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Maines, US
Brant H. Maines, Colleyville, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20110180146 | MICROVANES FOR AIRCRAFT AFT BODY DRAG REDUCTION - The invention relates a method and apparatus for reducing the drag on aircraft, particularly aircraft with an upswept afterbody. The method includes the steps of positioning a plurality of drag reducing elements on the fuselage of the aircraft, wherein the drag reducing elements are positioned on the fuselage from a position at the breakline of the fuselage and extending toward the tail of the aircraft. In preferred embodiments, each of the plurality of drag reducing elements is positioned such that a first end of the drag reducing element is at an angle of between approximately 15 and 35° nose up relative to the flow of air about the fuselage at the location where the drag reducing element is positioned. | 07-28-2011 |
Garen R. Maines, Byron Center, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20100162837 | BALLSCREW ASSEMBLY WITH DETECTION FEATURE - A ballscrew assembly for an actuator is provided. In an embodiment, the ballscrew assembly includes a ball nut assembly including a view port; a ballscrew provided within at least a portion of the ball nut assembly; an inner rod provided within the ballscrew in the direction of the longitudinal axis, the inner rod including an enlarged end portion; and a compression mechanism, such that at least a portion of the compression mechanism is provided between the enlarged end portion and the ballscrew. In another embodiment the assembly is configured such that when the inner rod is in a failed state, the compression mechanism provides a force that moves the visual indicator toward the view port. In another embodiment, the assembly includes a proximity sensor in addition to, or in lieu, of a view port to detect a failure. | 07-01-2010 |
Lois Jane Maines, Hamilton, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20090064390 | One piece, wearable sleep training system with illuminating section - A one piece sleep training garment used to progress an infant through three stages of swaddling positions. Stage one will swaddle both arms, stage two will only swaddle one arm and stage three will allow both arms to be free. | 03-12-2009 |
Lynn W. Maines, Hummelston, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20120122870 | Treatment Of Ischemia-Reperfusion Injury - Ischemia-reperfusion injury remains a primary cause of morbidity and mortality in individuals who experience disruption of normal blood flow to one or more major organs. For example, there are no clinically proven strategies that prevent acute renal failure following cardiac surgery. The present invention provides a variety of methods for the treatment or prevention of ischemia-reperfusion injury. In one aspect of the invention, a method for treating or preventing ischemia-reperfusion injury includes administering to a subject an effective amount of a sphingosine kinase inhibitor. Sphingosine kinase inhibitors are very effective in the protection against IR-induced acute renal failure and liver failure. Moreover, the effects occur very early after administration, requiring only a very short time of treatment. Toxicology studies with sphingosine kinase inhibitors demonstrate that they have low toxicity, even in long-term treatment. | 05-17-2012 |
Lynn W. Maines, Hummelstown, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20120058966 | Sphingosine Kinase Inhibitor Prodrugs - The invention relates to prodrugs of hydroxyl-substituted adamantane compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease. | 03-08-2012 |
Mahin D. Maines, Rochester, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090214627 | METHODS OF MODIFYING INSULIN SIGNALING USING BILIVERDIN REDUCTASE - The present invention relates to a method of modulating insulin signaling in a cell. This method involves modifying the nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, in a cell, whereby a change in nuclear or cellular concentration of biliverdin reductase, or fragments or variants thereof, modulates insulin signaling in the cell via biliverdin reductase interaction with one or both of insulin receptor kinase domain and insulin receptor substrate. Also disclosed are methods of treating a condition associated with insulin signaling and treating a patient for a condition associated with insulin-mediated glucose uptake. | 08-27-2009 |
| 20100303790 | USE OF BILIVERDIN REDUCTASE (BVR) AND BVR PEPTIDE FRAGMENTS TO TREAT CORONARY DISORDERS - The present invention relates to methods and compositions for treating coronary disorders and preventing cardiac cell death that involve the use of biliverdin reductase (“BVR”) or BVR peptides to stabilize the expression and activity of intracellular HO-2 in cardiac cells. The present invention also relates to methods and compositions for inducing cancer cell death in a patient having cancer that involve the use of inhibitory BVR peptides to destabilize intracellular HO-2 expression and activity, thereby augmenting cell death. | 12-02-2010 |
| 20110217279 | USE OF HUMAN BILIVERDIN REDUCTASE AND FRAGMENTS THEREOF FOR THE TREATMENT OF PROTEIN KINASE C-DELTA AND ERK RELATED CONDITIONS - The present invention is directed to methods of modulating PKC-δ activity and PKC-δ/ERK complex activity in cells via biliverdin reductase. Methods and compositions for diagnosing and treating a PKC-δ and PKC-δ/ERK complex related condition are also disclosed. | 09-08-2011 |
Michael Maines, Gainesville, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20090072698 | Microwave coupled excitation of solid state resonant arrays - An electronic receiver array for detecting microwave signals. Ultra-small resonant devices resonate at a frequency higher than the microwave frequency (for example, the optical frequencies) when the microwave energy is incident to the receiver. A microwave antenna couples the microwave energy and excites the ultra-small resonant structures to produce Plasmon activity on the surfaces of the resonant structures. The Plasmon activity produces detectable electromagnetic radiation at the resonant frequency. | 03-19-2009 |
Michael E. Maines, Gainesville, FL US
| Patent application number | Description | Published |
|---|---|---|
| 20080296517 | Coupling light of light emitting resonator to waveguide - A waveguide conduit is constructed and adapted to capture the light emitted by the at least one nano-resonant structure. The nano-resonant structure emits light in response to excitation by a beam of charged particles, The source of charged particles may be an ion gun, a thermionic filament, a tungsten filament, a cathode, a field-emission cathode, a planar vacuum triode, an electron-impact ionizer, a laser ionizer, a chemical ionizer, a thermal ionizer, or an ion-impact ionizer. | 12-04-2008 |
| 20090140178 | SWITCHING MICRO-RESONANT STRUCTURES BY MODULATING A BEAM OF CHARGED PARTICLES - When using micro-resonant structures, a resonant structure may be turned on or off (e.g., when a display element is turned on or off in response to a changing image or when a communications switch is turned on or off to send data different data bits). Rather than turning the charged particle beam on and off, the beam may be moved to a position that does not excite the resonant structure, thereby turning off the resonant structure without having to turn off the charged particle beam. In one such embodiment, at least one deflector is placed between a source of charged particles and the resonant structure(s) to be excited. When the resonant structure is to be turned on (i.e., excited), the at least one deflector allows the beam to pass by undeflected. When the resonant structure is to be turned off, the at least one deflector deflects the beam away from the resonant structure by an amount sufficient to prevent the resonant structure from becoming excited. | 06-04-2009 |
| 20090290604 | Micro free electron laser (FEL) - A charged particle beam including charged particles (e.g., electrons) is generated from a charged particle source (e.g., a cathode or scanning electron beam). As the beam is projected, it passes between plural alternating electric fields. The attraction of the charged particles to their oppositely charged fields accelerates the charged particles, thereby increasing their velocities in the corresponding (positive or negative) direction. The charged particles therefore follow an oscillating trajectory. When the electric fields are selected to produce oscillating trajectories having the same (or nearly the same) frequency as the emitted radiation, the resulting photons can be made to constructively interfere with each other to produce a coherent radiation source. | 11-26-2009 |