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Mahfouz

Mohamed M. Mahfouz, Knoxville, TN US

Patent application numberDescriptionPublished
20100198067Noninvasive Diagnostic System - A method for diagnosing a joint condition includes in one embodiment: creating a 3d model of the patient specific bone; registering the patient's bone with the bone model; tracking the motion of the patient specific bone through a range of motion; selecting a database including empirical mathematical descriptions of the motion of a plurality actual bones through ranges of motion; and comparing the motion of the patient specific bone to the database.08-05-2010

Mohamed R. Mahfouz, Knoxville, TN US

Patent application numberDescriptionPublished
20120029345NONINVASIVE DIAGNOSTIC SYSTEM - A device for acquiring data and diagnosing a musculoskeletal injury. The device includes a semi-flexible housing, at least one ultrasonic transducer, a positional localizer, and a transmission system. The semi-flexible housing is positioned proximate a portion of the musculoskeletal system of a patient and supports the at least one ultrasonic transducer and the positional localizer. The at least one ultrasonic transducer is configured to acquire an ultrasonic data indicative of a bone surface. The positional localizer is positioned at a select location relative to the at least one ultrasonic transducer and tracks movement of the housing. The transmission system transmits the ultrasonic data of the at least one ultrasonic transducer and the movement data of the positional localizer to a data analyzer for analysis and diagnosis.02-02-2012

Mohamed Rashwan Mahfouz, Knoxville, TN US

Patent application numberDescriptionPublished
20110087465IMPLANT DESIGN ANALYSIS SUITE - A method for anatomical analysis and joint implant design. Embodiments provide users with the ability to anatoically analyze a single bone or a series of bones that exist in a database, evaluate surgical landmarks and axes, identify differences among specific characteristics of a given population, and modify existing implants or create new implant designs based on anatomical analyses.04-14-2011
20110304332INTELLIGENT CARTILAGE SYSTEM - The exemplary embodiments of the present disclosure are described and illustrated below to encompass methods and devices for designing patient specific prosthetic cutting jigs and, more specifically, to devices and methods for segmenting bone of the knee and the resulting cutting guides themselves. Moreover, the present disclosure relates to systems and methods for manufacturing customized surgical devices, more specifically, the present disclosure relates to automated systems and methods of arthroplasty cutting guides, systems and methods for image segmentation in generating computer models of knee joint.12-15-2011
20110305379DEFORMABLE ARTICULATING TEMPLATE (formerly: CUSTOMIZED ORTHOPAEDIC IMPLANTS & RELATED METHODS) - A method of designing a prosthetic implant. Exemplary methods may include developing a three-dimensional model of an anatomic feature from one or more two-dimensional images. The three-dimensional model may include a plurality of radii of curvature representing the shape of respective portions of a contact surface. In some exemplary embodiments, three-dimensional models associated with a large number members of a population may be utilized to create templates for prosthetic implants. A three-dimensional model of an anatomic feature of a patient may be compared to the available templates, and a suitable template may be tested by virtually implanting the template on the three-dimensional model of the patient's anatomical feature. In some embodiments, a patient's three-dimensional model for which a suitable pre-made template is not available may be used to customize a pre-made template to design a suitable implant.12-15-2011

Tamer Mahfouz, Cairo EG

Patent application numberDescriptionPublished
20100070975DETERMINING THE PROCESSING ORDER OF A PLURALITY OF EVENTS - A method for operating a multi-threading computational system includes: identifying related events; allocating the related events to a first thread; allocating unrelated events to one or more second threads; wherein the events allocated to the first thread are executed in sequence and the events allocated to the one or more second threads are executed in parallel to execution of the first thread. A system for allocating incoming events among operational groups to create a multi-treaded computation process includes: incoming events; an event processing system configured to receive the incoming events; an event key generator within the event processing system, the event key generator being configured to generate event keys at run time, the event keys being associated with the incoming events; and a thread dispatcher, the thread dispatcher allocating the incoming events among the operational groups according to the associated incoming event keys.03-18-2010

Tamer A. Mahfouz, Cairo EG

Patent application numberDescriptionPublished
20090018983METHOD AND SYSTEM FOR DETECTING ANOMALOUS PROCESS BEHAVIOR - A method for learning a process behavior model based on a process past instances and on one or more process attributes, and a method for detecting an anomalous process using the corresponding process behavior model.01-15-2009

Tarek M. Mahfouz, Ada, OH US

Patent application numberDescriptionPublished
20100240727Model for Glutamate Racemase Inhibitors and Glutamate Racemase Antibacterial Agents - The increase in antibacterial resistance has created the demand for new antibiotics. The present invention relates to a more potent antibiotic that targets the enzyme glutamate racemase from known glutamate racemase inhibitors. Glutamate racemase catalyses the interconversion of L-glutamate to D-glutamate, making D-glutamate available, which is required for bacterial peptidoglycan biosynthesis. Knockout mutations have shown glutamate racemase to be necessary for bacterial cell survival and, before the present invention, no antibiotic on the market targeted this enzyme. The present invention relates to new, ligand based glutamate racemase inhibitors, developed using software to extract a pharmacophore model from a group of known glutamate racemase inhibitors. Forty-seven (47) known inhibitors were collected from the literature and several pharmacophore models were extracted therefrom. The functional groups common to all the known inhibitors were included in a pharmacophore model that described the requirements for glutamate racemase inhibition with 82% accuracy. Of these models, one was found to describe the requirements for glutamate racemase inhibition with 82% accuracy. The model was used to search databases of commercially available chemical compounds and 2-(2-(1H-indol-3-yl)ethylamino)-4-oxo-4-p-tolylbutanoic acid and 2-(2-(1H-indol-3-yl)ethylamino)-4-(4-fluorophenyl)-4-oxobutanoic acid were identified as showing antibacterial activity. These compounds were assayed against 09-23-2010