Patent application number | Description | Published |
20140238175 | TRANSMITTING TORQUE TO AN OPERATIVE ELEMENT THROUGH A WORKING CHANNEL - Methods, systems, and devices for providing treatment to a target site are described. The system may include a guide assembly, an expandable support device coupled with the distal end of the guide assembly, and an operative member disposed on the expandable support device. The expandable support device may be configured to transition between a collapsed and expanded configuration. The expandable support device may be supported by one or more flexible supports aligned in parallel with an axis about which the expandable support device collapses and/or multiple splines arranged in a pattern configured to promote transitioning of the expandable support device between an expanded and collapsed configuration. The guide assembly may be configured to provide torque to the expandable support device. The operative member can include multiple electrodes arranged in parallel to the axis about which the expandable support device collapses. | 08-28-2014 |
20140238176 | TRANSMITTING TORQUE WITH A HANDLE TO AN OPERATIVE ELEMENT THROUGH A WORKING CHANNEL - Methods, systems, and devices for providing treatment to a target site are described. The system may include a guide assembly, an expandable support device coupled with the distal end of the guide assembly, and an operative member disposed on the expandable support device. The expandable support device may be configured to transition between a collapsed and expanded configuration. The expandable support device may be supported by one or more flexible supports aligned in parallel with an axis about which the expandable support device collapses and/or multiple splines arranged in a pattern configured to promote transitioning of the expandable support device between an expanded and collapsed configuration. The guide assembly may be configured to provide torque to the expandable support device. The operative member can include multiple electrodes arranged in parallel to the axis about which the expandable support device collapses. | 08-28-2014 |
20140336636 | FLEXIBLE CIRCUIT FOR DELIVERY THROUGH A WORKING CHANNEL - Methods, systems, and devices for providing treatment to a target site are described. The system may include a guide assembly, an expandable support device coupled with the distal end of the guide assembly, and an operative member disposed on the expandable support device. The expandable support device may be configured to transition between a collapsed and expanded configuration. The expandable support device may be supported by one or more flexible supports aligned in parallel with an axis about which the expandable support device collapses and/or multiple splines arranged in a pattern configured to promote transitioning of the expandable support device between an expanded and collapsed configuration. The guide assembly may be configured to provide torque to the expandable support device. The operative member can include multiple electrodes arranged in parallel to the axis about which the expandable support device collapses. | 11-13-2014 |
20140350564 | EXPANDABLE SUPPORT STRUCTURE AND OPERATIVE ELEMENT FOR DELIVERY THROUGH A WORKING CHANNEL - Methods, systems, and devices for providing treatment to a target site are described. The system may include a guide assembly, an expandable support device coupled with the distal end of the guide assembly, and an operative member disposed on the expandable support device. The expandable support device may be configured to transition between a collapsed and expanded configuration. The expandable support device may be supported by one or more flexible supports aligned in parallel with an axis about which the expandable support device collapses and/or multiple splines arranged in a pattern configured to promote transitioning of the expandable support device between an expanded and collapsed configuration. The guide assembly may be configured to provide torque to the expandable support device. The operative member can include multiple electrodes arranged in parallel to the axis about which the expandable support device collapses. | 11-27-2014 |
20150119880 | UNFURLING ELECTRODE DEVICES WITH SPRING - Methods, systems, and devices for providing treatment to a tissue in body lumens are described. The system may include a catheter, an expansion member coupled with a distal portion of the catheter, an ablation structure including one or more longitudinal electrode segments, and an ablation structure support coupled to the ablation structure configured to at least partially unfurl as the expansion member expands and furl as the expansion member contracts. The ablation structure may include multiple separately wired and/or separately controlled longitudinal electrodes, longitudinal electrode zones, or both, such that each longitudinal electrode or longitudinal electrode zone may be selectively enabled or selectively disabled. In some instances, one or more springs are coupled to the ablation structure configured to promote unfurl or furl around the expansion member. In some instances, one or more protection elements are be positioned along the catheter. | 04-30-2015 |
Patent application number | Description | Published |
20110054590 | VASCULAR PROSTHESIS WITH STRESS RELIEF SLOTS - A vascular prosthesis comprises generally tubular body placeable in contracted and expanded states and has an axial length and a circumferential dimension in the expanded state. The body includes a series of circumferential elements having first lengths. First and second connectors have connector lengths and join alternating ends of adjacent circumferential elements. The first length plus the connector lengths joined thereto equal a total circumferential length. Each connector length is between 2.5% and 25% of the total circumferential length. Adjacent circumferential elements and connectors extending therefrom are separated by a stress relief slot having a relief slot length of more than 50% and less than 95% of the total circumferential length. The stress relief slots have narrow width portions over a majority of the relief slot lengths, the narrow width portions having lateral dimensions of no greater than about 3 mm. | 03-03-2011 |
20110218613 | Vascular Prosthesis Assembly with Retention Mechanism and Method - A vascular prosthesis assembly includes a self expanding prosthesis and a selectively releasable retention mechanism over the outer surface of the prosthesis which maintains the vascular prosthesis in a contracted state. The retention mechanism may include a removable strand extending along the length of the prosthesis having a series of slip knots. The retention mechanism may also include a removable strand which engages overlying layers of a wrapped prosthesis by the passage of the strand through openings in the overlying layers. Manipulation of a user-accessible release strand permits release of the retention mechanism. The retention mechanism may also include a generally cylindrical sheath housing the vascular prosthesis, the sheath constructed to be split and removed to release the prosthesis. A method releases the prosthesis to expand at a target site using a retention mechanism. | 09-08-2011 |
20130103130 | Catheter Assembly With User-Assisting Handle - A catheter assembly includes a catheter, including an inner member and a sheath, extending from a handle. The handle includes a housing, a braking assembly, a carriage and a carriage driver. The braking assembly comprises a braking element within the housing interior and a braking element rotator. The carriage comprises at least one carriage braking surface engaging the braking element. The carriage driver, such as a spring, biases the carriage towards the proximal end of the handle. The inner member has a proximal end secured to the housing. The sheath has a proximal end secured to the carriage. Rotating the braking element causes the carriage to move proximally as the carriage braking surface slides along the braking element. This causes the sheath to move proximally relative to the inner member. | 04-25-2013 |
Patent application number | Description | Published |
20080241834 | Method for improving neoadjuvant chemotherapy - Disclosed is a method and composition for optimizing the efficiency of breast cancer neoadjuvant chemotherapy, depending on the particular constitutional genotype characteristics of the gene BRCA1 in each patient. Generally, the invention concerns a new method to improve neoadjuvant therapy depending on a particular constitutional genotype. Subject of invention allow to synthesize DNA and identification of germline BRCA1 genetic abnormalities which are correlated with a significantly decreased clinical response to neoadjuvant chemotherapy based on taxane-derived cytostatics in breast cancer patients. | 10-02-2008 |
20090092984 | Determining a predisposition to cancer - The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene. | 04-09-2009 |
20090197255 | Determining a predisposition to cancer - The present invention relates to methods and kits for determining a predisposition for developing cancer, e.g., prostate and/or breast cancer, due to a germline mutation of a NBS1 gene. The present invention also relates to surveillance protocols for developing cancer, e.g., prostate and/or breast cancer, due to germline mutation of a NBS1 gene. | 08-06-2009 |
20110105342 | METHOD FOR DETERMINING REDUCED PREDISPOSITION TO CANCER BASED ON GENETIC PROFILE - The invention provide methods for early detection of a reduced risk of developing cancer, which comprises detecting the absence of a series of genetic polymorphisms associated with a predisposition of developing cancer, including the polymorphisms of the genes BRCA1, BRCA2, CARD15 (NOD2), CHEK2, CDKN2A (P16), CYP1B1, FGFR2 (KGFR2), MAP3K1 (MEKK1), p53 (TP53), TNRC9, XPD (ERCC2) and the genetic marker Rs6983267, in a biological sample from the analyzed subject, wherein the absence of the genetic polymorphisms is indicative of significantly decreased risk of developing, at least, breast cancer. | 05-05-2011 |
20110245095 | FAST ASSIGNMENT OF ADEQUATE CHEMOTHERAPY WITH LATINUM BASED DRUGS FOR CANCER PATIENTS BASED ON THE IDENTIFICATION OF CONSTITUTIONAL BRCAL MUTATIONS - A new method to improve therapy outcome depending on a particular constitutional genotype have been disclosed. Subject of invention allows to synthesize DNA and identification of germline BRCA1 genetic abnormalities which are correlated with a significantly increased clinical response to chemotherapy based on platinum derived drugs in cancer patients. | 10-06-2011 |
Patent application number | Description | Published |
20090098162 | Herpes simplex virus combined subunit vaccines and methods of use thereof - This invention provides vaccines comprising two or more recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of vaccinating a subject against HSV and treating, impeding, inhibiting, reducing the incidence of, or suppressing an HSV infection or a symptom or manifestation thereof, comprising administration of a vaccine of the present invention. | 04-16-2009 |
20090148467 | HERPES SIMPLEX VIRUS COMBINED SUBUNIT VACCINES AND METHODS OF USE THEREOF - This invention provides vaccines comprising two or more recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of impeding immune evasion by HSV thereby vaccinating a subject against HSV and treating, suppressing, inhibiting, and/or reducing an incidence of an HSV infection or a symptom or manifestation thereof, comprising administration of a vaccine of the present invention. | 06-11-2009 |
20110256176 | HERPES SIMPLEX VIRUS COMBINED SUBUNIT VACCINES AND METHODS OF USE THEREOF - This invention provides vaccines comprising two or more recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of impeding immune evasion by HSV thereby vaccinating a subject against HSV and treating, suppressing, inhibiting, and/or reducing an incidence of an an HSV infection or a symptom or manifestation thereof, comprising administration of a vaccine of the present invention. | 10-20-2011 |
20130028925 | HERPES SIMPLEX VIRUS COMBINED SUBUNIT VACCINES AND METHODS OF USE THEREOF - This invention provides immunogenic compositions comprising two or three recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of impeding immune evasion by HSV, inducing an anti-HSV immune response, and treating, suppressing, inhibiting, and/or reducing an incidence of an HSV infection or a symptom or manifestation thereof, comprising administration of a vaccine of the present invention. | 01-31-2013 |
Patent application number | Description | Published |
20110265765 | DIRECT INJECTION PUMP CONTROL STRATEGY FOR NOISE REDUCTION - A pump may have a first chamber and a solenoid coil to control movement of a first valve member. A second chamber may have a second valve member to control fluid moving into a third chamber. A first fluid passageway may link the first and second chambers, a second passageway may link second and third chambers and a third passageway may link third and fourth chambers. After pressurizing the third chamber causing fluid to flow into and leave a fourth chamber, the third chamber depressurizes due to downward movement of a plunger. Upon depressurization with a solenoid coil energized, second valve member floats and then moves against a valve seat. While the second valve member is moving toward the valve seat, the solenoid coil is de-energized causing the first valve member to move and strike the second valve member when the second valve member is moving at maximum velocity. | 11-03-2011 |
20120251367 | PUMP PRESSURE CONTROL VALVE WITH SHOCK REDUCTION FEATURES - A pump includes a pump casing defining a first chamber and a second chamber, and fluid moves from the first chamber to the second chamber during a stroke. The pump also includes a needle that is movably disposed in the first chamber and a valve carriage that is movably disposed in the second chamber. The valve carriage includes an internal stop, and the valve carriage also includes a cavity therein that is partially defined by the internal stop. The pump further includes a valve that is movably disposed within the cavity of the valve carriage, and the valve is operable to be impacted by the needle during the stroke. Also, the needle is operable to impact the valve carriage during the stroke. Moreover, the valve is operable to impact the internal stop during the stroke at a time different from the needle impacting the valve carriage. | 10-04-2012 |
20140161631 | DIRECT INJECTION PUMP CONTROL STRATEGY FOR NOISE REDUCTION - A pump may have a first chamber and a solenoid coil to control movement of a first valve member. A second chamber may have a second valve member to control fluid moving into a third chamber. A first fluid passageway may link the first and second chambers, a second passageway may link second and third chambers and a third passageway may link third and fourth chambers. After pressurizing the third chamber causing fluid to flow into and leave a fourth chamber, the third chamber depressurizes due to downward movement of a plunger. Upon depressurization with a solenoid coil energized, second valve member floats and then moves against a valve seat. While the second valve member is moving toward the valve seat, the solenoid coil is de-energized causing the first valve member to move and strike the second valve member when the second valve member is moving at maximum velocity. | 06-12-2014 |
20140161634 | DIRECT INJECTION PUMP CONTROL STRATEGY FOR NOISE REDUCTION - A pump may have a first chamber and a solenoid coil to control movement of a first valve member. A second chamber may have a second valve member to control fluid moving into a third chamber. A first fluid passageway may link the first and second chambers, a second passageway may link second and third chambers and a third passageway may link third and fourth chambers. After pressurizing the third chamber causing fluid to flow into and leave a fourth chamber, the third chamber depressurizes due to downward movement of a plunger. Upon depressurization with a solenoid coil energized, second valve member floats and then moves against a valve seat. While the second valve member is moving toward the valve seat, the solenoid coil is de-energized causing the first valve member to move and strike the second valve member when the second valve member is moving at maximum velocity. | 06-12-2014 |