Patent application number | Description | Published |
20090081383 | Carbon Nanotube Infused Composites via Plasma Processing - A continuous, plasma-based process for the production of carbon-nanotube-infused fibers is disclosed. | 03-26-2009 |
20090081441 | Fiber Tow Comprising Carbon-Nanotube-Infused Fibers - Fiber tows are formed by situating carbon-nanotube-infused filaments in close proximity to one another, enabling the nanotubes on the filaments to interdigitate. In some embodiment, this enables the formation of fiber tows that do not require do not require resin impregnation. | 03-26-2009 |
20100159240 | CNT-INFUSED METAL FIBER MATERIALS AND PROCESS THEREFOR - A composition includes a carbon nanotube (CNT)-infused metal fiber material which includes a metal fiber material of spoolable dimensions, a barrier coating conformally disposed about the metal fiber material, and carbon nanotubes (CNTs) infused to the metal fiber material. A continuous CNT infusion process includes: (a) disposing a barrier coating and a carbon nanotube (CNT)-forming catalyst on a surface of a metal fiber material of spoolable dimensions; and (b) synthesizing carbon nanotubes on the metal fiber material, thereby forming a carbon nanotube-infused metal fiber material. | 06-24-2010 |
20100178825 | CNT-INFUSED CARBON FIBER MATERIALS AND PROCESS THEREFOR - A composition includes a carbon nanotube (CNT)-infused carbon fiber material that includes a carbon fiber material of spoolable dimensions and carbon nanotubes (CNTs) infused to the carbon fiber material. The infused CNTs are uniform in length and uniform in distribution. The CNT infused carbon fiber material also includes a barrier coating conformally disposed about the carbon fiber material, while the CNTs are substantially free of the barrier coating. A continuous CNT infusion process includes: (a) functionalizing a carbon fiber material; (b) disposing a barrier coating on the functionalized carbon fiber material (c) disposing a carbon nanotube (CNT)-forming catalyst on the functionalized carbon fiber material; and (d) synthesizing carbon nanotubes, thereby forming a carbon nanotube-infused carbon fiber material. | 07-15-2010 |
20100260998 | FIBER SIZING COMPRISING NANOPARTICLES - A fiber sizing formulation includes (1) a nanoparticle (NP)solution that includes a dispersion of transition metal nanoparticles (NPs) in a solvent and (2) a first fiber sizing agent. The NPs disperse throughout the first fiber sizing agent after application of the fiber sizing formulation to a fiber and removal of the solvent. The NPs serve a function selected from a secondary sizing agent, a catalyst for further nanostructure growth on the fiber, and combinations thereof. A fiber includes a sizing disposed about the fiber. The sizing includes transition metal nanoparticles dispersed throughout the sizing. A method includes applying the sizing formulation to a fiber during manufacture of the fiber, and removing the solvent from the applied formulation. A method includes adding a solution of transition metal NPs to a sizing-coated fiber and baking, whereby the sizing solution of NPs is added before baking the sizing. | 10-14-2010 |
20100279569 | CNT-INFUSED GLASS FIBER MATERIALS AND PROCESS THEREFOR - A composition includes a carbon nanotube (CNT)-infused glass fiber material, which includes a glass fiber material of spoolable dimensions and carbon nanotubes (CNTs) bonded to it. The CNTs are uniform in length and distribution. A continuous CNT infusion process includes: (a) disposing a carbon-nanotube forming catalyst on a surface of a glass fiber material of spoolable dimensions; and (b) synthesizing carbon nanotubes on the glass fiber material, thereby forming a carbon nanotube-infused glass fiber material. The continuous CNT infusion process optionally includes extruding a glass fiber material from a glass melt or removing sizing material from a pre-fabricated glass fiber material. | 11-04-2010 |
20120189846 | CNT-INFUSED CERAMIC FIBER MATERIALS AND PROCESS THEREFOR - A composition includes a carbon nanotube (CNT)-infused ceramic fiber material, wherein the CNT-infused ceramic fiber material includes: a ceramic fiber material of spoolable dimensions; and carbon nanotubes (CNTs) bonded to the ceramic fiber material. The CNTs are uniform in length and uniform in distribution. A continuous CNT infusion process includes (a) disposing a carbon-nanotube forming catalyst on a surface of a ceramic fiber material of spoolable dimensions; and (b) synthesizing carbon nanotubes on the ceramic fiber material, thereby forming a carbon nanotube-infused ceramic fiber material. | 07-26-2012 |
Patent application number | Description | Published |
20120083005 | METHODS FOR IN VITRO CANCER CELL DETECTION, DIAGNOSIS AND THERAPY USING MULTIDOMAIN BIOTAGS - In one embodiment, a biotag for targeting a cancer biomarker is provided. The biotag may include a cancer biomarker binding domain, an internalization domain, an endosomal escape domain, a lysosomal escape domain, a reporter binding domain, and a reporter, wherein the reporter is a diagnostic agent. In some aspects, the cancer biomarker is ERBB 1-4, EGFRvIII or Transferrin Receptor (TfR). In other aspects, the binding domain is an scFv, an sdFv, a CDR or an SDR modified CDR. In some aspects, the reporter binding domain is a metal binding domain, which may be chelated to a metal nanoparticle tag. In some aspects, the metal nanoparticle tag is a noble metal, a superparamagnetic metal, a core-shell nanoparticle, or a fluorescent agent. In another embodiment, a targeted contrast composition for use with a diagnostic imaging technique is provided, which includes a contrast agent and a biotag for targeting a cancer biomarker. | 04-05-2012 |
20120083761 | METHODS FOR SELECTIVE ERADICATION OF METASTASIZING CANCER CELLS EX VIVO USING MULTIDOMAIN BIOTAGS - A method for treating cancer in a subject is provided, the method comprising administering to the subject an effective dose of a multidomain biotag that targets one or more cancer cells; establishing a vascular access in the subject; connecting the vascular access to a tube to establish an extracorporeal circulation of a bodily fluid; and exposing the extracorporeal circulation to one or more doses of radiation, killing biotag-targeted cancer cells. | 04-05-2012 |
20120087860 | METHODS FOR IN VIVO CANCER DETECTION, DIAGNOSIS AND THERAPY USING MULTIDOMAIN BIOTAGS - In another embodiment, a method for detecting and/or diagnosing a cancer in a subject is provided. The method may include administering an effective dose of a biotag to a subject, or alternatively, administering an effective dose of a targeted contrast to the subject, the targeted contrast comprising a contrast agent and a biotag as described herein for targeting a cancer biomarker. The method may further include exposing the subject to a diagnostic imaging technique; detecting a population of cells expressing the cancer biomarker; and quantifying the expression of the cancer biomarker in the population of cells, wherein an increased expression of the cancer biomarker indicates that the subject has cancer. | 04-12-2012 |
20120093730 | MOLECULAR DEATH TAGS AND METHODS OF THEIR USE - In one embodiment, a death tag for targeting a cell death marker is provided, the death tag comprising a death marker binding domain; a reporter binding domain (RBD); and a reporter component that is associated with the reporter binding domain. In another embodiment, a method of determining the efficacy of a cancer treatment is provided. The method may comprise administering to a subject an effective dose of a death tag that targets apoptotic, necrotic or dead cells; exposing the subject to an imaging technique; determining that the cancer treatment is effective when the imaging technique detects the presence of the death tag. In another embodiment, an in vivo, ex vivo, or in vitro method of determining the need for a treatment or determining the efficacy of a treatment in cell, tissue, and organ injuries. | 04-19-2012 |
20120093733 | MULTIDOMAIN BIOTAGS FOR CANCER DETECTION, DIAGNOSIS AND THERAPY AND METHODS OF THEIR USE - In one embodiment, a biotag for targeting a cancer biomarker is provided. The biotag may include a cancer biomarker binding domain, an internalization domain, an endosomal escape domain, a lysosomal escape domain, a reporter binding domain, and a reporter, wherein the reporter is a diagnostic agent. In some aspects, the cancer biomarker is ERBB 1-4, EGFRvIII or Transferrin Receptor (TfR). In other aspects, the binding domain is an scFv, an sdFv, a CDR or an SDR modified CDR. In some aspects, the reporter binding domain is a metal binding domain, which may be chelated to a metal nanoparticle tag. In some aspects, the metal nanoparticle tag is a noble metal, a superparamagnetic metal, a core-shell nanoparticle, or a fluorescent agent. In another embodiment, a targeted contrast composition for use with a diagnostic imaging technique is provided, which includes a contrast agent and a biotag for targeting a cancer biomarker. | 04-19-2012 |
20120095387 | METHODS FOR DETECTION, DIAGNOSIS AND SELECTIVE ERADICATION OF NEOPLASMS IN VIVO USING MULTIDOMAIN BIOTAGS - A method for treating cancer in a subject is provided, the method comprising administering to the subject an effective dose of a multidomain biotag that targets one or more cancer cells; and exposing the subject to one or more rounds of radiation. The one or more rounds of radiation kills the one or more cancer cells targeted by the biotag, but, in general, do not kill healthy cells or kills a negligible number of healthy cells. | 04-19-2012 |
Patent application number | Description | Published |
20120083005 | METHODS FOR IN VITRO CANCER CELL DETECTION, DIAGNOSIS AND THERAPY USING MULTIDOMAIN BIOTAGS - In one embodiment, a biotag for targeting a cancer biomarker is provided. The biotag may include a cancer biomarker binding domain, an internalization domain, an endosomal escape domain, a lysosomal escape domain, a reporter binding domain, and a reporter, wherein the reporter is a diagnostic agent. In some aspects, the cancer biomarker is ERBB 1-4, EGFRvIII or Transferrin Receptor (TfR). In other aspects, the binding domain is an scFv, an sdFv, a CDR or an SDR modified CDR. In some aspects, the reporter binding domain is a metal binding domain, which may be chelated to a metal nanoparticle tag. In some aspects, the metal nanoparticle tag is a noble metal, a superparamagnetic metal, a core-shell nanoparticle, or a fluorescent agent. In another embodiment, a targeted contrast composition for use with a diagnostic imaging technique is provided, which includes a contrast agent and a biotag for targeting a cancer biomarker. | 04-05-2012 |
20120083761 | METHODS FOR SELECTIVE ERADICATION OF METASTASIZING CANCER CELLS EX VIVO USING MULTIDOMAIN BIOTAGS - A method for treating cancer in a subject is provided, the method comprising administering to the subject an effective dose of a multidomain biotag that targets one or more cancer cells; establishing a vascular access in the subject; connecting the vascular access to a tube to establish an extracorporeal circulation of a bodily fluid; and exposing the extracorporeal circulation to one or more doses of radiation, killing biotag-targeted cancer cells. | 04-05-2012 |
20120087860 | METHODS FOR IN VIVO CANCER DETECTION, DIAGNOSIS AND THERAPY USING MULTIDOMAIN BIOTAGS - In another embodiment, a method for detecting and/or diagnosing a cancer in a subject is provided. The method may include administering an effective dose of a biotag to a subject, or alternatively, administering an effective dose of a targeted contrast to the subject, the targeted contrast comprising a contrast agent and a biotag as described herein for targeting a cancer biomarker. The method may further include exposing the subject to a diagnostic imaging technique; detecting a population of cells expressing the cancer biomarker; and quantifying the expression of the cancer biomarker in the population of cells, wherein an increased expression of the cancer biomarker indicates that the subject has cancer. | 04-12-2012 |
20120093730 | MOLECULAR DEATH TAGS AND METHODS OF THEIR USE - In one embodiment, a death tag for targeting a cell death marker is provided, the death tag comprising a death marker binding domain; a reporter binding domain (RBD); and a reporter component that is associated with the reporter binding domain. In another embodiment, a method of determining the efficacy of a cancer treatment is provided. The method may comprise administering to a subject an effective dose of a death tag that targets apoptotic, necrotic or dead cells; exposing the subject to an imaging technique; determining that the cancer treatment is effective when the imaging technique detects the presence of the death tag. In another embodiment, an in vivo, ex vivo, or in vitro method of determining the need for a treatment or determining the efficacy of a treatment in cell, tissue, and organ injuries. | 04-19-2012 |
20120093733 | MULTIDOMAIN BIOTAGS FOR CANCER DETECTION, DIAGNOSIS AND THERAPY AND METHODS OF THEIR USE - In one embodiment, a biotag for targeting a cancer biomarker is provided. The biotag may include a cancer biomarker binding domain, an internalization domain, an endosomal escape domain, a lysosomal escape domain, a reporter binding domain, and a reporter, wherein the reporter is a diagnostic agent. In some aspects, the cancer biomarker is ERBB 1-4, EGFRvIII or Transferrin Receptor (TfR). In other aspects, the binding domain is an scFv, an sdFv, a CDR or an SDR modified CDR. In some aspects, the reporter binding domain is a metal binding domain, which may be chelated to a metal nanoparticle tag. In some aspects, the metal nanoparticle tag is a noble metal, a superparamagnetic metal, a core-shell nanoparticle, or a fluorescent agent. In another embodiment, a targeted contrast composition for use with a diagnostic imaging technique is provided, which includes a contrast agent and a biotag for targeting a cancer biomarker. | 04-19-2012 |
20120095387 | METHODS FOR DETECTION, DIAGNOSIS AND SELECTIVE ERADICATION OF NEOPLASMS IN VIVO USING MULTIDOMAIN BIOTAGS - A method for treating cancer in a subject is provided, the method comprising administering to the subject an effective dose of a multidomain biotag that targets one or more cancer cells; and exposing the subject to one or more rounds of radiation. The one or more rounds of radiation kills the one or more cancer cells targeted by the biotag, but, in general, do not kill healthy cells or kills a negligible number of healthy cells. | 04-19-2012 |
Patent application number | Description | Published |
20110243719 | NON-CIRCULAR AFT NACELLE COWLING GEOMETRY - A nacelle for a turbofan propulsion system that extends along a centerline includes a forward cowling and an aft cowling. To improve the fit of a turbofan propulsion system in the space between the wing and ground of a fixed-wing aircraft, the aft cowling of the nacelle is modified. The aft cowling has a non-circular cross-sectional geometry disposed in a plane substantially perpendicular to the centerline. The non-circular cross-sectional geometry includes a radially recessed section disposed between first and second curved sections. The first and the second curved sections each have a radius that is greater than a radial distance between the centerline and a center point of the radially recessed section. | 10-06-2011 |
20130221124 | GAS TURBINE ENGINE THRUST REVERSER SYSTEM - An example thrust reverser blocker door includes a blocker door that is movable from a stowed position to a deployed position. Flow moves through an area of a bypass flowpath when the blocker door is in the stowed position. The blocker door blocks no less than about 70% and no more than about 85% of flow through this area when the blocker door is in the deployed position, wherein the area does not extend circumferentially past the blocker door. | 08-29-2013 |
20130319002 | NACELLE BIFURCATION FOR GAS TURBINE ENGINE - A nacelle structure for a gas turbine engine includes a core engine nacelle disposed about an engine axis and an outer nacelle disposed about the core engine nacelle. A bifurcation extends between the outer nacelle and the core engine nacelle along a bifurcation axis extending between the outer nacelle and the core engine nacelle. The bifurcation includes at least one mounting surface that is disposed at a non-normal angle relative to the bifurcation axis. | 12-05-2013 |
20140216005 | Gas Turbine Engine Assembly Including A Thrust Reverser - An exemplary gas turbine engine assembly includes a thrust reverser that is selectively moveable between a stowed position and a thrust reversing position. The thrust reverser includes an outer surface having a first outer surface area when the thrust reverser is in the stowed position and a second, smaller outer surface area when the thrust reverser is in the thrust reversing position. | 08-07-2014 |
20140246514 | TURBOMACHINE THRUST REVERSER - An example thrust reverser of a gas turbine engine is configured to connect to an aircraft wing via a pylon via one or more thrust reverser mounts located adjacent to a top circumferential apex of the engine according to an exemplary aspect of the present disclosure includes, among other things, a first cowl moveable between a stowed position and a deployed position relative to a second cowl. The first cowl in the deployed position configured to permit thrust to be redirected from an engine to slow the engine. The first cowl forming a portion of a substantially annular encasement of the engine. The first cowl directly interfaces with second cowl of the encasement at a cowl interface position that is more than 18 degrees circumferentially offset from the top circumferential apex when the first cowl is in the stowed position. | 09-04-2014 |
20140283501 | ELONGATED GEARED TURBOFAN WITH HIGH BYPASS RATIO - A propulsion system includes a fan, a gear, a turbine configured to drive the gear to, in turn, drive the fan. The turbine has an exit point, and a diameter (D | 09-25-2014 |
20140286754 | Elongated Geared Turbofan With High Bypass Ratio - A propulsion system includes a fan, a gear, a turbine configured to drive the gear to, in turn, drive the fan. The turbine has an exit point, and a diameter (D | 09-25-2014 |
20150044028 | LOW PRESSURE RATIO FAN ENGINE HAVING A DIMENSIONAL RELATIONSHIP BETWEEN INLET AND FAN SIZE - According to an example embodiment, a gas turbine engine assembly includes, among other things, a fan that has a plurality of fan blades. A diameter of the fan has a dimension D that is based on a dimension of the fan blades. Each fan blade has a leading edge. An inlet portion is situated forward of the fan. A length of the inlet portion has a dimension L between a location of the leading edge of at least some of the fan blades and a forward edge on the inlet portion. A dimensional relationship of L/D is between about 0.2 and about 0.45. | 02-12-2015 |
Patent application number | Description | Published |
20100168949 | System and Method for Autonomous Vehicle Control - A system for localizing an autonomous vehicle to a target area can include a position indicator adapted for association with the vehicle in a three dimensional configuration, a detection device configured to detect the position indicator, a computation device configured to compute a position of the vehicle based on the detected position indicator and the relationship of the configuration to the vehicle orientation, a transmitter configured to receive information from the computation device and produce a signal carrying the information, a receiver configured to receive the signal from the transmitter and filter the information therefrom, and a control system configured for association with and control of one or more directional control components of the vehicle, the control being based on the information received from the receiver relating to localizing the vehicle to the target area. A method of for localizing a vehicle to a target area is also disclosed. | 07-01-2010 |
20110128372 | System and Method for Determining an Orientation and Position of an Object - A system for determining an orientation and position of an object can include a computation device having an input module adapted to receive data defining a two dimensional image, an image analyzing module configured to receive the data and analyze the two dimensional image to determine a two dimensional orientation representative of a three dimensional orientation and position, a position calculating module configured to receive the two dimensional orientation from the image analyzing module and determine the three dimensional orientation and position of the object, and an output module adapted to send information relating to the three dimensional orientation and position of the object. A method for determining an orientation and position of an object is also disclosed. | 06-02-2011 |
20130301905 | SYSTEM AND METHOD FOR DETERMINING AN ORIENTATION AND POSITION OF AN OBJECT - A system includes a computation device having an input module adapted to receive data defining a single two dimensional image, an image analyzing module configured to receive the data and analyze the single two dimensional image to determine a two dimensional orientation representative of a three dimensional orientation and position, a position calculating module configured to receive the two dimensional orientation from the image analyzing module and determine the three dimensional orientation and position of the object, and an output module adapted to send information relating to the three dimensional orientation and position of the object. | 11-14-2013 |