Patent application number | Description | Published |
20100082776 | SYSTEM AND METHOD FOR STREAMING OF DYNAMIC WEATHER CONTENT TO THE DESKTOP - A method, system and program product for streaming of dynamic information content over an interactive media such as the Internet. The dynamic content, such as dynamic weather data, is collected from a plurality of collection sources such as geographically distributed local weather reporting stations. The data information can be relatively static or dynamic, constantly changing data. The dynamic content is stored in databases maintained on a direct access storage device at the dynamic content server. The selection of dynamic content to be transmitted to the end user client is based on a demographic profile that is completed at the time of end user client registration and which precedes delivery of any selected content in response to end user client requests. An application resident on the dynamic content server streams selected content simultaneously to a plurality of end user client devices for each end user client request. An application resident on each end user client device generates a plurality of processing threads for a series of independent commands, each of which is transmitted to the dynamic content server at specified preset intervals and generates a server-selected response. In a weather content collection and delivery embodiment, local, real-time weather data can be received continuously from thousands of weather reporting stations, and transmitted simultaneously by the weather content server to millions of end user desktop clients, with each user receiving current weather data that is generated from a nearby weather collection station. | 04-01-2010 |
20110040483 | Method and Apparatus for Detecting Lightning Activity - Described are methods and apparatuses, including computer program products, for detecting lightning activity. Waveform data indicative of lightning activity is received by a waveform sensor from one or more signal converters. The waveform data comprises a group of electromagnetic waveforms. The waveform data is filtered by a processor to remove noise frequencies. One or more uncompressed portions of the waveform data are transmitted to a processing server. Digital filter data based on the one or more uncompressed portions of waveform data are received from the processing server. One or more frequencies are removed from the waveform data based on the digital filter data. The waveform data is compressed. The compressing includes selecting one or more points on a waveform, wherein the one or more points are above a predetermined threshold. The compressing includes determining an inflection of the selected points based on a predefined algorithm. | 02-17-2011 |
20130009780 | PREDICTING THE POTENTIAL FOR SEVERE WEATHER - Methods and apparatuses, including computer program products, are described for predicting the potential for severe weather. Data associated with lightning activity is received by a computing device. A location, a movement speed, a movement direction, and a lightning rate of one or more cells of lightning activity are determined by the computing device based on the received data. The lightning rate is compared, by the computing device, to a threshold lightning rate. One or more geographical areas at risk are determined by the computing device based on the location, the movement speed and the movement direction of the one or more cells of lightning activity. An alert is issued by the computing device to one or more remote devices monitoring the geographical areas when the lightning exceeds a value of the threshold lightning rate. | 01-10-2013 |
20130345982 | Using Lightning Data to Generate Proxy Reflectivity Data - Methods, systems, and computer program products are described herein for generating proxy reflectivity data associated with lightning activity. A computing device receives data associated with lightning activity for one or more geographical areas. The computing device determines the logarithmic scale of the combined in-cloud and cloud-to-ground flash rate (dBR) for one or more grids of lightning activity based on the received data. The computing device generates proxy reflectivity data based on the dBR of the grids. | 12-26-2013 |
Patent application number | Description | Published |
20080209339 | PERSONALIZATION TECHNIQUES USING IMAGE CLOUDS - Systems and methods for personalization using image clouds to represent content. Image clouds can be used to identify initial user interest, present recommended content, present popular content, present search results, and present user profile information. Image clouds are interactive, allowing users to select images displayed in the image cloud, which can contribute to presenting more personalized content as well as updating a user's profile. | 08-28-2008 |
20080209340 | PEER-TO-PEER ACCESS OF PERSONALIZED PROFILES USING CONTENT INTERMEDIARY - A method for personalizing content for a particular user in a computing system comprising a user interface configured to display content. The method comprises identifying a content item accessed by a user, identifying features associated with the content item; using the features of the content item to identify one or more third party profiles that substantially match a content profile of the content item, and displaying a list of the identified third party profiles. | 08-28-2008 |
20080209349 | PERSONALIZATION TECHNIQUES USING IMAGE CLOUDS - Systems and methods for personalization using image clouds to represent content. Image clouds can be used to identify initial user interest, present recommended content, present popular content, present search results, and present user profile information. Image clouds are interactive, allowing users to select images displayed in the image cloud, which can contribute to presenting more personalized content as well as updating a user's profile. | 08-28-2008 |
20080209350 | ACTIVE AND PASSIVE PERSONALIZATION TECHNIQUES - A method for personalizing content for a particular user in a computing system comprising a user interface configured to display content. The method comprises identifying a long term profile having one or more features in a feature set and a long term level of importance associated with each term in the feature set, identifying a short term profile having one or more features in the feature set and a short term level of importance associated with each term in the feature set, identifying input related to the display of the one or more content items on the user interface, and using the input to modify the short term level of importance and the long term level of importance associated with each term in the feature set to form a modified user interest set. | 08-28-2008 |
20120089623 | ACTIVE AND PASSIVE PERSONALIZATION TECHNIQUES - A method for personalizing content for a particular user in a computing system comprising a user interface configured to display content. The method comprises identifying a long term profile having one or more features in a feature set and a long term level of importance associated with each term in the feature set, identifying a short term profile having one or more features in the feature set and a short term level of importance associated with each term in the feature set, identifying input related to the display of the one or more content items on the user interface, and using the input to modify the short term level of importance and the long term level of importance associated with each term in the feature set to form a modified user interest set. | 04-12-2012 |
20140108954 | PEER-TO-PEER ACCESS OF PERSONALIZED PROFILES USING CONTENT INTERMEDIARY - A method for personalizing content for a particular user in a computing system comprising a user interface configured to display content. The method comprises identifying a content item accessed by a user, identifying features associated with the content item; using the features of the content item to identify one or more third party profiles that substantially match a content profile of the content item, and displaying a list of the identified third party profiles. | 04-17-2014 |
Patent application number | Description | Published |
20110104474 | Solid polymer electrolyte composite membrane comprising a porous support and a solid polymer electrolyte including a dispersed reduced noble metal or noble metal oxide - A solid polymer electrolyte composite membrane and method of manufacturing the same. According to one embodiment, the composite membrane comprises a thin, rigid, dimensionally-stable, non-electrically-conducting support, the support having a plurality of cylindrical, straight-through pores extending perpendicularly between opposing top and bottom surfaces of the support. The pores are unevenly distributed, with some or no pores located along the periphery and more pores located centrally. The pores are completely filled with a solid polymer electrolyte, the solid polymer electrolyte including a dispersed reduced noble metal or noble metal oxide. The solid polymer electrolyte may also be deposited over the top and/or bottom surfaces of the support. | 05-05-2011 |
20110304964 | ELECTRICAL DEVICES CONTAINING CARBON NANOTUBE-INFUSED FIBERS AND METHODS FOR PRODUCTION THEREOF - Electrical devices having a plurality of stacked electrode layers are described. At least one of the electrode layers contains continuous fibers that are infused with carbon nanotubes. The continuous fibers can be disposed upon an electrically conductive base plate. The electrical devices can further contain an electrolyte contacting each electrode layer and a layer of separator material disposed between each electrode layer, in which case the electrical devices can form a supercapacitor. Such supercapacitors can have a capacitance of at least about 1 Farad/gram of continuous fibers. The capacitance can be increased by coating at least a portion of the infused carbon nanotubes with a material such as, for example, a conducting polymer, a main group metal compound, and/or a transition metal compound. Methods for producing the electrical devices are also described. | 12-15-2011 |
20120141880 | IONICALLY CONDUCTIVE POLYMERS, METHODS FOR PRODUCTION THEREOF AND ELECTRICAL DEVICES MADE THEREFROM - The electrical conductivity of ionically conductive polymers can be increased by polymerizing a mixture of a polymer precursor and an electrolyte in the presence of an electric field. Methods for making ionically conductive polymers can include providing a mixture containing an electrolyte and a polymer precursor, and polymerizing the polymer precursor while applying an electric field to the mixture. Ionically conductive polymers so prepared can be used in electrical devices. Methods for making electrical devices containing the ionically conductive polymers are also described. | 06-07-2012 |
20130095361 | HIGH SURFACE AREA FLOW BATTERY ELECTRODES - A flow cell battery includes at least one anode and at least one cathode, with a separator membrane disposed between each anode and each cathode. Each anode and cathode includes a bipolar plate and a carbon nanotube material positioned proximally at least one side of the bipolar plate. | 04-18-2013 |
20130143087 | CORE/SHELL STRUCTURED ELECTRODES FOR ENERGY STORAGE DEVICES - An energy storage device can include at least one electrode that comprise a plurality carbon nanostructure (CNS)-infused fibers in contact with an active material and an electrolyte. | 06-06-2013 |
20130236631 | RESISTANCE MEASUREMENT SYSTEM AND METHOD OF USING THE SAME - A quality control system for the manufacture of carbon nanostructure-laden substrates includes a resistance measurement module for continuously measuring resistance of the carbon nanostructure (CNS)-laden substrate. | 09-12-2013 |
20140065447 | HYBRID CAPACITOR-BATTERY AND SUPERCAPACITOR WITH ACTIVE BI-FUNCTIONAL ELECTROLYTE - An electrode includes a substrate having a carbon nanostructure (CNS) disposed thereon and a coating including an active material conformally disposed about the carbon nanostructure and the substrate. The electrode is used in a hybrid capacitor-battery having a bifunctional electrolyte capable of energy storage. | 03-06-2014 |
20140255746 | HIGH SURFACE AREA FLOW BATTERY ELECTRODES - A flow cell battery includes at least one anode compartment and at least one cathode compartment, with a separator membrane disposed between each anode compartment and each cathode compartment. Each anode compartment and cathode compartment includes a bipolar plate, a fluid electrolyte, and at least a carbon nanomaterial on the surface of the bipolar plate, wherein the fluid electrolyte flows around the carbon nanomaterial. | 09-11-2014 |
Patent application number | Description | Published |
20120111198 | Straight pore microfilter with efficient regeneration - A gas particulate filter well-suited for, but not limited to, removing airborne particulates from air. According to one embodiment, the filter is a composite structure including a porous support and an ionomer coating. The porous support is preferably made of a material designed to endow the filter with good mechanical properties. The pores of the porous support are preferably micron or smaller straight pores. The ionomer coating, which is applied to the porous support but does not completely seal the pores of the porous support, is preferably selected to provide the filter with good filtering properties and regeneration through controlled ionomer hydration/dehydration and corresponding ionomer swelling and contraction. | 05-10-2012 |
20140093728 | CARBON NANOSTRUCTURES AND METHODS OF MAKING THE SAME - A carbon nanostructure that is free of a growth substrate can include a plurality of carbon nanotubes that are branched, crosslinked, and share common walls with one another. The carbon nanostructure can be released from a growth substrate in the form of a flake material. Optionally, the carbon nanotubes of the carbon nanostructure can be coated, such as with a polymer, or a filler material can be present within the porosity of the carbon nanostructure. Methods for forming a carbon nanostructure that is free of a growth substrate can include providing a carbon nanostructure adhered to a growth substrate, and removing the carbon nanostructure from the growth substrate to form a carbon nanostructure that is free of the growth substrate. Various techniques can be used to affect removal of the carbon nanostructure from the growth substrate. Isolation of the carbon nanostructure can further employ various wet and/or dry separation techniques. | 04-03-2014 |
20140097146 | CARBON NANOSTRUCTURE SEPARATION MEMBRANES AND SEPARATION PROCESSES USING SAME - Carbon nanostructures can include a plurality of carbon nanotubes that are branched, crosslinked, and share common walls with one another, thereby defining a porous space having a tortuous path within the carbon nanostructures. The porous space can be used for sequestering a range of particulate sizes from various types of substances. Separation membranes can include a separation body having an effective pore size of about 1 micron or less and providing a tortuous path for passage of a substance therethrough. The separation body can include carbon nanostructures. | 04-10-2014 |
20140099493 | CARBON NANOSTRUCTURE LAYERS AND METHODS FOR MAKING THE SAME - A carbon nanostructure that is free of a growth substrate adhered to the carbon nanostructure can include a plurality of carbon nanotubes that are branched, crosslinked, and share common walls with one another. Carbon nanostructures can be agglomerated with one another and densified to form a carbon nanostructure layer in which at least a portion of the carbon nanotubes in each carbon nanostructure are aligned substantially parallel to one another. Methods for forming a carbon nanostructure layer can include providing a plurality of carbon nanostructures that are free of a growth substrate adhered to each carbon nanostructure, and forming a carbon nanostructure layer by depositing the carbon nanostructures on a surface. | 04-10-2014 |
20140151111 | CARBON NANOSTRUCTURE-COATED FIBERS OF LOW AREAL WEIGHT AND METHODS FOR PRODUCING THE SAME - Carbon nanostructures can convey enhanced electrical conductivity to various substrates, while maintaining a high surface area and low density per unit area. Such substrates can provide good shielding against electromagnetic radiation over a wide range of frequencies. Electrically conductive structures can include a support layer containing a plurality of fibers having apertures defined between the fibers, and a plurality of carbon nanostructures at least partially conformally coating the fibers and bridging across the apertures defined between adjacent fibers to form a continuous carbon nanostructure layer. Each carbon nanostructure can include a plurality of carbon nanotubes that are branched, crosslinked, and share common walls with one another. | 06-05-2014 |
Patent application number | Description | Published |
20140019635 | OPERATION AND ARCHITECTURE FOR DASH STREAMING CLIENTS - An adaptive HTTP streaming client may prevent network-level transcoding, may detect that transcoding takes place and implement a custom reaction, and/or may adopt rate estimation and stream switching logic, which may produce meaningful decisions in the presence of caching and transcoding operations in the network. A streaming client may use hash values of received segments, attributes of a received stream of content, and/or segment length checks of representations of segments to determine if the segments were transcoded. A streaming client may use random split range-based HTTP GET requests to deter transcoding. A streaming client may use split range-based HTTP GET requests to improve the accuracy of its bandwidth estimation. A streaming client may use any combination of the techniques described herein to detect transcoding, deter transcoding, adopt improved bandwidth and/or bitrate estimation, and adopt improved switching logic. | 01-16-2014 |
20140032714 | METHOD AND APPARATUS FOR PUBLISHING LOCATION INFORMATION FOR A CONTENT OBJECT - A method and apparatus are described for publishing location information for a content object. A content router (CR) may desire to publish location information for a content object and determine whether a utility function (e.g., popularity) of the content object is greater than a threshold. The CR may advertise the location information to a plurality of CRs on a condition that the utility function is greater than the threshold. Alternatively, the CR may provide the location information to a resolver as determined by a distributed hash table (DHT) scheme on a condition that the utility function is not greater than the threshold. The length of a name of the content object may be based on the popularity of the content object. Names of less popular content objects may be aggregated to reduce overhead. | 01-30-2014 |
20140036845 | CENTRALIZED CHANNEL SELECTION METHOD AND APPARATUS FOR WIRELESS NETWORKS IN A DENSE DEPLOYMENT ENVIRONMENT - A method and apparatus are described including scanning a channel, generating a report for the scanned channel, transmitting the channel report to an associated access point and receiving a channel assignment responsive to said channel report. Also described are a method and apparatus including scanning a channel, generating a first channel report, receiving a second channel report from an associated client, transmitting the first channel report and the second channel report to a server, receiving a channel assignment message from the server responsive to the first and second channel reports and transmitting the channel assignment message to the associated client. Further described are a method and apparatus including receiving a channel report from an associated access point, building an interference graph responsive to the channel report, determining channel assignments based on the interference graph and transmitting a channel assignment message to the associated access point. | 02-06-2014 |
20140115037 | METHOD AND APPARATUS FOR AUTOMATICALLY DISCOVERING AND RETRIEVING CONTENT BASED ON CONTENT IDENTITY - A method and apparatus for automatically discovering and retrieving content based on a content identity (ID) are disclosed. User agents and content control entities in the network interact for registering the content, discovering the content hosts and sources, and initiating and controlling the content session. A content name resolution handler (CNRH) is provided for mapping content IDs to network locations or addresses. Two or more content service provider networks may interconnect each other to discover and retrieve the content. A content request from a client device includes a content ID that uniquely identifies a content object. The content ID is resolved with a CNRH to obtain identity information of at least one content provider for serving the content request, and the content request is forwarded to the selected content provider. The content request may be routed to the selected content provider via IP multimedia subsystem (IMS) control plane entities. | 04-24-2014 |
20140173034 | CONTENT IDENTIFICATION, RETRIEVAL AND ROUTING IN THE INTERNET - A method and apparatus for content identification, retrieval, and routing in the Internet are provided. In the method and apparatus, content is uniquely identified using an object identifier (OID), and the OID is used for routing and retrieving content in an Internet network. Further, in the method and apparatus, OID summarization based on one or more OIDs may be performed, in which Bloom filters are applied to a portion of the one or more OIDs. Furthermore, hash functions may be applied to network node identities to determine location resolver nodes associated with content. | 06-19-2014 |
20140237078 | METHOD AND APPARATUS FOR MANAGING CONTENT STORAGE SUBSYSTEMS IN A COMMUNICATIONS NETWORK - A method and apparatus for managing content storage subsystems in a communications network are disclosed. The communications network is equipped with a plurality of content storage subsystems. The content storage subsystems store local copies of content to facilitate the delivery and distribution of the content to wireless transmit/receive units, WTRUs. The network, which is equipped with a proxy server and an entry server, receives requests for content or general-purpose data referencing content and determines whether the content is stored in the storage subsystems. In addition, the network also performs content ingestion in order to store copies of the content in the storage subsystems and content modification in order to move content from one storage location to another to achieve optimal content storage and distribution. | 08-21-2014 |
20140245359 | Content Delivery Network Interconnection (CDNI) Mechanism - Embodiments contemplate the movement of mobile node (MN) from a first access network to a second access network, while in communication with a CDN server (e.g. a surrogate providing a multimedia streaming session). The server selection may become sub-optimal as a result of this movement. A first CDN may learn about MN mobility event via the MN, an access network node, the server, or another node. The first CDN may trigger reselection by upstream CDN by sending a CDNI reselection request message, including information for the upstream CDN to perform request routing for the MN with the specified content, at a different location. The upstream CDN may perform the request routing procedure. The upstream CDN may return the request routing result to first CDN. The initial server may send a redirection message back to the application, which may interpret the message and continue streaming from a different server. | 08-28-2014 |
20140355411 | CELL DEPENDENT MULTI-GROUP HYBRID AUTOMATIC REPEAT METHOD FOR MULTICAST IN WIRELESS NETWORKS - A method and apparatus are described including determining address using an access point address and a multicast group address, transmitting a recovery request message to a recovery server to request recovery data using the address and receiving the recovery data from the recovery server. Also described are a method and apparatus including receiving a registration message, transmitting a reply to the registration message, receiving a recovery request message, transmitting recovery data responsive to the recovery request message and transmitting a message to a recovery multicast group to determine status of the recovery multicast group. | 12-04-2014 |
20150019649 | Peer to Peer (P2P) Operation by Integrating with Content Delivery Networks (CDN) - A method and apparatus for use in a network storage control peer (NSCP) supporting peer to peer (P2P) operation are disclosed. The method includes receiving a content map request message and transmitting a content map response message including an indication that a CDN-stored content piece is available from the NSCP; and, receiving a content fetch request message for the content piece and transmitting a response message including a redirection command and the CDN URI for the content piece. | 01-15-2015 |
20150026352 | METHOD AND SYSTEM FOR CDN EXCHANGE INTERCONNECTION - The disclosure pertains to CDNI interconnection at a global level. CDNXs are enhanced to provide logging services associated with bilateral or multilateral agreement with CDNs, where these CDNs are interconnected with other CDNs not using the same CDNX. Moreover, additional functions are added in CDNXs and CDN Interconnection protocols to support CDN capability advertisement, CDN peer discovery, and to bootstrap CDN Interconnection. | 01-22-2015 |
20150036528 | JOINT ASSOCIATION, ROUTING AND RATE ALLOCATION IN WIRELESS MULTI-HOP MESH NETWORKS - A method and apparatus are described including collecting network information, determining an association, bandwidth allocation and routing scheme based on the collected network information, notifying a mesh access point of the association, the bandwidth allocation and the routing scheme and notifying a client node of its association information. Also described are a method and apparatus including measuring link quality and channel conditions, reporting results of the measuring act to a controller, receiving a routing decision and data forwarding instructions from the controller and forwarding the routing decision and the data forwarding instructions to a client node. Further described are a method and apparatus including measuring link quality and channel conditions, reporting results of the measuring act to a controller, receiving association instructions from the centralized controller and updating previously stored association instructions with the received association instructions. | 02-05-2015 |
20150044989 | SPONSORING OF A MOBILE STATION SESSION BY ANOTHER MOBILE STATION IN A WIRELESS NETWORK - An apparatus and method are described for sponsoring service and preferential traffic handling, (i.e., data connectivity) by wireless transmit/receive units (WTRUs). A first WTRU may initiate user sponsoring of a second WTRU via an application server (AS). The first WTRU may receive a service trigger from the AS and forward the service trigger to the second WTRU. The second WTRU may then initiate a sponsored session with the AS using the service trigger in order to receive a service from the AS. The first WTRU may also request the AS to transfer a credit to the second WTRU. The AS may establish a direct communication link with a charging system including an online charging function (OCF) and a charging data function (CDF). The AS may send a request to a network to provide preferential traffic handling needed to deliver content to the second WTRU. | 02-12-2015 |
Patent application number | Description | Published |
20090203713 | Hedgehog pathway antagonists to treat disease - Compounds, compositions, kits and methods for modulating hedgehog pathway activity, and treating conditions related to abnormal or aberrant hedgehog pathway activity, are disclosed. | 08-13-2009 |
20100330148 | MEHODS AND COMPOSITIONS FOR INHIBITING IMPDH-1 ISOFORM 1 - Described herein are methods of inhibiting IMPDH type 1, and treating or preventing a disease or disorder (or symptoms thereof) associated with IMPDH type 1, wherein an IMPDH type 1 inhibitor compound is administered to a subject. | 12-30-2010 |
20100330156 | PHENAZINE DERIVATIVES AND USES THEREOF - The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. | 12-30-2010 |
20110124649 | INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS - Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject. | 05-26-2011 |
20110176998 | IMAGING AND THERAPY OF VIRUS-ASSOCIATED TUMORS - The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection. | 07-21-2011 |
20110262517 | CHIRALLY PURE ISOMERS OF ITRACONAZOLE AND INHIBITORS OF LANOSTEROL 14A-DEMETHYLASE FOR USE AS ANGIOGENESIS INHIBITORS - Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject. | 10-27-2011 |
20110301163 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS - Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1 and/or angiogenesis, wherein a compound of the invention is administered to a subject. | 12-08-2011 |
20120196852 | INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS - The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using various naphthoquinone, hydroxyquinonline, and naphthothiazole compounds. | 08-02-2012 |
20140221393 | Itraconazole Analogs and Use Thereof - Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs. | 08-07-2014 |
Patent application number | Description | Published |
20100118300 | CYLINDRICAL ILLUMINATION CONFOCAL SPECTROSCOPY SYSTEM - A cylindrical illumination confocal spectroscopy system has a fluidic device having a fluid channel defined therein, an objective lens unit arranged proximate the fluidic device, an illumination system in optical communication with the objective lens unit to provide light to illuminate a sample through the objective lens unit, and a detection system in optical communication with the objective lens unit to receive at least a portion of light that passes through the objective lens unit from the sample. The illumination system includes a beam-shaping lens unit constructed and arranged to provide a substantially planar illumination beam that subtends across, and is longer than, a lateral dimension of the fluid channel, the substantially planar illumination beam having a diffraction limited thickness in a direction substantially orthogonal to the lateral dimension of the fluid channel. The substantially planar illumination beam incident upon the fluidic device has a width that is substantially longer than the lateral dimension of the fluid channel such that the substantially planar illumination beam has an illumination intensity that is uniform across the lateral dimension of the fluid channel to within ±10%. The detection system comprises an aperture stop defining a substantially rectangular aperture having a longitudinal dimension and a transverse dimension. The aperture stop is arranged so that the substantially rectangular aperture is confocal with an illuminated portion of the fluid channel such that the transverse dimension of the substantially rectangular aperture substantially subtends the lateral dimension of the fluid channel without extending substantially beyond the fluid channel and allows light to pass from only a uniform excitation region while occluding light from outside the uniform excitation region, and the lateral dimension of the substantially rectangular aperture substantially matches the diffraction limited thickness of the planar illumination beam. | 05-13-2010 |
20110171741 | DNA INTEGRITY ASSAY (DIA) FOR CANCER DIAGNOSTICS, USING CONFOCAL FLUORESCENCE SPECTROSCOPY - The present invention relates, e.g., to a method for determining the size distribution of DNA molecules in a sample comprising cell-free nucleic acid, comprising labeling the DNA with a fluorescent dye in a stoichiometric manner, subjecting the DNA to molecular spectroscopy (e.g., cylindrical illumination confocal spectroscopy), analyzing suitable fluorescent burst parameters of the labeled DNA, and conducting single molecule DNA integrity analysis of the labeled DNA molecules in the sample. In one embodiment of the invention, the method is used as a diagnostic method for detecting cancer. | 07-14-2011 |
20110287976 | MICROFLUIDIC SOLUTION FOR HIGH-THROUGHPUT, DROPLET-BASED SINGLE MOLECULE ANALYSIS WITH LOW REAGENT CONSUMPTION - A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region. | 11-24-2011 |
20120135874 | SINGLE MOLECULE SPECTROSCOPY FOR ANALYSIS OF CELL-FREE NUCLEIC ACID BIOMARKERS - The present invention relates, e.g., to a method for detecting a nucleic acid molecule of interest in a sample comprising cell-free nucleic acids, comprising fluorescently labeling the nucleic acid molecule of interest, by specifically binding a fluorescently labeled nanosensor or probe to the nucleic acid of interest, or by enzymatically incorporating a fluorescent probe or dye into the nucleic acid of interest, illuminating the fluorescently labeled nucleic acid molecule, causing it to emit fluorescent light, and measuring the level of fluorescence by single molecule spectroscopy, wherein the detection of a fluorescent signal is indicative of the presence of the nucleic acid of interest in the sample. | 05-31-2012 |
20140106462 | MICROFLUIDIC SYSTEM FOR HIGH-THROUGHPUT, DROPLET-BASED SINGLE MOLECULE ANALYSIS WITH LOW REAGENT CONSUMPTION - A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region. | 04-17-2014 |
20150031573 | MIRNA ANALYSIS METHODS - The present invention provides a PCR-free, multiplexed ligation assay for miRNA expression analysis that produces highly quantitative, 10-100 plex miRNA profiling in a single reaction. The inventive methods use a 2-step ligation assay to generate an array of miRNA specific ligation products that can be decoded and quantified by a size discrimination method such as gel electrophoresis or single molecule separation. One embodiment is a low-cost assay that can be performed using standard tools available in nearly all molecular biology laboratories. This assay requires nothing more than a gel apparatus and reader for detection. Other embodiments include use of magnetic beads and other size exclusion apparatus which give increasingly higher sensitivity, lower sample consumption, and reduced processing steps. | 01-29-2015 |
Patent application number | Description | Published |
20110195068 | PD-1 ANTAGONISTS AND METHODS OF USE THEREOF - Compositions and methods for enhancing and/or prolonging the activation of T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) or overcoming T cell exhaustion and/or anergy are provided. Suitable compositions include PD-1 receptor antagonists that bind to and block the endogenous PD-1 receptor without triggering inhibitory signals from PD-1, or bind to and block PD-1 receptor ligands and preventing them from interacting with PD-1 receptors. Methods for using the PD-1 receptor antagonists to enhance immune responses in subjects in need thereof are provided. | 08-11-2011 |
20120114648 | COMPOSITIONS OF PD-1 ANTAGONISTS AND METHODS OF USE - Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed. | 05-10-2012 |
20120114649 | COMPOSITIONS OF PD-1 ANTAGONISTS AND METHODS OF USE - Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed. | 05-10-2012 |
20120177645 | METHODS AND COMPOSITIONS FOR THE INHIBITION OF TRANSPLANT REJECTION - Methods for modulating immune responses in a subject are provided. A preferred embodiment provides methods and compositions for reducing or inhibiting transplant rejection in a subject, preferably a human subject. Transplant rejection can be inhibited or reduced in a subject by administering an effective amount of B7-H4 polypeptide, fragments or fusions thereof to inhibit or reduce the biological activity of an immune cell or to reduce the amounts of proinflammatory molecules at a site of transplant. Th1, Th17 and Th22 cells are exemplary T cells that can be targeted for inhibition by B7-H4 polypeptides, fusion proteins or fragments thereof to inhibit or reduce inflammation. | 07-12-2012 |
20120276095 | B7-H4 FUSION PROTEINS AND METHODS OF USE THEREOF - Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1β, TNF-α, TGF-beta, IFN-γ, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof. | 11-01-2012 |
20130230514 | COMPOSITIONS OF PD-1 ANTAGONISTS AND METHODS OF USE - Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed. | 09-05-2013 |
20140044738 | Antibodies And Other Molecules That Bind B7-H1 And PD-1 - The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to B7-H1 or PD-1. In some embodiments such molecules are additionally capable of modulating the ability of B7-H1 or B7-DC to bind to PD-1 or are capable of affecting the signaling activity of the B7-H1 or PD-1. The invention additionally concerns the uses of such molecules in the diagnosis and treatment of cancer and other diseases. | 02-13-2014 |
20140356364 | Anti-B7-H4 Antibodies and Their Uses - The present invention relates to antibodies (including anti-B7-H4 antibodies) and their antigen-binding fragments and to other molecules (including fusion proteins that bind to the cognate antigen/receptor, etc.) that are capable of immunospecifically binding to B7-H4 and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases. The invention particularly concerns the use of such molecules to retard or prevent tumor growth, inhibit tumor-mediated suppression, eliminate tumors and/or deplete or block the activity of tumor associated macrophages (“TAMs”) so as to alter their activity and/or decrease TAM—mediated immune suppression. | 12-04-2014 |
Patent application number | Description | Published |
20120283516 | DARK FIELD ENDOSCOPIC MICROSCOPE - A dark field endoscopic microscope includes an illumination system, an objective lens unit arranged in an optical path of the illumination system, an optical fiber bundle optically coupled to the objective lens unit, and an observation system arranged in an optical return path from the optical fiber bundle. The illumination system provides oblique off-axial illumination while axial rays are at least attenuated. | 11-08-2012 |
20130128267 | AUTOMATIC CALIBRATION OF FOURIER-DOMAIN OPTICAL COHERENCE TOMOGRAPHY SYSTEMS - A method for calibrating a Fourier domain optical coherence tomography system includes receiving spectral data from an optical detector comprising a linear array of detector elements, each detector element having a position labeled n, wherein detected light was wavelength-dispersed across the linear array of detector elements; determining parameters of a preselected functional relationship between wave number, kn, corresponding to detector element n as a function of optical detector element n based on the spectral data; further receiving subsequent spectral data subsequent to the first-mentioned receiving, wherein detected light was wavelength-dispersed across the linear array of detector elements; converting the subsequent spectral data using the preselected functional relationship between wave number kn and optical detector element n to obtain converted spectral data; and performing an inverse Fourier transform of the converted spectral data to obtain a depth profile. | 05-23-2013 |
20130188196 | LATERAL DISTORTION CORRECTED OPTICAL COHERENCE TOMOGRAPHY SYSTEM - A lateral-distortion corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system and receive the detection signals. The data processing system can be configured to assemble an image corresponding to a scanning path by constructing a plurality of A-scans from the detection signals, determining displacement information from the plurality of A-scans, and arranging the plurality of A-scans according to the displacement information. | 07-25-2013 |
20130190734 | INTERFEROMETRIC FORCE SENSOR FOR SURGICAL INSTRUMENTS - A surgical tool system according to an embodiment of the current invention includes a surgical tool, and an interferometry system optically coupled to the surgical tool. The surgical tool includes a body section, a sensor section at least one of attached to or integral with the body section, and a surgical section at least one of attached to or integral with the sensor section at an opposing end of the sensor section from the body section. The sensor section comprises an interferometric optical sensor defining a reference distance that changes in response to at least one of a force or a torque when applied to the surgical section of the surgical tool. | 07-25-2013 |
20140160462 | SYSTEM AND METHOD FOR ASSESSING THE FLOW OF A FLUID - A system for assessing the flow of a fluid. The system can include a light source, a fiber-optic system optically coupled to the light source, which is arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to communicate with the optical detection system to receive the detection signals. The data processing system can be configured to use the detection signals to determine a speckle pattern corresponding to the fluid flow, wherein the speckle pattern includes a plurality of lines, and to calculate a correlation between adjacent lines perpendicular to the flow to determine at least one of a rate of the flow and a displacement of the flow. | 06-12-2014 |
20140160484 | DISTORTION CORRECTED OPTICAL COHERENCE TOMOGRAPHY SYSTEM - An axial motion distortion-corrected optical coherence tomography system. The system can include an optical coherence tomography sensor, a light source, a fiber-optic system arranged to provide a reference beam and an observation beam, an optical detection system arranged to receive combined light from the reference beam and the observation beam and to provide detection signals, and a data processing system arranged to receive said detection signals, construct a plurality of A-scans from said detection signals, and construct one or more images from said plurality of A-scans. The data processing system can be configured to correct distortion in the images caused by net axial motion of at least one of said optical coherence tomography sensor or a target of said optical coherence tomography sensor by calculating an estimate of the net axial motion using Doppler shift, and then shifting the A-scans according to the estimate. | 06-12-2014 |
20140160485 | DURABLE SINGLE MODE FIBER PROBE WITH OPTIMIZED REFERENCE REFLECTIVITY - A probe for a common path optical coherence tomography system includes a sheath having a proximal end and a distal end and defining a lumen therein, a single mode optical fiber disposed within the lumen of the sheath such that a portion of the single mode optical fiber extends beyond the distal end of the sheath. The single mode optical fiber has an end face for transmitting and receiving light. The probe also includes a layer of hardened epoxy encasing the portion of the single mode optical fiber that extends beyond the distal end of the sheath except for the end face. The single mode optical fiber has an optical axis extending along a longitudinal direction of the single mode optical fiber. The hardened epoxy is polished at a non-orthogonal angle relative to the optical axis at the end face. | 06-12-2014 |
Patent application number | Description | Published |
20100160372 | TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA antagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 06-24-2010 |
20100184803 | Treatment of Lysosomal Storage Diseases - Methods and compositions useful in the treatment or prevention of lysosomal storage diseases, such as Pompe's disease, Fabry's disease, Gaucher's disease, and Niemann-Pick disease, are provided. The treatment includes administering to a subject a farnesyl transferase inhibitor compound. The treatment may also include enzyme replacement therapy or gene therapy. | 07-22-2010 |
20100331363 | TREATMENT OF MITOCHONDRIAL DISORDERS USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject an amount of a farnesyl transferase inhibitor, wherein the amount administered is sufficient to cause an improvement in mitochondrial health in said subject. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 12-30-2010 |
20110060005 | TREATMENT OF MITOCHONDRIAL DISORDERS USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies and mitochondrial disorders are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject an amount of a farnesyl transferase inhibitor, wherein the amount administered is sufficient to stimulate mitophagy in said subject. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 03-10-2011 |
20110294794 | TREATMENT OF PROTEINOPATHIES USING A FARNESYL TRANSFERASE INHIBITOR - Methods and pharmaceutical compositions comprising a low dose of a farnesyl transferase inhibitor useful in the treatment of proteinopathies are provided. These low doses are below the doses used in oncological treatments for which these compounds were initially designed. The treatment includes administering to a subject in need thereof a therapeutically effective amount of a farnesyl transferase inhibitor, wherein the amount is effective to inhibit the farnesylation of a non-Ras FTase substrate involved in the autophagy pathway without substantially affecting the farnesylation of Ras or other oncology related substrates. Treatments in accordance with the present invention may also include an acetylcholinesterase inhibitor, an activator of neurotrophic receptors, an NMDA anatagonist, an amyloid deposit inhibitor, an antipsychotic agent, an antidepressant, an anxiolytic, or an antioxidant. | 12-01-2011 |