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Lothar Spies

Lothar Spies, Aachen DE

Patent application numberDescriptionPublished
20080228686Knowledge-Based Input Region of Interest Definition for Pharmacokinetic Modeling - The present invention provides a system, apparatus, and method that are based on a priori knowledge of the shape of the input function for defining an input region-if-interest (ROI) in pharmacokinetic modeling. Kinetic parameter estimation requires knowledge of tracer input activity and the present invention provides an automatic way to define an ROI for estimation of an input function that takes into account a priori knowledge of the shape of the input function based on an administered dose. As a result of the application of the present invention to existing imaging analysis systems, there is a reduction in the amount of manual interaction needed and operator dependence is thereby reduced in the evaluation of dynamic procedures.09-18-2008
20080253635Image-Wide Artifacts Reduction Caused by High Attenuating Objects in Ct Deploying Voxel Tissue Class - A reconstruction processor (10-16-2008
20080267351Radio-Therapeutic Treatment Planning Incorporating Functional Imaging Information - A radiation therapy planning procedure and device provides a model-based segmentation of co-registered anatomical and functional imaging information to provide a more precise radiation therapy plan. The biology-based segmentation models the imaging information to produce a parametric map, which is then clustered into regions of similar radiation sensitivity or other biological parameters relevant for treatment definition. Each clustered region is prescribed its own radiation prescription dose.10-30-2008
20110060205System For The Noninvasive Determination Of Tracer Concentration In Blood - The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (C03-10-2011
20110103551Radiotherapeutic Treatment Plan Adaptation - In a radiation therapy method, one or more planning images are acquired (05-05-2011

Patent applications by Lothar Spies, Aachen DE

Lothar Spies, Hamburg DE

Patent application numberDescriptionPublished
20090028408RADIATION THERAPY FLANNING PROCEDURE - An improved radiation therapy planning procedure is suggested. The procedure comprises the steps of specifying and determining the absolute grade of cell degeneracy by in-vitro tests, whereby marker(s) indicative for specific cell degeneracy are detected and quantified, establishing a biology-based segmentation of areas with similar grade of relative cell degeneracy and applying the absolute grade of cell degeneracy to the biology-based segmentation data, thereby establishing an improved radiation therapy planning procedure. Moreover, the present invention suggests a system for an improved radiation therapy planning procedure and its use in procedures of diagnosis and/or therapy management of cancer01-29-2009
20090171183PATIENT SCAN TIME OPTIMIZATION FOR PET/SPECT IMAGING - An imaging system (07-02-2009
20090208075ERROR ADAPTIVE FUNCTIONAL IIMAGING - A method for use in functional medical imaging includes adaptively partitioning functional imaging data as a function of a spatially varying error model. The functional image data is partitioned according to an optimization strategy. The data may be visualized or used to plan a course of treatment. In one implementation, the image data is partitioned so as to vary its spatial resolution. In another, the number of clusters is varied based on the error model.08-20-2009
20090264728BIOLOGY GUIDED ADAPTIVE THERAPY PLANNING - A therapy system (10-22-2009
20100201686METHOD, APPARATUS, COMPUTER-READABLE MEDIUM AND USE FOR PHARMACOKINETIC MODELING - Methods and systems for interworking in messaging systems are described. An event store can be accessible by different dispatchers associated with different message servers. The dispatchers may be co-located with the event store or non co-located with the event store.08-12-2010
20100232662METHOD TO INDIVIDUALIZE KINETIC PARAMETER ESTIMATON FOR DYNAMIC MOLECULAR IMAGING PROCEDURES - A method within dynamic molecular imaging comprising dynamically estimating a first parameter (β(x)) and a second parameter (k(x)) of an activity function describing the bio distribution of an administered tracer, is disclosed. More specifically, the method comprises specifying a first target variance (σ09-16-2010