Lute
Ken Lute, Winchester, OH US
Patent application number | Description | Published |
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20090252741 | HUMAN MONOCLONAL ANTI-CTLA4 ANTIBODIES IN CANCER TREATMENT - Although results from preclinical studies in animal models have proven the concept for use of anti-CTLA-4 antibodies in cancer immunotherapy, two major obstacles have hindered their successful application for human cancer therapy. First, the lack of in vitro correlates of the anti-tumor effect of the antibodies makes it difficult to screen for the most efficacious antibody by in vitro analysis. Second, significant autoimmune side-effects have been observed In a recent clinical trial. In order to address these two issues, we have generated human CTLA-4 gene knock-in mice and used them to compare a panel of anti-human CTLA-4 antibodies for their ability to induce tumor rejection and autoimmunity. Surprisingly, while all antibodies induced protection against cancer and demonstrated some autoimmune side effects, the antibody that induced the strongest protection also induced the least autoimmune side effects. These results demonstrate that autoimmune disease does not quantitatively correlate with cancer immunity. Our approach may be generally applicable to the development of human therapeutic antibodies. | 10-08-2009 |
Richard C. Lute, Mogadore, OH US
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20140063749 | AUTOMATED BANKING MACHINE WITH SLIDE MOUNTED DEVICES - An apparatus including an automated banking machine is operative to cause financial transfers responsive at least in part to data read from data bearing records. The machine includes a card reader that is operative to read card data usable to identify at least one of a user of the machine and a financial account. A computer associated with the machine is operative to cause card data to be read through operation of the card reader, and to cause a determination to be made that read card data corresponds to a financial account authorized to conduct a transaction through the machine. The computer is operative responsive at least in part to the determination to cause the financial account to be at least one of assessed and credited with a value associated with a financial transaction. Transaction function devices of the machine are supported through slides that can be configured in different ways to facilitate mounting of devices within the machine. | 03-06-2014 |
Samuel Lute, Orion, MI US
Patent application number | Description | Published |
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20150070694 | METHOD AND SYSTEM FOR CHARACTERIZING COLOR VARIATION OF A SURFACE - A system and method of characterizing a color variation of a surface includes a device having a light source and a plurality of sensors positioned at respective viewing angles. An algorithm is stored on and executable by a controller to cause the controller to direct a beam of light at the measurement location with the light source and measure the light leaving the measurement location with the sensors at a plurality of azimuth angles to obtain respective measured color values. The controller is configured to define a color vector function F(θ, φ) to represent the color variation of the surface. The controller is configured to determine the color vector function F(θ, φ) based at least partially on the respective measured color values. The system allows for a representation of color space of a surface at any azimuth and viewing angle. | 03-12-2015 |