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Lutz, MA

Charles R. Lutz, Seekonk, MA US

Patent application numberDescriptionPublished
20090261385BIPOLAR TRANSISTOR WITH ENHANCED BASE TRANSPORT - A bipolar transistor includes a base layer design and a method for fabricating such a bipolar transistor that employ a built-in accelerating field focused on a base region adjacent to a collector, where minority carrier transport is otherwise retarded. The accelerating field of the base layer includes on average, a relatively low p-doping level in a first region proximate to the collector and a relatively high p-doping level in a second region proximate to an emitter. Alternatively, the accelerating field can be derived from band gap grading, wherein the grade of band gap in the first region is greater than the grade of band gap in the second region, and the average band gap of the first region is lower than that of the second region.10-22-2009

Patent applications by Charles R. Lutz, Seekonk, MA US

Lisa L. Lutz, Sudbury, MA US

Patent application numberDescriptionPublished
20080271070Negotiated access to promotional insertion opportunity - A technique (and corresponding system) for controlling access to insertion opportunities in a multi-channel streaming media system is provided. The technique receives parameters for access to the insertion opportunities from multiple advertisers, such as desired audience viewership profile characteristics. The technique evaluates the received parameters to select which advertisers gain access to the insertion opportunities to place promotional content. The technique analyzes an audience of the placed promotional content and identifies which of the possible promotional content optimizes the value of the insertion opportunities or other maxima. Unlike traditional advertising in which advertisers pay per expected viewership, the technique may be arranged to charge advertisers only for a targeted audience that viewed the placed promotional content. The technique thus enables advertisers to access disparate insertion opportunities and to target an audience at lower cost without having to establish relationships with owners of insertion opportunities.10-30-2008

Mitchell E. Lutz, Fairhaven, MA US

Patent application numberDescriptionPublished
20090011861GOLF BALLS CONTAINING INTERPENETRATING POLYMER NETWORKS - The present invention is directed to a golf ball that contains an interpenetrating polymer network, or IPN, including at least two polymeric components. These IPNs may be present in any golf ball layer, although in an intermediate or cover layer in one preferred embodiment. The present invention is also directed to methods of forming a golf ball containing an IPN in one or more of the layers.01-08-2009
20100062877CASTABLE GOLF BALL COMPONENTS USING ACRYLATE FUNCTIONAL RESINS - Golf ball components, such as cores, intermediate layers, and covers, formed with compositions including precursors with acrylate functionality crosslinked with a curing agent.03-11-2010
20110165967CASTABLE GOLF BALL COMPONENTS USING ACRYLATE FUNCTIONAL RESINS - Golf ball components, such as cores, intermediate layers, and covers, formed with compositions including precursors with acrylate functionality crosslinked with a curing agent.07-07-2011

Patent applications by Mitchell E. Lutz, Fairhaven, MA US

Robert J. Lutz, Wayland, MA US

Patent application numberDescriptionPublished
20090076263ELIMINATION OF HETEROGENEOUS OR MIXED CELL POPULATION IN TUMORS - Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand suspected of being expressed on a particular cell population to also kill a cell population lacking the unique ligand. These conjugates have therapeutic use as they are delivered to a specific cell population to kill these cells and the cytotoxic drug is released to kill non-targeted cells, thereby eliminating the tumor.03-19-2009
20090081705NOVEL PEPTIDES AND COMPOSITIONS WHICH MODULATE APOPTOSIS - The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the “GD domain,” which is essential both to Bak's interaction with Bcl-x03-26-2009
20090291090ANTI-CD33 ANTIBODIES AND METHOD FOR TREATMENT OF ACUTE MYELOID LEUKEMIA USING THE SAME - The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved versions of these antibodies, immunoconjugates and compositions comprising these antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding these antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing these antibodies.11-26-2009
20100028346NOVEL SYNERGISTIC EFFECTS - The present invention encompasses a combination of at least one conjugate and one or more chemotherapeutic agent(s) which when administered exerts an unexpectedly enhanced therapeutic effect. The therapeutic effectiveness of the combination is greater than that of the conjugate alone or the administration of one or more of the drug(s) without the conjugate. The present invention is also directed to compositions comprising at least one conjugate and at one or more of chemotherapeutic agent and to methods of treating cancer using at least one conjugate and at least one or more of chemotherapeutic agent (s). The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of one or more chemotherapeutic agent(s) and at least one conjugate. In each case, such combination has therapeutic synergy or improves the therapeutic index in the treatment of cancer over the anticancer agent(s) alone.02-04-2010
20110008840ANTI-CD33 ANTIBODIES AND METHODS FOR TREATMENT OF ACUTE MYELOID LEUKEMIA USING THE SAME - The present invention relates to antibodies that bind CD33. More particularly, the invention relates to anti-CD33 antibodies, fragments and homologues of these antibodies, humanized and resurfaced versions of these antibodies, functional equivalents and improved versions of these antibodies, immunoconjugates and compositions comprising these antibodies, and the uses of same in diagnostic, research and therapeutic applications. The invention also relates to a polynucleotide encoding these antibodies, vectors comprising the polynucleotides, host cells transformed with polynucleotides and methods of producing these antibodies.01-13-2011

Patent applications by Robert J. Lutz, Wayland, MA US

Robert John Lutz, Wayland, MA US

Patent application numberDescriptionPublished
20110177064Compositions and Methods for Treatment of Ovarian Cancer - The present invention relates to surprisingly effective anti-cancer drug combinations, pharmaceutical compositions comprising the same, and uses thereof in the treatment of ovarian cancer. In particular, the present invention is based on the discovery that the administration of a CD56 antibody linked to a cytotoxic compound (e.g.,, an immunoconjugate) in combination with at least two chemotherapeutic agents (in particular a taxane compound and a platinum compound), improves the therapeutic index in the treatment of ovarian cancer over and above the additive effects of the anticancer agents used alone. In one embodiment of the invention, combinations of the CD56 antibody, or fragment thereof, linked to a cytotoxic compound plus additional chemotherapeutic agents have a synergistic effect in the ovarian cancer therapeutic index. The present invention also provides methods of modulating the growth of selected cell populations, such as ovarian cancer cells, by administering a therapeutically effective amount of such combinations.07-21-2011