Patent application number | Description | Published |
20090087346 | Method for Harvesting Nanoparticles and Sequestering Biomarkers - Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid. | 04-02-2009 |
20090148961 | SMART HYDROGEL PARTICLES FOR BIOMARKER HARVESTING - Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles may be changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles may be made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid. | 06-11-2009 |
20110236999 | Hydrogel Nanoparticle Based Immunoassay - An immunoassay device incorporating porous polymeric capture nanoparticles within either the sample collection vessel or pre-impregnated into a porous substratum within fluid flow path of the analytical device is presented. This incorporation of capture particles within the immunoassay device improves sensitivity while removing the requirement for pre-processing of samples prior to loading the immunoassay device. A preferred embodiment is coreshell bait containing capture nanoparticles which perform three functions in one step, in solution: a) molecular size sieving, b) target analyte sequestration and concentration, and c) protection from degradation. The polymeric matrix of the capture particles may be made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. This device is useful for point of care diagnostic assays for biomedical applications and as field deployable assays for environmental, pathogen and chemical or biological threat identification. | 09-29-2011 |
20120164749 | Smart Hydrogel Particles for Biomarker Harvesting - Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid. | 06-28-2012 |
20150338417 | BINDING DOMAIN MAPPING - The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions. | 11-26-2015 |
Patent application number | Description | Published |
20110079460 | SEISMIC GUN ASSEMBLY FOR SHOOTING INTO A BORE HOLE - A seismic gun assembly comprising a barrel and guide tube assembly for delivering a projectile to the bottom of a bore hole with a non-line-of-sight section. The guide tube being either a large diameter guide tube or a tight fitted guide tube. The large diameter guide tube allowing the projectile to perform shallow angle bounces to reach the bottom of a non-line-of-sight bore hole. The tight fitted guide tube allows the projectile to ride the inner wall of the guide tube to reach the bottom of a non-line-of-sight bore hole. The projectile comprises an outer jacket and a frangible core. The seismic gun barrel assembly additionally comprises a fluid exclusion puck for preventing fluids from entering the guide tube, a suppressing collar for suppressing seismic noise, and a method for modulating recoil. | 04-07-2011 |
20110290142 | Subsonic small-caliber ammunition and bullet used in same - A bullet comprises a casing engaging segment, a rifling leade mating segment, and a tip segment. The rifling leade mating segment has a frusto-conical shape tapering from a first diameter at a first end portion thereof to a second diameter at a second end portion thereof. The rifling leade mating segment extends from a first end portion of the casing engaging segment. The tip segment extends from the second end portion of the rifling leade mating segment. The first diameter is greater than the second diameter. | 12-01-2011 |
20120145474 | Seismic gun assembly for shooting into a bore hole - A seismic gun system for surveying underground geological topology, the seismic gun system comprising a projectile, a seismic gun body, a barrel, and a guide tube. The projectile includes an outer tubular jacket and a frangible material in its interior. A exterior surface of the tubular jacket is textured to regulate tubular jacket disruption. The barrel includes a breach end and a muzzle end. The breach end is connectable to the seismic gun body for receiving the projectile into said barrel and said muzzle end directing the projectile towards the bottom of a bore hole. The guide tube has an upper end and a terminal end. The upper end of the guide tube is connectable to the muzzle end of the barrel. The guide tube has walls to direct the projectile towards the bottom of the bore hole when aimed therein. | 06-14-2012 |
20130167747 | BULLET WITH CHAMBER SEALING STRUCTURE AND AMMUNITION COMPRISING SAME - A round of ammunition for use in a 5.56 NATO-specification chamber comprises a cartridge casing and a bullet having a casing engaging segment, a sealing band and a groove. The sealing band encircles the casing engaging segment. The casing engagement segment of the bullet is engaged within a bullet receiving opening of the cartridge casing with a rear surface of the sealing band abutting a front edge of the cartridge casing. The groove encircles the casing engagement segment. A rear portion of the sealing band intersects a front portion of the groove. A front face of the sealing band is substantially flat. An angle of the front face of the sealing band is approximately the same as an angle of a neck-to-throat transition portion of the 5.56 NATO-specification chamber. | 07-04-2013 |