Malamas, PA
Michael S. Malamas, Jamison, PA US
Patent application number | Description | Published |
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20090042912 | DIPHENYLIMIDAZOLYL COMPOUNDS AS INHIBITORS OF beta-SECRETASE - The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated β-amyloid deposits or β-amyloid levels in a patient. | 02-12-2009 |
20090093498 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE - The present invention provides a compound of formula I and the use thereof for the therapeutic treatment, prevention or amelioration of a disease or disorder characterized by elevated β-amyloid deposits or β-amyloid levels in a patient. | 04-09-2009 |
20090143361 | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 - The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical compositions which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10, as active compounds for treating central nervous system disorders, obesity, and metabolic disorders. | 06-04-2009 |
20090143367 | ARYL AND HETEROARYL FUSED IMIDAZO[1,5-a]PYRAZINES AS INHIBITORS OF PHOSPHODIESTERASE 10 - The invention relates to imidazo[1,5-a]pyrazine derivatives, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10 (PDE10), as active compounds for treating central nervous system diseases of mammals, including humans. | 06-04-2009 |
20100120762 | Triazine derivatives as inhibitors of phosphodiesterases - The invention relates to triazine derivatives of formula (I): | 05-13-2010 |
20100120763 | IMIDAZO[5,1-C][1,2,4]BENZOTRIAZINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASES - The invention relates to imidazo[5,1-c][1,2,4]benzotriazine derivatives of formula I: | 05-13-2010 |
Peter Malamas, Jamison, PA US
Patent application number | Description | Published |
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20140163663 | METHOD AND SYSTEM FOR SWITCHING SHOCK VECTORS AND DECREASING TRANSTHORACIC IMPEDANCE FOR CARDIOVERSION AND DEFIBRILLATION - A method and system for improving the effectiveness of cardioversion or defibrillation through the ability to switch shock vectors and to reduce transthoracic impedance. A “shock vector” or “shocking vector” is herein defined as the path and direction which electrical current follows in traversing a patient body cavity between two external adhesive electrode patches. An external multiple patch system comprises at least two options for a shocking vector once external patches are applied and adhered to desired locations on a patient's body. A manual switching mechanism in the system provides the ability to direct current from a defibrillator to either of two or more specified shocking vectors. A method and system of decreasing transthoracic impedance comprises wrapping material around a patient's body to apply pressure to adhered patches. This mechanism further reduces transthoracic impedance by increasing effective pressure on the patches through use of pressure-focusing mechanisms located between a patch and a strap. An integrated mechanism would provide qualitative and/or quantitative feedback on the force being applied to the desired patches. | 06-12-2014 |
20150221205 | METHOD AND SYSTEM FOR DECREASING TRANSTHORACIC IMPEDANCE FOR CARDIOVERSION AND DEFIBRILLATION - A method and system for improving the effectiveness of cardioversion and defibrillation through the ability to reduce transthoracic impedance. A method and system of decreasing transthoracic impedance that allows standardized pressure to be applied directly over desired defibrillator patches. This system reduces transthoracic impedance by increasing effective pressure on desired patches through use of a manual depressor device which incorporates a deformable patient body interface and mechanical and or electronic mechanisms to provide qualitative and or quantitative feedback on the force being applied to said patches. By depressing the device over desired external adhesive electrode patches until an audio and or visual signal indicates sufficient applied pressure, increased patch to skin contact is achieved to decrease the effective transthoracic impedance of a patient upon delivery of a defibrillation shock. | 08-06-2015 |