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A. Thomas Look, North Reading, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100087358 | NOTCH mutations leading to increased receptor signaling - The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients. | 04-08-2010 |
| 20110054001 | CHK1 SUPPRESSES A CASPASE-2 APOPTOTIC RESPONSE TO DNA DAMAGE THAT BYPASSES P53, BCL-2 AND CASPASE-3 - The invention describes methods that are useful for treating cancer by administering a Chk1 inhibitor which can induce apoptosis in p53-defective cells when combined with a chemotherapy and/or radiotherapy. Methods for screening candidates for a Chk1 inhibitor-based cancer treatment regimen are also described. | 03-03-2011 |
| 20110166028 | METHODS FOR PREDICTING TREATMENT RESPONSE BASED ON THE EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS - The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step. | 07-07-2011 |
Douglas G. Look, Ithaca, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090100368 | METHOD AND APPARATUS FOR PROVIDING ACCESS TO AND WORKING WITH ARCHITECTURAL DRAWINGS ON THE INTERNET - A method, apparatus, and article of manufacture provide access to architectural documents in a network based on-line web based system. Servers that are accessible from the Internet maintain persistent multiple architectural documents of different media types. An online user is provided, from the servers via the Internet, a set of basic virtual design tools that have persistent properties and may be copied. The virtual design tools may also be utilized to work with the architectural documents. A workspace is also provided for viewing, accessing, and modifying the architectural documents. | 04-16-2009 |
Heather Look, Bloomington, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20120064874 | MOVIE MODE AND CONTENT AWARDING SYSTEM AND METHOD - A system and method is presented for awarding content to users of mobile devices for attending events, appearing at locations, or viewing audiovisual content. One embodiment also automatically alters the configuration of mobile devices, which is particularly useful in movie theaters. An application on the device recognizes an audible signal provided at the location or in the audiovisual content. The signal can also be used to unlock content. In this way, desired content is available only when the user has attended an event such as an event sponsored by the content creator. The content can relate to the event, and can be synchronized to the event. The signal can also trigger an application or unlock content at a store location. For example, a scavenger hunt can be guided by an application on the mobile device. | 03-15-2012 |
Jee Loon Look, Gaithersburg, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20110172393 | NOVEL FORMULATIONS WHICH STABILIZE AND INHIBIT PRECIPITATION OF IMMUNOGENIC COMPOSITIONS - The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like. | 07-14-2011 |
Jee Loon Look, Cary, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20080206281 | Method For Producing Storage Stable Viruses and Immunogenic Compositions Thereof - The invention relates to methods for producing storage stable virus compositions. In certain embodiments, the invention relates to one or more formulations and process steps which result in storage stable virus compositions, wherein the composition is storage stable as a lyophilized solid composition or a frozen liquid composition. | 08-28-2008 |
Kal Look, Oxford GB
| Patent application number | Description | Published |
|---|---|---|
| 20110024733 | POLYMERISABLE COMPOSITIONS AND ORGANIC LIGHT-EMITTING DEVICES CONTAINING THEM - Compositions of a mixture of a thiol material and a material that contains a reactive unsaturated carbon-carbon bond that can be polymerised to form a charge-transporting or luminescent film are described, as is an organic light-emitting diode (OLED) device comprising at least one such charge-transporting or emissive layer that has been formed by polymerising a thiol material and an ene material. The process for forming such an OLED, including the deposition of a layer of material comprising the polymerisable composition, from solution, exposing said layer to actinic radiation through a mask, and then optionally developing said film to form a photopatterned film, is also disclosed. | 02-03-2011 |
Lena Look, Mantorp SE
| Patent application number | Description | Published |
|---|---|---|
| 20110139546 | HYDRAULIC SYSTEM FOR DOUBLE STACKER INDUSTRIAL TRUCK - The invention relates to hydraulic system for an double stacker truck comprising a pump for providing hydraulic fluid to the hydraulic system and a first hydraulic lifting cylinder for moving a first load carriage and a second hydraulic lifting cylinder for moving a second load carriage of the truck, the hydraulic lifting system is characterized in a flow divider for dividing the flow of hydraulic fluid between the first and the second hydraulic cylinder and a first directional valve which is arranged open in a first direction for leading hydraulic fluid to the first lifting cylinder or to open in a second direction for leading hydraulic fluid to the second hydraulic cylinder. The invention also relates to a double stacker truck comprising a hydraulic system for moving the load carriages of the truck. | 06-16-2011 |
Michael Wai-Haung Look, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100081216 | METHOD AND DEVICE FOR RAPID PARALLEL MICROFLUIDIC MOLECULAR AFFINITY ASSAYS - Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume flowing through a single channel. | 04-01-2010 |
Sally A. Look, Spicewood, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20110206769 | ORAL ANTIDEPRESSANT FORMULATION WITH REDUCED EXCIPIENT LOAD - Provided are methods for reducing the excipient load of pharmaceutical formulations containing 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide as the active pharmaceutical ingredient, and compositions related thereto. In particular, provided is a pharmaceutical product comprising 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide and a stabilizer admixed throughout a solid-form unilamellar matrix, wherein the ratio of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin 10,10-dioxide to stabilizer ranges from about 2:3 to about 1:10, and related methods of forming the pharmaceutical product. | 08-25-2011 |
Thomas A. Look, North Reading, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110110925 | Compositions and Methods for the Treatment and Diagnosis of Cancer - Compositions and methods for the diagnosis and treatment of cancer, particularly T-ALL, are disclosed. | 05-12-2011 |