Lower
Johannes Löwer, Dreieich DE
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20110020391 | RECOMBINANT MODIFIED VACCINIA VIRUS ANKARA (MVA)-BASED VACCINE FOR THE AVIAN FLU - The present invention relates to the use of a recombinant modified vaccinia virus Ankara (MVA) comprising a heterologous nucleic acid for the production of a medicament in particular a vaccine, wherein the sequence of heterologous nucleic acid is from influenza A virus class H5 antigen. In a further aspect of the invention the invention relates to a recombinant modified vaccinia virus Ankara (MVA) comprising a heterologous nucleic acid, wherein (a) the heterologous nucleic acid is incorporated into a non-essential site within the genome of MVA, (b) the heterologous nucleic acid is under the control of a vaccinia virus promoter, or orthopoxvirus promoter, or poxvirus-specific promoter and, (c) the heterologous nucleic acid is selected from the group of nucleic acids encoding a gene or a part of a gene from an influenza A virus class H5. | 01-27-2011 |
Johannes Löwer, Dreieich DE
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20110020391 | RECOMBINANT MODIFIED VACCINIA VIRUS ANKARA (MVA)-BASED VACCINE FOR THE AVIAN FLU - The present invention relates to the use of a recombinant modified vaccinia virus Ankara (MVA) comprising a heterologous nucleic acid for the production of a medicament in particular a vaccine, wherein the sequence of heterologous nucleic acid is from influenza A virus class H5 antigen. In a further aspect of the invention the invention relates to a recombinant modified vaccinia virus Ankara (MVA) comprising a heterologous nucleic acid, wherein (a) the heterologous nucleic acid is incorporated into a non-essential site within the genome of MVA, (b) the heterologous nucleic acid is under the control of a vaccinia virus promoter, or orthopoxvirus promoter, or poxvirus-specific promoter and, (c) the heterologous nucleic acid is selected from the group of nucleic acids encoding a gene or a part of a gene from an influenza A virus class H5. | 01-27-2011 |
Manuel Lower, Velbert DE
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20080265540 | Guiding Element for a Track Element in a Wheel Suspension of a Vehicle - A guide element for a guideway element in a wheel suspension of a vehicle has one of the elements arranged such that it is connected essentially rigidly to the body and the other element arranged such that it is connected essentially rigidly to the wheel and a plain bearing, which makes possible a displacing motion of the guide element on the guideway element, is formed between these elements. The guide element is guided in a rotatingly movable and/or pivotingly movable manner on the guideway element via a joint arrangement, within which the plain bearing ring is arranged, which is guided with its circular passage opening, adapted to the cross section of the guideway element, on the guideway element. This joint arrangement may be designed as a rubber bushing or as a ball and socket joint. A plurality of sliding rings may be arranged in a so-called ball layer hollow body one on top of another and at least with a section facing the guideway element essentially at right angles to the longitudinal axis of the guideway element in a slightly displaceable manner. A guideway extending in a curved shape can thus be embodied. The sliding ring may have an elastomer ring, to which a metal bushing is vulcanized on the outside and to which a plastic sliding ring, which is in contact by its inside with the guideway element, is vulcanized on the inside. | 10-30-2008 |
Martin Lower, Mainz DE
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20140178438 | INDIVIDUALIZED VACCINES FOR CANCER - The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method. | 06-26-2014 |
Martin Löwer, Wiesbaden DE
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20160125129 | PREDICTING IMMUNOGENICITY OF T CELL EPITOPES - The present invention relates to methods for predicting T cell epitopes. In particular, the present invention relates to methods for predicting whether modifications in peptides or polypeptides such as tumor-associated neoantigens are immunogenic or not. The methods of the invention are useful, in particular, for the provision of vaccines which are specific for a patient's tumor and, thus, in the context of personalized cancer vaccines. | 05-05-2016 |
Michal Lower, Warsaw PL
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20130005582 | PREPARATION OF RESTRICTION ENDONUCLEASES IN IVCS USING FRET AND FACS SELECTION - Method of preparation of restriction endonucleases, particularly those exhibiting the desired sequential specificity consists in that a fluorescence-marked DNA probe is used for screening a library of mutants, preferably in IVC format, and/or using other high-performance screening (HTS) technique, which is attained through expression of proteins included in the library of mutants in a cell-free system in the presence and by means of the DNA probe, and proteins thus obtained, resulting from expression of clones from the library, degrade the DNA probe, if their substrate specificity matches the searched one, the degradation of the DNA probe being detected as a disappearance of the FRET phenomenon between fluorescence markers included in the probe, and then microcompartments in which the FRET phenomenon ceases to occur, are separated from the remaining ones using Fluorescence Activated Cell Sorter (FACS) and/or other equipment for HTS analysis, and then DNA coding clones capable of degrading the probe are amplified using polymerase chain reaction (PCR) technique and are used as a basis for construction of the subsequent library of mutants, which is searched during the subsequent round of screening, according to the scheme mentioned above, and the subsequent rounds of screening are carried out until the enzyme having the desired properties is obtained. | 01-03-2013 |
Robert Lower, Rheinbach DE
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20090045542 | PROCESS FOR THE PRODUCTION OF HOLLOW BODIES OF THERMOPLASTIC MATERIAL - The invention concerns a process for the production of hollow bodies of thermoplastic material. In the process according to the invention preforms in web or band form of plasticized material are shaped in a multi-part tool forming a mold cavity comprising two outer molds and at least one central mold which perform an opening and closing movement relative to each other. The central mold is provided with at least one component holder which can be moved of and into the tool plane defined by the central mold. In a first step the component holder is fitted with at least one insert portion, then the insert portion is placed by means of the component holder against the inside wall of an outer mold. In a further step introduction and shaping of the preforms within the tool is effected in a two-stage procedure, wherein firstly the preforms are respectively applied against a contour forming a part of the mold cavity by means of increased pressure and/or reduced pressure and shaped and then the intermediate products forming respective parts of the hollow body are joined together to form a finished product. | 02-19-2009 |
20090047375 | MOLD TOOL FOR THE PRODUCTION OF EXTRUSION BLOW MOLDED PRODUCTS - The invention concerns a mold tool for the production of extrusion blow molded products, comprising at least three mold portions ( | 02-19-2009 |
20150232227 | CONTAINER OF THERMOPLASTIC MATERIAL - An article enclosing at least one built-in fitment component in the form of a hollow body of thermoplastic material. The hollow body is preferably in the form of a fuel tank. The built-in fitment component is pressed against the inside wall of the article while still plastic so that the plastic material of the hollow body penetrates through at least one recess or opening of the built-in fitment component and flows therebehind. | 08-20-2015 |