Patent application number | Description | Published |
20100160372 | TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA antagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 06-24-2010 |
20100331363 | TREATMENT OF MITOCHONDRIAL DISORDERS USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject an amount of a farnesyl transferase inhibitor, wherein the amount administered is sufficient to cause an improvement in mitochondrial health in said subject. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 12-30-2010 |
20110060005 | TREATMENT OF MITOCHONDRIAL DISORDERS USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies and mitochondrial disorders are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject an amount of a farnesyl transferase inhibitor, wherein the amount administered is sufficient to stimulate mitophagy in said subject. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 03-10-2011 |
20110294794 | TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 12-01-2011 |
Patent application number | Description | Published |
20080264456 | GUTTER CLEANING ROBOT - A gutter cleaning robot can traverse rain gutters to agitate and remove debris. The gutter cleaning robot is equipped with a debris auger at a front end that contacts and ejects the debris, and has a drive system for propelling the gutter cleaning robot along the rain gutter. The debris auger can include a spiral screw or various other forms of auger, and may be interchangeable by the user so as to enhance the effectiveness of the gutter cleaning robot in various environments or modes of operation. | 10-30-2008 |
20110040437 | Robot Confinement Method - A confinement device for a mobile robot. A confinement device for a mobile robot preventing the robot from entering a space or region in which the user would like to safeguard or to keep the robot bound within a given space eliminating travel into sensitive or dangerous areas. The confinement device comprises materials used to absorb | 02-17-2011 |
20110130877 | Mobile Fragrance Delivery System - A fragrance delivery system for a mobile robot. A fragrance containment and attachment device for a mobile robot allowing the robot to expel a fragrance in the space or region in which the robot is in operation. | 06-02-2011 |
20120192898 | GUTTER CLEANING ROBOT - A gutter cleaning robot can traverse rain gutters to agitate and remove debris. The gutter cleaning robot is equipped with a debris auger at a front end that contacts and ejects the debris, and has a drive system for propelling the gutter cleaning robot along the rain gutter. The debris auger can include a spiral screw or various other forms of auger, and may be interchangeable by the user so as to enhance the effectiveness of the gutter cleaning robot in various environments or modes of operation. | 08-02-2012 |
20150057800 | AUTONOMOUS ROBOT AUTO-DOCKING AND ENERGY MANAGEMENT SYSTEMS AND METHODS - A method for energy management in a robotic device includes providing a base station for mating with the robotic device, determining a quantity of energy stored in an energy storage unit of the robotic device, and performing a predetermined task based at least in part on the quantity of energy stored. Also disclosed are systems for emitting avoidance signals to prevent inadvertent contact between the robot and the base station, and systems for emitting homing signals to allow the robotic device to accurately dock with the base station. | 02-26-2015 |
20160023357 | REMOTE CONTROL SCHEDULER AND METHOD FOR AUTONOMOUS ROBOTIC DEVICE - A method of scheduling a robotic device enables the device to run autonomously based on previously loaded scheduling information. The method consists of a communication device, such as a hand-held remote device, that can directly control the robotic device, or load scheduling information into the robotic device such that it will carry out a defined task at the desired time without the need for further external control. The communication device can also be configured to load a scheduling application program into an existing robotic device, such that the robotic device can receive and implement scheduling information from a user. | 01-28-2016 |
20160075021 | AUTONOMOUS ROBOT AUTO-DOCKING AND ENERGY MANAGEMENT SYSTEMS AND METHODS - A method for energy management in a robotic device includes providing a base station for mating with the robotic device, determining a quantity of energy stored in an energy storage unit of the robotic device, and performing a predetermined task based at least in part on the quantity of energy stored. Also disclosed are systems for emitting avoidance signals to prevent inadvertent contact between the robot and the base station, and systems for emitting homing signals to allow the robotic device to accurately dock with the base station. | 03-17-2016 |
Patent application number | Description | Published |
20080223233 | Methods and apparatus for engaging web-material cores - A stencil printer apparatus is provided. The stencil printer apparatus may include a stencil, a material applicator to apply material on the stencil, a supply roller configured to receive a roll of web-material, the supply roller comprising a first shaft, a take-up roller to receive used web-material, the take-up roller comprising a second shaft, at least one spring-loaded protrusion element associated with one of the first shaft and the second shaft, and a drive configured to move web-material across the stencil between the supply roller and the take-up roller, and a frame to support the supply roller, the take-up roller and the drive. The at least one spring-loaded protrusion element may be configured and arranged on the at least one of the first shaft and the second shaft to resiliently engage at least one web-material core around which web-material may be disposed. Other embodiments and methods are provided. | 09-18-2008 |
20130199386 | PRINT HEAD FOR STENCIL PRINTER - A stencil printer for printing viscous material on an electronic substrate includes a stencil having apertures formed therein, and a print head positioned over the stencil and configured to deposit viscous material within the apertures of the stencil. The print head includes a housing defining an elongate chamber, a source port defining a passage having an inlet positioned to allow viscous material to flow into the elongate chamber, a pair of blades defining a slot that provides an outlet from which viscous material can flow out of the elongate chamber, an elongate plunger movable in the elongate chamber to reduce a volume of viscous material within the elongate chamber, and at least one sensor to detect pressure of the viscous material within the elongate chamber. | 08-08-2013 |
Patent application number | Description | Published |
20110207658 | High Purity Lipopeptides - The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of | 08-25-2011 |
20120149062 | High Purity Lipopeptides - The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of | 06-14-2012 |
20130280760 | HIGH PURITY LIPOPETIDES - The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of | 10-24-2013 |
20140371135 | HIGH PURITY LIPOPEPTIDES - The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography. The invention also discloses a method of purifying daptomycin by modified buffer enhanced anion exchange chromatography. The invention also discloses an improved method for producing daptomycin by fermentation of | 12-18-2014 |
Patent application number | Description | Published |
20080207615 | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments - The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 08-28-2008 |
20080234264 | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments - The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus, a diagnostic assay for these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 09-25-2008 |
20130316935 | METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS - Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 11-28-2013 |
20150176081 | METHOD TO DETERMINE RESPONSIVENESS OF CANCER TO EPIDERMAL GROWTH FACTOR RECEPTOR TARGETING TREATMENTS - Disclosed herein are methods and reagents for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) targeting treatment. The detection of these mutations will allow for the administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug. | 06-25-2015 |
Patent application number | Description | Published |
20130132089 | CONFIGURABLE SPEECH RECOGNITION SYSTEM USING MULTIPLE RECOGNIZERS - Techniques for combining the results of multiple recognizers in a distributed speech recognition architecture. Speech data input to a client device is encoded and processed both locally and remotely by different recognizers configured to be proficient at different speech recognition tasks. The client/server architecture is configurable to enable network providers to specify a policy directed to a trade-off between reducing recognition latency perceived by a user and usage of network resources. The results of the local and remote speech recognition engines are combined based, at least in part, on logic stored by one or more components of the client/server architecture. An indication of the availability of the remote speech recognition to perform speech recognition at a point in time may be provided to a user of the client device via a user interface of the client device. | 05-23-2013 |
20130275924 | LOW-ATTENTION GESTURAL USER INTERFACE - A system and method to generate a touch-based user interface that allows users to reliably carry out tasks in a low-attention environment. The touch-based user interface relies upon swipe and tap gestures that are easily entered by a user without having to concentrate on a touchscreen or display associated with a touchpad on which the gestures are entered. For gestures that are swipes, only the direction of the swipe is utilized by the system in interpreting the entered command. For tap gestures, only the number of taps in a sequence, as well as the duration of taps, is utilized by the system in interpreting the entered command. By not correlating the location of the entered gestures with what is displayed on the associated display screen, the touch interface disclosed herein is well suited for environments where a user is unable to look at the display screen while performing gestures. | 10-17-2013 |
20140095167 | SYSTEMS AND METHODS FOR PROVIDING A VOICE AGENT USER INTERFACE - Some embodiments relate to techniques performed at least in part by at least one voice agent executing on a computing device. The techniques comprise responsive to the at least one voice agent receiving input at least partially specifying a requested action to be performed at least partially by an application program, presenting visual feedback responsive to the input concurrently via a user interface of the at least one voice agent and a user interface of the application program. | 04-03-2014 |
20140095168 | SYSTEMS AND METHODS FOR PROVIDING A VOICE AGENT USER INTERFACE - Some embodiments provide techniques performed by at least one voice agent. The techniques include receiving voice input; accessing contextual information related to an application program that has focus of the computing device when the voice input is received; and using the contextual information to interpret the received voice input. | 04-03-2014 |
20140095171 | SYSTEMS AND METHODS FOR PROVIDING A VOICE AGENT USER INTERFACE - Some embodiments provide techniques performed by at least one voice agent. The techniques include receiving voice input specifying a requested action; and identifying a subject of the requested action from the voice input and information relating to a prior action invoked by the at least one voice agent, wherein the information identifies a subject of the prior action. | 04-03-2014 |
20140095172 | SYSTEMS AND METHODS FOR PROVIDING A VOICE AGENT USER INTERFACE - Some embodiments provide techniques performed by at least one voice agent. The techniques include receiving voice input from a user at least partially specifying a requested action to be performed at least in part by an application program, wherein the requested action requires a plurality of inputs to be fully specified; and in response to receiving the voice input, making the application program accessible to the user prior to completion of performance of the requested action, so as to enable the user to provide and/or edit at least one input of the plurality of inputs by directly interacting with the application program. | 04-03-2014 |
20140095173 | SYSTEMS AND METHODS FOR PROVIDING A VOICE AGENT USER INTERFACE - Some embodiments provide techniques performed by at least one voice agent. The techniques include receiving voice input; identifying at least one application program as relating to the received voice input; and displaying at least one selectable visual representation that, when selected, causes focus of the computing device to be directed to the at least one application program identified as relating to the received voice input. | 04-03-2014 |
20140164305 | SYSTEMS AND METHODS FOR VIRTUAL AGENT RECOMMENDATION FOR MULTIPLE PERSONS - Systems, methods, and apparatus for implementing at least one virtual agent. In some embodiments, the at least one virtual agent is programmed to analyze first information regarding a first person; analyze second information regarding a second person different from the first person; and make a joint recommendation for a plurality of persons based at least in part on the first and second information, wherein the plurality of persons comprises the first person and the second person. | 06-12-2014 |
20140164312 | SYSTEMS AND METHODS FOR INFORMING VIRTUAL AGENT RECOMMENDATION - Systems, methods, and apparatus for use in connection with at least one virtual agent. In some embodiments, at least one virtual agent is programmed to: identify a relationship between at least two persons; and make a recommendation for the at least two persons based at least in part on the relationship between the at least two persons. | 06-12-2014 |
20140164317 | SYSTEMS AND METHODS FOR STORING RECORD OF VIRTUAL AGENT INTERACTION - Systems, methods, and apparatus for use with at least one virtual agent. In some embodiments, at least one processor is programmed to store a receipt for an interaction between the at least one virtual agent and one or more users, wherein the receipt comprises at least some information provided by the one or more users to the at least one virtual agent during the interaction. | 06-12-2014 |
20140164508 | SYSTEMS AND METHODS FOR SHARING INFORMATION BETWEEN VIRTUAL AGENTS - Systems, methods, and apparatus for use with at least one first virtual agent executing on a first device. In some embodiments, the at least one first virtual agent is programmed to: share information with at least one second virtual agent executing on at least one second device different from the first device, wherein the at least one first virtual agent is associated with a first user and the at least one second virtual agent is associate with a second user; and use the information shared between the at least one first virtual agent and the at least one second virtual agent to make a joint recommendation for the first and second users. | 06-12-2014 |
20140164509 | SYSTEMS AND METHODS FOR PROVIDING INPUT TO VIRTUAL AGENT - Systems, methods, and apparatus for use in connection with at least one virtual agent. In some embodiments, at least one processor is programmed to use a record of a multiparty conversation to provide input to the at least one virtual agent. | 06-12-2014 |
20140164532 | SYSTEMS AND METHODS FOR VIRTUAL AGENT PARTICIPATION IN MULTIPARTY CONVERSATION - Systems, methods, and apparatus for use with at least one virtual agent. In some embodiments, the at least one virtual agent is programmed to: analyze first input provided by a first user during a multiparty conversation; analyze second input provided by a second user during the multiparty conversation, the second user being different from the first user; and use the first and second inputs to formulate at least one task to be performed by the virtual agent. | 06-12-2014 |
20140164533 | SYSTEMS AND METHODS FOR USER INTERFACE PRESENTATION OF VIRTUAL AGENT - Systems, methods, and apparatus for use in connection with at least one virtual agent. In some embodiments, at least one processor is programmed to present the at least one virtual agent as a participant in a multiparty conversation taking place via a messaging application. | 06-12-2014 |
20140164953 | SYSTEMS AND METHODS FOR INVOKING VIRTUAL AGENT - Systems, methods, and apparatus for use in connection with at least one virtual agent. In some embodiments, at least one processor is programmed to: intercept user input to a messaging application executing on the at least one processor and facilitating a multiparty conversation; and in response to detecting a trigger in the user input, inject the at least one virtual agent into the multiparty conversation facilitated by the messaging application. | 06-12-2014 |