Lü
Aifeng Lü, Jiangsu CN
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20100323949 | ERYTHROPOIETIN MIMETIC PEPTIDE DERIVATIVE AND ITS PHARMACEUTICAL SALTS, THE PREPARATION AND USES THEREOF - What is provided is EPO mimetic peptide derivatives defined as formula (I) and their pharmaceutical salts, the preparation thereof, wherein R | 12-23-2010 |
Aifeng Lü, Jiangsu CN
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20100323949 | ERYTHROPOIETIN MIMETIC PEPTIDE DERIVATIVE AND ITS PHARMACEUTICAL SALTS, THE PREPARATION AND USES THEREOF - What is provided is EPO mimetic peptide derivatives defined as formula (I) and their pharmaceutical salts, the preparation thereof, wherein R | 12-23-2010 |
Aifeng Lü, Lianyungang CN
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20130045251 | PHARMACEUTICAL COMPOSITION FOR IMPROVING SOLUBILITY OF PRASUGREL AND ITS PREPARATION METHOD - A pharmaceutical composition containing prasugrel and its pharmaceutically acceptable salts, and methods for preparing the same are disclosed. The pharmaceutical composition improves the dissolution rate of prasugrel and its salts at high pH by using solid dispersion technology, inclusion technology or adding surfactants. | 02-21-2013 |
Aifeng Lü, Lian Yungang CN
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20120129768 | GLP-1 ANALOGUES AND THEIR PHARMACEUTICAL SALTS AND USES - This invention discloses GLP-1 analogues and their pharmaceutical salts, wherein the GLP-1 analogue comprises an amino acid sequence of general formula (I), wherein Lys represents a modified lysine with a lipophilic acid. The GLP-1 analogues provided by this invention have the function of human GLP-1, and a longer half-life in vivo compared with the human GLP-1. Uses of such compounds and compositions include treating non-insulin-dependent diabetes, insulin-dependent diabetes, and obesity. | 05-24-2012 |
Aifeng Lü, Lianyungang CN
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20120196798 | GLP-1 ANALOGUES AND THEIR PHARMACEUTICAL SALTS AND USES - This invention discloses GLP-1 analogues and their pharmaceutical salts, wherein the GLP-1 analogue comprises an amino acid sequence of general formula (I), wherein Lys represents a modified lysine with a lipophilic acid. The GLP-1 analogues provided by this invention have the function of human GLP-1, and a longer half-life in vivo compared with the human GLP-1. Uses of such compounds and compositions include treating non-insulin-dependent diabetes, insulin-dependent diabetes, and obesity. | 08-02-2012 |
20130045251 | PHARMACEUTICAL COMPOSITION FOR IMPROVING SOLUBILITY OF PRASUGREL AND ITS PREPARATION METHOD - A pharmaceutical composition containing prasugrel and its pharmaceutically acceptable salts, and methods for preparing the same are disclosed. The pharmaceutical composition improves the dissolution rate of prasugrel and its salts at high pH by using solid dispersion technology, inclusion technology or adding surfactants. | 02-21-2013 |
Bo Lü, Hangzhou City CN
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20120197030 | STRUCTURE AND METHOD FOR SYNTHESIZING AND USING DIALKYL(2,4,6- OR 2,6-ALKOXYPHENYL)PHOSPHINE AND ITS TETRAFLUOROBORATE - The current invention relates to the structure, synthesis of dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, as well as its applications in the palladium catalyzed carbon-chlorine bond activation for Suzuki coupling reactions and carbon-nitrogen bond formation reactions. The dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate could coordinate with the palladium catalyst to activate the inert carbon-chlorine bond highly selectively and catalyze Suzuki coupling reaction with arylboronic acid or carbon-nitrogen bond formation reaction with organic amines. The current invention uses only one step to synthesize dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate is stable in the air. Compared with known synthetic routes of ligands used in activating carbon-chlorine bonds, the method of current invention is short, easy to operate. Moreover, with this type of ligands, the Suzuki coupling products of optically active chlorolactones and arylboronic acids would maintain their configuration and optical purity. | 08-02-2012 |
Hejun Lü, Minhang CN
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20130012705 | DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF - Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification. | 01-10-2013 |
Hejun Lü, Shanghai CN
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20100016314 | DERIVATIVES OF AZABICYCLO OCTANE, THE METHOD OF MAKING THEM AND THE USES THEREOF AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV - Derivatives of azabicyclo octane presented by formula (I), the method of making them, and the compositions containing the same and the uses thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV), wherein the substitutes in formula (I) have the same meanings as what is mentioned in the descriptions. | 01-21-2010 |
20100316601 | BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF - The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description. | 12-16-2010 |
20120164102 | SALTS OF BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION METHOD AND USE THEREOF - The pharmaceutically acceptable salts of bicycle-substituted pyrazolon azo derivatives represented by the general formula (I), their preparation methods, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor. The definitions of substituents in the general formula (I) are the same as the description. | 06-28-2012 |
Hejun Lü, Minhang CN
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20130012705 | DICYCLOAZAALKANE DERIVATIVES, PREPARATION PROCESSES AND MEDICAL USES THEREOF - Disclosed are new dicycloazaalkane derivates represented by general formula (I), preparation processes and pharmaceutical compositions containing them, and the uses for treatment especially for dipeptidyl peptidase inhibitor (DPP-IV), in which each substitute group of general formula (I) is as defined in specification. | 01-10-2013 |
Xinping Lü, Beijing CN
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20130150540 | CATALYST COMPONENT FOR POLYMERIZATION OF OLEFIN AND PREPARATION METHOD THEREOF - The present invention relates to a catalyst component for olefin polymerization, which comprises the reaction product of at least one organo-magnesium compound, at least one titanium-containing compound, at least one hydroxyl group-containing compound, at least one chlorine-containing organo-aluminum, boron, phosphorus or silicon compound, and at least one polybutadiene block copolymer. The catalyst component of the present invention has well-shaped particles, and a narrow particle size distribution; a polymerization reaction of olefins with the catalyst component produces well-shaped polymer particles with a high bulk density (BD) and an excellent comprehensive catalytic performance. The present invention also relates to a preparation method for said catalyst component and the application thereof, particularly in the homopolymerization and copolymerization of olefins such as ethylene, propylene, butene, hexene and octene. | 06-13-2013 |
Xinping Lü, Beijing CN
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20130150540 | CATALYST COMPONENT FOR POLYMERIZATION OF OLEFIN AND PREPARATION METHOD THEREOF - The present invention relates to a catalyst component for olefin polymerization, which comprises the reaction product of at least one organo-magnesium compound, at least one titanium-containing compound, at least one hydroxyl group-containing compound, at least one chlorine-containing organo-aluminum, boron, phosphorus or silicon compound, and at least one polybutadiene block copolymer. The catalyst component of the present invention has well-shaped particles, and a narrow particle size distribution; a polymerization reaction of olefins with the catalyst component produces well-shaped polymer particles with a high bulk density (BD) and an excellent comprehensive catalytic performance. The present invention also relates to a preparation method for said catalyst component and the application thereof, particularly in the homopolymerization and copolymerization of olefins such as ethylene, propylene, butene, hexene and octene. | 06-13-2013 |