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Lo, MA
Agnes Lo, Boston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090068095 | CARBONIC ANHYDRASE IX (G250) ANITBODIES AND METHODS OF USE THEREOF - The invention provides scFv antibodies and monoclonal antibodies that bind to and decrease an activity of Carbonic Anhydrase IX (G250). Also provided are methods of treating and/or preventing cancer, such as renal clear cell cancer. Also provided are methods of identifying a carbonic anhydrase IX (G250) protein. The invention additionally provides methods of modifying immune effector cells, and the immune effector cells modified thereby. | 03-12-2009 |
Andrew W. Lo, Weston, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100287113 | System and process for managing beta-controlled porfolios - A computer system is selectively programmed to support one or more investment portfolios that have applied to them a counter balancing investment so as to achieve and maintain a target sensitivity to one or more broad market parameters through dynamic multi-beta hedging. The computer system is programmed to process input data relating to a portfolio's expected volatility based on its broad market exposures and the volatility of these broad markets, a target portfolio volatility, and historical volatility performance over a selected interval, and based thereon, modify the portfolio so as to achieve a future volatility corresponding to the selected target. | 11-11-2010 |
| 20100287115 | System and Process for Managing Beta-Controlled Portfolios - A computer system is selectively programmed to support one or more investment portfolios that have applied to them a counter balancing investment so as to achieve and maintain a target sensitivity to one or more broad market parameters through dynamic multi-beta hedging. The computer system is programmed to process input data relating to a portfolio's expected volatility based on its broad market exposures and the volatility of these broad markets, a target portfolio volatility, and historical volatility performance over a selected interval, and based thereon, modify the portfolio so as to achieve a future volatility corresponding to the selected target. | 11-11-2010 |
Andrew W. Lo, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090271332 | COMPUTER SYSTEM AND METHOD FOR GENERATING AND MAINTAINING A FINANCIAL BENCHMARK - A method for generating and maintaining a benchmark using a long/short investment strategy is disclosed herein. The method for generating and maintaining a benchmark using a long/short investment strategy may involve generating a benchmark by selecting a group of securities from a broad-base index; evaluating the securities included in a benchmark; and monthly rebalancing the benchmark using a long/short investment strategy. The method may also include determining the value of the index and publishing the value of the index as a benchmark for long/short investment portfolios. The value of the index may be determined periodically, daily, dynamically, or every 15 seconds. The securities included in the broad-base index may form a universe of eligible securities and be ranked monthly using the 10 Credit Suisse factors. Also disclosed herein are a method for generating and managing a passive long/short investment portfolio that closely correlates with a passive long/short benchmark, and a method of using a passive long/short benchmark to rebalance a portfolio. Also, a computer system for generating or maintaining a passive long/short benchmark, a computer program for generating or maintaining a passive long/short benchmark, a computer-readable medium storing a program configured to generate or maintain a passive long/short benchmark, and methods of using the same are disclosed herein. | 10-29-2009 |
Ching Kam Lo, Malden, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110201574 | FATTY ACID AMIDE HYDROLASE INHIBITORS - The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same. | 08-18-2011 |
Eng Lo, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110129526 | COMPOSITIONS AND METHODS FOR TREATING VASCULAR DISEASE - The use of tPA to treat hemorrhagic transformation, neurotoxicity has been limited to short treatment time windows because a high dose of tPA required to generate sufficient amounts of the enzyme plasmin for clot lysis. The present invention combines tPA with recombinant Annexin A2 resulting in thrombolysis without hemorrhagic transformation at delayed times after stroke. This embodiment allows the administration of a lower, non-neurotoxic, tPA dose. Our results suggest this novel combination for stroke therapy may greatly improve both efficacy and safety, and prolong tPA therapeutic time window. | 06-02-2011 |
Jason Lo, Westborough, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100259517 | Display System with Single Crystal Si Thin Film Transistors - A liquid crystal display comprises a display panel that includes at least one pixel transistor, at least one pixel electrode in electrical communication with the pixel transistor, at least one common electrode, and a liquid crystal material between the pixel electrode and the common electrode. The pixel transistor includes a thin film layer of essentially single crystal silicon that has a thickness in a range of between about 100 nm and about 200 nm. The pixel electrode has a thickness in a range of between about 5 nm and about 20 nm. The common electrode has a thickness of between about 50 nm and about 200 nm. | 10-14-2010 |
Kai-Ming Lo, Westford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110260727 | Shim insert for high-field MRI magnets - The present invention is a portable in-bore shim coil insert suitable for correcting high-degree and high-order magnetic field inhomogeneities over a limited examination zone in a magnetic resonance assembly operating above 3 T magnetic field strengths, wherein the magnetic resonance assembly includes at least a MRI magnet having an internal bore of known configuration and volume, at least one set of gradient coils, and an arrangement of radio frequency coils. The in-bore shim coil insert and corresponding method of use is able to produce higher degree and order shimming effects on-demand (i.e., the correction of at least some 3 | 10-27-2011 |
Lawrence Lo, Lexinton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110294930 | FLAME RETARDANT THERMOPLASTIC ELASTOMERS - The invention relates to a thermoplastic elastomer composition comprising a thermoplastic elastomer and a flame retardant, wherein the flame retardant comprises at least a compound selected from the group consisting of piperazine phosphate, piperazine pyrophosphate and piperazine polyphosphate, and a phosphoric acid compound. | 12-01-2011 |
Shi-Lung Lo, North Attleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080286315 | Methionine Enkephalin as an Adjuvant for Vaccine Immunizations - The present invention provides a method of stimulating dendritic cells, comprising contacting the dendritic cells with methionine enkephalin. The present invention also provides methods of enhancing an immune response to an antigen in a mammal. In a first method, dendritic cells are isolated from the mammal. The dendritic cells are then contacted with methionine enkephalin for a time sufficient to stimulate the cells. Next, the stimulated dendritic cells are contacted with the antigen of interest for a time sufficient for the cells to process the antigen. The dendritic cells are then injected into the mammal. The dendritic cells may be injected into the animal either on their own, or along with methionine enkephalin and/or the antigen. In a second method, the antigen of interest and methionine enkephalin are administered to the mammal. The present invention also provides compositions for administration to a mammalian subject having a tumor. | 11-20-2008 |
Shi-Lung Lo, Attleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100016209 | Methods of Reducing Side Effects in Cancer Therapy - The present invention provides a method of decreasing side effects in a human or animal cancer patient due to radiation therapy or chemotherapy. With this method, methionine enkephalin is administered to the patient at least one time per week for a first time period, where the first time period is at least three weeks. In one embodiment, the first time period is one or two months. Methionine enkephalin is then administered to the patient one time per month for a second time period, where the second time period is at least one month, and where the second time period is consecutive to the first time period. In one embodiment, the total term of methionine enkephalin treatment is at least six months. Methionine enkephalin may be administered to the patient at the same time as, before, or after administration of radiation or chemotherapy. | 01-21-2010 |
Tim Jia-Ching Lo, Medford, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20110171239 | pH INDUCED SILK GELS AND USES THEREOF - This invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may be reversibly converted back to liquid form by applying reverse voltage or may be converted further to β-sheet structure by applying shear force or other treatments. The electrogelated silk may be used as an extracted bulk gel, spray or stream of gel for processing into materials or devices, or may be used as silk gel coating to devices. Active agents may be embedded in the silk gel for various medical applications. This invention also provides for methods and compositions for preparing adhesive silk pH-gels. For example, the method comprises reducing pH level of a silk fibroin solution to increase the bulk or local proton concentration of the silk fibroin solution, thereby forming adhesive silk gels. | 07-14-2011 |
Whe-Yong Lo, North Attleboro, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20080317830 | Compositions and Methods for the Treatment of Wounds and Scar Tissue - Compositions for the treatment of wounds and/or scars are described herein. The compositions contain between 1 and up to 30% by weight, more preferably between 1 and 20%, most preferably between about 5 and 10% by weight particles, such as titanium dioxide or a similar material in a pharmaceutically acceptable base or carrier, such as petrolatum. The compositions are less greasy than petrolatum alone, and thus are more aesthetically pleasing. The compositions exhibit occlusive properties comparable to petrolatum. The compositions are absorbed into the skin, unlike petrolatum, and exhibit significant wound healing characteristics not observed with petrolatum alone. In one embodiment, the pharmaceutically acceptable base is petrolatum and the particles are titanium dioxide. The compositions can be used to treat complex, hard to heal wounds, such as diabetic ulcers; pressure sores, such as bed sores; lacerations; bite wounds; burns; penetrating wounds; surgical wounds, etc. The composition can also be used to promote normal healing of scar tissue. The compositions can also be used for the topical delivery of one or more active agent. The compositions can be used to reduce fine lines and wrinkles, and to rehydrate skin or to treat dry skin. | 12-25-2008 |
Yuen Y. Lo, Cambridge, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090125805 | METHODS FOR OBTAINING IMPROVED TEXT SIMILARITY MEASURES - The embodiments of the invention provide methods for obtaining improved text similarity measures. More specifically, a method of measuring similarity between at least two electronic documents begins by identifying similar terms between the electronic documents. This includes basing similarity between the similar terms on patterns, wherein the patterns can include word patterns, letter patterns, numeric patterns, and/or alphanumeric patterns. The identifying of the similar terms also includes identifying multiple pattern types between the electronic documents. Moreover, the basing of the similarity on patterns identifies terms within the electronic documents that are within a category of a hierarchy. Specifically, the identifying of the terms reviews a hierarchical data tree, wherein nodes of the tree represent terms within the electronic documents. Lower nodes of the tree have specific terms; and, wherein higher nodes of the tree have general terms. | 05-14-2009 |