Patent application number | Description | Published |
20110245342 | 3,5,3'-TRIIODOTHYRONINE SULFATE AS THYROMIMETIC AGENT AND PHARMACEUTICAL FORMULATIONS THEREOF - The invention regards the use of triiodothyronine sulfate, commonly named T | 10-06-2011 |
20120165211 | Human Antibodies Cross-Reacting With A Bacterial And A Self Antigen From Atherosclerotic Plaques - The present invention refers to human antibodies derived from human antibody libraries prepared from atherosclerotic plaques. It further refers to human antibodies able to immunologically recognize both human transgelin or fragments thereof and a protein with at least 50% similarity to OmpK36 (Outer membrane protein, | 06-28-2012 |
20120245333 | PROCESS FOR THE PREPARATION OF CHELATED COMPOUND - The present invention generally relies on a process for the preparation of chelated compounds, comprising the selective interaction between a solid matrix and a chelating agent. In more details, the present invention enables the preparation of chelated compounds useful as diagnostic agents, in high yields and in a reliable way. | 09-27-2012 |
20130146502 | 3,5,3'-Triiodothyronine Sulfate As Thyromimetic Agent And Pharmaceutical Formulations Thereof - The invention regards the use of triiodothyronine sulfate, commonly named T | 06-13-2013 |
20130281536 | 3,5,3'-Triiodothyronine Sulfate As Thyromimetic Agent And Pharmaceutical Formulations Thereof - The invention regards the use of triiodothyronine sulfate, commonly named T | 10-24-2013 |
20140024717 | Process For The Preparation Of A Sulfated Derivative Of 3,5-Diiodo-O-[3-Iodophenyl]-L-Tyrosine - The present invention relates to a process for the preparation of the mono sodium salt of the derivative 3,5-diiodo-O-[3-iodo-4-(sulphooxy)phenyl]-L-tyrosine (T3S) by starting from the corresponding phenolic compound, in the presence of chloro-sulfonic acid and dimethylacetamide as a solvent. The so obtained T3S compound may conveniently be isolated in a pure form as a solid in good yields. The present invention further relates to the process for T3S preparation, wherein the starting reagent is T2 and further comprising the formulation of such compound in tablets. Furthermore, the invention discloses non-radioactive immunoassays based on T3S derivatives. | 01-23-2014 |
Patent application number | Description | Published |
20090319037 | RETAINING MECHANISMS FOR PROSTHETIC VALVES - Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support stent is delivered to a position on the surface of the outflow side of a native heart valve of a patient, the support stent defining a support-stent interior. An expandable prosthetic heart valve is delivered into the native heart valve from the inflow side of the native heart valve and into the support-stent interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic valve is in the support-stent interior and while the support stent is at the position on the surface of the outflow side of the heart valve, thereby causing one or more of the native leaflets of the native heart valve to be frictionally secured between the support stent and the expanded prosthetic heart valve. | 12-24-2009 |
20100161041 | ADJUSTABLE REPAIR CHORDS AND SPOOL MECHANISM THEREFOR - A method is provided, including implanting, at an intraventricular site of a ventricle of a patient, a spool coupled to a first end portion of a longitudinal member, and coupling a second end portion of the longitudinal member to a portion of tissue facing a lumen of the ventricle. Other embodiments are also described. | 06-24-2010 |
20100161042 | IMPLANTATION OF REPAIR CHORDS IN THE HEART - A method is provided, including positioning, at an intraventricular site of a ventricle of a patient, a spool coupled to a first end portion of a longitudinal member and coupling a second end portion of the longitudinal member to a portion of tissue facing a lumen of the ventricle. Other embodiments are also described. | 06-24-2010 |
20100161043 | IMPLANTATION OF REPAIR CHORDS IN THE HEART - Apparatus is provided for adjusting at least one dimension of an implant, including a rotatable structure having first and second openings and a channel extending between the first and second openings. The channel allows passage therethrough of an elongate tool. The second end of the structure has a lower surface having one or more recesses along a circumference thereof. A mechanical element provides a protrusion that is disposed within one of the recesses of the rotatable structure during a resting state of the mechanical element, in a manner that restricts rotation of the rotatable structure. The mechanical clement comprises a depressible portion coupled to the protrusion disposed in communication with the second opening of the lower surface, and configured to dislodge the protrusion from within the recess in response to a force applied thereto by the elongate tool. Other applications are also described. | 06-24-2010 |
20100280604 | OVER-WIRE ROTATION TOOL - Apparatus is provided that includes an implant structure, which includes a contracting mechanism, which includes a rotatable structure, arranged such that rotation of the rotatable structure contracts the implant structure. A longitudinal member is coupled to the contracting mechanism. A tool for rotating the rotatable structure is configured to be guided along the longitudinal member, to engage the rotatable structure, and to rotate the rotatable structure in response to a rotational force applied to the tool. Other embodiments are also described. | 11-04-2010 |
20110184510 | TRICUSPID VALVE REPAIR USING TENSION - A method is provided, including implanting at least a first tissue-engaging element in a first portion of tissue in a vicinity of a heart valve of a patient, implanting at least a second tissue-engaging element in a portion of a blood vessel that is in contact with an atrium of a heart of the patient, and drawing at least a first leaflet of the valve toward at least a second leaflet of the valve by adjusting a distance between the portion of the blood vessel and the first portion of tissue in the vicinity of the heart valve of the patient. Other applications are also described. | 07-28-2011 |
20110282361 | Delivery tool for implantation of spool assembly coupled to a helical anchor - Apparatus is provided, including a tissue-adjusting member configured to be coupled to tissue of a patient, a rotatable structure that is configured to adjust a tension of the tissue-adjusting member, a tissue anchor coupled to the tissue-adjusting member and configured to screw into the tissue of the patient, and a delivery tool reversibly coupleable to the rotatable structure. The delivery tool comprises a first actuating element configured to rotate the tissue anchor so as to facilitate screwing of the tissue anchor into the tissue of the patient while not facilitating rotation of the rotatable structure, and a second actuating element configured to rotate the rotatable structure while not facilitating rotation of the tissue anchor. Other applications are also described. | 11-17-2011 |
20120035712 | METHOD AND APPARATUS FOR TRICUSPID VALVE REPAIR USING TENSION - Apparatus is provided, including a radially-expandable percutaneous implant, a tissue anchor, and a connecting element shaped so as to provide an annular loop surrounding a proximal portion of the tissue anchor in a manner which enables rotation of the anchor about a central longitudinal axis thereof when surrounded by the annular loop. The apparatus also includes a flexible longitudinal member coupled at a first portion thereof to at least a portion of the percutaneous implant and at a second portion to the connecting element. The annular loop of the connecting element facilitates rotation of the tissue anchor about the central longitudinal axis such that the anchor can rotate about the central longitudinal axis with respect to the annular loop, the flexible longitudinal member, and the percutaneous implant. Other applications are also described. | 02-09-2012 |
20130018459 | METHOD AND APPARATUS FOR TRICUSPID VALVE REPAIR USING TENSION - Apparatus is provided including a first tissue-engaging element, a first flexible longitudinal member coupled at a first end portion thereof to at least a portion of the first tissue-engaging element, and a first flexible-longitudinal-member-coupling element coupled to the first flexible longitudinal member at a second end portion of the first flexible longitudinal member. Apparatus includes a second tissue-engaging element, a second flexible longitudinal member coupled at a first end portion thereof to at least a portion of the second tissue-engaging element, and a second flexible-longitudinal-member-coupling element coupled to the second flexible longitudinal member at a second end portion of the second flexible longitudinal member, the first and second flexible-longitudinal-member-coupling elements being couplable to couple together the first and second flexible longitudinal elements. Other applications are also described. | 01-17-2013 |
20130046380 | TRICUSPID VALVE REPAIR USING TENSION - Apparatus is provided including a stent, which is configured to assume compressed and expanded states. The stent includes one or more elongated members, and two or more rings, which are coupled together by the one or more elongated members and by no other elements of the stent. The rings define respective planes that are generally perpendicular to the elongated members when the stent is in its expanded state. A longitudinal member, having a proximal end and a distal end, is coupled to the stent at the proximal end of the longitudinal member. A tissue anchor is coupled to the distal end of the longitudinal member. Other applications are also described. | 02-21-2013 |
20130325115 | LOCKING CONCEPTS - Techniques are described for use with one or more sutures. For some applications, techniques are described for fixedly-coupling two or more sutures to each other. For some applications, such techniques are used for treating a heart valve of a subject. Techniques are also described for treating a heart valve of a subject by coupling leaflets of the heart valve to a support using tissue-piercing elements. Other embodiments are also described. | 12-05-2013 |
Patent application number | Description | Published |
20100137980 | Annular Prosthesis for a Mitral Valve - An annular prosthesis for a mitral valve that may include a posterior half-ring and an anterior half-ring coupled to each other on a first transverse plane which defines a maximum width section of the prosthesis. The ratio between the distance between the anterior half-ring and the posterior half-ring, as measured along a second plane, perpendicular to the first plane and equidistant to the couplings, and the maximum width of the prosthesis is lower than ¾. | 06-03-2010 |
20110301704 | Annuloplasty Rings for Repair of Abnormal Mitral Valves - A remodeling mitral annuloplasty ring with a reduced anterior-to-posterior dimension to restore coaptation between the mitral leaflets in mitral valve insufficiency (IMVI). The ring has a generally oval shaped body with a major axis perpendicular to a minor axis, both perpendicular to a blood flow axis. An anterior section lies between anteriolateral and posteriomedial trigones, while a posterior section defines the remaining ring body and is divided into P | 12-08-2011 |
20120172983 | METHODS OF REPAIRING AN ABNORMAL MITRAL VALVE - The present invention refers to an annular prosthesis for mitral valve. In one of its embodiments the annular prosthesis for mitral valve is made up of a posterior half-ring and an anterior half-ring coupled to each other on a first transverse plane which defines a maximum width section of the prosthesis, characterised in that the ratio between the distance between said anterior half-ring and said posterior half-ring, as measured along a second plane, perpendicular to said first plane and equidistant to said couplings, and said maximum width of the prosthesis is lower than 3/4. | 07-05-2012 |
20130090726 | RETAINING MECHANISMS FOR PROSTHETIC VALVES - A method of treating a deficient mitral valve without open heart surgery is disclosed. A support band is advanced from a delivery catheter and positioned around native leaflets of the deficient mitral valve. The support band is preferably formed of a shape memory material and is configured to assume a curved shape upon advancement from the delivery catheter. While the support band is positioned around the native leaflets of the mitral valve, an expandable prosthetic heart valve is delivered through an apex of the left ventricle and into the mitral valve. The expandable prosthetic heart valve is then expanded within the mitral valve, thereby causing one or more of the native leaflets of the mitral valve to be frictionally secured between the support band and the prosthetic heart valve. | 04-11-2013 |
20140088694 | TWO-PART PROSTHETIC VALVE SYSTEM - A prosthetic valve system for replacing a native aortic valve exhibiting regurgitation comprises a support structure and a transcatheter heart valve (THV) that is separate from the support structure. The support structure is radially collapsible and expandable, and deployable on an outflow side of the native aortic valve, circumscribing the native leaflets of the aortic valve. The THV is radially collapsible and expandable, and deployable in an annulus of the native aortic valve to frictionally engage the native leaflets between an interior surface of the support structure and the THY. | 03-27-2014 |
Patent application number | Description | Published |
20140309675 | FOSSA OVALIS PENETRATION - Apparatus and methods are described, including apparatus for puncturing a fossa ovalis of a heart. The apparatus comprises a catheter shaped to define a catheter lumen. A puncturing element is slidably disposed within the catheter lumen, and is configured to be deployed from a distal portion of the catheter and to puncture the fossa ovalis. One or more flexible longitudinal members are configured to be deployed from the distal portion of the catheter, and upon being deployed, facilitate the puncturing of the fossa ovalis by the puncturing element, by contacting tissue at a perimeter of the fossa ovalis. Other applications are also described. | 10-16-2014 |
20140309678 | FOSSA OVALIS PENETRATION USING BALLOONS - Apparatus and methods are described, including apparatus for puncturing a fossa ovalis of a heart. The apparatus comprises a catheter shaped to define a catheter lumen. A puncturing element is slidably disposed within the catheter lumen and configured to (a) be deployed from a distal portion of the catheter, and (b) puncture the fossa ovalis. A balloon is configured to be deployed from the distal portion of the catheter, be radially expanded, and upon being deployed and expanded, facilitate positioning of the puncturing element, by contacting at least a portion of the fossa ovalis. Other applications are also described. | 10-16-2014 |
20140309679 | FOSSA OVALIS PENETRATION USING PROBING ELEMENTS - Apparatus and methods are described, including apparatus for puncturing a fossa ovalis of a heart. The apparatus includes a catheter shaped to define a catheter lumen. A puncturing element is slidably disposed within the catheter lumen, and is deployed from a distal portion of the catheter and to puncture the fossa ovalis. A probing element is deployed from the distal portion of the catheter. Upon being deployed, the probing element probes tissue near the fossa ovalis, the probing element having a first configuration thereof upon probing the tissue near the fossa ovalis. Upon probing tissue of the fossa ovalis, the probing element facilitates positioning of the puncturing element, by automatically adopting a second configuration thereof that is different from the first configuration. Other applications are also described. | 10-16-2014 |
Patent application number | Description | Published |
20110214091 | PRESENTING OBJECT PROPERTIES - The present disclosure includes, among other things, systems, methods and program products for presenting object properties by receiving selection of a component of a model presented in a graphical user interface (GUI) of a computer aided design tool, the GUI including an interactive display element having an arrangement of property fields related to the selected component, determining property values associated with the property fields based on the selected component, and providing the determined property values in corresponding property fields of the interactive display element for presentation in the GUI in conjunction with the model, such that responsive to receiving selection of a different component of the model, the property fields are updated with property values corresponding to the different component. | 09-01-2011 |
20150033166 | Presenting Object Properties - The present disclosure includes, among other things, systems, methods and program products for presenting object properties by receiving selection of a component of a model presented in a graphical user interface (GUI) of a computer aided design tool, the GUI including an interactive display element having an arrangement of property fields related to the selected component, determining property values associated with the property fields based on the selected component, and providing the determined property values in corresponding property fields of the interactive display element for presentation in the GUI in conjunction with the model, such that responsive to receiving selection of a different component of the model, the property fields are updated with property values corresponding to the different component. | 01-29-2015 |