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Lu, San Diego
Dan Lu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120058177 | NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY - The present invention provides an aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. The liposome nanoparticles comprise a legumain-targeting lipid admixed with one or more other micelle or vesicle-forming lipid materials in the form of nanoparticulate liposomes dispersed in an aqueous carrier. A preferred tumor-targeting liposome nanoparticle composition comprises (a) a legumain-targeting lipid component, (b) a zwitterionic lipid component; (c) an amino-substituted lipid component; (d) a neutral lipid component; and (e) polyethylene glycol-conjugated lipid component. The legumain-targeting lipid component comprising a hydrophobic lipid portion covalenetly attached to a legumain-binding moiety. | 03-08-2012 |
Desheng Lu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090286246 | Methods for Identifying Compounds that Affect Expression of Cancer-Related Protein Isoforms - Provided herein are methods for screening compounds for their ability to modulate the expression of certain isoforms of proteins that are associated with cancer, such as isoforms of proteins that participate in Wnt signaling in cancer cells. | 11-19-2009 |
| 20100068708 | Methods for Identifying Compounds that Modulate WNT Signaling in Cancer Cells - Provided herein are methods for screening compounds for their ability to modulate Wnt signaling in cancer cells. | 03-18-2010 |
| 20110306671 | AMIDE DERIVATIVES OF ETHACRYNIC ACID - The invention provides ethacrynic acid derivatives useful to prevent, inhibit or treat a variety of disorders or diseases including cancer and inflammatory disorders. | 12-15-2011 |
Haw-Minn Lu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080285495 | Systems and Methods for Communicating to a Disassociated Station in a Protected Network - Stations in standby mode in a wireless local area network (WLAN) become disassociated with their access point. In the event traffic is intended for the station in standby mode, a wakeup message needs to be communicated to the station. Typically, a wakeup message could be broadcast on a broadcast or multicast address, and when the station checks for broadcasts, the station can determine whether it needs to wake up. However, in a protected network, a disassociated station cannot decrypt messages from the access point without reassociating. However, the cost of reassociating in time and power can be significant, so reassociating should not be performed unless the station needs to wake up, leading to a vicious cycle as the station does not know it must wake up unless it can decrypt the message. To address this issue, in one embodiment the access points do not encrypt messages on a select multicast address, whereby messages such as wakeup message can be transmitted. In another embodiment, the messages are still encrypted. However, the identification of which station must wake up is encoded as the length of the encrypted payload. These methods allow a general message of communicating to disassociated stations in a protected WLAN environment. | 11-20-2008 |
| 20110081640 | Systems and Methods for Protecting Websites from Automated Processes Using Visually-Based Children's Cognitive Tests - Visually based children's cognitive tests can be used as a human challenge or Turing test to verify that a human and not an automated process is operating a particular system, such as purchasing tickets, downloading files, accessing a database, or requesting a reprieve from an anti-spam system. Several different visually oriented cognitive tests can be used as a human challenge, for example, selecting one object in a group of object that is different, selecting an object from a group of objects which is most similar to a given object, selecting two objects in a group of objects that are most similar, finding a given object in a scene, counting the number of instances of an object in a scheme and object based analogies. | 04-07-2011 |
Lin Lu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090262481 | APPARATUS, SYSTEM, AND METHOD FOR ELECTROSTATIC DISCHARGE PROTECTION - An apparatus, system, and method provide electrostatic discharge (ESD) protection in electronic devices by guiding electrostatic charges to a ground through ESD channels within electrical insulation sheet. The ESD channels are positioned within the electrical insulation sheet to provide electrical paths to ground having a lower impedance than electrical paths to protected areas covered by the electrical insulation sheet. Accordingly, an ESD follows the path of least resistance safely to ground rather than to a critical component within the electronic device. In the exemplary embodiment, the ESD channels are openings in a dome contact layer of a keypad where the openings are positioned over one or more ground areas of a printed circuit board (PCB) and the insulting material of the dome contact layer covers areas of the PCB that are protected from ESD. By implementing dedicated GPIO lines, grounded metal domes cover the signal pads in the target discharge area to protected the GPIO lines from ESD. Device components are protected from ESD without additional ports or insulation. | 10-22-2009 |
| 20120021707 | APPARATUS AND METHOD FOR ADJUSTMENT OF TRANSMITTER POWER IN A SYSTEM - Certain aspects of the present disclosure propose methods for determining power level of one or more transmitters based on a power level of a primary transmitter when the transmitters are located in close proximity of each other. The power levels may be determined such that a combined power of all the transmitters is compliant with regulatory radio frequency (RF) safety requirements. For certain aspects, power level of the lower priority transmitters may be determined utilizing one or more look-up tables. For another aspect, power level of the lower priority transmitters may be calculated using an algorithm based on the power level of the priority transmitter. In aspects, the power level of lower priority transmitters and the time duration for which the transmitters are active may be selected dynamically so that the time averaged power of the transmitters for a defined period of time falls below the RF exposure limit. | 01-26-2012 |
Maolong Lu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080214443 | Compositions and Methods for Control of Insect Infestations in Plants - The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in controlling pest infestation by feeding one or more different recombinant double stranded RNA molecules to the pest in order to achieve a reduction in pest infestation through suppression of gene expression. The invention is also directed to methods for making transgenic plants that express the double stranded RNA molecules, and to particular combinations of transgenic pesticidal agents for use in protecting plants from pest infestation. | 09-04-2008 |
Shao Po Lu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100056582 | Modulators of LXR - Compounds of the invention, such as compounds of formula (I): | 03-04-2010 |
| 20100069367 | LXR and FXR Modulators - Compounds of the invention are disclosed, such as compounds of formulae LX-LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R | 03-18-2010 |
| 20100075964 | IMIDAZOLE BASED LXR MODULATORS - Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R | 03-25-2010 |
| 20100331295 | MODULATORS OF LXR - Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed. | 12-30-2010 |
Wenshuo Lu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090075996 | HETEROTETRACYCLIC COMPOUNDS AS TPO MIMETICS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TPO activity, particularly diseases or disorders that involve thrombocytopenia. | 03-19-2009 |
| 20100298295 | 2-BIPHENYLAMINO-4-AMINOPYRIMIDINE DERIVATIVES AS KINASE INHIBITORS - The invention provides novel pyrimidine derivatives of formula (1) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or anaplastic lymphoma kinase (ALK). | 11-25-2010 |
| 20110112063 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS - The invention provides novel pyrimidine derivatives of formula I and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK). | 05-12-2011 |
| 20110112096 | PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS - The invention provides novel pyrimidine derivatives of formula (I) and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-IR) or analplastic lymphoma kinase (ALK). | 05-12-2011 |
| 20110257154 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides novel pyrimidine and pyridine derivatives and pharmaceutical compositions thereof, and methods for using such compounds. For example, the pyrimidine and pyridine derivatives of the invention may be used to treat, ameliorate or prevent a condition which responds to inhibition of anaplastic lymphoma kinase (ALK) activity, focal adhesion kinase (FAK), zeta-chain-associated protein kinase 70 (ZAP-70), insulin-like growth factor (IGF-1R), or a combination thereof. | 10-20-2011 |
Xiao-Xiong Lu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110015438 | PROCESS FOR THE PREPARATION OF INTERMEDIATES RELATED TOTHE 5-HT2C AGONIST (R)-8-CHLORO-1-METHYL-2,3,4,5,-TETRAHYDRO-1H-3-BENZAZEPINE - The present invention provides processes and intermediates useful in the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, a serotonin (5-HT) receptor agonist that is useful in the treatment or prophylaxis of, for example, central nervous system disorders, such as obesity. | 01-20-2011 |