Madden
Alfred Madden, Ilminster GB
Patent application number | Description | Published |
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20150053603 | Filtration Apparatus - A filtration apparatus has a housing that has a main housing body and a base closure member. The base closure member is releasably attached to the main housing body, wherein the housing defines an enclosed space. A filter element is disposed in the enclosed space. The housing has a fluid inlet and a fluid outlet. The base closure member has a peripheral channel extending about an entire periphery of the base closure member, wherein the peripheral channel is in communication with the fluid inlet or the fluid outlet of the housing. The base closure member has a fluid inlet passage and/or a fluid outlet passage communicating with the peripheral channel and communicating with the filter element. | 02-26-2015 |
Chris Anthony Madden, Co. Dublin IE
Patent application number | Description | Published |
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20150161579 | POINT OF SALE SYSTEM - A point of sale system including a display subsystem including a viewable display array having multiple controllable display locations being operative to display non-trusted display content and trusted display content and a trusted/non-trusted display content controller operative to govern operation of the display subsystem and thereby to selectably allow a portion of the non-trusted display content from a non-trusted display content source to be viewed, at at least one display location on the viewable display array, which at least one display location is selected by the trusted/non-trusted content controller, without the trusted/non-trusted content controller needing to have knowledge of the non-trusted display content, to be incapable of enabling malicious content, forming part of the non-trusted display content, to be readably displayed, which could lead to unauthorized entry of confidential information by a user. | 06-11-2015 |
Chris Anthony Madden, Stepaside IE
Patent application number | Description | Published |
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20110239000 | PASSWORD-PROTECTED PHYSICAL TRANSFER OF PASSWORD-PROTECTED DEVICES - A method for password-protected physical transfer of password-protected devices including at a receiving location, generating at least one security file including an encrypted element generated using a one-way encryption function utilizing at least one secure code, transmitting the at least one security file to a shipping location at which the password-protected devices are located, at the shipping location, using at least one shipping location password, loading the at least one security file into at least one password-protected device, shipping the at least one password-protected device to the receiving location and at the receiving location, employing the at least one secure code to supply an input to the at least one password-protected device and employing the at least one security file to enable establishment of at least one receiving location password for the at least one password-protected device which replaces the at least one shipping location password. | 09-29-2011 |
20130304594 | PASSWORD-PROTECTED PHYSICAL TRANSFER OF PASSWORD-PROTECTED DEVICES - A method for password-protected physical transfer of password-protected devices including at a receiving location, generating at least one security file including an encrypted element generated using a one-way encryption function utilizing at least one secure code, transmitting the at least one security file to a shipping location at which the password-protected devices are located, at the shipping location, using at least one shipping location password, loading the at least one security file into at least one password-protected device, shipping the at least one password-protected device to the receiving location and at the receiving location, employing the at least one secure code to supply an input to the at least one password-protected device and employing the at least one security file to enable establishment of at least one receiving location password for the at least one password-protected device which replaces the at least one shipping location password. | 11-14-2013 |
20140129361 | SYSTEM FOR SECURE WEB-PROMPT PROCESSING ON POINT SALE DEVICES - A point of sale system including at least one proxy server having an internet connection, a web browser operative to download web pages from the internet via the proxy server, and a real time user input limiting trusted computing base module communicating with the web browser and being operative to limit user input to the web pages in real time. | 05-08-2014 |
20150281224 | PASSWORD-PROTECTED PHYSICAL TRANSFER OF PASSWORD-PROTECTED DEVICES - A method for password-protected physical transfer of password-protected devices including at a receiving location, generating at least one security file including an encrypted element generated using a one-way encryption function utilizing at least one secure code, transmitting the at least one security file to a shipping location at which the password-protected devices are located, at the shipping location, using at least one shipping location password, loading the at least one security file into at least one password-protected device, shipping the at least one password-protected device to the receiving location and at the receiving location, employing the at least one secure code to supply an input to the at least one password-protected device and employing the at least one security file to enable establishment of at least one receiving location password for the at least one password-protected device which replaces the at least one shipping location password. | 10-01-2015 |
Chris Anthony Madden, Dublin IE
Patent application number | Description | Published |
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20120117664 | SYSTEM FOR SECURE WEB-PROMPT PROCESSING ON POINT OF SALE DEVICES - A point of sale system including at least one proxy server having an internet connection, a web browser operative to download web pages from the internet via the proxy server, and a real time user input limiting trusted computing base module communicating with the web browser and being operative to limit user input to the web pages in real time. | 05-10-2012 |
Christopher J. Madden, Portland, OR US
Patent application number | Description | Published |
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20150258339 | DEEP BRAIN ELECTRODE PLACEMENT AND STIMULATION BASED ON BROWN ADIPOSE TISSUE TEMPERATURE - Systems and methods for deep brain electrode placement and deep brain stimulation (DBS) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a deep brain stimulating electrode in a target region of the brain of a patient, a temperature of brown adipose tissue (BAT) may be monitored, e.g., via a supraclavicular temperature sensor implanted in the patient, and used to identify an optimal location of electrode stimulation which causes an increase in BAT temperature. Additionally, BAT temperature measurements may be used to provide regulated closed-loop control to increase efficiency of DBS while reducing energy consumption of the pulse generator. Further, core temperature measurements may be obtained from the electrode in the brain and used to adjust DBS. | 09-17-2015 |
Frank Madden, Ballinhassig IE
Patent application number | Description | Published |
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20150356717 | A LABEL INSPECTION SYSTEM AND METHOD - A label inspection system fixture ( | 12-10-2015 |
Gerry Madden, Milton Keynes GB
Patent application number | Description | Published |
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20080213095 | Wind Turbine Pitch Bearing, and Use Hereof - The invention relates to a wind turbine including at least two pitch controlled wind turbine blades. Each blade has pitch bearings including two or more bearing rings, and pitch controlling means for pitching the blades by means of the bearings. The blades are mounted on a hubs via the pitch bearings and the pitch bearings include separate flexibility enhancing means for controlling loads in the bearings. | 09-04-2008 |
20090022442 | Pitch Bearing For A Wind Turbine, A Wind Turbine And A Method For Servicing A Bearing - The invention relates to a pitch bearing for a wind turbine comprising a first and second axial row of bearing rolling elements, said rows being positioned in a distance of each other, and one or more radial rows of bearing elements, where said one or more rows of bearing elements are positioned outside an area defined in between said first and second axial row. The invention also relates to a wind turbine and method for servicing a bearing hereof. | 01-22-2009 |
Gerry Madden, Leighton Buzzard GB
Patent application number | Description | Published |
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20140301847 | PITCH SYSTEM FOR A WIND TURBINE - A pitch system ( | 10-09-2014 |
Gillian J. Madden, Bothwell GB
Patent application number | Description | Published |
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20090256365 | Circuit insulation methods and systems for vehicle door latches - An injection molding method and system for an electrical circuit utilized in vehicle door latch mechanisms is disclosed herein. A mold is generally provided in which a mold cavity is formed therein from walls of the mold. An electrical circuit associated with vehicle door latch and/or integrated with the vehicle door latch can be located within the mold cavity. A plastics material can then be injection molded into the mold cavity of the mold, wherein the plastics material covers and seals the electrical circuit to provide insulation and environmental protection to the electrical circuit. | 10-15-2009 |
Ian Robert Madden, Victoria AU
Patent application number | Description | Published |
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20090306814 | PRODUCE HANDLING EQUIPMENT WITH AIR EJECTION - Produce sorting equipment comprising: a conveyor driving a plurality of carriers spaced along the conveyor to support a single produce between adjacent carriers; at least one exit conveyor positioned above the carriers; an air distribution sprocket positioned below at least two adjacent carriers, the sprocket being rotatable about an axis perpendicular to the conveying direction of the conveyor; the sprocket having a plurality of radial arms that terminate below the carriers; each arm including an air conduit; and means to control air flow along each air conduit; whereby as the sprocket rotates each arm passes underneath the carriers and an air blast via the conduit propels the produce supported by adjacent carriers up and off the carriers to fall onto the exit conveyor. | 12-10-2009 |
James Madden, Reading GB
Patent application number | Description | Published |
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20150057295 | New 6-Alkynyl Pyridine - This invention relates to 6-alkynyl-pyridine of general formula (I) | 02-26-2015 |
James Madden, Wokingham GB
Patent application number | Description | Published |
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20110201589 | NEW BRADYKININ B1 ANTAGONISTS - The invention relates to compounds of formula (I) wherein R | 08-18-2011 |
20140073627 | BRADYKININ B1 ANTAGONISTS - The invention relates to compounds of formula (I) | 03-13-2014 |
James Madden, Abingdon GB
Patent application number | Description | Published |
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20150191482 | Imidazopyrazine Derivatives as Modulators of TNF Activity - A series of imidazo[1,2-α]pyrazine derivatives, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorder; and oncological disorders. | 07-09-2015 |
20150203486 | Imidazopyridine Derivatives as Modulators of TNF Activity - A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. | 07-23-2015 |
Jeffery D. Madden, Fredericton CA
Patent application number | Description | Published |
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20140072684 | FRENCH PRESS BEVERAGE MAKER - A beverage maker for brewing a beverage utilizing a brewing material pod that includes an interior portion having a filter and a brewing material. The beverage maker includes a container having a bottom portion and a sidewall forming a cavity, and a top-opening mouth for receiving a quantity of a liquid into the cavity. The beverage maker also includes a cap sized to fit over the mouth of the container. A plunger assembly is coupled to the cap and includes a cavity configured for selective receipt of the brewing material pod. The plunger assembly includes punches that puncture the brewing material pod to provide a flow path therethrough. A user may brew a beverage by filling the container with hot liquid, and pressing the plunger assembly including the brewing material pod downward through the hot liquid. | 03-13-2014 |
Jeffery David Madden, Fredericton CA
Patent application number | Description | Published |
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20120199597 | DIP CLIP - A dip clip includes a container portion and a clip portion. The container portion is configured to hold a desired quantity of a dip such as salsa, dressings, or other such food items. The clip portion is configured to provide a point of attachment so that the container portion may be removably attached to a plate or other dish | 08-09-2012 |
Jeffery David Madden, New Brunswick CA
Patent application number | Description | Published |
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20140116264 | COOKIE DOUGH TRAY - A cookie dough tray is formed with a substantially rigid frame having a plurality of cavities formed from an elastomeric material, each of the cavities being sized to accommodate dough for a single cookie. The cavities may include a convex bottom portion to facilitate inversion of the cavities for removal of the dough. | 05-01-2014 |
John Madden, Friendswood, TX US
Patent application number | Description | Published |
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20150317463 | ACTIVE DIRECTORY FOR USER AUTHENTICATION IN A HISTORIZATION SYSTEM - A user authentication system enables control of access to historian data through a historian application. The user authentication system creates a user authentication directory for storing user authentication information. The system populates the directory with user authentication information. The system links the directory to a historian application and receives credential data from a user. The system grants access to the historian application when it determines that the credential data from the user matches a portion of the user authentication information on the directory. | 11-05-2015 |
John Madden, Vancouver CA
Patent application number | Description | Published |
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20080258137 | Thin Film Field Effect Transistors Having Schottky Gate-Channel Junctions - An active electronic device has drain and source electrodes that make ohmic conduct with a layer of a semiconductor. The semiconductor layer may be a thin layer of an organic or amorphous semiconductor. The drain and source electrodes are on a first face of the layer of semiconductor at locations that are spaced apart on either side of a channel. The device has a gate electrode on a second face of the layer of semiconductor adjacent to the channel. The gate electrode makes a Schottky contact with the semiconductor to produce a depletion region in the channel. The gate electrode may encapsulate the channel so that the channel is protected from contact with oxygen, water molecules or other materials in the environment. In some embodiments, the device has an additional gate electrode separated from the semiconductor layer by an insulating layer. Such embodiments combine features of OFETs and MESFETs. | 10-23-2008 |
John D. Madden, Vancouver CA
Patent application number | Description | Published |
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20110028676 | Molecular Actuators, and Methods of Use Thereof - The synthesis of thiophene based conducting polymer molecular actuators, exhibiting electrically triggered molecular conformational transitions is reported. Actuation is believed to be the result of conformational rearrangement of the polymer backbone at the molecular level, not simply ion intercalation in the bulk polymer chain upon electrochemical activation. Molecular actuation results from π-π stacking of thiophene oligomers upon oxidation, producing a reversible molecular displacement that leads to surprising material properties, such as electrically controllable porosity and large strains. The existence of active molecular conformational changes is supported by in situ electrochemical data. Single molecule techniques have been used to characterize the molecular actuators. | 02-03-2011 |
John D.w. Madden, Vancouver CA
Patent application number | Description | Published |
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20130092237 | ELECTROCHEMICAL PHOTOVOLTAIC CELLS - The invention provides a bio-photovoltaic device, in which a photoelectric center, exemplified by a biological photosynthetic reaction center (RC), is dispersed and mobile in a medium, such as an aqueous solution. The charges generated by the illuminated RC are transferred to electrodes via one or more mediators. In selected embodiments, the difference between the reaction rates of two types of mediator at the electrode surfaces, in conjunction with other charge transfer reaction equilibria, determines the direction of the photocurrent in the device. In an exemplified embodiment, the magnitude of the photocurrent is proportional to the incident light intensity, and the current increases nonlinearly with an increase in the RC concentration in the medium. | 04-18-2013 |
John William Madden, Barrie CA
Patent application number | Description | Published |
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20120036263 | System and Method for Monitoring and Controlling Access to Web Content - A system and a method are provided for controlling access to web pages. It includes receiving an input to access a web page, and then determining if the Web page is on a work list or a recreation list. The work list includes one or more web pages related to work and the recreation list includes one or more web pages related to recreation. If the web page is not on either list, then a request is issued for a categorization of the web page. Upon receiving the categorization, the web page is stored in the work list or the recreation list, and access is provided to the web page. | 02-09-2012 |
John William Madden, Markham CA
Patent application number | Description | Published |
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20110289216 | System and Method for Generating Subnets and Using Such Subnets for Controlling Access to Web Content - A system and a method are provided for generating a subnet and using the subnet to control access to web content. An Open Subnet (OSN) server is provided to receive proposed web pages to be added to a white list on the subnet, as well as votes from one or more users whether or not to add one or more of the web pages to the white list. A sync server is connected to the OSN through an intermediary. The sync server obtains a copy of the white list and, based on a user's license to the subnet, a user is allowed access to web pages on the white list. | 11-24-2011 |
Jonathan David Madden, Esbjerg V DK
Patent application number | Description | Published |
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20150128443 | On-Site Drying And Curing Of Paint Systems Using Catalytic Infrared Radiators - A method is disclosed for the on-site surface coating of a structure, the structure being part of a construction including a plurality of structures, the method including the steps of: a) applying one or more layers of a coating system on-site to at least a part of the structure, b) arranging at least one gas catalytic infrared emitting unit in a position so that the infrared radiation is adapted for heating the one or more layers of the protective coating system on-site and c) irradiating the coated surface with infrared radiation emitted by the at least one gas catalytic infrared emitting unit on-site. The method allows the drying and/or curing of the one or more layers of the coating system to be accelerated. | 05-14-2015 |
Kevin Madden, Limerick IE
Patent application number | Description | Published |
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20130023885 | Unidirectional Plunger Device For Syringe - A unidirectional plunger device for a syringe includes a base member and a ratchet mechanism. The base member is configured to attach to the proximal end of the syringe body such that the ratchet mechanism engages the plunger of the syringe. The ratchet mechanism may include a pawl configured to engage teeth on a plunger rod of the plunger. The ratchet mechanism is desirably configured to permit distal movement of the plunger while resisting proximal movement of the plunger. The unidirectional plunger device may be a retrofit that can be attached to (e.g., clipped onto) an existing syringe design. The device may be used in conjunction with a two-barrel syringe for dispensing a two-part curable composition, such as calcium phosphate bone cement or epoxy resin. | 01-24-2013 |
Kevin Eugene Madden, Cedar Park, TX US
Patent application number | Description | Published |
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20160055595 | SYSTEMS AND METHOD FOR QUANTIFYING FLOOD RISK - In various embodiments, a flood risk score may be determined for a property point that provides a comprehensive assessment of the property point's risk of flooding. Determining the flood risk score may include determining a flood risk characteristic for the property point and assigning a flood risk score that corresponds to the flood risk characteristic. In some embodiments, flood risk characteristics may include a difference in elevation between the elevation of the property point and an elevation of a calculated point (e.g., on a known flood risk zone boundary). Flood risk characteristics may also include a flood zone determination for the property point and/or proximity of the property point to a known flood risk zone boundary or a flood source. In some embodiments, flood risk scores may be provided on flood risk score reports. | 02-25-2016 |
Marshall Madden, Springfield, MO US
Patent application number | Description | Published |
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20150297936 | Freestanding Selectable Free Weight Assembly - A weight plate for use in an adjustable weight set includes a weight plate member having a plate surface. A locking mechanism on the weight plate member secures the weight plate to another weight plate of the set. The locking mechanism comprises a plurality of spaced apart locking elements each being formed by at least one cut in the weight plate member. At least a portion of each locking element is displaced from the plate surface forming a slot behind the locking element. The slot receives a locking element on another weight plate of the set to secure the weight plate to the other weight plate. The locking elements are arranged relative to each other and to a centrally disposed hole in the weight plate for securely retaining the weight plate and the weight plates to each other. | 10-22-2015 |
Michael Madden, County Galway IE
Patent application number | Description | Published |
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20090037220 | Portable medical monitoring and diagnostic system - A patient care distribution and management system is provided. The system allows for the seamless roaming of a patient within a particular medical facility or between medical facilities. The system includes body area network (BAN) management agents which process data within specified parts of a defined operational remit of a medical facility, a BAN hub agent associated with each patient that communicates with a BAN management agent and stores patient data delivered thereto by medical telemetry monitor diagnostic devices (MTMDDs) connected to each patient. The essential feature of the system is that the BAN hub agent has relatively little processing power compared to the BAN management agent which feeds it with patient monitoring rules to monitor the patient condition and to enable the BAN hub agent to set off alarms etc. as required. | 02-05-2009 |
Michael Gerard Madden, Galway IE
Patent application number | Description | Published |
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20100153323 | ENSEMBLE METHOD AND APPARATUS FOR CLASSIFYING MATERIALS AND QUANTIFYING THE COMPOSITION OF MIXTURES - A method of and system for generating models with which to classify or quantify spectra of unknown mixtures of compounds to permit the specific identification or quantification of a target analyte in complex mixtures based on spectral data, the method comprising the steps of: providing a training set of training spectra, each spectrum representing a mixture of known compounds and each having a plurality of spectral attributes, each at a different wavelength, choosing a plurality of wavelengths, determining at least the value of the spectral attribute at each chosen wavelength in each training spectrum in the training set, and building a model for each chosen wavelength by correlating the determined attribute values at said chosen wavelength, a method and system for classifying the spectrum of a mixture of unknown compounds, and a method and system for quantifying the spectrum of a mixture of unknown compounds to determine concentrations therein, using said models. | 06-17-2010 |
20100179934 | KERNEL-BASED METHOD AND APPARATUS FOR CLASSIFYING MATERIALS OR CHEMICALS AND FOR QUANTIFYING THE PROPERTIES OF MATERIALS OR CHEMICALS IN MIXTURES USING SPECTROSCOPIC DATA - A kernel-based method determines the similarity of a first spectrum and a second spectrum. Each spectrum represents a result of spectral analysis of a material or chemical and comprises a set of spectral attributes distributed across a spectral range. The method calculates a kernel function which makes use of the shape of the spectral response surrounding a spectral point. This is achieved by comparing the value of an spectral attribute in a spectrum and each of a set of neighbouring spectral attributes within a window around the spectral attribute. Weighting values can be applied to calculations when deriving the kernel function. The weighting values can assign different degrees of importance to different regions of the spectrum. The method can be used to: classify unknown spectra; predict the concentration of an analyte within a mixture; database searching for the closest match using a kernel-derived distance metric; visualisation of high-dimensional spectral data in two or three dimensions. | 07-15-2010 |
Paul Madden, Derby GB
Patent application number | Description | Published |
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20110072825 | AIR BLAST FUEL INJECTOR - An airblast fuel injector for the combustor of a gas turbine engine has, in order from radially inner to outer, a coaxial arrangement of an inner swirler passage, an annular fuel passage, an annular mid swirler passage, and an annular outer swirler passage. The fuel passage extends to a prefilming lip, and the inner and mid swirler passages swirl air past the prefilming lip so that fuel fed from the fuel passage to the prefilming lip is entrained by the swirling air into a fuel spray stream. The outer swirler passage has a convergent portion. The radially inward wall of said convergent portion is defined by a frustoconical separator element which separates the outer swirler passage from the mid swirler passage, the separator element converging in the direction of air flow to terminate in a lip at the mouths of the mid swirler passage and the outer swirler passage. | 03-31-2011 |
Samnel Ross Madden, Doha QA
Patent application number | Description | Published |
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20130212059 | Social Analytics - A computer-implemented method, comprises extracting a measure from a content article representing a probability that the article relates to a topic, allocating the article to a group of articles relating to at least one topic on the basis of the measure, using a set of social media objects relating to the article to extract a measure representing a sentiment for the article, and aggregating respective measures for the sentiment of articles in the group to provide an aggregate measure. | 08-15-2013 |
Scott Madden, Hollywood, FL US
Patent application number | Description | Published |
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20160097554 | SMARTPHONE-OPERATED WIRELESS HVAC ANEMOMETER DEVICE AND SYSTEM - A smartphone-operated wireless HVAC airflow anemometer device and system includes an anemometer device having an impeller assembly, an inductor and a controller. A magnet within the impeller assembly generates an oscillating current in the inductor which is proportional to the rotational rate of the impeller. A controller captures and transmits this information wirelessly to an airflow balancing application located on a smartphone device that includes a plurality of algorithms for calculating airflow information. An environmental sensor unit, and an electronic compass are also located within the wireless anemometer device. | 04-07-2016 |
20160097555 | SMARTPHONE-OPERATED HVAC ANEMOMETER DEVICE AND SYSTEM - A smartphone-operated HVAC airflow anemometer device and system includes an anemometer device having an impeller and a photo interrupter circuit. The circuit generates an output signal that is proportional to the rotation speed of the impeller, and transmits the same via a headphone jack to a smartphone device running an airflow balancing application. The airflow balancing application receives airflow data from the anemometer and provides power to the same. The application can apply one or more algorithms to the received airflow data to generate airflow information which can be stored or transmitted by the smartphone device. | 04-07-2016 |
Scott D. Madden, St. Petersburg, FL US
Patent application number | Description | Published |
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20150253781 | AIRFLOW BALANCING VALVE FOR HVAC SYSTEMS - An automatic airflow balancing valve ( | 09-10-2015 |
Thomas D. Madden, Vancouver CA
Patent application number | Description | Published |
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20090285878 | Compositions and methods for stabilizing liposomal drug formulations - The present invention is directed to liposomal compositions comprising a camptothecin, which are optimized to reduce camptothecin degradation and/or precipitation of camptothecin degradation products in the external medium. The invention further provides improved methods of formulating liposomal camptothecins, kits comprising liposome-encapsulated camptothecins, and methods of using the same to treat a variety of diseases and disorders, including cancer. | 11-19-2009 |
20110097720 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 04-28-2011 |
20110117125 | COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS - The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art. | 05-19-2011 |
20110256175 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS - The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art. | 10-20-2011 |
20120225434 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 09-06-2012 |
20130017223 | METHODS AND COMPOSITIONS FOR DELIVERY OF NUCLEIC ACIDS - A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties. | 01-17-2013 |
20130136787 | Liposomal Camptothecins and Uses Thereof - This invention relates to improved liposomal camptothecin compositions and methods of manufacturing and using such compositions for treating neoplasia and for inhibiting angiogenesis. | 05-30-2013 |
20140295449 | SCREENING METHOD FOR SELECTED AMINO LIPID-CONTAINING COMPOSITIONS - The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject. | 10-02-2014 |
20160095924 | AMINO LIPIDS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS - The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art. | 04-07-2016 |
Timothy John Madden, Wirral GB
Patent application number | Description | Published |
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20110212879 | CONCENTRATED SHAMPOO - Concentrated shampoo composition comprising from 25 to 38% wt. C10-C14 ether sulphate as cleansing surfactant, from 0.5 to 5% salt and wherein the zero shear viscosity of the composition is from 2 to 2000 Pa·s and the composition comprises 90% vol. or more composition in the nematic discotic phase. | 09-01-2011 |
20110280823 | COMPOSITION - Concentrated shampoo composition comprising from 32 to 38% wt. cleansing surfactant and from 0.5 to 3% wt. coconut oil or palm kernel oil and wherein the composition has a zero shear viscosity of from 2 to 2000 Pa·s and comprises 90% vol. or more composition in the nematic discotic phase. | 11-17-2011 |
Tomás Madden, Galway IE
Patent application number | Description | Published |
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20130241131 | Stent Holding Fixtures - Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent. | 09-19-2013 |
20130241132 | Stent Holding Fixtures - Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent. | 09-19-2013 |
20130241133 | Stent Holding Fixtures - Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent. | 09-19-2013 |
20160023234 | Stent Holding Fixtures - Disclosed are stent holding devices having a support mandrel and one or more stent retaining fixtures disposed on the mandrel. The retaining fixture may include a character identifier to facilitate tracking a stent mounted on the holding device. The retaining fixture may include a conical protrusion and a conical recess to allow any number of retaining fixtures to engage each other and be stacked on the mandrel. The retaining fixture may include a tubular member having a spiral cut that enables the diameter of the tubular member to be adjusted to allow for a frictional fit on the mandrel. The retaining fixture may have a Z-shaped or T-shaped structure configured to retain a stent. The stent retaining fixture may also have a filament for retaining a stent. | 01-28-2016 |
William Evan Madden, Denver, CO US
Patent application number | Description | Published |
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20150356523 | DECENTRALIZED IDENTITY VERIFICATION SYSTEMS AND METHODS - The present invention involves systems and methods that allow participants in cryptocurrency networks to exchange cryptocurrency for traditional currency legally and safely without requiring the use of a traditional exchange or online brokerage as a fiduciary. The invention accomplishes this through the use of a decentralized identity verification protocol that allows a service provider to verify the identity of a participant and then publish an identity signature on the participant's cryptocurrency address or addresses. The invention enables full compliance with Country specific customer identification program and anti-money laundering requirements, and maintains the ability to independently satisfy requests for information or data retention requirements if requested by legally authorized parties, but does not require that the participant store the private keys or access controls to their cryptocurrency on an exchange or brokerage service. | 12-10-2015 |