Loeffler
Bernd Michael Loeffler, Zug CH
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20100087485 | 4-AMINOPIPERIDINE DERIVATIVES - The present invention relates to compounds of the formula (I) | 04-08-2010 |
20100222340 | SUBSTITUTED PYRIDO [1,2-a] ISOQUINOLINE DERIVATIVES - The present invention relates to compounds of formula (I) | 09-02-2010 |
20120045509 | MODIFIED RELEASE COMPOSITIONS FOR DPP-IV INHIBITORS - The present invention refers to pharmaceutical composition comprising a DPP-IV inhibitor. | 02-23-2012 |
Bernhard Loeffler, Gleisdorf AT
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20090014819 | Micromechanical Component, Method for Fabrication and Use - A micromechanical component that can be produced in an integrated thin-film method is disclosed, which component can be produced and patterned on the surface of a substrate as multilayer construction. At least two metal layers that are separated from the substrate and with respect to one another by interlayers are provided for the multilayer construction. Electrically conductive connecting structures provide for an electrical contact of the metal layers among one another and with a circuit arrangement arranged in the substrate. The freely vibrating membrane that can be used for an inertia sensor, a microphone or an electrostatic switch can be provided with matching and passivation layers on all surfaces in order to improve its mechanical properties, said layers being concomitantly deposited and patterned during the layer producing process or during the construction of the multilayer construction. Titanium nitride layers are advantageously used for this. | 01-15-2009 |
20110117714 | Integration of Multiple Gate Oxides with Shallow Trench Isolation Methods to Minimize Divot Formation - A method of forming an isolation region is provided that in one embodiment substantially reduces divot formation. In one embodiment, the method includes providing a semiconductor substrate, forming a first pad dielectric layer on an upper surface of the semiconductor substrate and forming a trench through the first pad dielectric layer into the semiconductor substrate. In a following process sequence, the first pad dielectric layer is laterally etched to expose an upper surface of the semiconductor substrate that is adjacent the trench, and the trench is filled with a trench dielectric material, wherein the trench dielectric material extends atop the upper surface of the semiconductor substrate adjacent the trench and abuts the pad dielectric layer. | 05-19-2011 |
Jean-Philippe Loeffler, Berstett FR
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20120329767 | Methods and Compositions for Treating Cancer - The present invention relates to uses or methods for treating proliferative diseases, in particular cancer, implementing ruthenium compounds, as well as to composition containing same. | 12-27-2012 |
Joerg Loeffler, Schneisingen CH
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20080312736 | IMPLANT HAVING A SURFACE-PROXIMAL MAGNESIUM-CONTAINING DIFFUSION LAYER AND ASSOCIATED PRODUCTION METHOD - An implant comprising an implant material forming a base made of one or more metallic elements; a diffusion layer covering the base made of at least one of the metallic elements of the implant material and at least magnesium; and, optionally, a metal layer covering the diffusion layer made of magnesium or a biocorrodible magnesium alloy. | 12-18-2008 |
20090198320 | IMPLANT WITH A BASE BODY OF A BIOCORRODIBLE IRON ALLOY - An implant having a base body comprising entirely or in part a biocorrodible iron alloy wherein the base body of the implant comprises at least one of the following: (i) a biocorrodible iron alloy of formula (1): Fe—P where the amount of P in the alloy is from 0.01 to 5 wt %, and Fe plus impurities due to the production process account for the remainder of the alloy up to 100 wt %; or (ii) a biocorrodible iron alloy of the formula (2): Fe—Mn—X where the amount of Mn in the alloy is from 5 to 30 wt %, X stands for one or more elements selected from the group consisting of Pt, Pd, Ir, Rh, Re, Ru and Os, and the amount of X in the alloy is from 0 to 20 wt % and Fe plus impurities due to the production process account for the remainder of the alloy up to 100 wt %; or (iii) a biocorrodible iron alloy of formula (3): Fe-Z where Z is one or more elements selected from the group consisting of Pt, Ir and Os and the amount of Z in the alloy is from 5 to 30 wt %, and Fe plus impurities due to the production process account for the remainder of the alloy up to 100 wt %. | 08-06-2009 |
20110192500 | RESORBABLE MAGNESIUM ALLOY - A magnesium alloy shown includes magnesium as a principal ingredient, and 0.5 to 8.0 percent ytterbium; 0.1 to 2.0 percent calcium; and 0.2 to 6.0 percent zinc, percentages calculated by weight. The magnesium alloy may be employed as an implant. Examples of implants include a plate, specifically a bone plate, a screw, a nail, a bone nail, a stent, a rod. Implants made of the specified alloy are suitable for implantation in animal or human body. | 08-11-2011 |
Joerg Loeffler, Zurich CH
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20110311456 | MARKER ALLOY - A marker alloy foreign implant made of a biodegradable metallic material and having the composition MgxYbyMz wherein x is equal to 10-60 atomic percent; y is equal to 40-90 atomic percent; z is equal to 0-10 atomic percent; M is one or more element selected from the group consisting of Ag, Zn, Au, Ga, Pd, Pt, Al, Sn, Ca, Nd, Ba, Si, and Ge; and wherein x, y, and z, together, and including contaminants caused by production, result in 100 atomic percent. | 12-22-2011 |
Joerg Loeffler, Greifensee CH
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20140261911 | Magnesium Alloy With Adjustable Degradation Rate - An alloy and an implant having a three-dimensional structure based on such alloy. The alloy comprises a MgZnCa alloy containing nanosized precipitates being less noble than the Mg matrix alloy and having a Zn content ranging 0.1 wt. % Zn to 2 wt. % Zn and a calcium content ranging from 0.2 wt. % to 0.5 wt. %, and having less than 0.04 wt. % of one or more other elements with the remainder being Mg. For these micro-alloys, any second phase generated during the solidification process can be completely dissolved by a solution heat treatment. Finely dispersed nanosized precipitates can then be generated by a subsequent aging heat treatment step. These precipitates are used to “pin” the grain boundaries and to prevent the coarsening of the grain structure during further processing to achieve grain sizes below 5 μm. | 09-18-2014 |
20150080998 | MAGNESIUM-ALUMINUM-ZINC ALLOY, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF - A magnesium alloy and to a method for the production thereof and implants made thereof. The magnesium alloy includes up to 6.0% by weight Zn, and preferably 2.0 to 4.0% by weight Zn, 2.0 to 10.0% by weight Al, and preferably 3.0 to 6.0% by weight Al, where % by weight Al≧% by weight Zn shall apply, the remainder being magnesium containing impurities, which promote electrochemical potential differences and/or the formation of precipitations and/or intermetallic phases, in a total amount of no more than 0.0063% by weight of Fe, Si, Mn, Co, Ni, Cu, Zr, Y, Sc or rare earths having the ordinal numbers 21, 57 to 71 and 89 to 103, Be, Cd, In, Sn and/or Pb as well as P, and the matrix of the alloy is solid solution hardening due to Al and An and is also particle hardening due to the intermetallic phases formed of Mg and Al. | 03-19-2015 |
Joerg F. Loeffler, Zuerich CH
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20090291015 | MAGNESIUM-BASED ALLOY - The invention relates to a magnesium-based alloy and a semi-finished product produced therefrom with uniformly small grain size and high cold forming capability. In order to create a fine-grain billet from an ingot, the material of which is highly formable (deep-drawable) at increased temperature and at room temperature and has desirable corrosion properties, according to the invention a magnesium-based alloy (L | 11-26-2009 |
Markus Loeffler, Avon FR
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20090253778 | DNA composition against tumor stromal antigen FAP and methods of use thereof - A DNA composition effective for eliciting an immune response against tumor cells and tumor metastases comprising a DNA construct that encodes for at least one epitope of fibroblast activation protein (FAP), which is expressible in immune cells, and which is incorporated in a pharmaceutically acceptable carrier. The composition can encode a single epitope of FAP, a polypeptide comprising two or more epitopes of FAP, the entire FAP protein, or any portion thereof that will elicit the desired immune response. In one preferred embodiment, the composition also includes a DNA construct that encodes an immune effector protein, such as a cytokine. The DNA composition of the invention can be used alone or in combination with a chemotherapeutic agent to treat diseases such as tumors and tumor metastases. | 10-08-2009 |