Patent application number | Description | Published |
20090209945 | VALVELESS IMPEDANCE PUMP DRUG DELIVERY SYSTEMS - A drug-delivery unit suitable for implantation into a patient body may include a valveless impedance pump. In some implementations the unit may include an actuator, control electronics and a battery, and may communicate with an external patient interface unit. The patient interface unit can be used to control operation of the implant and to download data from the implant. The patient interface unit can also be used to charge the implant and/or a separate charger can be used. In other implementations, a drug-delivery implant unit may lack internal electronics and instead rely on an externally-supplied magnetic field to actuate the pump. | 08-20-2009 |
20100305551 | Valveless Impedance Pump Drug Delivery Systems - A drug-delivery unit suitable for implantation into a patient body may include a valveless impedance pump. In some implementations the unit may include an actuator, control electronics and a battery, and may communicate with an external patient interface unit. The patient interface unit can be used to control operation of the implant and to download data from the implant. The patient interface unit can also be used to charge the implant and/or a separate charger can be used. In other implementations, a drug-delivery implant unit may lack internal electronics and instead rely on an externally-supplied magnetic field to actuate the pump. | 12-02-2010 |
20110071493 | Flow-Induced Delivery from a Drug Mass - Drug solutions (or other combinations of vehicle with entrained drug) are prepared by removing drug from one or more masses of a solid form of the drug. The solid form of the drug may be sparingly soluble or insoluble in water. Examples of devices for holding solid drug and facilitating delivery of such drug to targeted regions are also described. | 03-24-2011 |
20110077579 | Cochlear implant with localized fluid transport - An apparatus for providing fluid communication with a cochlear lumen, the apparatus includes a delivery-tube configured for insertion into the cochlear lumen. Delivery-tube orifices on the delivery-tube provide fluid communication between a lumen defined by the delivery-tube and the cochlear lumen. | 03-31-2011 |
Patent application number | Description | Published |
20080255248 | Prodrug compounds with isoleucine - The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of making and using the compounds are also disclosed. | 10-16-2008 |
20090110753 | Enzyme-cleavable prodrug compounds - The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavable sequences within the conjugate and methods of treating patients with prodrugs of the invention. | 04-30-2009 |
20090175888 | METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE - The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention. | 07-09-2009 |