Man Young
Man Young Jang, Gyeonggi-Do KR
Patent application number | Description | Published |
---|---|---|
20160060319 | Development of Protein-Based Biotherapeutics That Induced Osteogenesis for Bone Healing Therapy: Cell-Permeable BMP2 and BMP7 Recombinant Proteins (CP-BMP2 & CP-BMP7), Polynucleotides Encoding the Same and Pro-osteogenic Compositions Comprising the Same - The present invention is about direct protein delivery system for bone morphogenetic proteins (BMPs) to enhance bone regeneration without the need of additional delivery carrier which requires open surgery for their implantation. The cell-permeable BMP (CP-BMP) recombinant proteins are fused with advanced macromolecule transduction domain (aMTD) to give them ability for cell penetration and with solubilization domain (SD) to increase their solubility and manufacturing yield. Because existing BMP recombinant proteins have short half-life, they have been delivered with polymeric or inorganic vehicles for their sustained release. However, CP-BMPs fused to combination of aMTD and SD can easily and rapidly penetrate into the cytosol after treating on cells that likes hiding in a shelter from wash off in body fluid, and avoid rapid degradation. For the development of CP-BMP, BMP2 and BMP7 have been selected among various types of BMP family due to their potent osteo-inductivity. Both of proteins are produced in mature form (MP) as an active domain and pro-peptide form (latency associated peptide (LAP)+MP) for prolonged stability of proteins. In the present art, three strategic steps are used to prove the validity of using CP-BMPs on bone regeneration and new bone formation. First, randomly selected aMTDs and various types of SDs have been fused to BMP proteins for determine the best structural composition for highest solubility/yield and cell-/tissue-permeability. Next, aMTDs are fused to BMP2 and BMP7 proteins with optimized structure to determine the best construct for maximized cell- and tissue-permeability. Finally, biological activity of BMP2, BMP7 and combination of BMP2 and BMP7 recombinant proteins have been evaluated to enhance in vitro osteogenic differentiation and in vivo bone regeneration. The CP-BMPs can be applied to repair skeletal injuries which are by bone fracture, osteogenesis imperfecta, and bone extraction. | 03-03-2016 |
Man Young Jung, Anyang-Si Gyeonggi-Do KR
Patent application number | Description | Published |
---|---|---|
20120287887 | TRANSMITTER HAVING MULTIPLE ANTENNAS - The present invention is directed to a wireless communication system, more specifically, a transmitter used for wireless communication and a method for the same. The transmitter used for wireless communication comprises a plurality of transmitting antennas; a plurality of radio frequency (RF) chains configured for each of the | 11-15-2012 |
20120320818 | ARCHITECTURE AND METHOD OF RELAY NODE RF FOR CARRIER AGGREGATION - A wireless communication system that includes a relay node is disclosed. The relay node supporting carrier aggregation (CA) comprises a first antenna for performing communication with a base station through a backhaul link; a plurality of backhaul link radio frequency (RF) chains connected with the first antenna, for transmitting and receiving a radio signal for backhaul link transmission; a second antenna for performing communication with a user equipment through an access link; a plurality of access link RF units connected with the second antenna, for transmitting and receiving a radio signal for access link transmission; and a control unit controlling the plurality of backhaul link RF chains and the plurality of access link RF chains to share at least a part of RF components between the backhaul link RF chains and the access link RF chains. | 12-20-2012 |
Man Young Jung, Seoul KR
Patent application number | Description | Published |
---|---|---|
20140044063 | METHOD FOR REDUCING TRANSMISSION POWER AND TERMINAL THEREOF - There is provided a method of reducing transmission power. The method may comprise: receiving a network signal, if a carrier aggregation (CA) is configured and if the configured CA corresponds to an intra-band contiguous CA; applying an additional maximum power reduction (A-MPR) for a transmission, based on the network signal. If a configuration of the CA corresponds to a CA_1C and if the aggregated transmission bandwidth is the summation of 75 RBs and 75 RBs, a value of the A-MPR is specified for L_CRB>10. The L_CRB is a length of a contiguous resource block allocation. | 02-13-2014 |
Man Young Kim, Gyeonggi-Do KR
Patent application number | Description | Published |
---|---|---|
20120273708 | BUTTERFLY VALVE HAVING FUNCTION OF MAINTAINING SEALING PERFORMANCE UNDER LOW AND HIGH TEMPERATURES - Disclosed is a butterfly valve capable of controlling a flow of a fluid according to a rotation of a disk. The butterfly valve includes a body provided with an inner space having two open ends; a disk unit having a disk rotatably installed at the inner space, and configured to selectively open and close the inner space according to a rotation of the disk; a first seat portion protruding from an outer circumferential surface of the disk; a second seat portion protruding from an inner circumferential surface of the body, and arranged to face the first seat portion; and a sealing unit mounted to the body, and formed to contact the first and second seat portions such that a gap between the outer circumferential surface of the disk and the inner circumferential surface of the body is sealed. Under this configuration, the butterfly valve may have an enhanced reliability under low and high temperatures and a high pressure. | 11-01-2012 |
20130026403 | BUTTERFLY VALVE HAVING MOVING DISC - Disclosed is a butterfly valve capable of controlling fluid flow according to rotation of a disc. The butterfly valve includes a valve body having an inner space of which two end portions are open; first and second discs disposed to face each other at the inner space, installed to be rotatable between an open state and a closed state of the inner space, and configured to selectively open and close the inner space; first and second sealing members mounted to the valve body, and configured to contact the first and second discs, respectively in the closed state; and a disc controlling apparatus configured to move the first and second discs to a direction contacting to or spacing from the first and second sealing members in the closed state. Under this configuration, durability and a sealing function may be enhanced. | 01-31-2013 |