurities. | 04-08-2010 |
| 20100120814 | Crystalline and Amorphous Forms of Naltrexone Hydrochloride - The present invention relates to novel crystalline forms of naltrexone hydrochloride including hydrated and solvated forms and a novel amorphous form. The invention also describes methods of preparing the various crystalline forms. The present invention also relates to pharmaceutical compositions containing crystalline and amorphous forms of naltrexone hydrochloride, as well as methods of treating addictive behavior by administering the pharmaceutical compositions. | 05-13-2010 |
Joseph Mannino, Bloomfield Hills, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20090160169 | DYNAMIC AIRBAG VENTING - An example airbag assembly includes an airbag and a duct having an opening for venting gas. The duct moves between a first position where the opening is outside the airbag and a second position where the opening is inside the airbag. Inflating the airbag moves the duct between the first position and the second position. | 06-25-2009 |
| 20090261564 | EXTERNAL AND INTERNAL AIRBAG TETHER ARRANGEMENT - An example tethered airbag arrangement includes an airbag movable to an expanded position. The airbag includes a contact face. An internal tether constrains expansion of the contact face. An external tether system includes tether portions and at least one bridge portion. The tether portions constrain expansion of the contact face. The bridge portion limits separation between one of the tether portions and an adjacent one of the tether portions as the airbag moves to an expanded position. | 10-22-2009 |
| 20110025032 | DYNAMIC AIRBAG VENTING - An example airbag assembly includes an airbag and a duct. The duct has a duct opening for venting gas. The duct is moveable between a first position where the duct opening is outside the airbag and a second position where the duct opening is inside the airbag. Inflating the airbag moves the duct between the first position and the second position. The airbag is configured to be inflated by a first stream of gas moving from the duct opening to an interior of the airbag and by a second stream of gas moving from an airbag inflator to the interior of the airbag. The first stream of gas is separate from the second stream of gas. | 02-03-2011 |
| 20110121549 | DYNAMIC AIRBAG VENTING - An example airbag assembly includes an airbag having an airbag opening and a duct adjacent the airbag opening. A tether is configured to move the duct between a first position and a second position. The duct communicates a first flow from the duct through the airbag opening in the first position. The duct communicates a second flow from the duct through the airbag opening in the second position. The first flow is greater than the second flow. | 05-26-2011 |
Paul V. Mannino, Scotch Plains, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20100319498 | Power assisted lever arm ratchet - An improved power assisted lever arm ratchet which has a 6″ to 30″ extension and drive shaft between the ratchet handle and the ratchet head. | 12-23-2010 |
Raphael J. Mannino, Annandale, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20080242625 | Nucleotide-Cochleate Compositions And Methods Of Use - The present invention is directed to cochleate composition that include a nucleotide. The nucleotide may generally be bound via a linker to a component of the cochleate, or to a lipophilic tail. Additionally or alternatively, the nucleotide may be associated with a transfection agent. The present invention also includes methods for making and using the compositions provided herein. | 10-02-2008 |
| 20090028904 | Novel cochleate formulations - A process for producing a small-sized, lipid-based cochleate. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca | 01-29-2009 |
| 20110091523 | Cochleate compositions directed against expression of proteins - Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions. | 04-21-2011 |
Rosario Mannino, North Haven, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20100019142 | YTTRIA-METAL THERMIONIC FILAMENTS - A thermionic electron source comprises a nonlinear metallic substrate, a coating of yttria deposited on the substrate, and a current source configured to drive current through the metallic substrate. | 01-28-2010 |
| 20110089333 | ASSEMBLIES FOR ION AND ELECTRON SOURCES AND METHODS OF USE - Certain embodiments described herein are directed to devices that can be used to align the components of a source assembly in a source housing. In some examples, a terminal lens configured to couple to the housing through respective alignment features can be used to retain the source components in a source housing to provide a source assembly. | 04-21-2011 |
Thomas C. Mannino, Farmington Hills, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20090191504 | INTRA-ORAL LIGHTING DEVICE AND LIGHTING METHOD - An intra-oral lighting device for illuminating a tooth located in the mouth of a patient, the device including a source of light, and a probe through which light from the source of light is transmitted, the probe including a tip from which light received from the source of light by the probe is emitted, the tip being insertable by a user into an aperture bored into the enamel of the patient's tooth whereby the tooth is illuminated from within by light emitted from the tip. Also, a method of illuminating a tooth disposed in the mouth of a patient, including the steps of drilling into the tooth a hole that extends into the tooth enamel, inserting into the drilled hole the tip of a light-transmitting probe connected to a source of light, and emitting light from the probe tip disposed in the drilled hole, whereby the tooth is illuminated from within by light transmitted into and through the tooth enamel from the probe tip. | 07-30-2009 |