| Patent application number | Description | Published |
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| 20090149673 | SYNTHETIC NON-FOULING AMINO ACIDS - Synthetic amino acids containing one or more non-fouling groups or moieties are described herein. In one embodiment, the amino acid has the following chemical formula: | 06-11-2009 |
| 20090155335 | NON-LEACHING NON-FOULING ANTIMICROBIAL COATINGS - Compositions containing one or more types of membrane-targeting antimicrobial agents immobilized on a substrate with activity in relevant biological environments, and methods of making and using thereof, are described herein. The antimicrobial agents retain their activity in the presence of blood proteins and/or in vivo due to improved molecular structures which allow for cooperative action of immobilized agents and hydrophilic chemistries which resist non-specific protein adsorption. Suitable molecular structures include branched structures, such as dendrimers and randomly branched polymers. The molecule structures may also include hydrophilic tethers which provide both flexibility and resistance to non-specific protein adsorption. The membrane targeting antimicrobial agent coatings can be applied to a variety of different types of substrates including medical implants such as vascular grafts, orthopedic devices, dialysis access grafts, and catheters; surgical tools, surgical garments; and bandages. The substrates can be composed of metallic materials, ceramics, polymers, fibers, inert materials such as silicon, and combinations thereof. The compositions described herein are substantially non-leaching, resistant to non-specific protein adsorption, and non-hemolytic. | 06-18-2009 |
| 20090258045 | STRUCTURES INCLUDING ANTIMICROBIAL PEPTIDES - A structure includes a substrate and a first plurality of bilayers on the substrate. The first plurality of bilayers includes a first layer including an antimicrobial peptide having a charge, and a second layer including a polyelectrolyte having a charge opposite the charge of the first layer. At least a portion of the structure is capable of degrading by sequential removal of the first layer and the second layer, and releasing the antimicrobial peptide from the structure. | 10-15-2009 |
| 20100076173 | SYSTEMS AND METHODS FOR GENERATING PEPTIDES - Antimicrobial peptides are small proteins used by the innate immune system to combat bacterial infection in multicellular eukaryotes. There is mounting evidence that these peptides are less susceptible to bacterial resistance than traditional antibiotics and that they may form the basis for a novel class of therapeutics. Systems and methods may treat the amino acid sequences of these peptides as a formal language and build a set of right-linear grammars that describe this language. These grammars may allow for rationally designed novel antimicrobial peptides in silico. These peptides conform to the syntax of natural antimicrobial peptides lack significant homology to any natural sequences, thus populating a previously unexplored region of protein sequence space. Synthesis of these peptides, leads to de novo AmPs. | 03-25-2010 |
| 20100145286 | LAYERED NON-FOULING, ANTIMICROBIAL ANTITHROMBOGENIC COATINGS - Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material | 06-10-2010 |
| 20100152708 | NON-FOULING, ANTI-MICROBIAL, ANTI-THROMBOGENIC GRAFT-FROM COMPOSITIONS - Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material. | 06-17-2010 |
| Patent application number | Description | Published |
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| 20080208483 | Sonar-Based Flow Meter Operable To Provide Product Identification - An apparatus and method for identifying one or more fluid products flowing within a pipe are provided having a flow meter mounted on the pipe and a processing unit. The flow meter has a plurality of sensors operable to detect vortical disturbances flowing with the fluid products and acoustic waves propagating through the fluid. The sensors produce signals indicative of the vortical disturbances and acoustic waves. The processing unit is operable to determine the speed of sound and volumetric flow rate of the one or more fluid products using the signals from the flow meter. The processing unit includes a database having speed of sound data for a predetermined group of products. The processing unit is operable to identify the type of each product flowing within the pipe given a temperature and pressure value of the products within the pipe. | 08-28-2008 |
| 20080223129 | Apparatus and method for providing a density measurement augmented for entrained gas - A flow measuring system combines a density measuring device and a device for measuring the speed of sound (SOS) propagating through the fluid flow and/or for determining the gas volume fraction (GVF) of the flow. The GVF meter measures acoustic pressures propagating through the fluids to measure the speed of sound α | 09-18-2008 |
| 20090044638 | VELOCITY BASED METHOD FOR DETERMINING AIR-FUEL RATIO OF A FLUID FLOW - A method for determining one or more fluid flow parameters for a fluid flowing within a pipe is provided. The fluid is a mixture of solid particles and gas. The method includes the steps of: a) providing a meter operable to determine the velocity of the fluid flow through the pipe, which meter is substantially insensitive to the particulate/gas mass ratio of the fluid flow; b) determining the velocity of the fluid flow within the pipe using the meter; and c) determining a particulate/gas mass ratio using a density value for the gas within the flow and the determined fluid flow velocity. | 02-19-2009 |
| 20100107727 | MEASUREMENT OF ENTRAINED AND DISSOLVED GASES IN PROCESS FLOW LINES - A device for measurement of entrained and dissolved gas has a first module arranged in relation to a process line for providing a first signal containing information about a sensed entrained air/gas in a fluid or process mixture flowing in the process line at a process line pressure. The device features a combination of a bleed line, a second module and a third module. The bleed line is coupled to the process line for bleeding a portion of the fluid or process mixture from the process line at a bleed line pressure that is lower than the process pressure. The second module is arranged in relation to the bleed line, for providing a second signal containing information about a sensed bleed line entrained air/gas in the fluid or process mixture flowing in the bleed line. The third module responds to the first signal and the second signal, for providing a third signal containing information about a dissolved air/gas flowing in the process line based on a difference between the sensed entrained air/gas and the sensed bleed line entrained air/gas. | 05-06-2010 |
| 20100332154 | Velocity Based Method for Determining Air-Fuel Ratio of a Fluid Flow - A method for determining one or more fluid flow parameters for a fluid flowing within a pipe is provided. The fluid is a mixture of solid particles and gas. The method includes the steps of: a) providing a meter operable to determine the velocity of the fluid flow through the pipe, which meter is substantially insensitive to the particulate/gas mass ratio of the fluid flow; b) determining the velocity of the fluid flow within the pipe using the meter; and c) determining a particulate/gas mass ratio using a density value for the gas within the flow and the determined fluid flow velocity. | 12-30-2010 |
| 20110118998 | APPLICATIONS OF PUMP PERFORMANCE MONITORING - The present invention provides a processor or signal processing module that features one or more modules configured to receive an input signal containing information about the unsteady pressures or acoustic emissions caused by a medium flowing through a pump, and also configured to provide of an output signal containing information about the performance of the pump. The information about the performance of the pump may include information about pump performance monitoring by a slip flow measurement, about predicting impeller wear, about pump impeller cavitation monitoring, about pump monitoring through acoustic emissions, about pump leak detection, about pump efficiency monitoring and about positive displacement pump monitoring. | 05-19-2011 |
