Inventors list |
Assignees list |
Classification tree browser |
Top 100 Inventors |
Top 100 Assignees |
Liu, San Diego
Chang C. Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090286279 | Genetically programmed expression of selectively sulfated proteins in eubacteria - The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as | 11-19-2009 |
Chang-Jun Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090142471 | PLANT ISOFLAVONOID HYDROXYLASES AND METHODS OF USE THEREOF - The invention provides plant isoflavonoid hydroxylase coding sequences. Also provided are constructs comprising these sequences, plants transformed therewith and methods of use thereof. In certain aspects of the invention, plants transformed with the nucleic acids are provided exhibiting improved pest and disease resistance. Plants provided by the invention may also exhibit improved nutritional qualities. | 06-04-2009 |
Changlu Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100145007 | CHIMERIC PEPTIDE ANTAGONIST FOR GPCR135 OR GPCR142 - The chimeric polypeptide R3(BΔ23-27)R/I5 is described, which is a high-affinity antagonist for GPCR1 35 and GPCR1 42 over LGR7. | 06-10-2010 |
| 20110104711 | GPR81-Ligand complexes and their preparation and use - Complexes of GPR81 receptor components and ligand components, such as L-lactate or GHB, may be used as an assay reagent for screening for modulators of GPR81 receptor activity. | 05-05-2011 |
Ernan Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100323652 | SYSTEMS, METHODS, APPARATUS, AND COMPUTER-READABLE MEDIA FOR PHASE-BASED PROCESSING OF MULTICHANNEL SIGNAL - Phase-based processing of a multichannel signal, and applications including proximity detection, are disclosed. | 12-23-2010 |
Feng Song Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110114070 | Apparatus and method for controlling swirl in a ported, two-stroke, internal combustion engine - An apparatus and a method for controlling swirl of air in a ported, two-stroke internal combustion engine include deflecting air into the intake port of a ported cylinder by an array of vanes disposed around the cylinder's intake port. The angle of deflection establishes the swirl of air in the cylinder. Swirl is varied by changing the angular positions of the vanes under the control of a vane drive mechanism coupled to an actuator. A swirl control mechanization controls vane angular position in response to engine operating parameters. | 05-19-2011 |
Haitian Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080306053 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands. | 12-11-2008 |
| 20080306093 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands. | 12-11-2008 |
| 20110224155 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands. | 09-15-2011 |
| 20110230502 | MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH - The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands. | 09-22-2011 |
Hanghui Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090074894 | IDENTIFICATION OF BITTER RECEPTORS FOR HYDROLYZED SOY PROTEIN - The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1 or hT2R67 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al. | 03-19-2009 |
| 20120041078 | METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER - The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers. | 02-16-2012 |
Huizhu Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110020830 | DESIGN FOR RAPIDLY CLONING ONE OR MORE POLYPEPTIDE CHAINS INTO AN EXPRESSION SYSTEM - The present invention provides methods and compositions for the generation and identification of expression constructs that can be used to express sufficient levels of a polypeptide of interest. The compositions include a population of expression vectors, wherein members of the population have a type IIS restriction enzyme recognition site adjacent to a regulatory sequence, and wherein the regulatory element is distinct in at least two members of the population of expression vectors. In various embodiments, the expression vectors further comprise a polynucleotide sequence encoding a polypeptide of interest, wherein the polynucleotide encoding the polypeptide, the polynucleotide of the regulatory sequence, or both, are distinct in at least two members of the population. The compositions are useful for identifying a combination of coding sequences and/or regulatory elements useful for the heterologous expression of the polypeptide of interest. | 01-27-2011 |
Ian Ernan Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110264447 | SYSTEMS, METHODS, AND APPARATUS FOR SPEECH FEATURE DETECTION - Implementations and applications are disclosed for detection of a transition in a voice activity state of an audio signal, based on a change in energy that is consistent in time across a range of frequencies of the signal. | 10-27-2011 |
| 20110288860 | SYSTEMS, METHODS, APPARATUS, AND COMPUTER-READABLE MEDIA FOR PROCESSING OF SPEECH SIGNALS USING HEAD-MOUNTED MICROPHONE PAIR - A noise cancelling headset for voice communications contains a microphone at each of the user's ears and a voice microphone. The headset shares the use of the ear microphones for improving signal-to-noise ratio on both the transmit path and the receive path. | 11-24-2011 |
| 20120020485 | SYSTEMS, METHODS, APPARATUS, AND COMPUTER-READABLE MEDIA FOR MULTI-MICROPHONE LOCATION-SELECTIVE PROCESSING - A multi-microphone system performs location-selective processing of an acoustic signal, wherein source location is indicated by directions of arrival relative to microphone pairs at opposite sides of a midsagittal plane of a user's head. | 01-26-2012 |
Jiajing Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110047374 | METHOD AND APPARATUS FOR A CONFIGURABLE ONLINE PUBLIC KEY INFRASTRUCTURE (PKI) MANAGEMENT SYSTEM - A method and apparatus are provided for generating identity data to be provisioned in product devices that are a part of a project. The method includes establishing a template associated with each CA in a hierarchical chain of CAs having a root CA at a highest level in the chain and a signing CA at a lowest level in the chain. The template associated with the signing CA inherits mandatory attribute fields specified in the root CA and any intermediate CA in the hierarchical chain. The mandatory attribute fields are user-specifiable fields to be populated with PKI data. A configuration file is generated upon receipt of an order for digital certificates using PKI data provided by a user to populate the mandatory attribute fields of the template associated with the signing CA. The digital certificates requested in the order are generated using the PKI data in the configuration file. | 02-24-2011 |
| 20110197061 | CONFIGURABLE ONLINE PUBLIC KEY INFRASTRUCTURE (PKI) MANAGEMENT FRAMEWORK - A method and apparatus is provided for establishing a process for provisioning a digital certificate service delivered by a PKI system. The method includes receiving a request for a digital certificate service and receiving data specifying a project that includes at least one product to be provisioned with a digital certificate. Data specifying an identification of an owner organization of the project and at least one participant organization participating in the project is also received. Attributes with which PKI data to be included in the digital certificates is to comply is received from the owner organization. Based on the received data and attributes, an account is established for each of the organizations associated with the project through which users associated with each of the organizations can respectively request digital certificates for the at least one product in accordance with the attributes received from the owner organization. | 08-11-2011 |
Jiewen Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100103840 | Techniques for LDPC decoding - Briefly, in accordance with one embodiment of the invention, a device may dynamically select a frequency on which to communicate on a wireless local area network by determining which channels are available and which are unoccupied, for example using a received signal power level measurement. A linear folding algorithm may be used to select an available channel at a midpoint in a larger gap between occupied channels. In the event there are multiple larger gaps of the same size, the larger gap at the higher frequency may be selected. | 04-29-2010 |
Justin Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110162883 | CABLE ORGANIZATION ASSEMBLIES - Cable organization assemblies and methods of making said assemblies are provided herein. Preferred assemblies are directed to releasably coupling two or more audio wires to prevent entanglement. Headphones having two audio cables configured to zip together to prevent entanglement and subsequently zip apart are provided herein. | 07-07-2011 |
| 20120045084 | CABLE ORGANIZATION ASSEMBLIES - Cable assemblies comprising at least a first wire and a second wire are provided. The wires are enclosed, using injection molding, by a respective layer of thermo-resistant material. During the injection molding, the first wire and second wire are kept substantially straight so as to avoid kinks in at least one of the first wire and the second wire that can develop subsequent to the molding if a wire is not substantially straight. The tension associated with the first wire and the second wire is kept within a predetermined range or below a predetermined threshold. The predetermined range/threshold depends on a temperature associated with the injection molding. The injection molding can provide a zip structure over the wires such that the zip structure can be zipped-together and zipped-apart to prevent entanglement of the wires when used by a user. | 02-23-2012 |
Kelvin Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090074951 | SUBSTRATES HAVING THROUGH-HOLE VIAS AND METHOD OF MAKING SAME - A sensor assembly for sensors such as microfabricated resonant sensors is disclosed. The disclosed assembly provides improved performance of the sensors by providing a thermally insensitive environment and short pathways for signals to travel to processing components. Further, the assembly provide modular construction for the sensors and housing modules, thereby allowing replacement of the sensors at a lower cost. The assembly includes a sensor module including a sensor formed on a conductive substrate with a cavity formed on one surface. The substrate has conductive vias extending from the cavity to a second surface of the substrate. A housing assembly accommodates the sensor and includes a rigid housing, preferably made from a ceramic. An electronic component, such as an amplifier, is mounted on the rigid housing. The electronic component electrically engages the vias substantially at the second surface of the substrate. The electronic component receive signals from the sensor through the vias. The signals are then processed through an amplifier and a digital signal processor using a modified periodogram. | 03-19-2009 |
Nurrachman Chih Yeh Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120030268 | Randomized value generation - A data processing apparatus is provided for producing a randomized value. A cell in the data processing apparatus comprises a dielectric oxide layer and stress voltage circuitry is configured to apply a stress voltage across the dielectric oxide layer of the cell to cause an oxide breakdown process to occur. Oxide breakdown detection circuitry is configured to determine a current extent of the oxide breakdown process by measuring a response of the dielectric oxide layer to the stress voltage and randomized value determination circuitry is configured to determine a randomized value in dependence on the current extent of the oxide breakdown process. | 02-02-2012 |
Puwei Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110133344 | CURABLE RESIN COMPOSITIONS USEFUL AS UNDERFILL SEALANTS FOR USE WITH LOW-K DIELECTRIC-CONTAINING SEMICONDUCTOR DEVICES - This invention relates to thermosetting resin compositions useful for flip chip (“FC”) underfill sealant materials, where a semiconductor chip is mounted directly onto a circuit through solder electrical interconnections. Similarly, the compositions are useful for mounting onto a circuit board semiconductor devices, such as chip size or chip scale packages (“CSPs”), ball grid arrays (“BGAs”), land grid arrays (“LGAs”) and the like, each of which having a semiconductor chip, such as large scale integration (“LSI”), on a carrier substrate. | 06-09-2011 |
Puwwi Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120042990 | ORGANIC ACID- OR LATENT ORGANIC ACID-FUNCTIONALIZED POLYMER-COATED METAL POWDERS FOR SOLDER PASTES - The present invention relates to organic acid- or latent organic acid-functionalized polymer-coated metal powders, such as metal powders used as appropriate in the formation of solder alloys, spheres and pastes. | 02-23-2012 |
Que Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090137466 | Use of GLP-1, Exendin and Agonists Thereof To Delay or Prevent Cardiac Remodeling - The present invention relates generally to the novel use of cardioprotective incretin compounds (CICs) such as GLP-1 and exendin and agonists thereof, including analogs and derivatives to prevent, delay, attenuate, or ameliorate cardiac remodeling. The present invention relates to methods for using CICs for the treatment of conditions associated with cardiac remodeling. The present invention further relates to methods for using CICs for the reduction of the risk or severity of congestive heart failure. | 05-28-2009 |
| 20100029554 | Composition and Methods for Treatment of Congestive Heart Failure - Provided herein is the use of GLP-1 molecules or agonists and analogs thereof, and the use of exendin molecules or agonists and analogs thereof, including their derivatives and active fragments, for the prevention or treatment of congestive heart failure. Pharmaceutical compositions for use in the methods described herein are also disclosed. Further provided are compositions and methods for the treatment and/or prevention of diabetes mellitus, hyperglycemia, insulin resistance and obesity, and for the reduction of food intake and suppression of appetite of subjects. | 02-04-2010 |
Rong (lauren) Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100098120 | VERY HIGH POWER LASER CHAMBER OPTICAL IMPROVEMENTS - An aspect of the disclosed subject matter includes a method of reducing the laser absorption of a beam reverser prism consisting of at least one of the following: increasing a first distance between a first incident point and a chamfered corner, wherein the first incident point is on a first reflective surface of the prism and the chamfered corner is formed between the first reflective surface and a second reflective surface of the prism, wherein the chamfered corner has a chamfered surface; increasing a second distance between a second incident point and the chamfered corner, wherein the second incident point is on the second reflective surface of the prism; and increasing a reflectivity of the chamfered surface of the chamfered corner of the prism. A method of determining a prime cut for an optical component is also disclosed. A laser including at least one prime cut optical component is also disclosed. | 04-22-2010 |
Shizhong Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080298469 | BITRATE REDUCTION TECHNIQUES FOR IMAGE TRANSCODING - This disclosure describes techniques for encoding data to compress image data to a reduced size. The techniques may be particularly effective in transcoding an image to a reduced size for transmission. An encoding device may transcode an image to an acceptable file size using bitrate control techniques that affect the entire image uniformly to transcode the image. For example, the encoding device may modify one or more quantization tables as a function of the near linear relationship between bitrate (R) and the number of zero-valued quantized transform coefficients to reduce the file size uniformly over the entire image. Alternatively, or additionally, the encoding device may transcode the image using bitrate control techniques that affect only specific localized regions of the image. | 12-04-2008 |
| 20090202158 | ROTATIONAL TRANSCODING FOR JPEG OR OTHER CODING STANDARDS - This disclosure describes techniques for rotating an encoded image, such as an image encoded according to a JPEG standard. In one example, a method for rotating an encoded image comprising reordering minimum coded units (MCUs) of the encoded image according to a specified rotation of the encoded image, rotating image data within the MCUs according to the specified rotation, and generating a rotated version of the encoded image comprising the reordered MCUs and the rotated image data within the MCUs. | 08-13-2009 |
| 20100235421 | FAST DCT ALGORITHM FOR DSP WITH VLIW ARCHITECTURE - A single stage computation method to perform a discrete cosine transform operation is provided. The discrete cosine transform operation is performed by executing a plurality of very large instruction words (VLIW) using a digital signal processor. The plurality of very large instruction words includes a first number of multiplications and a second number of additions, where the first number of multiplications is greater than the second number of additions. | 09-16-2010 |
| 20100254617 | APPARATUS AND METHOD TO ROTATE AN IMAGE - Image processing systems and methods are disclosed. In a particular embodiment, a method is disclosed that includes receiving image data of an image. The image data includes a plurality of image blocks. The method further includes calculating a first differential DC value during a rotation operation of the image by comparing a first DC coefficient value of a first block of a first row of the image to a second DC coefficient value of a first block of a second row of the image. The method further includes storing the first differential DC value in a memory prior to completing the rotation operation. | 10-07-2010 |
Thomas Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100240983 | MULTI-PHASE PSEUDO-CONTINUOUS ARTERIAL SPIN LABELING - Techniques, systems and apparatus are described for magnetic resonance imaging. A magnetic resonance imaging (MRI) system comprises a scanner comprising a magnet, gradient coils and a radio frequency (RF) system to perform various operations. The scanner can apply a gradient field and a train of RF pulses comprising more than two phases to tag a target blood vessel, and acquire magnetic resonance signals based on the applied train of RF pulses to sample the more than two phases. The MRI system includes a data processing system in communication with the scanner to receive the acquired magnetic resonance signals and process the received magnetic resonance signal to generate images proportional to perfusion. | 09-23-2010 |
Vincent C. Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090154546 | Method and Apparatus for Determining a Transport Bit Rate for a MultiProgram Transport Stream - Method and apparatus for determining a transport bit rate for a multiprogram transport stream (MPTS) is described. In one example, a plurality of transport bit rates is computed for a respective plurality of programs in the MPTS. A highest transport bit rate and a lowest transport bit rate are selected from the plurality of transport bit rates. An average transport bit rate is computed from the highest transport bit rate and the lowest transport bit rate. The average transport bit rate is provided as an initial transport bit rate for the MPTS. Jitter in the MPTS may be compensated using the initial transport bit rate. | 06-18-2009 |
Wensen Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090116660 | In-Band Parametric Sound Generation System - Parametric sound reproduction in high-intensity audio signaling, for example in hailing and warning at relatively large distances, is disclosed in one example by producing a primary audio signal in the audio frequency range, and producing a secondary audio signal in the audio frequency range by modulation of the primary audio signal, wherein the primary signal is chosen to enable an improved effect, for example one of directional reproduction, exploiting greater sensitivity of human hearing, exploiting an efficient or maximum intensity frequency range of a transducer used to reproduce the audio signals, and another parameter effecting distance, intelligibility, or intensity of an audio signal. | 05-07-2009 |
Xinjun Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080261829 | ANTIBODY-BASED ARRAYS FOR DETECTING MULTIPLE SIGNAL TRANSDUCERS IN RARE CIRCULATING CELLS - The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies. | 10-23-2008 |
| 20100167945 | DRUG SELECTION FOR BREAST CANCER THERAPY USING ANTIBODY-BASED ARRAYS - The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments. | 07-01-2010 |
| 20110071042 | BIOMARKERS FOR DETERMINING SENSITIVITY OF BREAST CANCER CELLS TO HER2-TARGETED THERAPY - The present invention provides compositions and methods for detecting the expression and/or activation states of components of signal transduction pathways in cells such as tumor cells. Information on the expression and/or activation states of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments. | 03-24-2011 |
| 20110281748 | DRUG SELECTION FOR GASTRIC CANCER THERAPY USING ANTIBODY-BASED ARRAYS - The present invention provides methods for selecting a suitable anticancer therapy, and for identifying and predicting response for the treatment of a gastric cancer. | 11-17-2011 |
Xuejun P. Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110070185 | IDENTIFICATION OF ANTIGENIC PEPTIDES FROM MULTIPLE MYELOMA CELLS - Multiple myeloma (MM) is a clonal B cell malignancy and remains essentially incurable by conventional anti-tumor therapy. Patients with MM have a median survival of only three years. MM is characterized by proliferation and accumulation of mature plasma cells in the bone marrow (BM) leading to bone destruction, BM failure, anemia, and reduced immune function. The identification of MHC Class I, HLA-A2, associated peptides presented on multiple myeloma cells is an important step in developing immunotherapies for MM. Presented here are methods for creating activated T lymphocytes that are cytotoxic to both peptide loaded T2 target cells and multiple myeloma cell lines. | 03-24-2011 |
| 20120045466 | IDENTIFICATION OF ANTIGENIC PEPTIDES FROM MULTIPLE MYELOMA CELLS - Multiple myeloma (MM) is a clonal B cell malignancy and remains essentially incurable by conventional anti-tumor therapy. Patients with MM have a median survival of only three years. MM is characterized by proliferation and accumulation of mature plasma cells in the bone marrow (BM) leading to bone destruction, BM failure, anemia, and reduced immune function. The identification of MHC Class I, HLA-A2, associated peptides presented on multiple myeloma cells is an important step in developing immunotherapies for MM. Presented here are methods for creating activated T lymphocytes that are cytotoxic to both peptide loaded T2 target cells and multiple myeloma cell lines. | 02-23-2012 |
| 20120045829 | IDENTIFICATION OF ANTIGENIC PEPTIDES FROM MULTIPLE MYELOMA CELLS - Multiple myeloma (MM) is a clonal B cell malignancy and remains essentially incurable by conventional anti-tumor therapy. Patients with MM have a median survival of only three years. MM is characterized by proliferation and accumulation of mature plasma cells in the bone marrow (BM) leading to bone destruction, BM failure, anemia, and reduced immune function. The identification of MHC Class I, HLA-A2, associated peptides presented on multiple myeloma cells is an important step in developing immunotherapies for MM. Presented here are methods for creating activated T lymphocytes that are cytotoxic to both peptide loaded T2 target cells and multiple myeloma cell lines. | 02-23-2012 |
| 20120046645 | IDENTIFICATION OF ANTIGENIC PEPTIDES FROM MULTIPLE MYELOMA CELLS - Multiple myeloma (MM) is a clonal B cell malignancy and remains essentially incurable by conventional anti-tumor therapy. Patients with MM have a median survival of only three years. MM is characterized by proliferation and accumulation of mature plasma cells in the bone marrow (BM) leading to bone destruction, BM failure, anemia, and reduced immune function. The identification of MHC Class I, HLA-A2, associated peptides presented on multiple myeloma cells is an important step in developing immunotherapies for MM. Presented here are methods for creating activated T lymphocytes that are cytotoxic to both peptide loaded T2 target cells and multiple myeloma cell lines. | 02-23-2012 |
Yaguang Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100214596 | Routing Component Ready Commands - Commands from a central controller of a printing system are received at a first component of a printing system. The commands include component ready commands and non-component ready commands. The component ready commands are routed unaltered to a second component of the printing system. | 08-26-2010 |
| 20100214597 | SERVICE STATION - A service station for a print system includes a dedicated controller and a network interface configured to couple the service station to a central controller of the print system and to other components of the print system over a network. The dedicated controller is configured to allow the service station to perform a task in response to receiving a command indicative of the task over the network from the central controller of the print system without the central controller knowing the details of the task. | 08-26-2010 |
Yahua Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080207635 | Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders - The present invention provides compounds capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use. | 08-28-2008 |
| 20100144798 | Modulators of ATP-Binding Cassette Transporters - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 06-10-2010 |
| 20110003790 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS - The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof. | 01-06-2011 |
| 20110003798 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS - The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT*, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS or combinations thereof. | 01-06-2011 |
| 20110053897 | COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS - Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity. | 03-03-2011 |
Yingnan Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100008174 | Adaptive training and adjustment to changing capacitor values based upon age and usage behavior - An apparatus includes logic to determine a discharge drop of a capacitor and to adjust an enablement charge level of the capacitor according to the discharge drop. | 01-14-2010 |
| 20110249515 | DIMM Memory Module Reference Voltage Switching Circuit - A non-volatile memory module includes a volatile memory circuit and a reference voltage generator coupled to supply a reference voltage to the volatile memory circuit. The reference voltage provides a level by which the volatile memory and external devices may communicate reliably at high speeds. The reference voltage is applied to an external interface of the non-volatile memory module through an isolation circuit. A control circuit coupled to the isolation interface and to a circuit which is adapted to detect when the non-volatile memory module no longer draws power from an external source. | 10-13-2011 |
Yinyin Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110081053 | METHODS AND SYSTEMS FOR OCCLUSION TOLERANT FACE RECOGNITION - Certain embodiments of the present disclosure relate to a method for face recognition that is occlusion tolerant and scale/shift invariant based on a combination of hierarchical maximization and adaptive representation technique. | 04-07-2011 |
| 20110188757 | IMAGE RECOGNITION SYSTEM BASED ON CASCADED OVER-COMPLETE DICTIONARIES - Certain embodiments of the present disclosure relate to a technique for image reconstruction that employs cascaded over-complete dictionaries (i.e., collections of bases) for extracting features and building representations for images at different reconstruction levels. Each dictionary on a different reconstruction level can be learned and optimized for the purpose of capturing either generic or discriminative features. By finding sparse representations through the cascaded dictionaries, an image can be reconstructed and recognized. | 08-04-2011 |
Yu-Tsueng Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100086918 | Methods for High Sensitivity Detection of Genetic Polymorphisms - Multiplex PCR-based methods for detecting a variant polynucleotide having a nucleotide sequence differing from the wild-type nucleotide sequence of a nucleic acid molecule, wherein the variant polynucleotide is in a sample containing an excess of the wild-type nucleic acid molecule. The methods are particularly useful for detection of deletions from, or translocations and inversions in, genomic DNA. The susceptibility to, diagnosis of, and progression of a disease clinically related to the occurrence of such polymorphisms in an individual may also be confirmed and monitored using the multiplex PCR-based methods or by detecting RNA fusion transcripts in a sample that correspond to previously identified deletions, translocations or inversions in genomic DNA. | 04-08-2010 |
Zhaowei Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20120069344 | HIGH RESOLUTION STRUCTURED ILLUMINATION MICROSCOPY - Disclosed are systems, apparatus, methods and devices, including a method that includes generating two or more sequential surface plasmon interference patterns, at least one of the two or more sequential surface plasmon interference patterns being different from another of the two or more sequential surface plasmon interference patterns, and capturing respective images of a specimen resulting from the interference patterns. Also disclosed is a method that includes generating two or more sequential optical interference patterns, at least one of the two or more sequential optical interference patterns being different from another of the interference patterns, and removing from each of the generated interference patterns, using a beam stopper, a corresponding zero-order diffraction light component included in the respective generated patterns to obtain resultant corresponding two or more sequential optical interference patterns, directed at a specimen, with missing respective zero-order light components. | 03-22-2012 |
Zhengwei Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100050039 | HANDLING OF DISRUPTED SYNCHRONOUS HYBRID AUTOMATIC REPEAT REQUEST (HARQ) CYCLE AT SYSTEM TIME ROLLOVER - Certain aspects of the present disclosure propose techniques for avoiding a disruption in synchronous hybrid automatic repeat request operation at system time rollover. The techniques define the behavior of a system before and after the system frame number (SFN) rollover point to ensure a known relationship between a hybrid automatic repeat request (HARQ) process identification number and system time. | 02-25-2010 |
| 20110292823 | SOUNDING REFERENCE SIGNAL (SRS) IN HETEROGENEOUS NETWORK (HETNET) WITH TIME DIVISION MULTIPLEXING (TDM) PARTITIONING - Methods and apparatus for uplink (UL) radio link monitoring (RLM) in a Long Term Evolution (LTE) heterogeneous network (HetNet) with enhanced inter-cell interference coordination (eICIC) are described. Various options are presented in an effort to transmit a sounding reference signal (SRS) of a user equipment device (UE) served by a Node B in the HetNet, avoiding both interference from UL transmissions from other UEs being served by neighboring Node Bs and collisions with the UE's own channel quality information (CQI) or physical uplink shared channel (PUSCH), for example. | 12-01-2011 |
| 20110292917 | SYSTEM AND METHOD FOR TIMING ADJUSTMENT TO PROTECT CQI - Certain aspects of the present disclosure propose methods for protecting channel quality indicator (CQI) modulation symbols in a subframe (e.g., a localized frequency division multiplexing (LFDM) subframe). For some aspects, a timing adjustment method may be utilized to adjust time of a UE with respect to an eNodeB. The timing adjustment method may introduce a positive time offset to be used for reducing time mismatch between the UE and the eNodeB. In another aspect, a buffer may be used at the eNodeB to store symbols received by the eNodeB before removing the cyclic prefix information from the subframe. The eNodeB may use the stored symbols and an artificial time delay to ensure that the CQI information is protected. For some aspects, the CQI modulation symbols may not be located at the beginning of an LFDM symbol. | 12-01-2011 |
Zuosheng Liu, San Diego, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100029605 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 and TrkB kinases. | 02-04-2010 |
| 20100081656 | COMPOSITIONS AND METHODS FOR MODULATING C-KIT AND PDGFR RECEPTORS - The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof. | 04-01-2010 |
| 20100168182 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly TrkA, TrkB, TrkC, PDGFR and c-kit. | 07-01-2010 |
| 20100184765 | Protein Kinase Inhibitors and Methods for Using Thereof - The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of Alk, Abl, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, CSK, C-Src, EphB1, EphB2, EphB4, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRα, PDGFRβ, PKCα, SAPK2α, Src, SIK, Syk, Tie2 and TrkB kinases. | 07-22-2010 |
| 20110052578 | Compounds and Compositions as Protein Kinase Inhibitors - The present invention provides compounds of Formula I or II: | 03-03-2011 |
| 20110306625 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf. | 12-15-2011 |