| Patent application number | Description | Published |
|---|
| 20090068144 | TETRAHYDRO-ISOQUINOLIN-1-ONES FOR THE TREATMENT OF CANCER - The present invention provides a compound selected from compounds of formula I as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy. Compounds of formula (I) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events, heart valvular degenerative disease Moreover, compounds of formula (I) can be used to decrease the side effects from cytotoxic cancer agents and to treat viral infections. | 03-12-2009 |
| 20090306130 | NOVEL TETRAHYDRO-ISOQUINOLINES - The present invention provides a compound selected from compounds of formula (A) as ligand binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. Compounds of formula (A) can be used as therapeutics for treating stroke, myocardial infarction, ischemia, multi-organ failure, spinal cord injury, Alzheimer's Disease, injury from ischemic events and heart valvular degenerative disease. Moreover, compounds of formula (A) can be used to decrease the side effects from cytotoxic cancer agents, radiation and to treat viral infections. | 12-10-2009 |
| 20100075949 | NOVEL PYRROLIDIN-2-ONES - The present invention provides compounds of formula (I) or (Ia) which are ligands binding to the HDM2 protein, inducing apoptosis and inhibiting proliferation, and having therapeutic utility in cancer therapy and prevention. | 03-25-2010 |
| 20100111930 | Methods and Compositions for Detecting Receptor Ligand Mimetics - A method to determine the utility of small molecules as functional replacements (mimetics) for protein receptor ligands is described. The method uses cellular biological assays on a systematic array of compounds, comprising known protein receptor ligands and other biologically active molecules to determine if a proposed small molecule is a functional equivalent of a receptor ligand, having therapeutic utility as a pharmaceutically relevant and useful agent either alone or in combination with other molecules. | 05-06-2010 |
| 20100130449 | Use of Tri-Substituted Glycerol Compounds for the Treatment of Radiation Injuries - The present invention relates to the use of a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention and/or treatment of radiation injuries. Furthermore, the invention relates to in vitro corresponding methods for preventing or treating of radiation damage or injury in one or more cells comprising contacting said cells with a medicament as defined in the invention. | 05-27-2010 |
| 20100136029 | Use of Tri-Substituted Glycerol Compounds for the Treatment of Hematological Malignancies - The present invention relates to the use of a tri-substituted glycerol compound for the manufacture of a medicament for the treatment of hematological malignancies. The invention also refers to a kit-of-parts comprising such a medicament. Finally, the invention also relates to a corresponding method for the treatment of such conditions as well as to an in vitro method for determining the susceptibility of such malignant cells to a medicament as defined in the invention. | 06-03-2010 |
| 20100137230 | NEW PYRIDIN-2-ONE COMPOUNDS - The present invention relates to compounds of the formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria: | 06-03-2010 |
| 20100179226 | Topical Dosage Form Comprising Tri-Substituted Glycerol Compounds - The present invention relates to pharmaceutical dosage forms for topical administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases. | 07-15-2010 |
| 20110055233 | Methods, Computer Systems, Software and Storage Media for Handling Many Data Elements for Search and Annotation - The invention refers to a method creating a data structure including many data elements comprising the steps of receiving multiple data elements to be stored from an input data structure, providing a continuous array in memory, allocating memory space within the continuous array for the data elements and storing the data elements in the allocated memory space. | 03-03-2011 |
| 20110110984 | Oral Dosage Form Comprising Tri-Substituted Glycerol Compounds - The present invention relates to pharmaceutical solid dosage forms for oral administration comprising a tri-substituted glycerol compound or a pharmaceutically acceptable salt thereof. The invention also relates to a corresponding method for preparing such dosage forms as well as to their use as medicaments for the treatment of cancer and immune diseases. | 05-12-2011 |
