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Luo, PA
Chi Luo, New Hope, PA US
Jeffrey Luo, Radnor, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090186020 | Melanocortin Receptor Binding Mimetibodies, Compositions, Methods and Uses - Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed. | 07-23-2009 |
Jia Luo, Philadelphia, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100093058 | High Transgene Expression Of A Pseudotyped Adeno-Associated Virus Type - The present invention related to methods and compositions comprising recombinant vectors comprising chimeric capsids and recombinant pseudotyped vectors with non-native capsid protein(s). The recombinant vectors of the invention confer an altered tropism that permits selective targeting of desired cells. | 04-15-2010 |
Jianhua Luo, Wexford, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090004658 | INTEGRIN ALPHA 7 MUTATIONS IN PROSTATE CANCER, LIVER CANCER, GLIOBLASTOMA MULTIFORME, AND LEIOMYOSARCOMA - Methods are provided for determining the presence of a cancer in a biological sample, such as a tissue biopsy. The methods comprise determining if integrin alpha 7 expression is decreased in the biopsy which is indicative of the presence of a cancer or likelihood of relapse of a cancer. This can be accomplished by determining if levels of integrin alpha 7 mRNA or protein are decreased as compared to a control. This also can be accomplished by determining if a mutation in the integrin alpha 7 gene is present in the biopsy. | 01-01-2009 |
Jiazhong Luo, Lansdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080287627 | Perfluoroelastomer compositions and methods of preparing same - The present invention includes crosslinked perfluoroelastomeric compositions and molded articles formed from a cross-linkable perfluoroelastomeric composition having a first curable perfluoropolymer having a cure site monomer and a second perfluoropolymer having a cure site monomer. The molar ratio of the tetrafluoroethylene monomer to perfluoroalkylvinyl ether in one perfluoropolymer is about 0 to 100 to about 65 to 35 in the perfluoropolymer. The molar ratio of the tetrafluoroethylene monomer to the perfluoroalkylvinyl ether monomer in the second polymer is about 65:35 to about 95:5 in the second perfluoropolymer. The composition further includes a curative. One fluorine-containing elastomer composition herein, having a short crosslinking time, has perfluoroelastomers (A) having a tetrafluoroethylene unit, a perfluoralkylvinyl ether unit (a) and a monomer unit (b) having at least one kind selected from the group consisting of a nitrile group, a carboxyl group and an alkoxycarbonyl group, wherein the composition has two or more kinds of perfluoroelastomers (A) having differing contents of perfluoroalkylvinyl ether unit (a). | 11-20-2008 |
| 20100151254 | Perfluoroelastomer Compositions Including Barium Titanate Fillers - Provided herein is a fluorine-containing elastomer composition having a first curable perfluoropolymer comprising tetrafluoroethylene, at least one perfluoroalkylvinyl ether and at least one cure site monomer having a functional group to permit crosslinking of the perfluoropolymer; and barium titanate. | 06-17-2010 |
| 20110086229 | PERFLUOROELASTOMER COMPOSITIONS AND METHODS OF PREPARING SAME - The present invention includes crosslinked perfluoroelastomeric compositions and molded articles formed from a cross-linkable perfluoroelastomeric composition having a first curable perfluoropolymer having a cure site monomer and a second perfluoropolymer having a cure site monomer. The molar ratio of the tetrafluoroethylene monomer to perfluoroalkylvinyl ether in one perfluoropolymer is about 0 to 100 to about 65 to 35 in the perfluoropolymer. The molar ratio of the tetrafluoroethylene monomer to the perfluoroalkylvinyl ether monomer in the second polymer is about 65:35 to about 95:5 in the second perfluoropolymer. The composition further includes a curative. One fluorine-containing elastomer composition herein, having a short crosslinking time, has perfluoroelastomers (A) having a tetrafluoroethylene unit, a perfluoralkylvinyl ether unit (a) and a monomer unit (b) having at least one kind selected from the group consisting of a nitrile group, a carboxyl group and an alkoxycarbonyl group, wherein the composition has two or more kinds of perfluoroelastomers (A) having differing contents of perfluoroalkylvinyl ether unit (a). | 04-14-2011 |
Peizhi Luo, Lansdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110124528 | Generation and affinity maturation of antibody library in silico - The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human. In one embodiment, a method for constructing a library of designed proteins, comprising the steps of: providing an amino acid sequence derived from a lead protein, the amino acid sequence being designated as a lead sequence; comparing the lead sequence with a plurality of tester protein sequences; and selecting from the plurality of tester protein sequences at least two peptide segments that have at least 15% sequence identity with the lead sequence, the selected peptide segments forming a hit library; and forming a library of designed proteins by substituting the lead sequence with the hit library. The library of designed proteins can be expressed in vitro or in vivo to produce a library of recombinant proteins that can be screened for novel or improved function(s) over the lead protein, such as an antibody against therapeutically important target. | 05-26-2011 |
Peter Luo, Lansdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090232795 | 1B20 PCSK9 ANTAGONISTS - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 09-17-2009 |
| 20090246192 | 1D05 PCSK9 antagonists - Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure. | 10-01-2009 |
Peter Peizhi Luo, Lansdale, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090082221 | Cross-Species and Multi-Species Display Systems - The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for multi-species and cross-species display of polypeptides on the outer surface of prokaryotic genetic packages and/or eukaryotic host cells. The multi-species and cross-species display systems can be practiced using the vector sets of the invention without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of phage, bacterial host cells, yeast cells, and mammalian cells. | 03-26-2009 |
| 20090136523 | ANTI-CD26 ANTIBODIES AND METHODS OF USE THEREOF - The present invention provides novel anti-CD26 antibodies and other, related polypeptides, as well as novel polynucleotides encoding the antibodies and polypeptides. The invention also provides methods of making the antibodies and polypeptides. Compositions and cells comprising the antibodies or polypeptides are further provided. Methods of using the antibodies and/or polypeptides, such as to inhibit cell proliferation and in the treatment of conditions associated with CD26, are also provided. | 05-28-2009 |
| 20090163379 | Eukaryotic cell display systems - The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells. | 06-25-2009 |
Wenzhe Luo, Allentown, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100144389 | CORDLESS TELEPHONE WITH MP3 PLAYER CAPABILITY - A cordless telephone which allows a user to play MP3 digital audio bit stream music, a video game, either alone or with a user of another cordless telephone, using the remote handset of a cordless telephone to control the functions of the MP3 player. The cordless telephone remains usable as a typical cordless telephone with all the features and conveniences of a cordless telephone including, but not limited to, connection of a telephone call between a calling party and a called party, caller ID information, voice messaging features, etc. MP3 digital audio bit stream music may be downloaded from a remote source through, e.g., the Internet and a PC. | 06-10-2010 |
Xukun Luo, Allentown, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20080279746 | Process for the Fluorination of Boron Hydrides - A process for fluorination of borohydride salts including providing a reaction medium comprising HF and a superacid. A borohydride salt compound is added to the reaction medium. The borohydride salt is reacted with the with the reaction medium under conditions to form a fluorinated borohydride salt. In addition, reactor vessels may be provided for reacting the HF, superacid additive and borohydride that are fabricated from materials resistant to superacid compositions. | 11-13-2008 |
Yongyi Luo, Doylestown, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090320572 | THE QUANTITATIVE DETERMINATION OF RISEDRONATE IN URINE BY SPE-LC-MS-MS - The present invention is directed to a SPE-LC-MS-MS method for quantitatively determining risedronate in a urine sample. | 12-31-2009 |