Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Lu, MA
Chafen Lu, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100113742 | Modified polypeptides stabilized in a desired conformation and methods for producing same - The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. | 05-06-2010 |
| 20110111528 | MODIFIED POLYPEPTIDES STABILIZED IN A DESIRED CONFORMATION AND METHODS FOR PRODUCING SAME - The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. | 05-12-2011 |
| 20110305691 | MODIFIED POLYPEPTIDES STABILIZED IN A DESIRED CONFORMATION AND METHODS FOR PRODUCING SAME - The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where crysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. | 12-15-2011 |
Chenfeng Lu, Watertown, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100168481 | GREEN PROCESS AND COMPOSITIONS FOR PRODUCING POLY(5HV) AND 5 CARBON CHEMICALS - Recombinant hosts for producing polyhydroxyalkanoates and methods of producing polyhydroxyalkanoates from renewable carbon substrates are provided. Certain recombinant hosts that produce 5 carbon chemicals such as 5-aminopentanoate (5AP), 5-hydroxyvalerate (5HV), glutarate, and 1,5 pentanediol (PDO) are also provided. One embodiment provides a recombinant host expressing a gene encoding a heterologous enzyme selected from the group consisting of a polyhydroxyalkanoate synthase and a 5-hydroxyvalerate-CoA (5HV-CoA) transferase, wherein the host produces a polymer containing 5-hydroxyvalerate. Preferably, the host expresses both a polyhydroxyalkanoate synthase and a 5HV-CoA transferase. The host can be prokaryotic or eukaryotic. A preferred prokaryotic host is | 07-01-2010 |
Chris Lu, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100003256 | Use of TGF-Beta Antagonists in Treatment of Parathyroid-Related Disorders - The present invention relates to the use of TGF-β antagonists for the treatment, amelioration, and diagnosis of parathyroid-related disorders, e.g., HPT-JT, familial isolated primary hyperparathyroidism (FIPH), and hyperparathyroidism-jaw tumor (HPT-JT) syndrome, as well as its attendant complications. The present invention also relates to the use of modulators of HRPT2 and its related PAF1 complex for the treatment, amelioration, and diagnosis of TGFβ-related disorders, e.g., pulmonary hypertension, cancer, hypertension, fibrosis, wound healing. Assays of the identification of modulators of HRPT2/PAF1 and SMAD/TGFβ are also provided. | 01-07-2010 |
| 20100272734 | COMPOSITIONS AND METHODS FOR INCREASING MUSCLE GROWTH - This disclosure is in the field of anti-Activin receptor IIB (ActRIIB) antibodies. In particular, it relates to the use of said antibodies for treating muscle disorders, such as muscle wasting due to disease or disuse. | 10-28-2010 |
| 20120003219 | Compositions and Methods to Treat Bone Related Disorders - The present invention relates to the use of modulators of the sclerostin:sclerostin-binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders, e.g., osteoporosis and sclerosteosis, and sclerostin-related disorders, e.g., cancers and cardiovascular disorders. The invention also relates to the use of sclerostin-binding-partner mimetics for the treatment, amelioration, and diagnosis of sclerostin-related disorders. Assays for the identification of modulators of the sclerostin:sclerostin-binding-partner interaction, as well as the resulting signaling, are also provided. | 01-05-2012 |
Chris Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100028335 | Compositions and Methods to Treat Bone Related Disorders - The present invention relates to the use of modulators of the sclerostin: sclerostin-binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders, e.g., osteoporosis and sclerosteosis, and sclerostin-related disorders, e.g., cancers and cardiovascular disorders. The invention also relates to the use of sclerostin-binding-partner mimetics for the treatment amelioration, and diagnosis of sclerostin-related disorders. Assays for the identification of modulators of the sclerostin: sclerostin-binding-partner interaction, as well as the resulting signaling, are also provided. | 02-04-2010 |
Dai Lu, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090163557 | Cannabinergic Lipid Ligands - One aspect of this disclosure relates generally to lipid compounds that exert diverse effects in the endocannabinoid system, such as regulating CB1 and CB2 receptor or moderating other bio-macromolecules within the endocannabinoid system. Some of the compounds showed improved receptor binding affinity, and/or improved receptor subtype selectivity, and improved bio-stability. Some of the compounds exhibit activities to regulate the enzymes that moderate the bio-disposal of endogenous cannabinoids, such as the fatty acid amide hydrolase (FAAH). Some of the compounds exhibit activities to inhibit the anandamide transporter. Other aspects of the invention are pharmaceutical preparations employing these ligands and methods of administering therapeutically effective amounts of the preparations to provide a physiological effect. | 06-25-2009 |
Dongling Lu, Franklin, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090043078 | GDF-5 PROTEIN STORAGE - Improved compositions and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an aqueous solution of GDF-5 and a biocompatible acid, such as hydrochloric, acetic, phosphoric, or trifluoroacetic acid, wherein the solution has a pH of from about 3.0 to about 3.6, thereby providing for improved stability of the GDF-5 protein during handling and prolonged storage at reduced temperatures. | 02-12-2009 |
Fang Lu, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120029902 | MODE SUPPORTING MULTIPLE LANGUAGE INPUT FOR ENTERING TEXT - Strings entered into a computer system are converted to a common language. The process of converting strings to a common language comprises determining a user-selected target language, associating a user-selected primary input language with the target language and associating a user-selected secondary input language with the target language. The process further comprises obtaining a string of at least one character, converting the obtained string from the primary input language to the target language if the obtained string corresponds to a valid string in the primary input language and converting the obtained string from the secondary input language to the target language if the obtained string corresponds to a valid string in the secondary input language and is not a valid string in the primary input language. | 02-02-2012 |
Gang Lu, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120023241 | SSL Cache Session Selection - In one embodiment, a gateway implements: selecting, from a plurality of instances, an instance with which to begin a secure initial communication session; establishing, with the selected instance, a secure initial communication session; generating information regarding the session, the information including a session identifier associated with the session and an instance identifier associated with the selected instance; receiving a request to resume the session, the request including the session identifier and the instance identifier; using the instance identifier to identify a processing instance from the plurality of instances; and resuming the initial communication session using the identified processing instance, wherein at least a portion of the information associated with the initial communication session is re-used for the resumed session. | 01-26-2012 |
Genliang Lu, Winchester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090175794 | INHIBITORS OF CARBONIC ANHYDRASE IX - Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by over expression of CA-IX comprise a complex that contains a sulfonamide moiety which is capable of binding the active catalytic site of CA-IX, and a radionuclide adapted for radioimaging and/or radiotherapy: | 07-09-2009 |
| 20090281088 | BICYCLIC NITROIMIDAZOLE-SUBSTITUTED PHENYL OXAZOLIDINONES - The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as | 11-12-2009 |
| 20100178246 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA - A compound of Formula I, a pharmaceutically acceptable salt, or solvate thereof: | 07-15-2010 |
| 20100178247 | CA-IX SPECIFIC RADIOPHARMACEUTICALS FOR THE TREATMENT AND IMAGING OF CANCER - A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus, pharmaceutical compositions may be prepared with one or more of the compounds of Formula I, II, III, or IV. | 07-15-2010 |
| 20100183509 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF - Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin. | 07-22-2010 |
Hairong Lu, West Roxbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120064117 | TETRAVALENT INFLUENZA VACCINE AND USE THEREOF - Disclosed herein is the finding that baculovirus display of multiple influenza virus hemagglutinin (HA) proteins elicits broadly reactive immune responses against influenza. Thus provided herein are recombinant baculovirus vectors having a first, second, third and fourth nucleic acid sequence, each encoding an influenza hemagglutinin (HA) fusion protein. The first, second, third and fourth nucleic acid sequences each encode an influenza HA with a different amino acid sequence. Also provided are recombinant baculoviruses displaying a first, second, third and fourth influenza virus HA fusion protein in the baculovirus envelope, wherein each HA fusion protein comprises a different HA amino acid sequence. Tetravalent influenza virus vaccines comprising the recombinant baculoviruses disclosed herein are further provided. In addition, methods of immunizing a subject against influenza virus using the tetravalent influenza virus vaccines are provided. In particular examples of the compositions and methods disclosed herein, the HA polypeptides are from H5N1 influenza virus. | 03-15-2012 |
Harry Lu, Bedford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100138268 | PROGRESS MANAGEMENT PLATFORM - A device receives milestone information and dependency information associated with a project, generates a milestone flow chart based on the milestone information and the dependency information, and represents one or more milestones, in the milestone flow chart, with one or more nodes. The device also represents one or more dependencies among the one or more milestones with one or more directed arcs provided between corresponding nodes of the one or more nodes, and calculates a critical path associated with the one or more milestones. The device further represents the critical path with bolded directed arcs provided between corresponding nodes of the one or more nodes, and provides the milestone flow chart, including the representations of the one or more milestones, the one or more dependencies, and the critical path, for display. | 06-03-2010 |
Hong Lu, Wayland, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110263128 | SELECTIVE WET ETCHING AND TEXTURED SURFACE PLANARIZATION PROCESSES - The present invention relates to systems and methods associated with selective wet etching and textured surface planarization. The systems and methods described herein can be used to etch a component of a multi-layer stack, such as a GaN layer. In some embodiments, the multi-layer stack can include a substrate having a patterned surface and a light generating region. The substrate can be removed from the first multi-layer stack to form a second multi-layer stack. In some embodiments, the pattern on the surface of the substrate can leave behind a pattern on a surface of the second multi-layer stack. Accordingly, in some cases, the surface of the second multi-layer stack can be wet etched, for example, to smoothen the surface. In some embodiments, removing the substrate can expose an N-face of a GaN layer, and the wet etch can be performed such that the N-face of the GaN layer is etched. In some embodiments, the multi-layer stack includes a light generating region and can be part of a light emitting device. | 10-27-2011 |
Hong Lu, Belmont, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090309114 | WAVELENGTH CONVERTING LIGHT-EMITTING DEVICES AND METHODS OF MAKING THE SAME - Wavelength converting light-emitting devices and methods of making the same are provided. In some embodiments, the devices include a phosphor material region designed to convert the wavelength of emitted light. | 12-17-2009 |
| 20100219767 | LIGHT-EMITTING DEVICE INCLUDING INDEPENDENTLY ELECTRICALLY ADDRESSABLE SECTIONS - Light-emitting devices are described herein. Some embodiments relate to light-emitting diodes with light-emitting sections that are independently electrically addressable. The devices may be used in a variety of applications including illumination and general lighting. | 09-02-2010 |
Jianrong Lu, Quincy, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090087412 | Methods and compositions relating to HDAC 4 and 5 regulation of cardiac gene expression - The present invention relates to cardiac hypertrophy. More particularly, the present invention defines the molecular events linking calcium stimulation to cardiac hypertrophy. More specifically, the present invention shows that Ca | 04-02-2009 |
Kun Ping Lu, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080214470 | Pin1-Modulating Compounds and Methods of Use Thereof - The invention is directed to peptide modulators of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer or neurodegenerative disease. | 09-04-2008 |
| 20090258352 | Pin1 as a marker for abnormal cell growth - Methods for the use of Pin1 as a marker of abnormal cell growth are disclosed. In one embodiment, the method includes detecting a level of Pin1 to stage an abnormal cell growth, such as breast or prostate cancer. In another embodiment, the method includes evaluating the efficacy of a treatment of an abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the method includes evaluating the extent of metastasis of abnormal cell growth, such as cancer. The levels of Pin1 can be protein levels or nucleic acid levels. | 10-15-2009 |
Michael Lu, Lexington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100012147 | ARTICLE PROCESSING APPARATUS AND RELATED METHOD - The present invention relates generally to systems and methods of disinfecting and/or decontaminating articles, and more specifically to a system and method of efficiently disinfecting and/or decontaminating articles such as pieces of mail that may have been exposed to diverse biological and/or chemical contaminants. | 01-21-2010 |
| 20100183476 | ARTICLE PROCESSING APPARATUS AND RELATED METHOD - The present invention relates generally to systems and methods of disinfecting and/or decontaminating articles, and more specifically to a system and method of efficiently disinfecting and/or decontaminating articles such as pieces of mail that may have been exposed to diverse biological and/or chemical contaminants. | 07-22-2010 |
Peichao Lu, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090137495 | Organic Compounds and Their Uses - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 05-28-2009 |
| 20120015907 | Furopyridine compounds and uses thereof - The present invention provides a compound of formula I; | 01-19-2012 |
Peichao Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090197856 | ANTIVIRAL COMPOUNDS - Provided are compounds of Formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds and compositions are useful for treating viral infections caused by the Flaviviridae family of viruses. | 08-06-2009 |
| 20110275819 | ORGANIC COMPOUNDS AND THEIR USES - The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases. | 11-10-2011 |
Peter J. Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100195868 | TARGET-LOCKING ACQUISITION WITH REAL-TIME CONFOCAL (TARC) MICROSCOPY - Presented herein is a real-time target-locking confocal microscope that follows an object moving along an arbitrary path, even as it simultaneously changes its shape, size and orientation. This Target-locking Acquisition with Realtime Confocal (TARC) microscopy system integrates fast image processing and rapid image acquisition using, for example, a Nipkow spinning-disk confocal microscope. The system acquires a 3D stack of images, performs a full structural analysis to locate a feature of interest, moves the sample in response, and then collects the next 3D image stack. In this way, data collection is dynamically adjusted to keep a moving object centered in the field of view. The system's capabilities are demonstrated by target-locking freely-diffusing clusters of attractive colloidal particles, and actively-transported quantum dots (QDs) endocytosed into live cells free to move in three dimensions for several hours. During this time, both the colloidal clusters and live cells move distances several times the length of the imaging volume. Embodiments may be applied to other applications, such as manufacturing, open water observation of marine life, aerial observation of flying animals, or medical devices, such as tumor removal. | 08-05-2010 |
Peter James Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100124758 | APPARATUS AND METHOD FOR DETECTING GLYCOL - A method and apparatus are provided for detecting contaminants, such as ethylene glycol and diethylene glycol, in various materials, including household products, and medicines. The contaminants can be detected using enzyme assays that produce measurable changes in light absorption and/or light fluorescence. | 05-20-2010 |
Rongzhen Lu, Lincoln, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080227114 | COMPOSITIONS AND METHODS FOR MODULATING C-REL-DEPENDENT CYTOKINE PRODUCTION - The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NFκB and/or the amount of IκB. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of c-Rel but where the level of expression of NFκB and/or the amount of IκB is materially unaltered. | 09-18-2008 |
| 20110288081 | PYRIMIDINE COMPOUNDS AND USES THEREOF - This invention features pyrimidine compounds of formula (I): | 11-24-2011 |
Shan Lu, Franklin, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090053256 | Poxvirus Methods And Compositions - Methods and compositions for inducing immune responses against poxviruses are disclosed. The compositions include nucleic acids that encode modified vaccinia and variola antigens. Compositions that include recombinant vaccinia and variola polypeptides are also disclosed. | 02-26-2009 |
| 20090098144 | IMMUNOGEN PRESENTING HIV GP120 V3 LOOP IN A CONFORMATION THAT INDUCES BROADLY NEUTRALIZING ANTIBODIES - Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related | 04-16-2009 |
| 20090291472 | INFLUENZA NUCLEIC ACIDS, POLYPEPTIDES, AND USES THEREOF - Codon-optimized nucleic acids encoding influenza polypeptides and uses of the nucleic acids and polypeptides for inducing immune responses are provided herein. | 11-26-2009 |
| 20110171258 | POLYVALENT, PRIMARY HIV-1 GLYCOPROTEIN DNA VACCINES AND VACCINATION METHODS - Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV is disclosed. The compositions and methods described herein are for the use of a DNA composition that encodes one or more different HIV envelope glycoproteins. The DNA composition can encode an HIV Gag protein. The DNAs encoding one or more HIV proteins are a combination of different nucleic acids, such as DNA plasmids, generated from primary isolate DNA of different HIV major group genetic clades and/or different proteins. HIV protein compositions for inducing an immune response against HIV are disclosed. Methods for using the protein compositions as boosts following administration of the DNA compositions are provided. | 07-14-2011 |
Shi-Jiang Lu, Shrewsbury, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110064705 | HEMANGIO COLONY FORMING CELLS AND NON-ENGRAFTING HEMANGIO CELLS - Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Human non-engrafting hemangio cells are a novel progenitor cell population that is related to but distinct from the hemangioblast and human hemangio-colony forming cells. The invention also provides compositions, preparations, and solutions comprising hemangio-colony forming cells, non-engrafting hemangio cells or cells differentiated therefrom. The compositions, preparations, and solutions include cryopreserved preparations and substantially purified preparations, as well as mixed compositions formulated in combination with related hemangioblast progenitor cell types that can engraft into the bone marrow. | 03-17-2011 |
| 20110086424 | METHODS FOR PRODUCING ENUCLEATED ERYTHROID CELLS DERIVED FROM PLURIPOTENT STEM CELLS - Methods for generating enucleated erythroid cells using pluripotent stem cells are provided. The methods permit the production of large numbers of cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Methods for generating megakaryocyte and platelets are also provided. | 04-14-2011 |
| 20110171185 | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof - The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells. | 07-14-2011 |
| 20110286978 | Genetically Intact Induced Pluripotent Cells Or Transdifferentiated Cells And Methods For The Production Thereof - The present disclosure relates to methods for dedifferentiating and transdifferentiating recipient cells, preferably human somatic cells. These methods minimize the risk of undesired genome sequence alteration. These methods employ reprogramming factors, which may be used alone or in certain combinations with one another. These methods have application especially in the context of cell-based therapies, establishment of cell lines, and the production of genetically modified cells. | 11-24-2011 |
| 20120027731 | HEMANGIO-COLONY FORMING CELLS - Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. | 02-02-2012 |
Sijia Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100252750 | SYSTEMS AND METHODS FOR STIMULATED EMISSION IMAGING - A microscopy imaging system is disclosed that includes a light source system, focusing optics, an optical detector and a processor. The light source system is for providing an excitation beam at a center optical frequency ω | 10-07-2010 |
Tao Lu, Brookline, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080274456 | Methods and Compositions for Modifying Gene Regulation and Dna Damage in Ageing - The invention relates to gene regulation in ageing, and age-related cognitive decline. The invention, in particular relates to methods for screening a subject for a propensity to develop diseases associated with oxidative stress, and for age-related conditions, by examining the up-regulation and/or down-regulation of at least one gene associated within the central nervous system. | 11-06-2008 |
Timothy Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120003630 | MODULAR NUCLEIC ACID-BASED CIRCUITS FOR COUNTERS, BINARY OPERATIONS, MEMORY, AND LOGIC - We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for encoding memory in cells and cellular systems. Our designs are easily extended to compute to high numbers, by utilizing the >100 known recombinases to create subsequent modules. Flexibility in our engineered genetic counter designs is provided by daisy-chaining individual modular components, i.e., SIMMs together. These modular components of the engineered genetic counters can be combined in other network topologies to create circuits that perform, amongst other things, logic and memory. Our novel engineered genetic counter designs allow for the maintenance of memory and provide the ability to count between discrete states by expressing the recombinases between their cognate recognition sites. | 01-05-2012 |
Timothy Kuan-Ta Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110097721 | IN VIVO GENE SENSORS - Described are methods and compositions for the detection of target genes. The inventors have developed a synthetic nucleic acid sensor-effector gene circuit. In cells without a target gene, the circuit suppresses e.g., effector production, but in the presence of the target gene the suppression is subject to competition, such that the synthetic sensor is de-repressed and permits expression of the effector gene. The methods and compositions described further permit the selective expression of an effector gene in those cells expressing the target gene. In this manner, cells expressing a target gene can be selectively targeted for treatment or elimination. In certain aspects, the methods and compositions described permit the selective expression of an agent such as a therapeutic gene product, in a specifically targeted population of cells in an organism. | 04-28-2011 |
Timothy Kuan-Ta Lu, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090155215 | ENGINEERED ENZYMATICALLY ACTIVE BACTERIOPHAGE AND METHODS FOR DISPERSING BIOFILMS - The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been also engineered to express biofilm-degrading enzymes, particularly dispersin B (DspB), an enzyme that hydrolyzes β-1,6-N-acetyl-D-glucosamine, a crucial adhesion molecule needed for biofilm formation and integrity in | 06-18-2009 |
| 20100322903 | ENGINEERED BACTERIOPHAGES AS ADJUVANTS FOR ANTIMICROBIAL AGENTS AND COMPOSITIONS AND METHODS OF USE THEREOF - The present invention relates to the treatment and prevention of bacteria and bacterial infections. In particular, the present invention relates to engineered bacteriophages used in combination with antimicrobial agents to potentiate the antimicrobial effect and bacterial killing by the antimicrobial agent. The present invention generally relates to methods and compositions comprising engineered bacteriophages and antimicrobial agents for the treatment of bacteria, and more particularly to bacteriophages comprising agents that inhibit antibiotic resistance genes and/or cell survival genes, and/or bacteriophages comprising repressors of SOS response genes or inhibitors of antimicrobial defense genes and/or expressing an agent which increases the sensitivity of bacteria to an antimicrobial agent in combination with at least one antimicrobial agent, and their use thereof. | 12-23-2010 |
Vivian Lu, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110271097 | Loosely-Coupled Encryption Functionality for Operating Systems - Described are computer-based methods and apparatuses, including computer program products, for loosely-coupled encryption functionality for operating systems. A data packet is processed through one or more internet protocol stack layers to generate a processed data packet. Modified encryption information is determined that does not comprise a desired security policy for the data packet and comprises null parameter(s) and is based on encryption information that comprises the desired security policy. A message comprising data indicative of the encryption information is transmitted. An operating system is unaware of a security nature of the transmission. A null-encryption routine is executed to generate an unencrypted data packet, wherein the null-encryption routine does not encrypt the processed data packet. The unencrypted data packet is transmitted to the second computing device. The unencrypted data packet is encrypted based on the message transmitted from the first computing device to generate an encrypted data packet. | 11-03-2011 |
Wentao Lu, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090040132 | Anisotropic metal-dielectric metamaterials for broadband all-angle negative refraction and superlens imaging - A metamaterial comprises a plurality of metallic nanowires embedded in a dielectric matrix. The metamaterial composite media provide broadband all-angle negative refraction and flat lens, superlens and curved hyperlens imaging in specific spectral regions over a wide range of frequencies including, for example, from deep infrared to ultraviolet frequencies. | 02-12-2009 |
Wentao T. Lu, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090086322 | Photonic Crystal Devices Using Negative Refraction - Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses. Demonstration of negative refraction of visible light is also performed for the grism. These lenses can be used in optical circuits, astronomical applications, etc. | 04-02-2009 |
Xiancheng Lu, Leicester, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110265667 | BAR BUNDLER - Apparatus for bundling bars comprising an accumulator rotatable about a horizontal axis. The accumulator has a plurality of notches spaced angularly around its axis. A drive rotates the accumulator about its axis to sequentially locate the notches at: | 11-03-2011 |
Yalin Lu, Chelmsford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090302866 | ANALYTICAL SCANNING EVANESCENT MICROWAVE MICROSCOPE AND CONTROL STAGE - A scanning evanescent microwave microscope (SEMM) that uses near-field evanescent electromagnetic waves to probe sample properties is disclosed. The SEMM is capable of high resolution imaging and quantitative measurements of the electrical properties of the sample. The SEMM has the ability to map dielectric constant, loss tangent, conductivity, electrical impedance, and other electrical parameters of materials. Such properties are then used to provide distance control over a wide range, from to microns to nanometers, over dielectric and conductive samples for a scanned evanescent microwave probe, which enable quantitative non-contact and submicron spatial resolution topographic and electrical impedance profiling of dielectric, nonlinear dielectric and conductive materials. The invention also allows quantitative estimation of microwave impedance using signals obtained by the scanned evanescent microwave probe and quasistatic approximation modeling. The SEMM can be used to measure electrical properties of both dielectric and electrically conducting materials. | 12-10-2009 |
Yanhui Lu, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090172319 | SYSTEMS AND METHODS FOR RECOVERING ELECTRONIC INFORMATION FROM A STORAGE MEDIUM - In one embodiment of the invention, a method is provided for retrieving certain electronic information previously stored on certain storage media after a threshold set in the storage retention criteria has been exceeded in an electronic information storage system that stores electronic information on storage media in accordance with a storage retention criteria is provided. The method includes storing a record in a memory associated with a system manager that assigns the storage retention criteria to the certain electronic data, designating the storage media available for overwrite after the threshold set in the storage retention policy has been exceeded, identifying the certain storage media available for overwrite, and retrieving information from the certain media after the threshold set in the storage retention policy has been exceeded. | 07-02-2009 |
| 20110093672 | SYSTEMS AND METHODS FOR RECOVERING ELECTRONIC INFORMATION FROM A STORAGE MEDIUM - In one embodiment of the invention, a method is provided for retrieving certain electronic information previously stored on certain storage media after a threshold set in the storage retention criteria has been exceeded in an electronic information storage system that stores electronic information on storage media in accordance with a storage retention criteria is provided. The method includes storing a record in a memory associated with a system manager that assigns the storage retention criteria to the certain electronic data, designating the storage media available for overwrite after the threshold set in the storage retention policy has been exceeded, identifying the certain storage media available for overwrite, and retrieving information from the certain media after the threshold set in the storage retention policy has been exceeded. | 04-21-2011 |
Yichen Lu, Wellesley, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100311105 | METHODS OF DELIVERY OF EXOGENOUS PROTEINS TO THE CYTOSOL AND USES THEREOF - The present invention is directed to a method for delivering exogenous proteins to the cytosol, by binding a target antigen (such as a protein) to a transport factor that contains a fragment of a bipartite protein exotoxin, but not the corresponding protective antigen. Preferably, the target antigen is fused to the transport factor. Preferred transport factors include the protective antigen binding domain of lethal factor (LFn) from | 12-09-2010 |
Yingjie Lu, Chestnut Hill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110159040 | NOVEL IMMUNOGENS AND METHODS FOR DISCOVERY AND SCREENING THEREOF - An aspect of the present invention provides for methods for identifying novel immunogens that when administered as vaccines elicit a cellular or humoral immunogenic response. In a particular embodiment, a method identified pneumococcal T-cell immunogens that elicit systemic IL-17A responses, and reduce or protect against pneumococcal colonization. | 06-30-2011 |
Ying-Jie Lu, Chestnut Hill, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110206716 | SYNERGISTIC IMMUNOGENIC FUSION PROTEIN-POLYSACCHARIDE CONJUGATE - An immunogenic composition comprising a fusion protein-polysaccharide conjugate consisting of a polysaccharide (PS) or pneumococcal bacterial cell wall polysaccharide (CWPS) conjugated to X:PdT where PdT represents the nonhemolytic variant of pneumolysin and X represents an antigenic peptide or protein of interest is provided. The immunity to X is synergistically enhanced by the fusion conjugate. Methods of protecting a subject from pneumococcal colonization or disease by administering an immunogenic composition including a fusion protein (PsaA:PdT) containing truncated PsaA and the nonhemolytic variant of pneumolysin (PdT) conjugated with CWPS (PsaA:PdT-CWPS) is also provided. | 08-25-2011 |
Yipin Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100105653 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES - The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein. | 04-29-2010 |
| 20110152244 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES - The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein. | 06-23-2011 |
Yue Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110096811 | Method and an apparatus for adaptively learning a sparse impulse response of a continuous channel - A method for adaptively learning a sparse impulse response ( | 04-28-2011 |
Yue Lu, Arlington, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110249157 | CAMERA DESIGN FOR THE SIMULTANEOUS CAPTURE OF NEAR-INFRARED AND VISIBLE IMAGES - The present invention aims to capture two images simultaneously in the visible part of the spectrum and a NIR image. This is achieved through a camera for simultaneously capturing a visible and near-infrared image by at least a sensor producing sensor response data and having at least one colour filter array (CFA) comprising at least four different filters, said colour filter array having visible and near-infrared light filters, and said camera comprising means to obtain a visible image while using the sensor response data from the visible part of the spectrum and a NIR image using the sensor response data from the near-infrared part of the spectrum. | 10-13-2011 |
Yumin Lu, Chelmsford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090102568 | VOLTAGE CONTROLLED OSCILLATOR WITH CASCADED EMITTER FOLLOWER BUFFER STAGES - A voltage controlled oscillator (VCO) is provided that includes an output buffer having a first buffer stage including a first transistor and a second buffer stage including a second transistor. The first and second transistors are connected in a cascaded emitter follower buffer arrangement. | 04-23-2009 |
| 20090160502 | FREQUENCY MULTIPLIER - A frequency multiplier is provided that includes a switching component having a plurality of differential pairs of transistors. The frequency multiplier further includes a gain stage. A common mode feedback generated by the switching component is also provided to the gain stage. | 06-25-2009 |
| 20100123536 | TUNABLE CAPACITIVELY LOADED TRANSFORMER PROVIDING SWITCHED INDUCTANCE FOR RF/MICROWAVE INTEGRATED CIRCUITS - A tunable transformer providing switched inductance includes a primary winding and a secondary winding. A switch is connected to the secondary winding of the transformer. At least one capacitor is also connected to the secondary winding of the transformer with the switch. | 05-20-2010 |
Yuran Lu, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100293004 | PAYER ESTIMATION AND IDENTIFICATION METHODS AND APPARATUS - Methods and apparatus for generating a list of likely payers for a medical practice based on historical data stored on a practice management system and practice-specific information. Information about the claim volumes for payers during a predetermined time range in a geographical region are used to estimate a subset of likely payer that a medical practice may like to enroll with. User-selectable billing frequency indicators for each of the payers identified in the subset facilitate claim billing management and enrollment strategies for billing personnel at the medical practice resulting in fewer disruptions in claim processing and cash flow as the medical practice is implemented on the practice management system. | 11-18-2010 |
Zhidong Lu, Boxborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20120030060 | DETERMINING A LIKELIHOOD OF SUITABILITY BASED ON HISTORICAL DATA - Some embodiments of the invention determine whether a particular item is likely to suit a consumer from a fit and/or style standpoint, using objective data produced as a result of the consumer's experiences. For example, some embodiments of the invention analyze information regarding a consumer's experiences with certain products (e.g., purchase and return history, identification of “favorite” items, etc.) and data regarding attributes of those items (e.g., technical dimension data, stylistic and fit attributes, etc.) to determine the consumer's measurements and fit and/or style preferences, so that a prediction may be made regarding how a particular size of an item may suit the consumer. | 02-02-2012 |
| 20120030061 | FIT RECOMMENDATION VIA COLLABORATIVE INFERENCE - Some embodiments of the invention provide techniques for recommending a size of a subject item to fit a subject consumer. In some embodiments, clusters of consumers with fit characteristics similar to the subject consumer are identified, using one or more data clustering algorithms, based on any of numerous consumer attributes (e.g., self-reported and/or inferred height, weight, body shape, body characteristics, and/or purchase histories (e.g., consumers with high overlap in terms of sets of products purchased)). Information on other consumers in the cluster may be analyzed to draw conclusions on how different sizes of the subject item may fit the subject consumer. For example, the purchase history of other members of the cluster may be analyzed to determine whether other members purchased a particular size of the item, and if so, the size purchased by the other members may serve as a basis to recommend a size that may best fit the consumer. For example, if other members of the cluster purchased a particular size, then that size may be recommended to the subject consumer, or if other members of the cluster purchased and then returned a particular size (e.g., for being too small), then another (e.g., larger) size may be recommended to the subject consumer. | 02-02-2012 |