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Lorbach
Elke Lorbach, Koln DE
| Patent application number | Description | Published |
|---|---|---|
| 20080220527 | MODULAR TRANSFECTION SYSTEMS - The present invention relates to a method for transfection of cells using at least one protein capable of forming nucleoprotein filaments, wherein the protein is initially modified with at least one functional component which influences one or more steps of the transfection, the nucleic acid to be transfected is then loaded with the modified protein, whereby the nucleic acid and the protein form a filament-like complex, and this complex is finally added to the cells to be transfected. The invention further relates to a transfection agent consisting of nucleoprotein filaments (NPF), with at least one nucleoprotein filament-forming protein being modified with at least one functional component for the transfection. Furthermore, the present invention relates to the use of the transfection agent according to the invention for producing a drug for gene therapeutic treatment of humans and animals. The present inventions also includes corresponding pharmaceutical preparations, especially for use in gene therapy as well as the use of such transfection agents as component in kits. | 09-11-2008 |
| 20090023131 | CIRCUIT ARRANGEMENT FOR INJECTING NUCLEIC ACIDS AND OTHER BIOLOGICALLY ACTIVE MOLECULES INTO THE NUCLEUS OF HIGHER EUCARYONTIC CELLS USING ELECTRICAL CURRENT - The invention relates to a novel circuit arrangement for electrotransfection or electrofusion, which enables the transportation of DNA and/or other biologically active molecules to the nucleus of higher eukaryotic cells or the fusion of cells, independent of cell division and with reduced cell mortality. | 01-22-2009 |
Elke Lorbach, Cologne DE
| Patent application number | Description | Published |
|---|---|---|
| 20110117654 | BUFFER SOLUTION FOR ELECTROPORATION AND A METHOD COMPRISING THE USE OF THE SAME - A method for introducing biologically active molecules into animal or human cells using an electric current includes suspending the cells and dissolving the biologically active molecules in a buffer solution including HEPES and at least 10 mmol×1 | 05-19-2011 |
Richard Lorbach, Waukesha, WI US
| Patent application number | Description | Published |
|---|---|---|
| 20100223155 | ONLINE SYSTEM FOR COLLABORATIVE PUBLISHING AND COMMERCE - An online system for managing collaborative greeting cards, gift cards, and guest books comprising an interface system including a creator interface and a contributor interface for creating the card and contributing to the card. The system may further include a messaging system, for circulating invitations to contribute signatures, messages, and other media to the card, notify contributors of card status, and/or deliver the card to a recipient and/or notify recipient of the card and/or gift. The system may further include a payment system for contributing to a group gift and/or create an individual gift. | 09-02-2010 |
Volker Lorbach, Duren DE
| Patent application number | Description | Published |
|---|---|---|
| 20080311631 | Biosynthetic Production of 4-Amino 4-Deoxychorismate (Adc) and [3R,4R]-4-Amino-3-Hydroxycyclohexa-1,5-Diene-1-Carboxylic Acid (3,4-Cha) - The invention relates to a process for the biosynthetic production of 4-amino-4-deoxychorismate (ADC) performed fermentatively in vivo with a 4-amino-4-deoxychorismate synthase, preferably a PabAB bipartite protein (which may be a fusion protein), at an increased level of activity, thereby obtaining a broth comprising ADC and 4-amino-4-deoxyprephenate (ADP), that are recovered. The invention also relates to a further process of converting the ADP into p-aminophenylalanine. The invention, moreover relates to biosynthetic production of [3R,4R]-4-amino-3-hydroxycyclohexa-1,5-diene-1-carboxylic acid (3,4-CHA), by concerted action of such 4-amino-4-deoxychorismate synthase and of an enzyme capable of converting isochorismate into [5S,6S]-5,6 dihydroxycyclohexa-1,3-diene-1-carboxylic acid (2,3-CHD), preferably a phenazine biosynthesis protein PhzD, including recovery of 3,4-CHA. The invention also relates to expression vectors and host cells for use in any of such processes. The invention further relates to the use of 3,4-CHA as a catalytically active product, in particular as a chiral catalyst. And the invention finally relates to synthesis of oseltamivir phosphate from 3,4-CHA. | 12-18-2008 |
Wolfgang Lorbach, Haan DE
| Patent application number | Description | Published |
|---|---|---|
| 20090165602 | Tongs - The invention relates to a pair of tongs ( | 07-02-2009 |