Makarova
Elina Makarova, Ogres District LV
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20150313862 | "Pharmaceutical composition for reducing the trimethylamine N-oxide level" - The invention discloses the use of pharmaceutical compositions containing 3-(2,2,2-trimethylhydrazinium)propionate dihydrate and pharmaceutically acceptable salts thereof for trimethylamine N-oxide level decrease in a body. | 11-05-2015 |
Olga Makarova, Naperville, IL US
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20100276829 | High Aspect Ratio Microstructures and Method for Fabricating High Aspect Ratio Microstructures From Powder Composites - Methods to fabricate high aspect ratio powder composite microstructures is provided by filling a molding composition containing a powdered material and a binder into a patterned mold, and releasing the cured composite microstructures from the mold. An alternate method is by filling a mix of powdered dense metals and low-melt alloys into a patterned mold, and releasing the melted and solidified composite microstructures from the mold. The mold is derived from lithographically defined parent mold. One example of the application is in the field of x-ray anti-scatter grids and nuclear collimators. | 11-04-2010 |
20120183946 | Fabrication of Microfilters and Nanofilters and Their Applications - Micro- and nanofilters with precision pore sizes and pore layout have applications in many fields including capturing circulating tumor cells and fetal cells in blood, water treatment, pathogen detection in water, etc. Methods to fabricate micro- and nanofilters not using track etching or reactive ion etching are provided, allowing easy fabrication of single layer or stack of films simultaneously, and/or stack of films on rolls. Microfilter can be made using one or more layers of material. Invention enables mass production of microfilters with lithographic quality at low cost. Isolation, enumeration and characterization of circulating tumor cells using microfilters provides (i) guides to cancer treatment selection and personalize dosage, (ii) low cost monitoring for treatment response, disease progression and recurrence, (iii) assessment of pharmacodynamic effects, (iv) information on mechanisms of resistance to therapy, and (v) cancer staging. Microfabrication methods are also applicable to fabrication of any free standing patterned polymeric films. | 07-19-2012 |
20140315295 | POLYMER MICROFILTERS, DEVICES COMPRISING THE SAME, METHODS OF MANUFACTURING THE SAME, AND USES THEREOF - A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells. | 10-23-2014 |
Olga Alexandrovna Makarova, Moscow RU
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20090258087 | Method to increase and accelerated rehabilitate the capacity for work - The method to increase and accelerated rehabilitate the capacity for work is characterized in that the person is exposed to gaseous products having the property to improve physical and psychological human capabilities during a period of preparing for extreme strains and/or after extreme strains; the exposure to gaseous products is performed during a period from several weeks to several minutes before undergoing extreme strains by inhaling the gaseous mixture composed of oxygen and/or air and at least one inert gas, mainly xenon, with the contents of oxygen or air from 20% to 98% and at least one inert gas from 2% to 80%. The inhalation with the gaseous mixture is carried out until the state of euphoria emerges but no longer than for 20 minutes with breaks or without them; preferably, the inhalation with the gaseous mixture is performed no less than for 10 seconds and no longer than for 20 minutes with breaks or without them. Permanent and accelerated rehabilitation of the organism's capabilities and work capacity improvement during preparatory periods for extreme strains and in the course of extreme stressful strains as well as prompt rehabilitation of the diminished organism after extreme physical strains is provided due to the impact of gaseous products, i.e. oxygen cocktails having the property to improve human physical and psychological abilities and relieve mental, emotional and physical strain, pain and tiredness. | 10-15-2009 |
Olga V. Makarova, Naperville, IL US
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20100181288 | Method of fabrication of micro- and nanofilters - Micro- and nanofilters have a wide range of applications in many fields, including medical diagnostics, drug delivery, medical implants, and hemodialysis. Some issues that limit commercial application of current nanofilters in medicine are low pore density, non-uniform pore size, and the use of materials that are not biocompatible. A method is described to fabricate high porosity polymer and diamond micro- and nanofilters producing smooth, uniform and straight pores of high aspect ratio. Pore size, density, and shape can be predetermined with a high degree of precision by masks and controlled etch. The method combines energetic neutral atom beam lithography and a mask. This technology allows etching polymeric materials in a clean, well-controlled, and charge-free environment, making it very suitable for fabricating nanofilters and other components for biomedical applications. | 07-22-2010 |
Olga V. Makarova, Potomac, MD US
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20130059308 | POLYMER MICROFILTERS AND METHODS OF MANUFACTURING THE SAME - A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defmed by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. | 03-07-2013 |