Lopez, MA
David E. Lopez, East Boston, MA US
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20100089699 | SYSTEM AND APPARATUS FOR SUPPORTIVE SCAFFOLDING - A scaffold system includes at least two essentially vertical support assemblies having an upper end and a lower end, wherein each essentially vertical support assembly includes at least two vertical support members connected by at least one horizontal member. A platform is attached proximate to the upper ends of the at least two essentially vertical support assemblies, wherein the vertical support assemblies are positioned to be proximate to a structure. One or more gap fillers are movably attached adjacent to the platform along at least a portion of the platform length and are configured to extend at least a portion of the platform towards the structure. One or more movable gates are attached to the essentially vertical support assemblies of one or more movable scaffolds, wherein the movable scaffolds are configured to be positioned on opposite sides of the structure to enable access to a top of the structure, and the movable gates may be connected to each other over the top of the structure. | 04-15-2010 |
Erasmo A. Lopez, Abington, MA US
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20140012378 | Intervertebral Disc Prosthesis Having Multiple Bearing Surfaces - An intervertebral disc prosthesis comprises a left prosthesis component and a symmetric right prosthesis component positioned in an intervertebral space. Each prosthesis component includes a superior vertebra facing surface, an inferior vertebra facing surface, and a substantially spherical bearing surface. The bearing surface is positioned between the superior vertebra facing surface and the inferior vertebra facing surface. The superior vertebra facing surface is provided on a superior endplate and the inferior vertebra facing surface is provided on an inferior endplate. The superior endplate is operable to rotate relative to the inferior endplate upon the bearing surface. Each prosthesis component further comprises an elastic member positioned between an endplate and the bearing surface. The elastic member may be substantially cylindrical with a plurality of resilient ribs. Flexion/extension, lateral bending, and torsional movement are allowed by a combination of endplate rotation upon the bearing surface and compression of the elastic member. | 01-09-2014 |
Gilberto Lopez, Cambridge, MA US
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20120031920 | LID ASSEMBLY FOR SHIPPING CONTAINER - A container for storage and shipping of objects includes a lid assembly having two configurations and an open-top box. In the first configuration the container can be loaded with objects for storage or collection while limiting physical and visual access to the contents of the box and in the second configuration, the container is sealed for shipping. The lid assembly contains side flaps which may be used to stabilize the lid assembly in the first configuration, and in the second configuration, secure the lid assembly to the open-top box. Preferably, the container is formed from one contiguous blank. The blank is preferably made of corrugated cardboard but may be formed from any substantially rigid material. | 02-09-2012 |
Jesse Lopez, Newtonville, MA US
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20110219366 | SYSTEM AND METHOD OF ADVERTISING FOR USE ON INTERNET AND/OR DIGITAL NETWORKING CAPABLE DEVICES - A system and method of advertising for use on an internet and/or digital networking capable device, wherein the system allows advertisers to use a loading space generated during the initiation of a process on the device to post any media and/or advertising content during the time between when a program or web page is requested and when it actually loads. | 09-08-2011 |
Jesse Lopez, Newton, MA US
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20140081765 | SYSTEM AND METHOD OF ADVERTISING FOR USE ON INTERNET AND/OR DIGITAL NETWORKING CAPABLE DEVICES - A system and method of advertising for use on an internet and/or digital networking capable device, wherein the system allows advertisers to use a loading space generated during the initiation of a process on the device to post any media and/or advertising content during the time between when a program or web page is requested and when it actually loads. | 03-20-2014 |
Julius Lopez, Dorchester, MA US
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20090259023 | LIQUID BUFFERED GDF-5 FORMULATIONS - Improved formulations and methods are provided for stabilizing a solution of bone morphogenetic protein. The compositions comprise an acetate buffered solution of GDF-5 and other excipients wherein the solution has a pH of from about 4.2 to about 5.3, thereby providing for a biologically isotonic solution having improved stability of the GDF-5 protein during storage, handling, and use. | 10-15-2009 |
20090318343 | Protein Formulations for Use at Elevated Temperatures - Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5, trehalose, and one or more biocompatible excipients that provide stability to the protein for at least 30 days at temperatures up to body temperature. | 12-24-2009 |
20100130730 | PROTEIN FORMULATIONS FOR USE AT ELEVATED TEMPERATURES - Liquid formulations of bone morphogenetic proteins are provided for prolonged use at elevated temperatures. More specifically, the invention relates to liquid formulations comprising rhGDF-5, trehalose, and one or more biocompatible excipients that provide stability to the protein for at least 30 days at temperatures up to body temperature. | 05-27-2010 |
20120165787 | COMPOSITIONS AND METHODS FOR TREATING JOINTS - Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”) | 06-28-2012 |
20130178827 | COMPOSITIONS AND METHODS FOR TREATING JOINTS - Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”) | 07-11-2013 |
20140343012 | COMPOSITIONS AND METHODS FOR TREATING JOINTS - Compositions and methods are provided for treating joint conditions, such as osteoarthritis and/or the pain associated therewith. The compositions and methods utilize a first component, namely hyaluraonic acid (“HA”), in combination with a lyophilized second component that is effective to at least temporarily reduce the viscosity of the HA. In an exemplary embodiment, the second component is one or more glycosaminoglycans (“GAG”), such as chondroitin sulfate (“CS”), including CS4 and/or CS6, dermatan sulfate, heparin, heparan sulfate, and keratan sulfate. The composition can optionally include other joint supplements, such as glucosamine (“GlcN”) | 11-20-2014 |
Mary F. Lopez, Bedford, MA US
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20080286814 | Biomarkers for Detecting Cancer - The disclosure features, inter alia, a variety of biomarkers (e.g., biomarker peptides), compositions, and kits for use in methods for diagnosing a cancer. The biomarkers can be used, e.g., in methods for detecting a cancer in a subject. In addition, the disclosure also features methods of selecting a therapy for, and/or administering a therapy (e.g., a therapy comprising an anti-cancer agent) to, a subject having a cancer. | 11-20-2008 |
Mary Frances Lopez, Boston, MA US
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20110151568 | Assay for Monitoring Parathyroid Hormone (PTH) Variants by Tandem Mass Spectrometry - Methods are described for monitoring the amounts of PTH variants in a biological sample by digesting the sample to produce surrogate peptides specific to the targeted PTH variants, and detecting and quantifying the surrogate peptides by selective reaction monitoring (SRM) mass spectrometry, using a set of precursor-to-product ion transitions optimized for sensitivity and selectivity. The PTH variants, or a portion thereof, may be concentrated in the sample by means of immunoaffinity capture or other suitable technique. The mass spectrometric method described herein enables the concurrent measurement of peptides representative of a plurality of targeted PTH variants in a single assay. | 06-23-2011 |
20120064558 | Assays for Differentiating between Ischemic and Hemorrhagic Stroke in a Human Patient - Methods are disclosed for rapidly and reliably differentiating between ischemic and hemorrhagic stroke events in a human patient. The methods include obtaining a biological sample, such as blood serum, and analyzing the sample or a derivative thereof by mass spectrometry to measure the amount of one or more targeted proteins differentially present and ischemic and hemorrhagic stroke patients. The analysis may include proteolytic digestion of the biological sample and selective reaction monitoring (SRM) tandem mass spectrometry of the digested sample to determine the amounts of surrogate peptides corresponding to the targeted proteins. | 03-15-2012 |
20130217058 | Assay for Monitoring Parathyroid Hormone (PTH) Variants by Tandem Mass Spectrometry - Methods are described for monitoring the amounts of PTH variants in a biological sample by digesting the sample to produce surrogate peptides specific to the targeted PTH variants, and detecting and quantifying the surrogate peptides by selective reaction monitoring (SRM) mass spectrometry, using a set of precursor-to-product ion transitions optimized for sensitivity and selectivity. The PTH variants, or a portion thereof, may be concentrated in the sample by means of immunoaffinity capture or other suitable technique. The mass spectrometric method described herein enables the concurrent measurement of peptides representative of a plurality of targeted PTH variants in a single assay. | 08-22-2013 |
Mary Frances Lopez, Bostson, MA US
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20100216250 | Methods for Predicting Trisomy 21 in a Fetus - The present invention relates to biomarkers in maternal serum samples and methods for predicting whether a fetus has Trisomy 21 during the first trimester of pregnancy based on the differential expression of a combination, or subcombination, of the same. | 08-26-2010 |
Michael John Lopez, Walpole, MA US
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20140059323 | SYSTEMS AND METHODS OF DATA EXTRACTION IN A VECTOR PROCESSOR - Systems and methods of data extraction in a vector processor are disclosed. In a particular embodiment a method of data extraction in a vector processor includes copying at least one data element to a source register of a permutation network. The method includes reordering multiple data elements of the source register, populating a destination register of the permutation network with the reordered data elements, and copying the reordered data elements from the destination register to a memory. | 02-27-2014 |
Robert R. Lopez, Boxford, MA US
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20100036295 | METHOD AND APPARATUS FOR FRACTIONAL DEFORMATION AND TREATMENT OF CUTANEOUS AND SUBCUTANEOUS TISSUE - Devices and methods of treatment of tissue, such as skin tissue and subcutaneous tissue, with thermal control elements are disclosed. Some disclosed devices and methods employ local deformation of tissue in small areas. Devices and methods employing local deformation are used to produce fractional thermal treatments. Some devices and methods are external to a subject's skin others are beneath the subject's skin in the subcutaneous tissue. | 02-11-2010 |
20110184334 | PHOTOTREATMENT DEVICE FOR USE WITH COOLANTS AND TOPICAL SUBSTANCES - Methods and systems are disclosed for phototreatment in which replaceable containers comprising one or more adjuvant (consumable or re-usable) substances are employed. The adjuvant substance can be, for example, a topical substance or a coolant. Systems are disclosed for using a topical substance to detect contact of a phototreatment device with a tissue, detect speed of a phototreatment device over the tissue, detect regions of tissue that have been treated by a phototreatment device and/or to provide other benefits to the tissue such as improved skin tone and texture, tanning, etc. Safety systems are also disclosed that ensure that a proper consumable substance and/or container is connected to a phototreatment device and/or directed to a proper target. Additionally, cooling systems and methods that utilize phase change materials for extracting heat from a light generating device are disclosed. | 07-28-2011 |
Scott Lopez, Winchester, MA US
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20080319892 | Systems and methods for allocating size among trading accounts - A system and method for allocating trades of financial instruments among multiple accounts comprising aggregating orders, wherein each order is associated with an account, and wherein each order has an original order size; allocating an executed order based on the aggregated order in a phase I allocation, wherein the phase I allocation is allocated on a pro-rata basis based on the original order size for each account, except for those accounts that would receive an amount less than a minimum allocation; allocating a remainder from the phase I allocation in a phase II allocation, wherein the phase II allocation is allocated among selected accounts in an amount greater than or equal to the minimum allocation or an amount that fills the original order size; repeating the phase II allocation until a remainder from the phase II allocation is less than the minimum allocation; and allocating a reminder from the phase II allocation in a phase III allocation according to predetermined criteria. | 12-25-2008 |
20090094152 | Systems and Methods for Allocating Size Among Trading Accounts - A system and method for allocating trades of financial instruments among multiple accounts comprising aggregating orders, wherein each order is associated with an account, and wherein each order has an original order size; allocating an executed order based on the aggregated order in a phase I allocation, wherein the phase I allocation is allocated on a pro-rata basis based on the original order size for each account, except for those accounts that would receive an amount less than a minimum allocation; allocating a remainder from the phase I allocation in a phase II allocation, wherein the phase II allocation is allocated among selected accounts in an amount greater than or equal to the minimum allocation or an amount that fills the original order size; repeating the phase II allocation until a remainder from the phase II allocation is less than the minimum allocation; and allocating a reminder from the phase II allocation in a phase III allocation according to predetermined criteria. | 04-09-2009 |