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Majeti, US

Bharat Majeti, La Jolla, CA US

Patent application numberDescriptionPublished
20120021036COMPOSITE NANOSTRUCTURES AND METHODS FOR MAKING AND USING THEM - The invention provides nanostructures or products of manufacture for use as ex vivo or in vivo composition (e.g., a drug, or a therapeutic, diagnostic or imaging reagent) delivery vehicles. In one aspect, the invention provides nanoparticles comprising several compartments which in unison function as a composite nanostructure. In one embodiment, the nanoparticles of the invention comprise a combination of polymer core/lipid bilayer interface which incorporate covalently attached lipid-vascular targeting ligands. These composite nanoparticles can deliver highly effective and selective payloads for diagnostic, prophylactic or therapeutic applications.01-26-2012

Bharat Kumar Majeti, La Jolla, CA US

Patent application numberDescriptionPublished
20100234289INTEGRIN BINDING RGD-LIPOPEPTIDES WITH GENE TRANSFER ACTIVITIES - The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides high L27 (transformed S1 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since 127 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins).09-16-2010

Ravindra Majeti, Stanford, CA US

Patent application numberDescriptionPublished
20090191202Methods for manipulating phagocytosis mediated by CD47 - Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable.07-30-2009
20110014119Methods for Manipulating Phagocytosis Mediated by CD47 - Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.01-20-2011
20110015090Markers of Acute Myeloid Leukemia Stem Cells - Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets.01-20-2011

Ravindra Majeti, Standford, CA US

Patent application numberDescriptionPublished
20090191164HUMAN HEMATOPOIETIC MULTIPOTENT PROGENITOR CELLS - A substantially enriched human multipotent progenitor cell population is provided, which is characterized as a progenitor cell capable of giving rise to the multipotent lineage but which lacks certain long-term self-renewal properties of the hematopoietic stem cell. Methods are provided for the isolation and culture of these cells. The cell enrichment methods employ reagents that specifically recognize CD34, CD38, CD90 and CD45RA, in conjunction with lineage specific markers. These cells give rise to all types of hematopoietic cells, e.g. myeloid and lymphoid cells, in vivo.07-30-2009

Satyanarayana Majeti, Liberty Township, OH US

Patent application numberDescriptionPublished
20110274728Compositions and Methods for Alleviating Hyposalivation and for Providing Oral Comfort - Various compositions and methods are provided to alleviate one or more symptoms associated with hyposalivation or xerostomia. Preferred compositions and methods employ one or more plant extracts and/or a proanthocyanidin at a concentration effective to reduce or eliminate the symptoms. Especially preferred extracts are isolated from a fruit and/or seed (e.g., grape, cranberry, blue berry, black berry, etc.), and where a second extract is present, such extract is preferably isolated from a citrus fruit (e.g., lemon, orange, lime, grapefruit, tangerine, mandarin orange, ugli fruit, etc.).11-10-2011

Suryakala Majeti, Rochester Hills, MI US

Patent application numberDescriptionPublished
20080229572Micro-Electromechanical Capacitive Strain Sensor - A micro-electromechanical capacitive strain sensor. The micro-electromechanical capacitive strain sensor comprises a first bent beam, a second bent beam, and a straight center beam. The first bent beam, second bent beam, and straight center beam are aligned in the X-axis with the straight center beam located between the first and second bent beams. The first bent beam, second bent beam, and straight center beam are disposed between two anchors. The two anchors are aligned in the Y-axis. The first bent beam is bent away from the center beam and the second bent beam is bent towards the center beam to provide a set of differential capacitors with respect to the center beam, wherein the center beam serves as a common reference with respect to the first and second bent beams.09-25-2008
20090320607Micro-Electromechanical Capacitive Strain Sensor - A micro-electromechanical capacitive strain sensor. The micro-electromechanical capacitive strain sensor comprises a first bent beam, a second bent beam, and a straight center beam. The first bent beam, second bent beam, and straight center beam are aligned in the X-axis with the straight center beam located between the first and second bent beams. The first bent beam, second bent beam, and straight center beam are disposed between two anchors. The two anchors are aligned in the Y-axis. The first bent beam is bent away from the center beam and the second bent beam is bent towards the center beam to provide a set of differential capacitors with respect to the center beam, wherein the center beam serves as a common reference with respect to the first and second bent beams.12-31-2009

Venkata Chalapathi Majeti, Naperville, IL US

Patent application numberDescriptionPublished
20100020972Wireless mobile device that permits toggling of whether to transmit information contained in SMS messages as encrypted or clear text - An exemplary method is implemented by a wireless mobile device that transmits and receives short message system (SMS) text messages. Entered first text to be transmitted as a first SMS text message from the wireless mobile device is accepted and stored by a resident application. A user selectable input is received by the resident application of the wireless mobile device, where the user selectable input controls whether a resident encryption algorithm will be used to convert the first text into an encrypted first text message. A user control input is received by the resident application that causes the transmission of the first SMS text message from the wireless mobile device. The text of the transmitted first SMS text message contains the first text if the resident encryption algorithm is not selected by the user. The text of the transmitted first SMS text message contains encrypted first text if the resident encryption algorithm is selected by the user.01-28-2010
20100024010Mobile device with customizable login screen - An exemplary method controls the display of information on the screen of a mobile device during a request for login information. Independently controlled regions of the screens are used to concurrently convey different information associated with each region to a user of the mobile device during the rendering of a login request that is contained in one of the regions.01-28-2010
20100024020Wireless mobile device with privacy groups that independently control access to resident application programs - An exemplary method implemented by a wireless mobile device controls user access to programs and files defining items that are resident on the mobile device. A first icon associated with a corresponding first program installed on the wireless mobile device is displayed on the screen of the wireless mobile device, where the first icon can be seen by any person using the wireless mobile device and the corresponding first program is available for execution to said person. A privacy gate and a corresponding privacy icon displayed on the screen are created using a privacy interface program installed on the wireless mobile device. A password associated with the privacy gate is entered by a first user so that a subsequent request by a user to traverse the privacy gate will require entry of this password. The first program and the privacy gate are linked so that a user must traverse the privacy gate in order to execute the first program.01-28-2010
20100024028Wireless mobile device with user selectable privacy for groups of resident application programs and files - An exemplary method implemented by a wireless mobile device provides user selectable access to programs and files defining items that are resident on the mobile device. Screen icons associated with a privacy group are visually differentiated from icons associated with a public group. On receiving a user first input to initially access one of the items, where the first input is the first attempt by the user to access any item since a power up activation of the mobile device, determining whether the first input is a request to access an item associated with the privacy group or public group. If the sought access is to one item associated with the privacy group, a request is displayed on the screen requesting the user to enter a predetermined group privacy password and access is inhibited to the item unless the predetermined group privacy password is input to the mobile device by the user. The same predetermined group privacy password is required to initially access any of the items associated with the privacy group. If the sought access is to one item associated with the public group, the first user input is permitted to be conveyed to the associated one item causing the one item associated with the public group to be accessed without requiring an input by the user of the group privacy password.01-28-2010
20100162387Mobile device with separate access to private and public information stored in the device - An exemplary method is implemented by a wireless mobile device that transmits and receives text-based messages. Public records are stored in a public contact database in the mobile device, the public records containing public contact information for persons. Public contact information contained in a public record corresponding to a person selected by a public user is displayed upon the request of any public user of the device. Private records are stored in a private contact database in the mobile device, the private records containing private contact information for persons. Upon a valid password being received by the device from a private user, access to the private contact information is provided to the private user. In response to the receipt of a request from the private user, private contact information for a selected person from a corresponding private record is displayed on the screen of the mobile device.06-24-2010
20100162388Wireless mobile device with automatic segregation of received messages for private and public access - An exemplary method is implemented by a wireless mobile device that transmits and receives text-based messages. Received messages are stored in memory of the wireless mobile device. Based on a privacy criteria stored in the memory, some of the received messages are automatically identified as public and others of the received messages are automatically identified as private. Access is provided to stored received messages that are designated as public to any user of the mobile device. Access is provided to stored received messages that are designated as private only after receipt of a password entered by a user of the wireless mobile device that permits access to the privately identified messages.06-24-2010