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Alrik Pieter Los, 'S-Gravenhage NL
| Patent application number | Description | Published |
|---|---|---|
| 20110318752 | METHOD FOR IMPROVING THE YEILD OF A POLYPEPTIDE - The present invention relates to a method for improving protein yield. The method comprises modifying the value of a set of relevant protein features to fall within an optimal range or to become more close to an optimal value for one or more protein features in the eukaryotic host. | 12-29-2011 |
Alrik Pieter Los, Dijkstraat NL
| Patent application number | Description | Published |
|---|---|---|
| 20100317599 | PROCESS FOR THE PRODUCTION OF A PEPTIDE - The present invention describes a polypeptide, comprising at least one repeat domain, further comprising a recombinant peptide of interest. The present invention further describes a process for the production of a recombinant peptide of interest. The invention further describes the use of a repeat protein for the production of a recombinant peptide of interest. | 12-16-2010 |
Georgyi V. Los, Madison, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20080274488 | Covalent tethering of functional groups to proteins and substrates therefor - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 11-06-2008 |
| 20090098627 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 04-16-2009 |
| 20110171673 | COVALENT TETHERING OF FUNCTIONAL GROUPS TO PROTEINS AND SUBSTRATES THEREFOR - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 07-14-2011 |
| 20110201024 | COMPOSITIONS COMPRISING A DEHALOGENASE SUBSTRATE AND A FLUORESCENT LABEL AND METHODS OF USE - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 08-18-2011 |
| 20110207195 | METHOD OF IMMOBILIZING A PROTEIN OR MOLECULE VIA A MUTANT DEHALOGENASE THAT IS BOUND TO AN IMMOBILIZED DEHALOGENASE SUBSTRATE AND LINKED DIRECTLY OR INDIRECTLY TO THE PROTEIN OR MOLECULE - A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two amino acid substitutions relative to the wild-type hydrolase. Substrates for hydrolases comprising one or more functional groups are also provided, as well as methods of using the mutant hydrolase and the substrates of the invention. Also provided is a fusion protein capable of forming a stable bond with a substrate and cells which express the fusion protein. | 08-25-2011 |
Irina Sergeevna Los, Penza RU
| Patent application number | Description | Published |
|---|---|---|
| 20110250465 | MULTILAYER MATERIAL WITH ENHANCED CORROSION RESISTANCE (VARIANTS) AND METHODS FOR PREPARING SAME - The present invention relates to the development of variants of multilayer structural materials with enhanced corrosion resistance, including successively connected outer main layers which directly contact corrosive operating environments on one or both sides of the multilayer material and, disposed therebetween, alternating internal main and internal sacrificial layers. The main layers are made of metallic materials which are characterized by a state of passivity over a prolonged period with subsequent development therein of pitting-type corrosion, while the internal sacrificial layers, which contact the corrosive operating environment as deep foci of pitting corrosion develop in the preceding outer and internal main layers, are characterized by the development of general corrosion and have a protective action in relation to the outer and internal main layers. Methods for preparing such materials are proposed. | 10-13-2011 |
Kathleen D.a. Los, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110250264 | METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES - The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated. | 10-13-2011 |
Mario Los, Buenos Aires AR
| Patent application number | Description | Published |
|---|---|---|
| 20090197873 | COMPOSITIONS COMPRISING ALPRAZOLAM FOR TREATING PRIMARY INSOMNIA AND INSOMNIA ASSOCIATE WITH ANXIETY STATES AND PROCESS FOR PREPARING THEM - Disclosed is a composition comprising alprazolam for treating primary insomnia and insomnia associated with anxiety states and the corresponding use and method comprising the administration of alprazolam sublingual tablets having a disintegration time lower than 30 seconds and having the alprazolam preferably in non-crystalline or partially crystalline form according to the X-ray diffraction crystallography expanded for the position delta 9-12.5 (2 theta), to a patient suffering from said disorder. There is also disclosed a method for preparing a composition according to the invention, where the alprazolam is solved in a pharmaceutical acceptable solvent and a binder, preferably polyvinylpyrrolidone, is incorporated to the solution. A pre-made mixture of part of the cross-linked carboxymethyl-cellulose and the rest of the ingredients of the composition is impregnated with the solution and is dried and grinded, and is added to the rest of the cross-linked carboxymethyl-cellulose and the flavoring additives, being then mixed and compressed. | 08-06-2009 |
Mario Atilio Los, Buenos Aires AR
| Patent application number | Description | Published |
|---|---|---|
| 20100160382 | ANTI-ACID PHARMACEUTICAL COMPOSITION IN POWDER FORM AND PROCESS FOR MAKING IT - An anti-acid pharmaceutical composition for the rapid and prolonged neutralization of gastric acidity with mucosa-protecting activity in powder form to prepare, by dispersion in water, a pharmaceutical solution or suspension for oral use characterized in that the composition includes sodium alginate; an anti-acid soluble agent or a combination of anti-acids; an inhibitor of proton pump; diluent and sweetening agents, wherein a) at least 30% of sodium alginate present in the formulation along with the total of the inhibitor of proton pump are homogeneously distributed over the surface of the total soluble anti-acid agent [or] of the combination of anti-acids of the composition; and b) the rest, about 70%, of sodium alginate present in the formulation contains a percentage of humidity of less than 2%. | 06-24-2010 |
Nigel A. Los, Alliance, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20120128279 | METHOD AND APPARATUS FOR SETTING ROLLING ELEMENT BEARINGS IN ROLLING MILLS - A method for assembling a set of bearing assemblies | 05-24-2012 |
Oleg Los, Buffalo Grove, IL US
| Patent application number | Description | Published |
|---|---|---|
| 20100085688 | GROUNDING CONNECTOR FOR AN ELECTRONIC DEVICE - A grounding connector for an electronic device having a first housing element and a second housing element comprising a ground clip, a cam surface and a follower. The ground clip is electrically coupled to a first housing element, and selectably electrically coupled with the second housing element. A cam surface is positioned on the first housing element and in proximity to the ground clip. The follower is slidably positionable on the second housing element, and has a first end that engages the cam surface and a second end that engages the ground clip. The ground clip is electrically coupled to a second housing element while the electronic device is in each of the collapsed orientation and the articulated orientation. Upon movement between the collapsed orientation and the articulated orientation, the cam surface directs the follower to electrically decouple the ground clip from the second housing element. | 04-08-2010 |
Przemyslaw Los, Dundee GB
| Patent application number | Description | Published |
|---|---|---|
| 20080280248 | Dental Electrode Assembly - There is described an electrode assembly for passing electrical current through at least part of a tooth, the assembly comprising: an electrode holder; and a plurality of resilient projecting elements coupled to the holder, each element comprising one or more electrodes, the assembly being arranged in use such that when the assembly is positioned adjacent a tooth, the electrodes contact respective parts of at least one surface of the tooth. The assembly is preferably for use in A.C. impedance spectroscopy for caries detection and monitoring. | 11-13-2008 |
Przemyslaw Los, Zurawice, PL
| Patent application number | Description | Published |
|---|---|---|
| 20120093680 | METHOD FOR OBTAINING COPPER POWDERS AND NANOPOWDERS FROM INDUSTRIAL ELECTROLYTES INCLUDING WASTE INDUSTRIAL ELECTROLYTES - The method for obtaining copper powders and nanopowders from industrial electrolytes including waste industrial electrolytes through electrochemical deposition of metallic copper on a cathode consists in using potentiostatic pulse electrolysis without the current direction change or with the current direction change, using the cathode potential value close to the plateau or on the plateau of the current voltage curve on which the plateau of the current potential range is from −0.2 V÷−1 V, and a moveable or static ultramicroelectrode or an array of ultramicroelectrodes made of gold, platinum or stainless steel wire or foil is used as a cathode, whereas metallic copper is used as an anode and the process is carried out at temperature from 18-60° C., and the electrolysis lasts from 0.005 to 60 s. Said method can be used to obtain nanopowders and powders characterised by particle structure and dimension repeatability and purity from 99%+ to 99.999% from waste industrial electrolytes and wastewaters from copper industry and electroplating plants without additional treatment. | 04-19-2012 |
Remco Los, Eindhoven NL
| Patent application number | Description | Published |
|---|---|---|
| 20100067092 | COLOUR DISPLAY DEVICE - A colour display device ( | 03-18-2010 |